A Novel Bispecific Antibody Targeting EGFR and cMet Is Effective against EGFR Inhibitor-Resistant Lung Tumors von Moores, Sheri L, Chiu, Mark L, Bushey, Barbara S, Chevalier, Kristen, Luistro, Leopoldo, Dorn, Keri, Brezski, Randall J, Haytko, Peter, Kelly, Thomas, Wu, Sheng-Jiun, Martin, Pauline L, Neijssen, Joost, Parren, Paul W H I, Schuurman, Janine, Attar, Ricardo M, Laquerre, Sylvie, Lorenzi, Matthew V, Anderson, G Mark

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A stable, engineered TL1A ligand co-stimulates T cells via specific binding to DR3 von Zwolak, Adam, Chan, Szeman Ruby, Harvilla, Paul, Mahady, Sally, Armstrong, Anthony A., Luistro, Leopoldo, Tamot, Ninkka, Yamada, Douglas, Derebe, Mehabaw, Pomerantz, Steven, Chiu, Mark, Ganesan, Rajkumar, Chowdhury, Partha

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Combination GITR targeting/PD-1 blockade with vaccination drives robust antigen-specific antitumor immunity von Villarreal, Daniel O, Chin, Diana, Smith, Melissa A, Luistro, Leopoldo L, Snyder, Linda A

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Blockade of VLA4 sensitizes leukemic and myeloma tumor cells to CD3 redirection in the bone marrow microenvironment von Nair-Gupta, Priyanka, Rudnick, Stephen I., Luistro, Leopoldo, Smith, Melissa, McDaid, Ronan, Li, Yingzhe, Pillarisetti, Kodandaram, Joseph, Jocelin, Heidrich, Bradley, Packman, Kathryn, Attar, Ricardo, Gaudet, François

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Discovery of siRNA Lipid Nanoparticles to Transfect Suspension Leukemia Cells and Provide In Vivo Delivery Capability von He, Wei, Bennett, Michael J, Luistro, Leopoldo, Carvajal, Daisy, Nevins, Thomas, Smith, Melissa, Tyagi, Gaurav, Cai, James, Wei, Xin, Lin, Tai-An, Heimbrook, David C, Packman, Kathryn, Boylan, John F

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Targeting of CD122 enhances antitumor immunity by altering the tumor immune environment von Villarreal, Daniel O, Allegrezza, Michael J, Smith, Melissa A, Chin, Diana, Luistro, Leopoldo L, Snyder, Linda A

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RG7212 Anti-TWEAK mAb Inhibits Tumor Growth through Inhibition of Tumor Cell Proliferation and Survival Signaling and by Enhancing the Host Antitumor Immune Response von XUEFENG YIN, LUISTRO, Leopoldo, XIAOQIAN WANG, PACKMAN, Kathryn, ROSINSKI, Jim, BERKOFSKY-FESSLER, Windy, TANG, Jian-Ping, PANT, Saumya, GEHO, David, VEGA-HARRING, Suzana, DEMARIO, Mark, LEVITSKY, Hy, HUA ZHONG, SIMCOX, Mary, SMITH, Melissa, NEVINS, Tom, SCHOSTACK, Kathleen, HILTON, Holly, LIN, Tai-An, TRUITT, Theresa, BIONDI, Denise

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In vitro and in vivo activity of R547: a potent and selective cyclin-dependent kinase inhibitor currently in phase I clinical trials von DePinto, Wanda, Chu, Xin-Jie, Yin, Xuefeng, Smith, Melissa, Packman, Kathryn, Goelzer, Petra, Lovey, Allen, Chen, Yingsi, Qian, Hong, Hamid, Rachid, Xiang, Qing, Tovar, Christian, Blain, Roger, Nevins, Tom, Higgins, Brian, Luistro, Leopoldo, Kolinsky, Kenneth, Felix, Bernardo, Hussain, Sazzad, Heimbrook, David

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Development and characterization of a preclinical ovarian carcinoma model to investigate the mechanism of acquired resistance to trastuzumab von LUISTRO, LEOPOLDO L, ROSINSKI, JAMES A, BIAN, HONGJIN, BISHAYEE, SUBAL, RAMESHWAR, PRANELA, PONZIO, NICHOLAS M, RITLAND, STEVE R

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A T-cell–redirecting bispecific G-protein–coupled receptor class 5 member D x CD3 antibody to treat multiple myeloma von Pillarisetti, Kodandaram, Edavettal, Suzanne, Mendonça, Mark, Li, Yingzhe, Tornetta, Mark, Babich, Alexander, Majewski, Nate, Husovsky, Matt, Reeves, Dara, Walsh, Eileen, Chin, Diana, Luistro, Leopoldo, Joseph, Jocelin, Chu, Gerald, Packman, Kathryn, Shetty, Shoba, Elsayed, Yusri, Attar, Ricardo, Gaudet, François

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Characterization of JNJ-79635322, a Novel BCMAxGPRC5DxCD3 T-Cell Redirecting Trispecific Antibody, for the Treatment of Multiple Myeloma von Pillarisetti, Ram, Yang, Danlin, Yao, Jianhong, Smith, Melissa, Luistro, Leopoldo, Vulfson, Peter, Testa, James, Packman, Kathryn, Brodeur, Scott, Attar, Ricardo M., Elsayed, Yusri, Philippar, Ulrike

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Teclistamab is an active T cell–redirecting bispecific antibody against B-cell maturation antigen for multiple myeloma von Pillarisetti, Kodandaram, Powers, Gordon, Luistro, Leopoldo, Babich, Alexander, Baldwin, Eric, Li, Yingzhe, Zhang, Xiaochun, Mendonça, Mark, Majewski, Nate, Nanjunda, Rupesh, Chin, Diana, Packman, Kathryn, Elsayed, Yusri, Attar, Ricardo, Gaudet, François

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Discovery of a Novel, First-in-Class Bfl-1 BH3 Mimetic with Pro-Apoptotic Activity von Derks, Maarten, Bryan, Marian C., Rockx, Cindy, Schults, Tamara, Verhulst, Tinne, Pietrak, Beth, Maehigashi, Tatsuya, Robertson, James C., DeMaria, Andrew H., Holt, Kimberly, Ji, Shaofei, Wong, Victoria, Bueters, Ruud, Koo, Seong Joo, Masure, Stefan, Bhogal, Balpreet, Kelly, Christopher B., Mitra, Kaushik, Luistro, Leopoldo, Shaffer, Paul L., Szewczuk, Lawrence, Elsayed, Yusri, Philippar, Ulrike

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Discovery of JNJ-63576253: A Clinical Stage Androgen Receptor Antagonist for F877L Mutant and Wild-Type Castration-Resistant Prostate Cancer (mCRPC) von Zhang, Zhuming, Connolly, Peter J, Lim, Heng Keang, Pande, Vineet, Meerpoel, Lieven, Teleha, Christopher, Branch, Jonathan R, Ondrus, Janine, Hickson, Ian, Bush, Tammy, Luistro, Leopoldo, Packman, Kathryn, Bischoff, James R, Ibrahim, Salam, Parrett, Christopher, Chong, Yolanda, Gottardis, Marco M, Bignan, Gilles

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Preclinical Profile of a Potent γ-Secretase Inhibitor Targeting Notch Signaling with In vivo Efficacy and Pharmacodynamic Properties von LUISTRO, Leopoldo, WEI HE, LINN, Michael, FLOHR, Alexander, JAKOB-RØTNE, Roland, JACOBSEN, Helmut, GLENN, Kelli, HEIMBROOK, David, BOYLAN, John F, SMITH, Melissa, PACKMAN, Kathryn, VILENCHIK, Maria, CARVAJAL, Daisy, ROBERTS, John, CAI, James, BERKOFSKY-FESSLER, Windy, HILTON, Holly

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Abstract 5567: In vivo administration of the STING agonist, JNJ-67544412, leads to complete regression of established murine subcutaneous tumors von Smith, Melissa, Chin, Diana, Chan, Szeman, Mahady, Sally, Campion, Liam, Morgan, Caitlin, Patel, Shefali, Chu, Gerald, Hughes, Anna, Bignan, Gilles, Connolly, Pete, Emanuel, Stuart, Packman, Kathryn, Luistro, Leopoldo L.

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Abstract 3636: Potent antitumor activity of duvortuxizumab, a CD19 x CD3 DART® molecule, in lymphoma models von Izhak, Liat, Cullen, Dana E., Elgawly, Maha, Luistro, Leopoldo, Johnson, Syd, Bald, Jaime, Sasser, A Kate, Balasubramanian, Sriram

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Abstract 2179: Antitumor activity of JNJ-63576253 (TRC253), a small molecule antagonist of F877L mutant and wild-type androgen receptor von Bush, Tammy L., Ndikuyeze, Georges Habineza, Bignan, Gilles, Branch, Jonathan, Ondrus, Janine, Shi, Yifan, Luistro, Leopoldo, Hastings, James, Erhardt, Joseph, Hickson, Ian, Patel, Shefali, Connolly, Peter, Zhang, Zhuming, Bischoff, James, Rupnow, Brent, Gottardis, Marco, Packman, Kathryn

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Abstract 1101: Telomerase inhibitor imetelstat in combination with the BCL-2 inhibitor venetoclax enhances apoptosis in vitro and increases survival in vivo in acute myeloid leukem... von Rusbuldt, Joshua J., Luistro, Leopoldo, Chin, Diana, Smith, Melissa, Wong, Amy, Romero, Margarita, Rizo, Aleksandra, Bussolari, Jacqueline, Huang, Fei, Sasser, Amy (Kate)

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The Impact of the Bone Marrow Microenvironment on T Cell Redirection Therapeutics von Nair-Gupta, Priyanka, Rudnick, Stephen, Luistro, Leopoldo, Chin, Diana, Smith, Melissa, McDaid, Ronan, Li, Yingzhe, Pillarisetti, Kodandaram, Baldwin, Eric, Packman, Kathryn, Elsayed, Yusri, Attar, Ricardo M., Gaudet, François

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