Design, Formulation, and Evaluation of Novel Dissolving Microarray Patches Containing Rilpivirine for Intravaginal Delivery von Mc Crudden, Maelíosa T. C., Larrañeta, Eneko, Clark, Annie, Jarrahian, Courtney, Rein‐Weston, Annie, Creelman, Benjamin, Moyo, Yolanda, Lachau‐Durand, Sophie, Niemeijer, Nico, Williams, Peter, McCarthy, Helen O., Zehrung, Darin, Donnelly, Ryan F.

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Preclinical toxicity and pharmacokinetics of a new orally bioavailable flubendazole formulation and the impact for clinical trials and risk/benefit to patients von Lachau-Durand, Sophie, Lammens, Lieve, van der Leede, Bas-Jan, Van Gompel, Jacky, Bailey, Graham, Engelen, Marc, Lampo, Ann

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Macrofilaricidal efficacy of single and repeated oral and subcutaneous doses of flubendazole in Litomosoides sigmodontis infected jirds von Hübner, Marc P, Ehrens, Alexandra, Koschel, Marianne, Dubben, Bettina, Lenz, Franziska, Frohberger, Stefan J, Specht, Sabine, Quirynen, Ludo, Lachau-Durand, Sophie, Tekle, Fetene, Baeten, Benny, Engelen, Marc, Mackenzie, Charles D, Hoerauf, Achim

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Absorption, Metabolism, and Excretion of Darunavir, a New Protease Inhibitor, Administered Alone and with Low-Dose Ritonavir in Healthy Subjects von Vermeir, Marc, Lachau-Durand, Sophie, Mannens, Geert, Cuyckens, Filip, van Hoof, Bart, Raoof, Araz

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Efficacy of subcutaneous doses and a new oral amorphous solid dispersion formulation of flubendazole on male jirds (Meriones unguiculatus) infected with the filarial nematode Brugi... von Fischer, Chelsea, Ibiricu Urriza, Iosune, Bulman, Christina A, Lim, K C, Gut, Jiri, Lachau-Durand, Sophie, Engelen, Marc, Quirynen, Ludo, Tekle, Fetene, Baeten, Benny, Beerntsen, Brenda, Lustigman, Sara, Sakanari, Judy

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Antiviral Activity and Mode of Action of TMC647078, a Novel Nucleoside Inhibitor of the Hepatitis C Virus NS5B Polymerase von MARTIN BERKE, Jan, VIJGEN, Leen, VAN DEN EYNDE, Christel, LECLERCQ, Laurent, JONCKERS, Tim H. M, RABOISSON, Pierre, NILSSON, Magnus, SAMUELSSON, Bertil, ROSENQUIST, Asa, FANNING, Gregory C, LIN, Tse-I, LACHAU-DURAND, Sophie, POWDRILL, Megan H, RAWE, Svea, SJUVARSSON, Elena, ERIKSSON, Staffan, GÖTTE, Matthias, FRANSEN, Els, DEHERTOGH, Pascale

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Safety, Tolerability, and Pharmacokinetics of JNJ-1802, a Pan-serotype Dengue Direct Antiviral Small Molecule, in a Phase 1, Double-Blind, Randomized, Dose-Escalation Study in Heal... von Ackaert, Oliver, Vanhoutte, Frédéric, Verpoorten, Nathalie, Buelens, Annemie, Lachau-Durand, Sophie, Lammens, Lieve, Hoetelmans, Richard, Van Loock, Marnix, Herrera-Taracena, Guillermo

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Design, formulation and evaluation of novel dissolving microarray patches containing a long-acting rilpivirine nanosuspension von Mc Crudden, Maelíosa T.C., Larrañeta, Eneko, Clark, Annie, Jarrahian, Courtney, Rein-Weston, Annie, Lachau-Durand, Sophie, Niemeijer, Nico, Williams, Peter, Haeck, Clement, McCarthy, Helen O., Zehrung, Darin, Donnelly, Ryan F.

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Efficacy of Long-Acting Bedaquiline Regimens in a Mouse Model of Tuberculosis Preventive Therapy von Kaushik, Amit, Ammerman, Nicole C, Tasneen, Rokeya, Lachau-Durand, Sophie, Andries, Koen, Nuermberger, Eric

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Activity of a Long-Acting Injectable Bedaquiline Formulation in a Paucibacillary Mouse Model of Latent Tuberculosis Infection von Kaushik, Amit, Ammerman, Nicole C, Tyagi, Sandeep, Saini, Vikram, Vervoort, Iwan, Lachau-Durand, Sophie, Nuermberger, Eric, Andries, Koen

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Exacerbation of Background Nuclear Cataracts in Sprague-Dawley Rats in Embryo-Fetal Development Studies With JNJ-42165279, a Fatty Acid Amide Hydrolase Inhibitor von van Heerden, Marjolein, Roosen, Wendy, Lachau-Durand, Sophie, Bailey, Graham, Ndifor, Anthony

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Blocking NS3–NS4B interaction inhibits dengue virus in non-human primates von Goethals, Olivia, Kaptein, Suzanne J. F., Kesteleyn, Bart, Bonfanti, Jean-François, Van Wesenbeeck, Liesbeth, Bardiot, Dorothée, Verschoor, Ernst J., Verstrepen, Babs E., Fagrouch, Zahra, Putnak, J. Robert, Kiemel, Dominik, Ackaert, Oliver, Straetemans, Roel, Lachau-Durand, Sophie, Geluykens, Peggy, Crabbe, Marjolein, Thys, Kim, Stoops, Bart, Lenz, Oliver, Tambuyzer, Lotke, De Meyer, Sandra, Dallmeier, Kai, McCracken, Michael K., Gromowski, Gregory D., Rutvisuttinunt, Wiriya, Jarman, Richard G., Karasavvas, Nicos, Touret, Franck, Querat, Gilles, de Lamballerie, Xavier, Chatel-Chaix, Laurent, Milligan, Gregg N., Beasley, David W. C., Bourne, Nigel, Barrett, Alan D. T., Marchand, Arnaud, Jonckers, Tim H. M., Raboisson, Pierre, Simmen, Kenny, Chaltin, Patrick, Bartenschlager, Ralf, Bogers, Willy M., Neyts, Johan, Van Loock, Marnix

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Blocking NS3-NS4B interaction inhibits dengue virus in non-human primates von Goethals, Olivia, Kaptein, Suzanne J.F, Kesteleyn, Bart, Bonfanti, Jean-Francois, Van Wesenbeeck, Liesbeth, Bardiot, Dorothee, Verschoor, Ernst J, Verstrepen, Babs E, Fagrouch, Zahra, Putnak, J. Robert, Kiemel, Dominik, Ackaert, Oliver, Straetemans, Roel, Lachau-Durand, Sophie, Geluykens, Peggy, Crabbe, Marjolein, Thys, Kim, Stoops, Bart, Lenz, Oliver, Tambuyzer, Lotke, De Meyer, Sandra, Dallmeier, Kai, McCracken, Michael K, Gromowski, Gregory D, Rutvisuttinunt, Wiriya, Jarman, Richard G, Karasavvas, Nicos, Touret, Franck, Querat, Gilles, de Lamballerie, Xavier, Chatel-Chaix, Laurent, Milligan, Gregg N, Beasley, David W.C, Bourne, Nigel, Barrett, Alan D.T, Marchand, Arnaud, Jonckers, Tim H.M, Raboisson, Pierre, Simmen, Kenny, Chaltin, Patrick, Bartenschlager, Ralf, Bogers, Willy M, Neyts, Johan, Van Loock, Marnix

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Evaluation of Three Amorphous Drug Delivery Technologies to Improve the Oral Absorption of Flubendazole von Vialpando, Monica, Smulders, Stefanie, Bone, Scott, Jager, Casey, Vodak, David, Van Speybroeck, Michiel, Verheyen, Loes, Backx, Katrien, Boeykens, Peter, Brewster, Marcus E., Ceulemans, Jens, Novoa de Armas, Hector, Van Geel, Katrien, Kesselaers, Emma, Hillewaert, Vera, Lachau-Durand, Sophie, Meurs, Greet, Psathas, Petros, Van Hove, Ben, Verreck, Geert, Voets, Marieke, Weuts, Ilse, Mackie, Claire

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Nucleotide Prodrugs of 2′-Deoxy-2′-spirooxetane Ribonucleosides as Novel Inhibitors of the HCV NS5B Polymerase von Jonckers, Tim H. M., Vandyck, Koen, Vandekerckhove, Leen, Hu, Lili, Tahri, Abdellah, Van Hoof, Steven, Lin, Tse-I, Vijgen, Leen, Berke, Jan Martin, Lachau-Durand, Sophie, Stoops, Bart, Leclercq, Laurent, Fanning, Gregory, Samuelsson, Bertil, Nilsson, Magnus, Rosenquist, Åsa, Simmen, Kenny, Raboisson, Pierre

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Discovery of 1‑((2R,4aR,6R,7R,7aR)‑2-Isopropoxy-2-oxidodihydro‑4H,6H‑spiro[furo[3,2‑d][1,3,2]dioxaphosphinine-7,2′-oxetan]-6-yl)pyrimidine-2,4(1H,3H)‑dione (JNJ-54257099), a 3′-5′-... von Jonckers, Tim H. M, Tahri, Abdellah, Vijgen, Leen, Berke, Jan Martin, Lachau-Durand, Sophie, Stoops, Bart, Snoeys, Jan, Leclercq, Laurent, Tambuyzer, Lotke, Lin, Tse-I, Simmen, Kenny, Raboisson, Pierre

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Efficacy of subcutaneous doses and a new oral amorphous solid dispersion formulation of flubendazole on male jirds von Ibiricu Urriza, Iosune, Gut, Jiri, Fischer, Chelsea, Engelen, Marc, Quirynen, Ludo, Lachau-Durand, Sophie, Tekle, Fetene, Baeten, Benny, Lim, KC, Beerntsen, Brenda, Lustigman, Sara, Sakanari, Judy, Bulman, Christina A

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Discovery of 1-((2 R ,4a R ,6 R ,7 R ,7a R )-2-Isopropoxy-2-oxidodihydro-4 H ,6 H -spiro[furo[3,2- d ][1,3,2]dioxaphosphinine-7,2′-oxetan]-6-yl)pyrimidine-2,4(1 H ,3 H )-dione (JNJ... von Jonckers, Tim H. M., Tahri, Abdellah, Vijgen, Leen, Berke, Jan Martin, Lachau-Durand, Sophie, Stoops, Bart, Snoeys, Jan, Leclercq, Laurent, Tambuyzer, Lotke, Lin, Tse-I, Simmen, Kenny, Raboisson, Pierre

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Preclinical Evaluation of TMC-278 LA, a Long-acting Formulation of Rilpivirine, Demonstrates Significant Protection from Vaginal HIV Infection von Snyder, Olivia, Vincent, Heather, Lachau-Durant, Sophie, Kraus, Guenter, Williams, Peter, Garcia, J. Victor

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Design, Formulation, and Evaluation of Novel Dissolving Microarray Patches Containing Rilpivirine for Intravaginal Delivery von Mc Crudden, Maelíosa TC, Larrañeta, Eneko, Clark, Annie, Jarrahian, Courtney, Rein‐Weston, Annie, Creelman, Benjamin, Moyo, Yolanda, Lachau‐Durand, Sophie, Niemeijer, Nico, Williams, Peter, McCarthy, Helen O, Zehrung, Darin, Donnelly, Ryan F

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