MK-5172, a Selective Inhibitor of Hepatitis C Virus NS3/4a Protease with Broad Activity across Genotypes and Resistant Variants von SUMMA, Vincenzo, LUDMERER, Steven W, GATES, Adam T, GRAHAM, Donald J, HARPER, Steven, HAZUDA, Daria J, MCHALE, Carolyn, MONTEAGUDO, Edith, PUCCI, Vincenzo, ROWLEY, Michael, RUDD, Michael T, SORIANO, Aileen, MCCAULEY, John A, STAHLHUT, Mark W, VACCA, Joseph P, OLSEN, David B, LIVERTON, Nigel J, CARROLL, Steven S, FANDOZZI, Christine, BURLEIN, Christine, CLAUDIO, Giuliano, COLEMAN, Paul J, DIMUZIO, Jillian M, FERRARA, Marco, DI FILIPPO, Marcello

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Susceptibilities of genotype 1a, 1b, and 3 hepatitis C virus variants to the NS5A inhibitor elbasvir von Liu, Rong, Curry, Stephanie, McMonagle, Patricia, Yeh, Wendy W, Ludmerer, Steven W, Jumes, Patricia A, Marshall, William L, Kong, Stephanie, Ingravallo, Paul, Black, Stuart, Pak, Irene, DiNubile, Mark J, Howe, Anita Y M

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Discovery of MK-8742: An HCV NS5A Inhibitor with Broad Genotype Activity von Coburn, Craig A., Meinke, Peter T., Chang, Wei, Fandozzi, Christine M., Graham, Donald J., Hu, Bin, Huang, Qian, Kargman, Stacia, Kozlowski, Joseph, Liu, Rong, McCauley, John A., Nomeir, Amin A., Soll, Richard M., Vacca, Joseph P., Wang, Dahai, Wu, Hao, Zhong, Bin, Olsen, David B., Ludmerer, Steven W.

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Multi-step parallel synthesis enabled optimization of benzofuran derivatives as pan-genotypic non-nucleoside inhibitors of HCV NS5B von Xiao, Dong, Dai, Xing, Liu, Hong, He, Shuwen, Shi, Zhi-Cai, Ludmerer, Steven W., Li, Fangbiao, Nargund, Ravi, Palani, Anandan

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MK-7009, a Potent and Selective Inhibitor of Hepatitis C Virus NS3/4A Protease von LIVERTON, Nigel J, CARROLL, Steven S, OLSEN, David B, RUDD, Michael T, STAHLHUT, Mark, VACCA, Joseph P, DIMUZIO, Jillian, FANDOZZI, Christine, GRAHAM, Donald J, HAZUDA, Daria, KATHERINE HOLLOWAY, M, LUDMERER, Steven W, MCCAULEY, John A, MCINTYRE, Charles J

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Discovery of Vaniprevir (MK-7009), a Macrocyclic Hepatitis C Virus NS3/4a Protease Inhibitor von McCauley, John A, McIntyre, Charles J, Rudd, Michael T, Nguyen, Kevin T, Romano, Joseph J, Butcher, John W, Gilbert, Kevin F, Bush, Kimberly J, Holloway, M. Katharine, Swestock, John, Wan, Bang-Lin, Carroll, Steven S, DiMuzio, Jillian M, Graham, Donald J, Ludmerer, Steven W, Mao, Shi-Shan, Stahlhut, Mark W, Fandozzi, Christine M, Trainor, Nicole, Olsen, David B, Vacca, Joseph P, Liverton, Nigel J

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Vaniprevir plus peginterferon alfa-2b and ribavirin in treatment-naive Japanese patients with hepatitis C virus genotype 1 infection: a randomized phase III study von Hayashi, Norio, Nakamuta, Makoto, Takehara, Tetsuo, Kumada, Hiromitsu, Takase, Akiko, Howe, Anita Yee Mei, Ludmerer, Steven W., Mobashery, Niloufar

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Design and evaluation of novel tetracyclic benzofurans as palm site allosteric inhibitors of HCV NS5B polymerase von Liu, Hong, Dai, Xing, He, Shuwen, Brockunier, Linda, Marcantonio, Karen, Ludmerer, Steven W., Li, Fangbiao, Feng, Kung-I, Nargund, Ravi P., Palani, Anandan

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Sustained Viral Response in a Hepatitis C Virus-Infected Chimpanzee via a Combination of Direct-Acting Antiviral Agents von OLSEN, David B, DAVIES, Mary-Ellen, CARROLL, Steven S, HANDT, Larry, KOEPLINGER, Kenneth, RENA ZHANG, Nanyan, LUDMERER, Steven W, GRAHAM, Donald, LIVERTON, Nigel, MACCOSS, Malcolm, HAZUDA, Daria

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Virologic Resistance Analysis From a Phase 2 Study of MK-5172 Combined With Pegylated Interferon/Ribavirin in Treatment-Naive Patients With Hepatitis C Virus Genotype 1 Infection von Howe, Anita Y. M., Black, Stuart, Curry, Stephanie, Ludmerer, Steven W., Liu, Rong, Barnard, Richard J. O., Newhard, William, Hwang, Peggy M. T., Nickle, David, Gilbert, Christopher, Caro, Luzelena, DiNubile, Mark J., Mobashery, Niloufar

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Robust Antiviral Efficacy upon Administration of a Nucleoside Analog to Hepatitis C Virus-Infected Chimpanzees von CARROLL, Steven S, LUDMERER, Steven, HANDT, Larry, KOEPLINGER, Kenneth, ZHANG, Nanyan Rena, GRAHAM, Donald, DAVIES, Mary-Ellen, MACCOSS, Malcolm, HAZUDA, Daria, OLSEN, David B

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Development of a New Structural Class of Broadly Acting HCV Non‐Nucleoside Inhibitors Leading to the Discovery of MK‐8876 von McComas, Casey C., Palani, Anandan, Chang, Wei, Holloway, M. Katharine, Lesburg, Charles A., Li, Peng, Liverton, Nigel, Meinke, Peter T., Olsen, David B., Peng, Xuanjia, Soll, Richard M., Ummat, Ajay, Wu, Jie, Wu, Jin, Zorn, Nicolas, Ludmerer, Steven W.

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Replication Fitness and NS5B Drug Sensitivity of Diverse Hepatitis C Virus Isolates Characterized by Using a Transient Replication Assay von LUDMERER, Steven W, GRAHAM, Donald J, LAFEMINA, Robert L, BOOTS, Evelyn, MURRAY, Edward M, SIMCOE, Amy, MARKEL, Eric J, GROBLER, Jay A, FLORES, Osvaldo A, OLSEN, David B, HAZUDA, Daria J

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Identification of Two Novel Drosophila melanogaster Histamine-gated Chloride Channel Subunits Expressed in the Eye von Zheng, Yingcong, Hirschberg, Birgit, Yuan, Jeffrey, Wang, Alice P., Hunt, David C., Ludmerer, Steven W., Schmatz, Dennis M., Cully, Doris F.

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HCV evolutionary genetics of SVR versus virologic failure assessed from the vaniprevir phase III registration trials von Ludmerer, Steven W, Hirano, Tomona, Black, Stuart, Howe, Anita Y M, Chang, Wei, Takase, Akiko, Nakamura, Keisuke, Tanaka, Yoshiyuki, Kumada, Hiromitsu, Hayashi, Norio, Nickle, David

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Discovery of MK-5172, a Macrocyclic Hepatitis C Virus NS3/4a Protease Inhibitor von Harper, Steven, McCauley, John A, Rudd, Michael T, Ferrara, Marco, DiFilippo, Marcello, Crescenzi, Benedetta, Koch, Uwe, Petrocchi, Alessia, Holloway, M. Katharine, Butcher, John W, Romano, Joseph J, Bush, Kimberly J, Gilbert, Kevin F, McIntyre, Charles J, Nguyen, Kevin T, Nizi, Emanuela, Carroll, Steven S, Ludmerer, Steven W, Burlein, Christine, DiMuzio, Jillian M, Graham, Donald J, McHale, Carolyn M, Stahlhut, Mark W, Olsen, David B, Monteagudo, Edith, Cianetti, Simona, Giuliano, Claudio, Pucci, Vincenzo, Trainor, Nicole, Fandozzi, Christine M, Rowley, Michael, Coleman, Paul J, Vacca, Joseph P, Summa, Vincenzo, Liverton, Nigel J

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Characterization of Resistance to Non-obligate Chain-terminating Ribonucleoside Analogs That Inhibit Hepatitis C Virus Replication in Vitro von Migliaccio, Giovanni, Tomassini, Joanne E., Carroll, Steven S., Tomei, Licia, Altamura, Sergio, Bhat, Balkrishen, Bartholomew, Linda, Bosserman, Michele R., Ceccacci, Alessandra, Colwell, Lawrence F., Cortese, Riccardo, De Francesco, Raffaele, Eldrup, Anne B., Getty, Krista L., Hou, Xiaoli S., LaFemina, Robert L., Ludmerer, Steven W., MacCoss, Malcolm, McMasters, Daniel R., Stahlhut, Mark W., Olsen, David B., Hazuda, Daria J., Flores, Osvaldo A.

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Front Cover: Development of a New Structural Class of Broadly Acting HCV Non‐Nucleoside Inhibitors Leading to the Discovery of MK‐8876 (ChemMedChem 17/2017) von McComas, Casey C., Palani, Anandan, Chang, Wei, Holloway, M. Katharine, Lesburg, Charles A., Li, Peng, Liverton, Nigel, Meinke, Peter T., Olsen, David B., Peng, Xuanjia, Soll, Richard M., Ummat, Ajay, Wu, Jie, Wu, Jin, Zorn, Nicolas, Ludmerer, Steven W.

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P2-Quinazolinones and Bis-Macrocycles as New Templates for Next-Generation Hepatitis C Virus NS3/4a Protease Inhibitors: Discovery of MK-2748 and MK-6325 von Rudd, Michael T., Butcher, John W., Nguyen, Kevin T., McIntyre, Charles J., Romano, Joseph J., Gilbert, Kevin F., Bush, Kimberly J., Liverton, Nigel J., Holloway, M. Katharine, Harper, Steven, Ferrara, Marco, DiFilippo, Marcello, Summa, Vincenzo, Swestock, John, Fritzen, Jeff, Carroll, Steven S., Burlein, Christine, DiMuzio, Jillian M., Gates, Adam, Graham, Donald J., Huang, Qian, McClain, Stephanie, McHale, Carolyn, Stahlhut, Mark W., Black, Stuart, Chase, Robert, Soriano, Aileen, Fandozzi, Christine M., Taylor, Anne, Trainor, Nicole, Olsen, David B., Coleman, Paul J., Ludmerer, Steven W., McCauley, John A.

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MK-5172, a Selective Inhibitor of Hepatitis C Virus NS3/4a Protease with Broad Activity across Genotypes and Resistant Variants von Summa, Vincenzo, Ludmerer, Steven W, McCauley, John A, Fandozzi, Christine, Burlein, Christine, Claudio, Giuliano, Coleman, Paul J, DiMuzio, Jillian M, Ferrara, Marco, Filippo, Marcello Di, Gates, Adam T, Graham, Donald J, Harper, Steven, Hazuda, Daria J, Huang, Qian, McHale, Carolyn, Monteagudo, Edith, Pucci, Vincenzo, Rowley, Michael, Rudd, Michael T, Soriano, Aileen, Stahlhut, Mark W, Vacca, Joseph P, Olsen, David B, Liverton, Nigel J, Carroll, Steven S

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