Toward Hydrogen Sulfide Based Therapeutics: Critical Drug Delivery and Developability Issues von Zheng, Yueqin, Yu, Bingchen, La Cruz, Ladie Kimberly, Roy Choudhury, Manjusha, Anifowose, Abiodun, Wang, Binghe

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Enrichment-triggered prodrug activation demonstrated through mitochondria-targeted delivery of doxorubicin and carbon monoxide von Zheng, Yueqin, Ji, Xingyue, Yu, Bingchen, Ji, Kaili, Gallo, David, Csizmadia, Eva, Zhu, Mengyuan, Choudhury, Manjusha Roy, De La Cruz, Ladie Kimberly C., Chittavong, Vayou, Pan, Zhixiang, Yuan, Zhengnan, Otterbein, Leo E., Wang, Binghe

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Strategies to target the Hedgehog signaling pathway for cancer therapy von Xin, Minhang, Ji, Xinyue, La Cruz, Ladie Kimberly, Thareja, Suresh, Wang, Binghe

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Esterase-Sensitive and pH-Controlled Carbon Monoxide Prodrugs for Treating Systemic Inflammation von Ji, Xingyue, Pan, Zhixiang, Li, Chunjie, Kang, Ting, De La Cruz, Ladie Kimberly C, Yang, Lingyun, Yuan, Zhengnan, Ke, Bowen, Wang, Binghe

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pH-Sensitive metal-free carbon monoxide prodrugs with tunable and predictable release rates von Ji, Xingyue, De La Cruz, Ladie Kimberly C, Pan, Zhixiang, Chittavong, Vayou, Wang, Binghe

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Nitro reduction-based fluorescent probes for carbon monoxide require reactivity involving a ruthenium carbonyl moiety von Yuan, Zhengnan, Yang, Xiaoxiao, De La Cruz, Ladie Kimberly, Wang, Binghe

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Click and release: bioorthogonal approaches to "on-demand" activation of prodrugs von Ji, Xingyue, Pan, Zhixiang, Yu, Bingchen, De La Cruz, Ladie Kimberly, Zheng, Yueqin, Ke, Bowen, Wang, Binghe

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Click and Release: A High-Content Bioorthogonal Prodrug with Multiple Outputs von Ji, Xingyue, Aghoghovbia, Robert E, De La Cruz, Ladie Kimberly C, Pan, Zhixiang, Yang, Xiaoxiao, Yu, Bingchen, Wang, Binghe

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Toward Direct Protein S‑Persulfidation: A Prodrug Approach That Directly Delivers Hydrogen Persulfide von Yu, Bingchen, Zheng, Yueqin, Yuan, Zhengnan, Li, Shanshan, Zhu, He, De La Cruz, Ladie Kimberly, Zhang, Jun, Ji, Kaili, Wang, Siming, Wang, Binghe

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Click, Release, and Fluoresce: A Chemical Strategy for a Cascade Prodrug System for Codelivery of Carbon Monoxide, a Drug Payload, and a Fluorescent Reporter von De La Cruz, Ladie Kimberly C, Benoit, Stéphane L, Pan, Zhixiang, Yu, Bingchen, Maier, Robert J, Ji, Xingyue, Wang, Binghe

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Iron porphyrin-mediated production of carbon monoxide from phenylpyruvic acid: from potential therapeutic and diagnostic use to physiological implications von Lu, Wen, Ghorpade, Rujuta, Yang, Xiaoxiao, Leonard, William, De La Cruz, Ladie Kimberly, Wang, Binghe

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Role of Carbon Monoxide in Host–Gut Microbiome Communication von Hopper, Christopher P, De La Cruz, Ladie Kimberly, Lyles, Kristin V, Wareham, Lauren K, Gilbert, Jack A, Eichenbaum, Zehava, Magierowski, Marcin, Poole, Robert K, Wollborn, Jakob, Wang, Binghe

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Adapting decarbonylation chemistry for the development of prodrugs capable of in vivo delivery of carbon monoxide utilizing sweeteners as carrier molecules von De La Cruz, Ladie Kimberly, Yang, Xiaoxiao, Menshikh, Anna, Brewer, Maya, Lu, Wen, Wang, Minjia, Wang, Siming, Ji, Xingyue, Cachuela, Alyssa, Yang, Haichun, Gallo, David, Tan, Chalet, Otterbein, Leo, de Caestecker, Mark, Wang, Binghe

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Upregulation of p53 through induction of MDM2 degradation: Anthraquinone analogs von Draganov, Alexander B., Yang, Xiaoxiao, Anifowose, Abiodun, De La Cruz, Ladie Kimberly C., Dai, Chaofeng, Ni, Nanting, Chen, Weixuan, De Los Santos, Zeus, Gu, Lubing, Zhou, Muxiang, Wang, Binghe

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Carbon Monoxide Signaling: Examining Its Engagement with Various Molecular Targets in the Context of Binding Affinity, Concentration, and Biologic Response von Yuan, Zhengnan, De La Cruz, Ladie Kimberly, Yang, Xiaoxiao, Wang, Binghe

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Activated charcoal dispersion of carbon monoxide prodrugs for oral delivery of CO in a pill von Yang, Xiaoxiao, Lu, Wen, Wang, Minjia, De La Cruz, Ladie Kimberly, Tan, Chalet, Wang, Binghe

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Towards “CO in a pill”: Pharmacokinetic studies of carbon monoxide prodrugs in mice von Wang, Minjia, Yang, Xiaoxiao, Pan, Zhixiang, Wang, Yingzhe, De La Cruz, Ladie Kimberly, Wang, Binghe, Tan, Chalet

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Light-Activated CO Donor as a Universal CO Surrogate for Pd-Catalyzed and Light-Mediated Carbonylation von De La Cruz, Ladie Kimberly, Bauer, Nicola, Cachuela, Alyssa, Tam, Wing Sze, Tripathi, Ravi, Yang, Xiaoxiao, Wang, Binghe

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Click, release, and fluoresce: In-vivo generation of CO with concomitant synthesis of a fluorescent reporter von De La Cruz, Ladie Kimberly, Ji, Xingyue, Yang, Xiaoxiao, Wang, Binghe

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pH-Sensitive metal-free carbon monoxide prodrugs with tunable and predictable release ratesElectronic supplementary information (ESI) available. See DOI: 10.1039/c7cc04866a von Ji, Xingyue, De La Cruz, Ladie Kimberly C, Pan, Zhixiang, Chittavong, Vayou, Wang, Binghe

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