COMPOSTO; COMPOSIÇÃO FARMACÊUTICA; MÉTODO DE PREPARAÇÃO DO COMPOSTO; COMPOSTO PREPARADO PELO MÉTODO; E MÉTODO DE TRATAMENTO DE UM TRANSTORNO EM UM MAMÍFERO NECESSITADO von JOSHUA JAMES SABATINI, DAVID BRIAN HOW, GULNAZ KHAFIZOVA, SABRINA LOMBARDI, LEIF MARK LAAKSO, PHAIK-ENG SUM, MATTHEW G. BURSAVICH, ADAM M. GILBERT, JEREMY J. CLEMENS

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8-hydroxyquinoline compounds and methods thereof von Bursavich, Matthew G, Lombardi, Sabrina, Gilbert, Adam M, Laakso, Leif Mark, Khafizova, Gulnaz, How, David Brian, Sabatini, Joshua James, Sum, Phaik-Eng, Clemens, Jeremy

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8-hydroxyquinoline compounds and methods thereof von GILBERT ADAM M, LAAKSO LEIF MARK, HOW DAVID BRIAN, SUM PHAIK-ENG, BURSAVICH MATTHEW G, KHAFIZOVA GULNAZ, LOMBARDI SABRINA, SABATINI JOSHUA JAMES, CLEMENS JEREMY

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8-HYDROXYQUINOLINE COMPOUNDS AND METHODS THEREOF von LOMBARDI, SABRINA, HOW, DAVID, BRIAN, LAAKSO, LEIF, MARK, SUM, PHAIK-ENG, SABATINI, JOSHUA, JAMES, CLEMENS, JEREMY, J, KHAFIZOVA, GULNAZ, BURSAVICH, MATTHEW, G, GILBERT, ADAM, M

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8-Hydroxyquinoline compounds and methods thereof von GILBERT ADAM M, LAAKSO LEIF MARK, HOW DAVID BRIAN, SUM PHAIK-ENG, BURSAVICH MATTHEW G, KHAFIZOVA GULNAZ, LOMBARDI SABRINA, SABATINI JOSHUA JAMES, CLEMENS JEREMY

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8-HYDROXYQUINOLINE COMPOUNDS AND METHODS THEREOF von LOMBARDI, SABRINA, HOW, DAVID, BRIAN, LAAKSO, LEIF, MARK, SUM, PHAIK-ENG, SABATINI, JOSHUA, JAMES, CLEMENS, JEREMY, J, KHAFIZOVA, GULNAZ, BURSAVICH, MATTHEW, G, GILBERT, ADAM, M

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8-Hydroxyquinoline Compounds and methods thereof von JOSHUA JAMES SABATINI, DAVID BRIAN HOW, GULNAZ KHAFIZOVA, SABRINA LOMBARDI, LEIF MARK LAAKSO, PHAIK-ENG SUM, ADAM M. GILBERT, MATTHEW G. BURSAVICH, JEREMY J. CLEMENS

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8-HYDROXYQUINOLINE COMPOUNDS AND METHODS THEREOF von SABATINI, JOSHUA JAMES, LOMBARDI, SABRINA, LAAKSO, LEIF MARK, GILBERT, ADAM M, SUM, PHAIK-ENG, HOW, DAVID BRIAN, CLEMENS, JEREMY J, KHAFIZOVA, GULNAZ, BURSAVICH, MATTHEW G

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8-HYDROXYQUINOLINE COMPOUNDS AND METHODS THEREOF von LOMBARDI, SABRINA, HOW, DAVID, BRIAN, LAAKSO, LEIF, MARK, SUM, PHAIK-ENG, SABATINI, JOSHUA, JAMES, CLEMENS, JEREMY, J, KHAFIZOVA, GULNAZ, BURSAVICH, MATTHEW, G, GILBERT, ADAM, M

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Acetylenic alpha-amino acid-based sulfonamide hydroxamic acid TACE inhibitors von LAAKSO, LEIF MARK, CHEN, JAMES MING, DU, MILA TI, COLE, DEREK CECIL, LEVIN, JEREMY IAN

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8-hydroxyquinoline compounds and methods thereof von LAAKSO LEIF MARK, HOW DAVID BRIAN, SUM PHAIK ENG, KHAFIZOVA GULNAZ, LOMBARDI SABRINA, SABATINI JOSHUA JAMES

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8-HYDROXYQUINOLINE COMPOUNDS AND METHODS THEREOF von JOSHUA JAMES SABATINI, DAVID BRIAN HOW, GULNAZ KHAFIZOVA, SABRINA LOMBARDI, PHAIK-ENG SUM, LEIF MARK LAAKSO, MATTHEW G. BURSAVICH, ADAM M. GILBERT, JEREMY J. CLEMENS

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Landscape of multi-nucleotide variants in 125,748 human exomes and 15,708 genomes von Wang, Qingbo, Pierce-Hoffman, Emma, Cummings, Beryl B., Alföldi, Jessica, Francioli, Laurent C., Gauthier, Laura D., Hill, Andrew J., O’Donnell-Luria, Anne H., Karczewski, Konrad J., MacArthur, Daniel G.

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Characterising the loss-of-function impact of 5’ untranslated region variants in 15,708 individuals von Whiffin, Nicola, Karczewski, Konrad J., Zhang, Xiaolei, Chothani, Sonia, Smith, Miriam J., Evans, D. Gareth, Roberts, Angharad M., Quaife, Nicholas M., Schafer, Sebastian, Rackham, Owen, Alföldi, Jessica, O’Donnell-Luria, Anne H., Francioli, Laurent C., Cook, Stuart A., Barton, Paul J. R., MacArthur, Daniel G., Ware, James S.

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A Genome-Wide Association Study of Diabetic Kidney Disease in Subjects With Type 2 Diabetes von van Zuydam, Natalie R, Ahlqvist, Emma, Sandholm, Niina, Deshmukh, Harshal, Rayner, N William, Abdalla, Moustafa, Ladenvall, Claes, Ziemek, Daniel, Fauman, Eric, Robertson, Neil R, McKeigue, Paul M, Valo, Erkka, Forsblom, Carol, Harjutsalo, Valma, Perna, Annalisa, Rurali, Erica, Marcovecchio, M Loredana, Igo, Jr, Robert P, Salem, Rany M, Perico, Norberto, Lajer, Maria, Käräjämäki, Annemari, Imamura, Minako, Kubo, Michiaki, Takahashi, Atsushi, Sim, Xueling, Liu, Jianjun, van Dam, Rob M, Jiang, Guozhi, Tam, Claudia H T, Luk, Andrea O Y, Lee, Heung Man, Lim, Cadmon K P, Szeto, Cheuk Chun, So, Wing Yee, Chan, Juliana C N, Ang, Su Fen, Dorajoo, Rajkumar, Wang, Ling, Clara, Tan Si Hua, McKnight, Amy-Jayne, Duffy, Seamus, Pezzolesi, Marcus G, Marre, Michel, Gyorgy, Beata, Hadjadj, Samy, Hiraki, Linda T, Ahluwalia, Tarunveer S, Almgren, Peter, Schulz, Christina-Alexandra, Orho-Melander, Marju, Linneberg, Allan, Christensen, Cramer, Witte, Daniel R, Grarup, Niels, Brandslund, Ivan, Melander, Olle, Paterson, Andrew D, Tregouet, David, Maxwell, Alexander P, Lim, Su Chi, Ma, Ronald C W, Tai, E Shyong, Maeda, Shiro, Lyssenko, Valeriya, Tuomi, Tiinamaija, Krolewski, Andrzej S, Rich, Stephen S, Hirschhorn, Joel N, Florez, Jose C, Dunger, David, Pedersen, Oluf, Hansen, Torben, Rossing, Peter, Remuzzi, Giuseppe, Brosnan, Mary Julia, Palmer, Colin N A, Groop, Per-Henrik, Colhoun, Helen M, Groop, Leif C, McCarthy, Mark I

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Sex-dimorphic genetic effects and novel loci for fasting glucose and insulin variability von Lagou, Vasiliki, Mägi, Reedik, Grallert, Harald, Jansen, Rick, Dimas, Antigone S., Ulrich, Anna, Zudina, Liudmila, Gådin, Jesper R., Faggian, Alessia, Tanaka, Toshiko, Webster, Rebecca J., Saxena, Richa, Salo, Perttu, Shin, So-Youn, Amin, Najaf, Li, Guo, Verweij, Niek, Johnson, Paul C. D., Johnson, Toby, Rasmussen-Torvik, Laura J., Esko, Tõnu, Fall, Tove, Fraser, Ross M., Kanoni, Stavroula, Giedraitis, Vilmantas, Kleber, Marcus E., Sanna, Serena, Boettcher, Yvonne, Rayner, N. William, Nolte, Ilja M., Iperen, Erik van, Kovacs, Peter, Campbell, Susan, Polasek, Ozren, Egan, Josephine, Kiess, Wieland, Willemsen, Gonneke, Kuusisto, Johanna, Laakso, Markku, Thorand, Barbara, Miljkovic, Iva, Lind, Lars, Doney, Alex, Perola, Markus, Kivimaki, Mika, Kumari, Meena, Bennett, Amanda J., Groves, Christopher J., Koistinen, Heikki A., Bakker, Stephan J. L., Uusitupa, Matti, Palmer, Colin N. A., Pouta, Anneli, Krus, Ulrika, de Geus, Eco J. C. N., Wolffenbuttel, Bruce H. R., Abecasis, Goncalo R., Wright, Alan F., Dedoussis, George V., Schwarz, Peter E. H., Winkelmann, Bernhard R., Boehm, Bernhard O., März, Winfried, Metspalu, Andres, Price, Jackie F., Keinanen-Kiukaanniemi, Sirkka M., Saaristo, Timo E., Bergman, Richard N., Tuomilehto, Jaakko, Langenberg, Claudia, Vitart, Veronique, Visvikis-Siest, Sophie, Altshuler, David, Illig, Thomas, Ferrucci, Luigi, Pramstaller, Peter P., Peyser, Patricia A., Palmer, Lyle J., Penninx, Brenda W., Harst, Pim van der, Forouhi, Nita G., Loos, Ruth J. F., Boomsma, Dorret I., Hofman, Albert, Munroe, Patricia B., Gudnason, Vilmundur, Stefansson, Kari, Hamsten, Anders, Nicholson, George, Dermitzakis, Emmanouil T., Lindgren, Cecilia M., Froguel, Philippe, Kaakinen, Marika A., Lyssenko, Valeriya, Watanabe, Richard M., Ingelsson, Erik, Florez, Jose C., Barroso, Inês, Morris, Andrew P., Prokopenko, Inga

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The effect of LRRK2 loss-of-function variants in humans von Whiffin, Nicola, Armean, Irina M., Kleinman, Aaron, Marshall, Jamie L., Minikel, Eric V., Goodrich, Julia K., Quaife, Nicholas M., Cole, Joanne B., Wang, Qingbo, Karczewski, Konrad J., Cummings, Beryl B., Francioli, Laurent, Laricchia, Kristen, Guan, Anna, Alipanahi, Babak, Morrison, Peter, Baptista, Marco A. S., Merchant, Kalpana M., Ware, James S., Havulinna, Aki S., Iliadou, Bozenna, Lee, Jung-Jin, Nadkarni, Girish N., Whiteman, Cole, Daly, Mark, Esko, Tõnu, Hultman, Christina, Loos, Ruth J. F., Milani, Lili, Palotie, Aarno, Pato, Carlos, Pato, Michele, Saleheen, Danish, Sullivan, Patrick F., Alföldi, Jessica, Cannon, Paul, MacArthur, Daniel G.

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Determinants of penetrance and variable expressivity in monogenic metabolic conditions across 77,184 exomes von Son, Rachel, England, Eleina, Cole, Joanne B., Weisburd, Ben, Watts, Nick, Caulkins, Lizz, Dornbos, Peter, Koesterer, Ryan, Zappala, Zachary, Zhang, Haichen, Maloney, Kristin A., Dahl, Andy, Aguilar-Salinas, Carlos A., Atzmon, Gil, Barajas-Olmos, Francisco, Barzilai, Nir, Blangero, John, Boerwinkle, Eric, Bonnycastle, Lori L., Bottinger, Erwin, Bowden, Donald W., Chami, Nathalie, Chan, Edmund, Chan, Juliana, Cheng, Ching-Yu, Cho, Yoon Shin, DeFronzo, Ralph A., Duggirala, Ravindranath, Dupuis, Josée, Garay-Sevilla, Ma Eugenia, Gieger, Christian, Glaser, Benjamin, González-Villalpando, Clicerio, Gonzalez, Ma Elena, Grarup, Niels, Groop, Leif, Gross, Myron, Han, Sohee, Hansen, Torben, Heard-Costa, Nancy L., Henderson, Brian E., Hernandez, Juan Manuel Malacara, Islas-Andrade, Sergio, Jørgensen, Marit E., Kang, Hyun Min, Kim, Bong-Jo, Kim, Young Jin, Koistinen, Heikki A., Kooner, Jaspal Singh, Kuusisto, Johanna, Kwak, Soo-Heon, Laakso, Markku, Lee, Juyoung, Lehman, Donna M., Linneberg, Allan, Loos, Ruth J. F., Ma, Ronald C. W., Martínez-Hernández, Angélica, Meigs, James B., Mendoza-Caamal, Elvia, Mohlke, Karen L., Morris, Andrew D., Morrison, Alanna C., Ng, Maggie C. Y., Nilsson, Peter M., Orozco, Lorena, Palmer, Colin N. A., Park, Kyong Soo, Pedersen, Oluf, Reiner, Alexander P., Revilla-Monsalve, Cristina, Rich, Stephen S., Rotter, Jerome I., Sim, Xueling, Sladek, Rob, Small, Kerrin S., So, Wing Yee, Spector, Timothy D., Strauch, Konstantin, Strom, Tim M., Tai, E. Shyong, Tam, Claudia H. T., Teo, Yik Ying, Thameem, Farook, Tomlinson, Brian, Tracy, Russell P., Tuomi, Tiinamaija, Tuomilehto, Jaakko, Tusié-Luna, Teresa, van Dam, Rob M., Wilson, James G., Witte, Daniel R., Wong, Tien-Yin, McCarthy, Mark I., Boehnke, Michael, O’Donnell-Luria, Anne, Baxter, Samantha, Florez, Jose C., MacArthur, Daniel G., Udler, Miriam S.

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Identification and validation of N-acetyltransferase 2 as an insulin sensitivity gene von Knowles, Joshua W, Xie, Weijia, Zhang, Zhongyang, Chennamsetty, Indumathi, Chennemsetty, Indumathi, Assimes, Themistocles L, Paananen, Jussi, Hansson, Ola, Pankow, James, Goodarzi, Mark O, Carcamo-Orive, Ivan, Morris, Andrew P, Chen, Yii-Der I, Mäkinen, Ville-Petteri, Ganna, Andrea, Mahajan, Anubha, Guo, Xiuqing, Abbasi, Fahim, Greenawalt, Danielle M, Lum, Pek, Molony, Cliona, Lind, Lars, Lindgren, Cecilia, Raffel, Leslie J, Tsao, Philip S, Schadt, Eric E, Rotter, Jerome I, Sinaiko, Alan, Reaven, Gerald, Yang, Xia, Hsiung, Chao A, Groop, Leif, Cordell, Heather J, Laakso, Markku, Hao, Ke, Ingelsson, Erik, Frayling, Timothy M, Weedon, Michael N, Walker, Mark, Quertermous, Thomas

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Identification and validation of N-acetyltransferase 2 as an insulin sensitivity gene von Knowles, Joshua W., Xie, Weijia, Zhang, Zhongyang, Chennemsetty, Indumathi, Assimes, Themistocles L., Paananen, Jussi, Hansson, Ola, Pankow, James, Goodarzi, Mark O., Carcamo-Orive, Ivan, Morris, Andrew P., Chen, Yii-Der I., Maekinen, Ville-Petteri, Ganna, Andrea, Mahajan, Anubha, Guo, Xiuqing, Abbasi, Fahim, Greenawalt, Danielle M., Lum, Pek, Molony, Cliona, Lind, Lars, Lindgren, Cecilia, Raffel, Leslie J., Tsao, Philip S., Schadt, Eric E., Rotter, Jerome I., Sinaiko, Alan, Reaven, Gerald, Yang, Xia, Hsiung, Chao A., Groop, Leif, Cordell, Heather J., Laakso, Markku, Hao, Ke, Ingelsson, Erik, Frayling, Timothy M., Weedon, Michael N., Walker, Mark, Quertermous, Thomas

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