Follicular helper T cell profiles predict response to costimulation blockade in type 1 diabetes von Edner, Natalie M., Heuts, Frank, Thomas, Niclas, Wang, Chun Jing, Petersone, Lina, Kenefeck, Rupert, Kogimtzis, Alexandros, Ovcinnikovs, Vitalijs, Ross, Ellen M., Ntavli, Elisavet, Elfaki, Yassin, Eichmann, Martin, Baptista, Roman, Ambery, Philip, Jermutus, Lutz, Peakman, Mark, Rosenthal, Miranda, Walker, Lucy S. K.

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Evolution of protease activation and specificity via alpha-2-macroglobulin-mediated covalent capture von Knyphausen, Philipp, Rangel Pereira, Mariana, Brear, Paul, Hyvönen, Marko, Jermutus, Lutz, Hollfelder, Florian

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Resolution of NASH and hepatic fibrosis by the GLP-1R and GCGR dual-agonist cotadutide via modulating mitochondrial function and lipogenesis von Boland, Michelle L., Laker, Rhianna C., Mather, Karly, Nawrocki, Arkadiusz, Oldham, Stephanie, Boland, Brandon B., Lewis, Hilary, Conway, James, Naylor, Jacqueline, Guionaud, Silvia, Feigh, Michael, Veidal, Sanne S., Lantier, Louise, McGuinness, Owen P., Grimsby, Joseph, Rondinone, Cristina M., Jermutus, Lutz, Larsen, Martin R., Trevaskis, James L., Rhodes, Christopher J.

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Major adverse cardiovascular events in people with chronic kidney disease in relation to disease severity and diabetes status von Currie, Craig J, Berni, Ellen R, Berni, Thomas R, Jenkins-Jones, Sara, Sinsakul, Marvin, Jermutus, Lutz, Ambery, Philip, Jain, Meena

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Structural and Pharmacological Characterization of Novel Potent and Selective Monoclonal Antibody Antagonists of Glucose-dependent Insulinotropic Polypeptide Receptor von Ravn, Peter, Madhurantakam, Chaithanya, Kunze, Susan, Matthews, Evelyn, Priest, Claire, O'Brien, Siobhan, Collinson, Andie, Papworth, Monika, Fritsch-Fredin, Maria, Jermutus, Lutz, Benthem, Lambertus, Gruetter, Markus, Jackson, Ronald H.

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Expression of high-affinity human antibody fragments in bacteria von Rouet, Romain, Lowe, David, Dudgeon, Kip, Roome, Brendan, Schofield, Peter, Langley, David, Andrews, John, Whitfeld, Peter, Jermutus, Lutz, Christ, Daniel

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Glucagon and exenatide improve contractile recovery following ischaemia/reperfusion in the isolated perfused rat heart von Lindsay, Ross T., Ambery, Philip, Jermutus, Lutz, Murray, Andrew J.

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A Therapeutic Uricase with Reduced Immunogenicity Risk and Improved Development Properties von Nyborg, Andrew C, Ward, Chris, Zacco, Anna, Chacko, Benoy, Grinberg, Luba, Geoghegan, James C, Bean, Ryan, Wendeler, Michaela, Bartnik, Frank, O'Connor, Ellen, Gruia, Flaviu, Iyer, Vidyashankara, Feng, Hui, Roy, Varnika, Berge, Mark, Miner, Jeffrey N, Wilson, David M, Zhou, Dongmei, Nicholson, Simone, Wilker, Clynn, Wu, Chi Y, Wilson, Susan, Jermutus, Lutz, Wu, Herren, Owen, David A, Osbourn, Jane, Coats, Steven, Baca, Manuel

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Engineering neprilysin activity and specificity to create a novel therapeutic for Alzheimer's disease von Webster, Carl I, Burrell, Matthew, Olsson, Lise-Lotte, Fowler, Susan B, Digby, Sarah, Sandercock, Alan, Snijder, Arjan, Tebbe, Jan, Haupts, Ulrich, Grudzinska, Joanna, Jermutus, Lutz, Andersson, Christin

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Combining phenotypic and proteomic approaches to identify membrane targets in a 'triple negative' breast cancer cell type von Rust, Steven, Guillard, Sandrine, Sachsenmeier, Kris, Hay, Carl, Davidson, Max, Karlsson, Anders, Karlsson, Roger, Brand, Erin, Lowne, David, Elvin, John, Flynn, Matt, Kurosawa, Gene, Hollingsworth, Robert, Jermutus, Lutz, Minter, Ralph

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Design and rationale for a global novel non-invasive screening observational study using genetics and non-invasive methodologies to identify at-risk MASLD participants: The ALIGN s... von Daniels, Samuel J., Nelander, Karin, Eriksson, John, Jermutus, Lutz, Saillard, Jelena, Oyesola, Stephanie, Tavaglione, Federica, Arrese, Marco, Ladrón de Guevara, Alma Laura, Vespasiani-Gentilucci, Umberto, Alkhouri, Naim, Blau, Jenny E.

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A CD80-Biased CTLA4-Ig Fusion Protein with Superior In Vivo Efficacy by Simultaneous Engineering of Affinity, Selectivity, Stability, and FcRn Binding von Douthwaite, Julie, Moisan, Jacques, Privezentzev, Cyril, Soskic, Blagoje, Sabbah, Shereen, Cohen, Suzanne, Collinson, Andie, England, Elizabeth, Huntington, Catherine, Kemp, Ben, Zhuang, Li, Hudak, Suzanne, Rees, D Gareth, Goldberg, Debbie, Barton, Chris, Chang, Linda, Vainshtein, Inna, Liang, Meina, Iciek, Laurie, Ambery, Philip, Peakman, Mark, Vaughan, Tristan J, Tree, Tim I M, Sansom, David M, Bowen, Michael A, Minter, Ralph R, Jermutus, Lutz

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Engineering a therapeutic IgG molecule to address cysteinylation, aggregation and enhance thermal stability and expression von Buchanan, Andrew, Clementel, Veronica, Woods, Rob, Harn, Nicholas, Bowen, Michael A, Mo, Wenjun, Popovic, Bojana, Bishop, Steven M., Dall'Acqua, William, Minter, Ralph, Jermutus, Lutz, Bedian, Vahe

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The effect of pH dependence of antibody-antigen interactions on subcellular trafficking dynamics von Devanaboyina, Siva Charan, Lynch, Sandra M, Ober, Raimund J, Ram, Sripad, Kim, Dongyoung, Puig-Canto, Alberto, Breen, Shannon, Kasturirangan, Srinath, Fowler, Susan, Peng, Li, Zhong, Haihong, Jermutus, Lutz, Wu, Herren, Webster, Carl, Ward, E Sally, Gao, Changshou

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Tailoring in vitro Evolution for Protein Affinity or Stability von Jermutus, Lutz, Honegger, Annemarie, Schwesinger, Falk, Hanes, Jozef, Plückthun, Andreas

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Effects of Cotadutide on Metabolic and Hepatic Parameters in Adults With Overweight or Obesity and Type 2 Diabetes: A 54-Week Randomized Phase 2b Study von Nahra, Rajaa, Wang, Tao, Gadde, Kishore M, Oscarsson, Jan, Stumvoll, Michael, Jermutus, Lutz, Hirshberg, Boaz, Ambery, Philip

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Unbinding Forces of Single Antibody-Antigen Complexes Correlate with Their Thermal Dissociation Rates von Schwesinger, F, Ros, R, Strunz, T, Anselmetti, D, Güntherodt, H J, Honegger, A, Jermutus, L, Tiefenauer, L, Pluckthun, A

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Correction: A CD80-Biased CTLA4-Ig Fusion Protein with Superior In Vivo Efficacy by Simultaneous Engineering of Affinity, Selectivity, Stability, and FcRn Binding von Douthwaite, Julie, Moisan, Jacques, Privezentzev, Cyril, Soskic, Blagoje, Sabbah, Shereen, Cohen, Suzanne, Collinson, Andie, England, Elizabeth, Huntington, Catherine, Kemp, Ben, Zhuang, Li, Hudak, Suzanne, Rees, D Gareth, Goldberg, Debbie, Barton, Chris, Chang, Linda, Vainshtein, Inna, Liang, Meina, Iciek, Laurie, Ambery, Philip, Peakman, Mark, Vaughan, Tristan J, Tree, Tim I M, Sansom, David M, Bowen, Michael A, Minter, Ralph R, Jermutus, Lutz

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Challenges and opportunities for non-antibody scaffold drugs von Vazquez-Lombardi, Rodrigo, Phan, Tri Giang, Zimmermann, Carsten, Lowe, David, Jermutus, Lutz, Christ, Daniel

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cytokine-neutralizing antibody as a structural mimetic of 2 receptor interactions von Grütter, Christian, Wilkinson, Trevor, Turner, Richard, Podichetty, Sadhana, Finch, Donna, McCourt, Matthew, Loning, Scott, Jermutus, Lutz, Grütter, Markus G

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