Clinical and Biological Efficacy of Recombinant Human Interleukin-21 in Patients with Stage IV Malignant Melanoma without Prior Treatment: A Phase IIa Trial von Davis, Ian D, Brady, Ben, Kefford, Richard F, Millward, Michael, Cebon, Jonathan, Skrumsager, Birte K, Mouritzen, Ulrik, Hansen, Lasse Tengbjerg, Skak, Kresten, Lundsgaard, Dorthe, Frederiksen, Klaus Stensgaard, Kristjansen, Paul E G, McArthur, Grant

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An Open-Label, Two-Arm, Phase I Trial of Recombinant Human Interleukin-21 in Patients with Metastatic Melanoma von Davis, Ian D, Skrumsager, Birte K, Cebon, Jonathan, Nicholaou, Theo, Barlow, John W, Moller, Niels Peter Hundahl, Skak, Kresten, Lundsgaard, Dorthe, Frederiksen, Klaus Stensgaard, Thygesen, Peter, McArthur, Grant A

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Evaluating IL-21 as a Potential Therapeutic Target in Crohn’s Disease von Frederiksen, Klaus Stensgaard, Haase, Claus, Lundsgaard, Dorthe, Holgersen, Kristine, Hermit, Mette Brunsgaard, Hansen, Lene, Sondergaard, Bodil-Cecilie, Kvist, Peter H., Søndergaard, Henrik, Tornehave, Ditte, Lindebo Holm, Thomas, Vergo, Sandra

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Inhibition of NKG2D receptor function by antibody therapy attenuates transfer‐induced colitis in SCID mice von Kjellev, Stine, Haase, Claus, Lundsgaard, Dorthe, Ursø, Birgitte, Tornehave, Ditte, Markholst, Helle

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In Vivo Control of Diabetogenic T-Cells by Regulatory CD4+CD25+ T-Cells Expressing Foxp3 von LUNDSGAARD, Dorthe, HOLM, Thomas Lindebo, HORNUM, Lars, MARKHOLST, Helle

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Interleukin‐21 activates human natural killer cells and modulates their surface receptor expression von Skak, Kresten, Frederiksen, Klaus Stensgaard, Lundsgaard, Dorthe

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Detection of gene expression signatures related to underlying disease and treatment in rheumatoid arthritis patients von Serikawa, Kyle A., Jacobsen, Søren, Lundsgaard, Dorthe, Fox, Brian A., Hummelshoj, Lone, Poulsen, Lars K., Fleckner, Jan, Frederiksen, Klaus Stensgaard

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Improved β-Cell Survival and Reduced Insulitis in a Type 1 Diabetic Rat Model After Treatment With a β-Cell–Selective KATP Channel Opener von SKAK, Kresten, GOTFREDSEN, Carsten F, LUNDSGAARD, Dorthe, HANSEN, John Bondo, STURIS, Jeppe, MARKHOLST, Helle

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Reactivity of naive CD4+CD25- T cells against gut microflora in healthy mice von Gad, Monika, Lundsgaard, Dorthe, Kjellev, Stine, Kristensen, Nanna N, Seremet, Tina, Straten, Per Thor, Claesson, Mogens H

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Flow sorting from organ material by intracellular markers von Moerch, Ulrik, Nielsen, Henriette S., Lundsgaard, Dorthe, Oleksiewicz, Martin B.

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Blockade of IL-21 promotes the induction of T regulatory cells in healthy controls and IBD patients (P5158) von Wu, Rebecca, Cox, Jennifer, Blumberg, Hal, Levin, Steven, Lundsgaard, Dorthe

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Combined Pharmacodynamic and Transcriptome Profiling of Recombinant Human Interleukin-21 Responses in Patients with Stage IV Malignant Melanoma von Lundsgaard, Dorthe, Research Scientist, Project Manager, Novo Nordisk A/S, Maaloev, Denmark, Frederiksen, Klaus Stensgaard, Senior Scientist, Novo Nordisk A/S, Bagsvaerd, Denmark, Hansen, Lasse Tengbjerg, Clinical Scientist, Novo Nordisk A/S, Bagsvaerd, Denmark, Skrumsager, Birte K., Senior Clinical Pharmacologist, Novo Nordisk A/S, Bagsvaerd, Denmark, Mouritzen, Ulrik, International Medical Officer, Novo Nordisk A/S, Bagsvaerd, Denmark, McArthur, Grant, Professor, Cancer Trials Australia, Peter MacCallum Cancer Centre, Melbourne, Australia, Davis, Ian D., Professor, Cancer Trials Australia, Austin Hospital, Melbourne, Australia, Skak, Kresten, Senior Scientist, Novo Nordisk A/S, Bagsvaerd, Denmark

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IL-21 neutralizing antibody inhibits human TFH proliferation and TFH-mediated maturation of naïve B cells (P5220) von Hussell, Scott, Smith, Patricia, Fox, Brian, Serikawa, Kyle, Levin, Steven, Cox, Jennifer, Lundsgaard, Dorthe

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IL-21 induces in vivo immune activation of NK cells and CD8+ T cells in patients with metastatic melanoma and renal cell carcinoma von Frederiksen, Klaus Stensgaard, Lundsgaard, Dorthe, Freeman, Jeremy A., Hughes, Steven D., Holm, Thomas L., Skrumsager, Birte K., Petri, Andreas, Hansen, Lasse T., McArthur, Grant A., Davis, Ian D., Skak, Kresten

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PolyI:C Induction of Diabetes Is Controlled by Iddm4 in Rats with a Full Regulatory T Cell Pool von HORNUM, LARS, LUNDSGAARD, DORTHE, MARKHOLST, HELLE

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Tu1672 IL-21 Production and Function in Peripheral Immune Cells From Crohn's Disease Patients von Cox, Jennifer H, Thomas, Evan, Wu, Rebecca P, Valliant-Saunders, Kem, Hussell, Scott, Smith, Patricia, Stucky, Jason, Blasius, Amanda, Serikawa, Kyle, Blumberg, Hal, Levin, Steve, Lundsgaard, Dorthe

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Expression of IL-21 receptor in synovial tissue and blood of patients with rheumatoid arthritis von Frleta, Marina, King, Vicky, Reilly, James H, Kerr, Shauna, Gilchrist, Derek S, Tornehave, Ditte, Lundsgaard, Dorthe, Miller, Ashley M, McInnes, Iain B

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Immune activation in advanced cancer patients treated with recombinant IL-21: multianalyte profiling of serum proteins von Dodds, Michael G, Frederiksen, Klaus Stensgaard, Skak, Kresten, Hansen, Lasse Tengbjerg, Lundsgaard, Dorthe, Thompson, John A, Hughes, Steven D

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Erratum to: Detection of gene expression signatures related to underlying disease and treatment in rheumatoid arthritis patients von Serikawa, Kyle A., Jacobsen, Søren, Lundsgaard, Dorthe, Fox, Brian A., Hummelshoj, Lone, Poulsen, Lars K., Fleckner, Jan, Frederiksen, Klaus Stensgaard

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Erratum to: Detection of gene expression signatures related to underlying disease and treatment in rheumatoid arthritis patients von Serikawa, Kyle A., Jacobsen, Søren, Lundsgaard, Dorthe, Fox, Brian A., Hummelshoj, Lone, Poulsen, Lars K., Fleckner, Jan, Frederiksen, Klaus Stensgaard

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