New pharmacodynamic parameters linked with ibrutinib responses in chronic lymphocytic leukemia: Prospective study in real-world patients and mathematical modeling von Cadot, Sarah, Audebert, Chloe, Dion, Charlotte, Ken, Soleakhena, Dupré, Loic, Largeaud, Laetitia, Laurent, Camille, Ysebaert, Loic, Crauste, Fabien, Quillet-Mary, Anne

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Somatic genetic alterations predict hematological progression in GATA2 deficiency von Largeaud, Laetitia, Collin, Matthew, Monselet, Nils, Vergez, Francois, Fregona, Vincent, Larcher, Lise, Hirsch, Pierre, Duployez, Nicolas, Bidet, Audrey, Luquet, Isabelle, Bustamante, Jacinta, Dufrechou, Stephanie, Prade, Nais, Nolla, Marie, Hamelle, Camille, Tavitian, Suzanne, Habib, Christophe, Meynier, Mateo, Bellanne-Chantelot, Christine, Donadieu, Jean, De Fontbrune, Flore Sicre, Fieschi, Claire, Ferster, Alina, Delhommeau, Francois, Delabesse, Eric, Pasquet, Marlene

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Occurrence of a paroxysmal nocturnal hemoglobinuria clone in an essential thrombocythemia: a link between PIGV and MPL von Knaus, Alexej, Vergez, François, Garcia, Cédric, Engels, Hartmut, Hundertmark, Hela, Ribes, David, Largeaud, Laetitia, Tavitian, Suzanne, Payrastre, Bernard, Krawitz, Peter, Faguer, Stanislas, Ribes, Agnes

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Genomic landscape of hyperleukocytic acute myeloid leukemia von Largeaud, Laetitia, Bertoli, Sarah, Bérard, Emilie, Tavitian, Suzanne, Picard, Muriel, Dufrechou, Stéphanie, Prade, Naïs, Vergez, François, Rieu, Jean Baptiste, Luquet, Isabelle, Sarry, Audrey, Huguet, Françoise, Ruiz, Jean, De Mas, Véronique, Delabesse, Eric, Récher, Christian

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Impact of TP53 mutations in acute myeloid leukemia patients treated with azacitidine von Bories, Pierre, Prade, Naïs, Lagarde, Stéphanie, Cabarrou, Bastien, Largeaud, Laetitia, Plenecassagnes, Julien, Luquet, Isabelle, De Mas, Véronique, Filleron, Thomas, Cassou, Manon, Sarry, Audrey, Fornecker, Luc-Matthieu, Simand, Célestine, Bertoli, Sarah, Recher, Christian, Delabesse, Eric, Bertolini, Francesco

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Longitudinal CITE-Seq profiling of chronic lymphocytic leukemia during ibrutinib treatment: evolution of leukemic and immune cells at relapse von Cadot, Sarah, Valle, Carine, Tosolini, Marie, Pont, Frederic, Largeaud, Laetitia, Laurent, Camille, Fournie, Jean Jacques, Ysebaert, Loic, Quillet-Mary, Anne

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GATA2 mutated allele specific expression is associated with a hyporesponsive state of HSC in GATA2 deficiency syndrome von Largeaud, Laetitia, Fregona, Vincent, Jamrog, Laura A., Hamelle, Camille, Dufrechou, Stéphanie, Prade, Naïs, Sellam, Esmaa, Enfedaque, Pauline, Bayet, Manon, Hébrard, Sylvie, Bouttier, Mathieu, Didier, Christine, Gerby, Bastien, Delabesse, Eric, Pasquet, Marlène, Broccardo, Cyril

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Phenotypically-defined stages of leukemia arrest predict main driver mutations subgroups, and outcome in acute myeloid leukemia von Vergez, François, Largeaud, Laetitia, Bertoli, Sarah, Nicolau, Marie-Laure, Rieu, Jean-Baptiste, Vergnolle, Inès, Saland, Estelle, Sarry, Audrey, Tavitian, Suzanne, Huguet, Françoise, Picard, Muriel, Vial, Jean-Philippe, Lechevalier, Nicolas, Bidet, Audrey, Dumas, Pierre-Yves, Pigneux, Arnaud, Luquet, Isabelle, Mansat-De Mas, Véronique, Delabesse, Eric, Carroll, Martin, Danet-Desnoyers, Gwenn, Sarry, Jean-Emmanuel, Récher, Christian

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Imatinib with intensive chemotherapy in AML with t(9;22)(q34.1;q11.2)/BCR::ABL1. A DATAML registry study von Gondran, Camille, Dumas, Pierre-Yves, Bérard, Emilie, Bidet, Audrey, Delabesse, Eric, Tavitian, Suzanne, Leguay, Thibaut, Huguet, Françoise, Borel, Cécile, Forcade, Edouard, Vergez, François, Vial, Jean-Philippe, Rieu, Jean Baptiste, Lechevalier, Nicolas, Luquet, Isabelle, Canali, Alban, Klein, Emilie, Sarry, Audrey, de Grande, Anne-Charlotte, Pigneux, Arnaud, Récher, Christian, Largeaud, Laetitia, Bertoli, Sarah

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Acute myeloid leukemia with myelodysplasia-related changes and basophilic differentiation von Rieu, Jean-Baptiste, Largeaud, Laetitia, Vergez, Francois, Evrard, Solene

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How to diagnose lymphoplasmacytic lymphoma without infiltration of plasmacytoid lymphocytes? von Kassir, Ali El, Largeaud, Laetitia, Vergnolle, Inès, Oberic, Lucie, Schavgoulidze, Anais, Rieu, Jean-Baptiste

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Dismal outcome of refractory or relapsing patients with myelodysplasia‐related acute myeloid leukemia partially alleviated by intensive chemotherapy von Leroy, Harmony, Gadaud, Noémie, Bérard, Emilie, Klein, Emilie, Luquet, Isabelle, Vial, Jean‐Philippe, Rieu, Jean‐Baptiste, Lechevalier, Nicolas, Tavitian, Suzanne, Leguay, Thibaut, Largeaud, Laetitia, Bidet, Audrey, Delabesse, Eric, Sarry, Audrey, Grande, Anne‐Charlotte, Récher, Christian, Pigneux, Arnaud, Bertoli, Sarah, Dumas, Pierre‐Yves

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When dystrophic plasma cells do not recognize themselves in the mirror von Rieu, Jean‐Baptiste, Perrot, Aurore, Vergez, Francois, Largeaud, Laetitia, Corre, Jill

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Do not jump to hasty conclusions: all gamma delta T-cells neoplasms are not aggressive von Vergez, François, Largeaud, Laetitia, Oberic, Lucie, Rieu, Jean-Baptiste

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S162: LOSS OF HEMATOPOIETIC PROGENITORS HETEROGENEITY IS AN ADVERSE PROGNOSTIC FACTOR IN MYELODYSPLASTIC SYNDROMES von Dussiau, Charles, Comont, Thibault, Knosp, Camille, Vergnolle, Ines, Bravetti, Clotilde, Canali, Alban, Houvert, Amandine, Largeaud, Laetitia, Daveaux, Christian, Zaroili, Laila, Friedrich, Chloe, Boussaid, Ismael, Zalmai, Loria, Almire, Carole, Beyne-Rauzy, Odile, Willems, Lise, Bouscary, Didier, Gandrillon, Olivier, Fontenay, Michaela, Kosmider, Oliver, Vergez, Francois, Chapuis, Nicolas

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Prognostic impact of DDX41 germline mutations in intensively treated acute myeloid leukemia patients: an ALFA-FILO study von Duployez, Nicolas, Largeaud, Laëtitia, Duchmann, Matthieu, Kim, Rathana, Rieunier, Julie, Lambert, Juliette, Bidet, Audrey, Larcher, Lise, Lemoine, Jean, Delhommeau, François, Hirsch, Pierre, Fenwarth, Laurène, Kosmider, Olivier, Decroocq, Justine, Bouvier, Anne, Le Bris, Yannick, Ochmann, Marlène, Santagostino, Alberto, Adès, Lionel, Fenaux, Pierre, Thomas, Xavier, Micol, Jean-Baptiste, Gardin, Claude, Itzykson, Raphael, Soulier, Jean, Clappier, Emmanuelle, Recher, Christian, Preudhomme, Claude, Pigneux, Arnaud, Dombret, Hervé, Delabesse, Eric, Sébert, Marie

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Chronic Myeloid Leukaemia with isolated massive thrombocytosis and BCR‐ABL1 detection failure using RT‐MLPA (positive RT‐qPCR) von Coster, Lucie, Mansat‐De MAS, Véronique, Largeaud, Laetitia, Voisin, Sophie, Corre, Jill, Gauthier, Martin

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A case of cup‐like blasts associated with B‐lymphoblastic leukemia without NPM1 and FLT3 internal tandem duplication mutations von Rieu, Jean‐Baptiste, Coster, Lucie, Corre, Jill, Tavitian, Suzanne, Recher, Christian, Huynh, Anne, Picard, Muriel, Derreumaux, Celine, Bertoli, Sarah, Vergez, Francois, Largeaud, Laetitia

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Clonal haematopoiesis is increased in early onset in systemic sclerosis von Ricard, Laure, Hirsch, Pierre, Largeaud, Laëtitia, Deswarte, Caroline, Jachiet, Vincent, Mohty, Mohamad, Rivière, Sébastien, Malard, Florent, Tenon, Maxime, de Vassoigne, Frédéric, Fain, Olivier, Gaugler, Béatrice, Rossignol, Julien, Delhommeau, François, Mekinian, Arsène

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UBTF tandem duplications define a distinct subtype of adult de novo acute myeloid leukemia von Duployez, Nicolas, Vasseur, Loïc, Kim, Rathana, Largeaud, Laëtitia, Passet, Marie, L’Haridon, Anaïs, Lemaire, Pierre, Fenwarth, Laurène, Geffroy, Sandrine, Helevaut, Nathalie, Celli‑Lebras, Karine, Adès, Lionel, Lebon, Delphine, Berthon, Céline, Marceau-Renaut, Alice, Cheok, Meyling, Lambert, Juliette, Récher, Christian, Raffoux, Emmanuel, Micol, Jean-Baptiste, Pigneux, Arnaud, Gardin, Claude, Delabesse, Eric, Soulier, Jean, Hunault, Mathilde, Dombret, Hervé, Itzykson, Raphael, Clappier, Emmanuelle, Preudhomme, Claude

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