Drug–Drug Interaction Studies: Regulatory Guidance and An Industry Perspective von Prueksaritanont, Thomayant, Chu, Xiaoyan, Gibson, Christopher, Cui, Donghui, Yee, Ka Lai, Ballard, Jeanine, Cabalu, Tamara, Hochman, Jerome

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Predicted serotype-specific effectiveness of pneumococcal conjugate vaccines V114 and PCV20 against invasive pneumococcal disease in children von Ryman, Josiah, Sachs, Jeffrey R, Yee, Ka Lai, Banniettis, Natalie, Weaver, Jessica, Weiss, Thomas

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Adhesive Dynamics Simulation of Neutrophil Arrest with Deterministic Activation von Krasik, Ellen F., Yee, Ka Lai, Hammer, Daniel A.

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Development of In Vitro–In Vivo Correlation for Amorphous Solid Dispersion Immediate-Release Suvorexant Tablets and Application to Clinically Relevant Dissolution Specifications an... von Kesisoglou, Filippos, Hermans, Andre, Neu, Colleen, Yee, Ka Lai, Palcza, John, Miller, Jessica

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Multiple Doses of Rifabutin Reduce Exposure of Doravirine in Healthy Subjects von Khalilieh, Sauzanne G., Yee, Ka Lai, Sanchez, Rosa I., Liu, Rachel, Fan, Li, Martell, Maureen, Jordan, Heather, Iwamoto, Marian

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Effects of suvorexant, an orexin receptor antagonist, on sleep parameters as measured by polysomnography in healthy men von Sun, Hong, Kennedy, William P, Wilbraham, Darren, Lewis, Nicole, Calder, Nicole, Li, Xiaodong, Ma, Junshui, Yee, Ka Lai, Ermlich, Susan, Mangin, Eric, Lines, Christopher, Rosen, Laura, Chodakewitz, Jeffrey, Murphy, Gail M

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PBPK-PD modeling for the preclinical development and clinical translation of tau antibodies for Alzheimer's disease von Bloomingdale, Peter, Bumbaca-Yadav, Daniela, Sugam, Jonathan, Grauer, Steve, Smith, Brad, Antonenko, Svetlana, Judo, Michael, Azadi, Glareh, Yee, Ka Lai

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Results of a Doravirine-Atorvastatin Drug-Drug Interaction Study von Khalilieh, Sauzanne, Yee, Ka Lai, Sanchez, Rosa I, Triantafyllou, Ilias, Fan, Li, Maklad, Noha, Jordan, Heather, Martell, Maureen, Iwamoto, Marian

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A time-to-event analysis of the exposure–response relationship for bezlotoxumab concentrations and CDI recurrence von Yee, Ka Lai, Kleijn, Huub Jan, Zajic, Stefan, Dorr, Mary Beth, Wrishko, Rebecca E.

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A Study to Evaluate Doravirine Pharmacokinetics When Coadministered With Acid‐Reducing Agents von Khalilieh, Sauzanne G., Yee, Ka Lai, Sanchez, Rosa I., Fan, Li, Vaynshteyn, Kate, Deschamps, Kathleen, Martell, Maureen, Jordan, Heather R., Iwamoto, Marian

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Physiologically Based Pharmacokinetic Modeling of Doravirine and Its Major Metabolite to Support Dose Adjustment With Rifabutin von Yee, Ka Lai, Cabalu, Tamara D., Kuo, Yuhsin, Fillgrove, Kerry L., Liu, Yang, Triantafyllou, Ilias, McClain, Sasha, Dreyer, Daniel, Wenning, Larissa, Stoch, S. Aubrey, Iwamoto, Marian, Sanchez, Rosa I., Khalilieh, Sauzanne G.

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Orexin 2 Receptor Antagonism is Sufficient to Promote NREM and REM Sleep from Mouse to Man von Gotter, Anthony L., Forman, Mark S., Harrell, Charles M., Stevens, Joanne, Svetnik, Vladimir, Yee, Ka Lai, Li, Xiaodong, Roecker, Anthony J., Fox, Steven V., Tannenbaum, Pamela L., Garson, Susan L., Lepeleire, Inge De, Calder, Nicole, Rosen, Laura, Struyk, Arie, Coleman, Paul J., Herring, W. Joseph, Renger, John J., Winrow, Christopher J.

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Safety, Tolerability, and Pharmacokinetics of Suvorexant: A Randomized Rising-Dose Trial in Healthy Men von Yee, Ka Lai, McCrea, Jacqueline, Panebianco, Deborah, Liu, Wen, Lewis, Nicole, Cabalu, Tamara, Ramael, Steven, Wrishko, Rebecca E.

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Pharmacokinetics, safety and tolerability of long‐acting parenteral intramuscular injection formulations of doravirine von Yee, Ka Lai, Mittal, Sachin, Fan, Li, Triantafyllou, Ilias, Dockendorf, Marissa F., Fackler, Paul H., Stoch, S. Aubrey, Khalilieh, Sauzanne G., Iwamoto, Marian

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The duration of sleep promoting efficacy by dual orexin receptor antagonists is dependent upon receptor occupancy threshold von Gotter, Anthony L, Winrow, Christopher J, Brunner, Joseph, Garson, Susan L, Fox, Steven V, Binns, Jacquelyn, Harrell, Charles M, Cui, Donghui, Yee, Ka Lai, Stiteler, Mark, Stevens, Joanne, Savitz, Alan, Tannenbaum, Pamela L, Tye, Spencer J, McDonald, Terrence, Yao, Leon, Kuduk, Scott D, Uslaner, Jason, Coleman, Paul J, Renger, John J

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Comparative Bioavailability of Oral Granule Formulations of the HIV Antiretroviral Drugs Doravirine, Lamivudine, and Tenofovir Disoproxil Fumarate von Yee, Ka Lai, DiBenedetto, Adrienne, Fan, Li, Khalilieh, Sauzanne, Triantafyllou, Ilias, Vallee, Marie-Helene, Fackler, Paul, Stoch, S. Aubrey, Iwamoto, Marian

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Population Pharmacokinetic and Pharmacodynamic Analysis To Evaluate a Switch to Doravirine/Lamivudine/Tenofovir Disoproxil Fumarate in People Living with HIV-1 von Vaddady, Pavan, Kandala, Bhargava, Yee, Ka Lai

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Coproporphyrin I as an endogenous biomarker to detect reduced OATP1B activity and shift in elimination route in chronic kidney disease von Takita, Hiroyuki, Scotcher, Daniel, Chu, Xiaoyan, Yee, Ka Lai, Ogungbenro, Kayode, Galetin, Aleksandra

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Clinical Pharmacokinetics of the Novel HIV-1 Non-Nucleoside Reverse Transcriptase Inhibitor Doravirine: An Assessment of the Effect of Patient Characteristics and Drug–Drug Interac... von Khalilieh, Sauzanne, Yee, Ka Lai, Sanchez, Rosa, Stoch, S. Aubrey, Wenning, Larissa, Iwamoto, Marian

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Doravirine and the Potential for CYP3A-Mediated Drug-Drug Interactions von Khalilieh, Sauzanne G, Yee, Ka Lai, Sanchez, Rosa I, Fan, Li, Anderson, Matt S, Sura, Monali, Laethem, Tine, Rasmussen, Scott, van Bortel, Luc, van Lancker, Griet, Iwamoto, Marian

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