Systems analysis of eleven rodent disease models reveals an inflammatome signature and key drivers von Wang, I‐Ming, Zhang, Bin, Yang, Xia, Zhu, Jun, Stepaniants, Serguei, Zhang, Chunsheng, Meng, Qingying, Peters, Mette, He, Yudong, Ni, Chester, Slipetz, Deborah, Crackower, Michael A, Houshyar, Hani, Tan, Christopher M, Asante‐Appiah, Ernest, O'Neill, Gary, Jane Luo, Mingjuan, Thieringer, Rolf, Yuan, Jeffrey, Chiu, Chi‐Sung, Yee Lum, Pek, Lamb, John, Boie, Yves, Wilkinson, Hilary A, Schadt, Eric E, Dai, Hongyue, Roberts, Christopher

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Integrating genotypic and expression data in a segregating mouse population to identify 5-lipoxygenase as a susceptibility gene for obesity and bone traits von Schadt, Eric E, Mehrabian, Margarete, Allayee, Hooman, Stockton, Jirina, Lum, Pek Yee, Drake, Thomas A, Castellani, Lawrence W, Suh, Michael, Armour, Christopher, Edwards, Stephen, Lamb, John, Lusis, Aldons J

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Genomics and Cardiovascular Drug Development von Plump, Andrew S., MD, PhD, Lum, Pek Yee, PhD

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A Gene Expression Signature That Classifies Human Atherosclerotic Plaque by Relative Inflammation Status von Puig, Oscar, Yuan, Jeffrey, Stepaniants, Sergey, Zieba, Renata, Zycband, Emanuel, Morris, Mark, Coulter, Silvija, Yu, Xiang, Menke, John, Woods, John, Chen, Fabian, Ramey, Dena R, He, Xuanmin, OʼNeill, Edward A, Hailman, Eric, Johns, Douglas G, Hubbard, Brian K, Yee Lum, Pek, Wright, Samuel D, DeSouza, Mary M, Plump, Andrew, Reiser, Vladimír

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Integrating QTL and high-density SNP analyses in mice to identify Insig2 as a susceptibility gene for plasma cholesterol levels von Cervino, Alessandra C., Li, Guoya, Edwards, Steve, Zhu, Jun, Laurie, Cathy, Tokiwa, George, Lum, Pek Yee, Wang, Susanna, Castellini, Lawrence W., Lusis, Aldons J., Carlson, Sonia, Sachs, Alan B., Schadt, Eric E.

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Variations in DNA elucidate molecular networks that cause disease von Chen, Yanqing, Zhu, Jun, Lum, Pek Yee, Yang, Xia, Pinto, Shirly, MacNeil, Douglas J., Zhang, Chunsheng, Lamb, John, Edwards, Stephen, Sieberts, Solveig K., Leonardson, Amy, Castellini, Lawrence W., Wang, Susanna, Champy, Marie-France, Zhang, Bin, Emilsson, Valur, Doss, Sudheer, Ghazalpour, Anatole, Horvath, Steve, Drake, Thomas A., Lusis, Aldons J., Schadt, Eric E.

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Systematic genetic and genomic analysis of cytochrome P450 enzyme activities in human liver von Yang, Xia, Zhang, Bin, Molony, Cliona, Chudin, Eugene, Hao, Ke, Zhu, Jun, Gaedigk, Andrea, Suver, Christine, Zhong, Hua, Leeder, J Steven, Guengerich, F Peter, Strom, Stephen C, Schuetz, Erin, Rushmore, Thomas H, Ulrich, Roger G, Slatter, J Greg, Schadt, Eric E, Kasarskis, Andrew, Lum, Pek Yee

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Elucidating host cell response pathways and repurposing therapeutics for SARS-CoV-2 and other coronaviruses von Shen, Zhewei, Halberg, Anna, Fong, Jia Yi, Guo, Jingyu, Song, Gavin, Louie, Brent, Luedtke, Gregory R., Visuthikraisee, Viwat, Protter, Andrew A., Koh, Xiaoying, Baik, Taegon, Lum, Pek Yee

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A survey of the genetics of stomach, liver, and adipose gene expression from a morbidly obese cohort von Greenawalt, Danielle M, Dobrin, Radu, Chudin, Eugene, Hatoum, Ida J, Suver, Christine, Beaulaurier, John, Zhang, Bin, Castro, Victor, Zhu, Jun, Sieberts, Solveig K, Wang, Susanna, Molony, Cliona, Heymsfield, Steven B, Kemp, Daniel M, Reitman, Marc L, Lum, Pek Yee, Schadt, Eric E, Kaplan, Lee M

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An integrative genomics approach to infer causal associations between gene expression and disease von Schadt, Eric E, Lamb, John, Yang, Xia, Zhu, Jun, Edwards, Steve, GuhaThakurta, Debraj, Sieberts, Solveig K, Monks, Stephanie, Reitman, Marc, Zhang, Chunsheng, Lum, Pek Yee, Leonardson, Amy, Thieringer, Rolf, Metzger, Joseph M, Yang, Liming, Castle, John, Zhu, Haoyuan, Kash, Shera F, Drake, Thomas A, Sachs, Alan, Lusis, Aldons J

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Liver and adipose expression associated SNPs are enriched for association to type 2 diabetes von Zhong, Hua, Beaulaurier, John, Lum, Pek Yee, Molony, Cliona, Yang, Xia, Macneil, Douglas J, Weingarth, Drew T, Zhang, Bin, Greenawalt, Danielle, Dobrin, Radu, Hao, Ke, Woo, Sangsoon, Fabre-Suver, Christine, Qian, Su, Tota, Michael R, Keller, Mark P, Kendziorski, Christina M, Yandell, Brian S, Castro, Victor, Attie, Alan D, Kaplan, Lee M, Schadt, Eric E

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Development of the Digital Arthritis Index, a Novel Metric to Measure Disease Parameters in a Rat Model of Rheumatoid Arthritis von Lim, Maria A, Louie, Brenton, Ford, Daniel, Heath, Kyle, Cha, Paulyn, Betts-Lacroix, Joe, Lum, Pek Yee, Robertson, Timothy L, Schaevitz, Laura

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Discovering Modes of Action for Therapeutic Compounds Using a Genome-Wide Screen of Yeast Heterozygotes von Lum, Pek Yee, Armour, Christopher D., Stepaniants, Sergey B., Cavet, Guy, Wolf, Maria K., Butler, J.Scott, Hinshaw, Jerald C., Garnier, Philippe, Prestwich, Glenn D., Leonardson, Amy, Garrett-Engele, Philip, Rush, Christopher M., Bard, Martin, Schimmack, Greg, Phillips, John W., Roberts, Christopher J., Shoemaker, Daniel D.

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Clustering of Hepatotoxins Based on Mechanism of Toxicity Using Gene Expression Profiles von Waring, Jeffrey F., Jolly, Robert A., Ciurlionis, Rita, Lum, Pek Yee, Praestgaard, Jens T., Morfitt, David C., Buratto, Bruno, Roberts, Chris, Schadt, Eric, Ulrich, Roger G.

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Elucidating the murine brain transcriptional network in a segregating mouse population to identify core functional modules for obesity and diabetes von Lum, Pek Yee, Chen, Yanqing, Zhu, Jun, Lamb, John, Melmed, Shlomo, Wang, Susanna, Drake, Tom A., Lusis, Aldons J., Schadt, Eric E.

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An eQTL biological data visualization challenge and approaches from the visualization community von Bartlett, Christopher W, Cheong, Soo Yeon, Hou, Liping, Paquette, Jesse, Lum, Pek Yee, Jäger, Günter, Battke, Florian, Vehlow, Corinna, Heinrich, Julian, Nieselt, Kay, Sakai, Ryo, Aerts, Jan, Ray, William C

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Gene expression profiling of rat liver reveals a mechanistic basis for ritonavir-induced hyperlipidemia von Lum, Pek Yee, He, Yudong D., Slatter, J. Greg, Waring, Jeffrey F., Zelinsky, Nicollete, Cavet, Guy, Dai, Xudong, Fong, Olivia, Gum, Rebecca, Jin, Lixia, Adamson, Gary E., Roberts, Christopher J., Olsen, David B., Hazuda, Daria J., Ulrich, Roger G.

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Parallel analysis of tagged deletion mutants efficiently identifies genes involved in endoplasmic reticulum biogenesis von Wright, Robin, Parrish, Mark L., Cadera, Emily, Larson, Lynnelle, Matson, Clinton K., Garrett‐Engele, Philip, Armour, Chris, Lum, Pek Yee, Shoemaker, Daniel D.

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Obesity and genetics regulate microRNAs in islets, liver, and adipose of diabetic mice von Zhao, Enpeng, Keller, Mark P, Rabaglia, Mary E, Oler, Angie T, Stapleton, Donnie S, Schueler, Kathryn L, Neto, Elias Chaibub, Moon, Jee Young, Wang, Ping, Wang, I-Ming, Lum, Pek Yee, Ivanovska, Irena, Cleary, Michele, Greenawalt, Danielle, Tsang, John, Choi, Youn Jeong, Kleinhanz, Robert, Shang, Jin, Zhou, Yun-Ping, Howard, Andrew D, Zhang, Bei B, Kendziorski, Christina, Thornberry, Nancy A, Yandell, Brian S, Schadt, Eric E, Attie, Alan D

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Serotonin‑2 Receptor Agonists Produce Anti-inflammatory Effects through Functionally Selective Mechanisms That Involve the Suppression of Disease-Induced Arginase 1 Expression von Flanagan, Thomas W., Foster, Timothy P., Galbato, Thomas E., Lum, Pek Yee, Louie, Brent, Song, Gavin, Halberstadt, Adam L., Billac, Gerald B., Nichols, Charles D.

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