4-Hydroxy-5,6-dihydropyrones as Inhibitors of HIV Protease:  The Effect of Heterocyclic Substituents at C-6 on Antiviral Potency and Pharmacokinetic Parameters von Hagen, Susan E, Domagala, John, Gajda, Christopher, Lovdahl, Michael, Tait, Bradley D, Wise, Eric, Holler, Tod, Hupe, Donald, Nouhan, Carolyn, Urumov, Andrej, Zeikus, Greg, Zeikus, Eric, Lunney, Elizabeth A, Pavlovsky, Alexander, Gracheck, Stephen J, Saunders, James, VanderRoest, Steve, Brodfuehrer, Joanne

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Design, Synthesis, and Cocrystal Structure of a Nonpeptide Src SH2 Domain Ligand von Plummer, Mark S, Holland, Debra R, Shahripour, Aurash, Lunney, Elizabeth A, Fergus, James H, Marks, James S, McConnell, Patrick, Mueller, W. Thomas, Sawyer, Tomi K

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A Novel Nonpeptide HIV-1 Protease Inhibitor: Elucidation of the Binding Mode and Its Application in the Design of Related Analogs von Lunney, Elizabeth A, Hagen, Susan E, Domagala, John M, Humblet, Christine, Kosinski, Janet, Tait, Bradley D, Warmus, Joseph S, Wilson, Michael, Ferguson, Donna

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An Alpha-Mercaptoacrylic Acid Derivative is a Selective Nonpeptide Cell-Permeable Calpain Inhibitor and is Neuroprotective von Kevin K. W. Wang, Nath, Rathna, Posner, Avigail, Raser, Kadee J., Buroker-Kilgore, Michelle, Hajimohammadreza, Iradj, Probert, Albert W., Marcoux, Frank W., Ye, Qizhuang, Takano, Emiko, Hatanaka, Masakazu, Maki, Masatoshi, Caner, Hakan, Collins, Jennifer L., Fergus, Andrea, Lee, Kevin S., Lunney, Elizabeth A., Hays, Sheryl J., Yuen, Po-Wai

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Renin inhibitors containing isosteric replacements of the amide bond connecting the P3 and P2 sites von Kaltenbronn, James S, Hudspeth, J. P, Lunney, E. A, Michniewicz, B. M, Nicolaides, E. D, Repine, J. T, Roark, W. H, Stier, M. A, Tinney, F. J

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X-ray crystallographic analysis of inhibition of endothiapepsin by cyclohexyl renin inhibitors von Cooper, J, Quail, W, Frazao, C, Foundling, S. I, Blundell, T. L, Humblet, C, Lunney, E. A, Lowther, W. T, Dunn, B. M

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5,6-Dihydropyran-2-ones Possessing Various Sulfonyl Functionalities:  Potent Nonpeptidic Inhibitors of HIV Protease von Boyer, Frederick E, Vara Prasad, J. V. N, Domagala, John M, Ellsworth, Edmund L, Gajda, Christopher, Hagen, Susan E, Markoski, Larry J, Tait, Bradley D, Lunney, Elizabeth A, Palovsky, Alexander, Ferguson, Donna, Graham, Neil, Holler, Tod, Hupe, Donald, Nouhan, Carolyn, Tummino, Peter J, Urumov, A, Zeikus, Eric, Zeikus, Greg, Gracheck, Stephen J, Sanders, James M, VanderRoest, Steven, Brodfuehrer, Joanne, Iyer, Krishna, Sinz, Michael, Gulnik, Sergei V, Erickson, John W

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4-Hydroxy-5,6-dihydropyrones. 2. Potent Non-Peptide Inhibitors of HIV Protease von Tait, Bradley D, Hagen, Susan, Domagala, John, Ellsworth, Edmund L, Gajda, Christopher, Hamilton, Harriet W, Vara Prasad, J. V. N, Ferguson, Donna, Graham, Neil, Hupe, Donald, Nouhan, Carolyn, Tummino, Peter J, Humblet, Christine, Lunney, Elizabeth A, Pavlovsky, Alexander, Rubin, John, Gracheck, Stephen J, Baldwin, Eric T, Bhat, T. N, Erickson, John W, Gulnik, Sergei V, Liu, Beishan

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Nonpeptidic HIV protease inhibitors: 6-alkyl-5,6-dihydropyran-2-ones possessing a novel and achiral 3-(2- t-butyl-5-methyl-4-sulfamate)phenylthio moiety von Vara Prasad, J.V.N, Markoski, Larry J, Boyer, Fred E, Domagala, John M, Ellsworth, Edmund L, Gajda, Christopher, Hagen, Susan E, Tait, Bradley D, Lunney, Elizabeth A, Tummino, Peter J, Ferguson, Donna, Holler, Tod, Hupe, Donald, Nouhan, Carolyn, Gracheck, Stephen J, VanderRoest, Steven, Saunders, James, Iyer, K, Sinz, M

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Synthesis of 5,6-Dihydro-4-hydroxy-2- pyrones as HIV-1 Protease Inhibitors:  The Profound Effect of Polarity on Antiviral Activity von Hagen, Susan E, Vara Prasad, J. V. N, Boyer, Frederick E, Domagala, John M, Ellsworth, Edmund L, Gajda, Christopher, Hamilton, Harriet W, Markoski, Larry J, Steinbaugh, Bruce A, Tait, Bradley D, Lunney, Elizabeth A, Tummino, Peter J, Ferguson, Donna, Hupe, Donald, Nouhan, Carolyn, Gracheck, Stephen J, Saunders, James M, VanderRoest, Steven

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Novel Series of Achiral, Low Molecular Weight, and Potent HIV-1 Protease Inhibitors von Vara Prasad, J. V. N, Para, Kimberly S, Lunney, Elizabeth A, Ortwine, Daniel F, Dunbar, James B, Ferguson, Donna, Tummino, Peter J, Hupe, Donald, Tait, Bradley D

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Specificity in the binding of inhibitors to the active site of human/primate aspartic proteinases: analysis of P2-P1-P1'-P2' variation von Rao, Chetana M, Scarborough, Paula E, Kay, John, Batley, Brian, Rapundalo, Stephen, Klutchko, Sylvester, Taylor, Michael D, Lunney, Elizabeth A, Humblet, Christine C, Dunn, Ben M

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Analysis of the Binding of Hydroxamic Acid and Carboxylic Acid Inhibitors to the Stromelysin-1 (Matrix Metalloproteinase-3) Catalytic Domain by Isothermal Titration Calorimetry von Parker, Matthew H, Lunney, Elizabeth A, Ortwine, Daniel F, Pavlovsky, Alexander G, Humblet, Christine, Brouillette, Christie G

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Computing in drug discovery: the design phase von Lunney, E.A.

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Characterization of two structurally novel HIV-1 protease inhibitors identified by rational selection von Humblet, C.C., Lunney, E.A., Buckheit, R.W., Doggett, C., Wong, R., Antonucci, T.K.

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Structure-based design of caspase-1 inhibitor containing a diphenyl ether sulfonamide von Shahripour, Aurash B, Plummer, Mark S, Lunney, Elizabeth A, Sawyer, Tomi K, Stankovic, Charles J, Connolly, Michael K, Rubin, John R, Walker, Nigel P.C, Brady, Kenneth D, Allen, Hamish J, Talanian, Robert V, Wong, Winnie W, Humblet, Christine

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Renin inhibitors containing .alpha.-heteroatom amino acids as P2 residues von Repine, Joseph T, Kaltenbronn, James S, Doherty, Annette M, Hamby, James M, Himmelsbach, Richard J, Kornberg, Brian E, Taylor, Michael D, Lunney, ELizabeth A, Humblet, Christine

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Inhibitors of HIV protease: Unique non-peptide active site templates von Tait, Bradley D., Domagala, John, Ellsworth, Edmund L., Ferguson, Donna, Gajda, Christopher, Hupe, Donald, Lunney, Elizabeth A., Tummino, Peter J.

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Design, synthesis and solution structure of a renin inhibitor Structural constraints from NOE, and homonuclear and heteronuclear coupling constants combined with distance geometry... von Reily, Michael D., Thanabal, Venkataraman, Lunney, Elizabeth A., Repine, Joseph T., Humblet, Christine C., Wagner, Gerhard

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Nonpeptidic HIV protease inhibitors possessing excellent antiviral activities and therapeutic indices. PD 178390 : A lead HIV protease inhibitor von VARA PRASAD, J. V. N, BOYER, F. E, HUMBLET, C, LUNNEY, E. A, PAVLOVSKY, A, RUBIN, J. R, FERGUSON, D, GRAHAM, N, HOLLER, T, HUPE, D, NOUHAN, C, TUMMINO, P. J, DOMAGALA, J. M, URUMOV, A, ZEIKUS, E, ZEIKUS, G, GRACHECK, S. J, SAUNDERS, J. M, VANDERROEST, S, BRODFUEHRER, J, IYER, K, SINZ, M, GULNIK, S. V, ELLSWORTH, E. L, ERICKSON, J. W, GAJDA, C, HAMILTON, H. W, HAGEN, S. E, MARKOSKI, L. J, STEINBAUGH, B. A, TAIT, B. D

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