CAR-T cell-mediated depletion of immunosuppressive tumor-associated macrophages promotes endogenous antitumor immunity and augments adoptive immunotherapy von Rodriguez-Garcia, Alba, Lynn, Rachel C., Poussin, Mathilde, Eiva, Monika A., Shaw, Lauren C., O’Connor, Roddy S., Minutolo, Nicholas G., Casado-Medrano, Victoria, Lopez, Gonzalo, Matsuyama, Takami, Powell, Daniel J.

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Intra-tumoral delivery of CXCL11 via a vaccinia virus, but not by modified T cells, enhances the efficacy of adoptive T cell therapy and vaccines von Moon, Edmund K., Wang, Liang-Chuan S., Bekdache, Kheng, Lynn, Rachel C., Lo, Albert, Thorne, Stephen H., Albelda, Steven M.

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Defining ‘T cell exhaustion’ von Blank, Christian U., Haining, W. Nicholas, Held, Werner, Hogan, Patrick G., Kallies, Axel, Lugli, Enrico, Lynn, Rachel C., Philip, Mary, Rao, Anjana, Restifo, Nicholas P., Schietinger, Andrea, Schumacher, Ton N., Schwartzberg, Pamela L., Sharpe, Arlene H., Speiser, Daniel E., Wherry, E. John, Youngblood, Benjamin A., Zehn, Dietmar

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c-Jun overexpression in CAR T cells induces exhaustion resistance von Lynn, Rachel C., Weber, Evan W., Sotillo, Elena, Gennert, David, Xu, Peng, Good, Zinaida, Anbunathan, Hima, Lattin, John, Jones, Robert, Tieu, Victor, Nagaraja, Surya, Granja, Jeffrey, de Bourcy, Charles F. A., Majzner, Robbie, Satpathy, Ansuman T., Quake, Stephen R., Monje, Michelle, Chang, Howard Y., Mackall, Crystal L.

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Tissue Exit: a Novel Control Point in the Accumulation of Antigen-Specific CD8 T Cells in the Influenza A Virus-Infected Lung von Jennrich, Silke, Lee, Michael H, Lynn, Rachel C, Dewberry, Kristofer, Debes, Gudrun F

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Transient rest restores functionality in exhausted CAR-T cells through epigenetic remodeling von Weber, Evan W, Parker, Kevin R, Sotillo, Elena, Lynn, Rachel C, Anbunathan, Hima, Lattin, John, Good, Zinaida, Belk, Julia A, Daniel, Bence, Klysz, Dorota, Malipatlolla, Meena, Xu, Peng, Bashti, Malek, Heitzeneder, Sabine, Labanieh, Louai, Vandris, Panayiotis, Majzner, Robbie G, Qi, Yanyan, Sandor, Katalin, Chen, Ling-Chun, Prabhu, Snehit, Gentles, Andrew J, Wandless, Thomas J, Satpathy, Ansuman T, Chang, Howard Y, Mackall, Crystal L

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Tuning the Antigen Density Requirement for CAR T-cell Activity von Majzner, Robbie G, Rietberg, Skyler P, Sotillo, Elena, Dong, Rui, Vachharajani, Vipul T, Labanieh, Louai, Myklebust, June H, Kadapakkam, Meena, Weber, Evan W, Tousley, Aidan M, Richards, Rebecca M, Heitzeneder, Sabine, Nguyen, Sang M, Wiebking, Volker, Theruvath, Johanna, Lynn, Rachel C, Xu, Peng, Dunn, Alexander R, Vale, Ronald D, Mackall, Crystal L

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A Universal Strategy for Adoptive Immunotherapy of Cancer through Use of a Novel T-cell Antigen Receptor von URBANSKA, Katarzyna, LANITIS, Evripidis, POUSSIN, Mathilde, LYNN, Rachel C, GAVIN, Brian P, KELDERMAN, Sander, YU, Jason, SCHOLLER, Nathalie, POWELL, Daniel J

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Targeting of folate receptor β on acute myeloid leukemia blasts with chimeric antigen receptor–expressing T cells von Lynn, Rachel C., Poussin, Mathilde, Kalota, Anna, Feng, Yang, Low, Philip S., Dimitrov, Dimiter S., Powell Jr, Daniel J.

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Strength in Numbers: Identifying Neoantigen Targets for Cancer Immunotherapy von Kishton, Rigel J., Lynn, Rachel C., Restifo, Nicholas P.

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Pharmacologic control of CAR-T cell function using dasatinib von Weber, Evan W., Lynn, Rachel C., Sotillo, Elena, Lattin, John, Xu, Peng, Mackall, Crystal L.

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Dynamic chromatin regulatory landscape of human CAR T cell exhaustion von Gennert, David G., Lynn, Rachel C., Granja, Jeff M., Weber, Evan W., Mumbach, Maxwell R., Zhao, Yang, Duren, Zhana, Sotillo, Elena, Greenleaf, William J., Wong, Wing H., Satpathy, Ansuman T., Mackall, Crystal L., Chang, Howard Y.

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Regulation of chemotropic guidance of nerve growth cones by microRNA von Han, Liang, Wen, Zhexing, Lynn, Rachel C, Baudet, Marie-Laure, Holt, Christine E, Sasaki, Yukio, Bassell, Gary J, Zheng, James Q

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Strain-dependent Lethal Toxicity in NKG2D Ligand-targeted CAR T-cell Therapy von Lynn, Rachel C, Powell, Daniel J

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Targeted cancer immunotherapy via combination of designer bispecific antibody and novel gene-engineered T cells von Urbanska, Katarzyna, Lynn, Rachel C, Stashwick, Caitlin, Thakur, Archana, Lum, Lawrence G, Powell, Jr, Daniel J

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Neurotoxicity Associated with a High-Affinity GD2 CAR-Letter von Majzner, Robbie G, Weber, Evan W, Lynn, Rachel C, Xu, Peng, Mackall, Crystal L

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Treating Tumors With a Vaccinia Virus Expressing IFNβ Illustrates the Complex Relationships Between Oncolytic Ability and Immunogenicity von Wang, Liang-Chuan S, Lynn, Rachel C, Cheng, Guanjun, Alexander, Edward, Kapoor, Veena, Moon, Edmund K, Sun, Jing, Fridlender, Zvi G, Isaacs, Stuart N, Thorne, Stephen H, Albelda, Steven M

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278 Preclinical development of LYL119, a ROR1-targeted CAR T-cell product incorporating four novel T-cell reprogramming technologies to overcome barriers to effective cell therapy... von Lam, Viola C, Li, Aileen, Casas, Meritxell Galindo, Barragan, Jessica, Cheung, Christina, Briones, Jessica, Afreen, Esha, Vavra, Grant, Lu, Jia, Sundar, Purnima, Martinez, Rowena, Sims, Candace, Ta, Christina, Nigatu, Eskedar, Potluri, Shobha, Ali, Omar, Cheung, Alexander S, Lynn, Rachel C

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Abstract LB-111: Precise regulation of CAR signaling prevents and reverses CAR T cell exhaustion von Weber, Evan W., Lynn, Rachel C., Malipatlolla, Meena, Sotillo, Elena, Xu, Peng, Mackall, Crystal L.

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Transient “rest” restores functionality in exhausted CAR-T cells via epigenetic remodeling von Weber, Evan W., Parker, Kevin R., Sotillo, Elena, Lynn, Rachel C., Anbunathan, Hima, Lattin, John, Good, Zinaida, Belk, Julia A., Daniel, Bence, Klysz, Dorota, Malipatlolla, Meena, Xu, Peng, Bashti, Malek, Heitzeneder, Sabine, Labanieh, Louai, Vandris, Panayiotis, Majzner, Robbie G., Qi, Yanyan, Sandor, Katalin, Chen, Ling-Chun, Prabhu, Snehit, Gentles, Andrew J., Wandless, Thomas J., Satpathy, Ansuman T., Chang, Howard Y., Mackall, Crystal L.

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