Total Synthesis of Phorboxazole B von Lucas, Brian S., Gopalsamuthiram, Vijayagopal, Burke, Steven D.

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Desymmetrization of a Propane-1,3-diol to Introduce the Quaternary Chiral Center of an AMG 176 Drug Substance Intermediate von Ananthoji, Padmini K., Arunachalampillai, Athimoolam, Beaver, Matthew G., Fang, Yuan-Qing, Hedley, Simon J., Lucas, Brian S., Tedrow, Jason S., Faul, Margaret M.

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Synthesis of the C1−C17 Segment of Phorboxazole B von Lucas, Brian S, Luther, Laura M, Burke, Steven D

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An Expeditious Synthesis of the MDM2–p53 Inhibitor AM-8553 von Lucas, Brian S, Fisher, Benjamin, McGee, Lawrence R, Olson, Steven H, Medina, Julio C, Cheung, Eugene

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Discovery and in Vivo Evaluation of the Potent and Selective PI3Kδ Inhibitors 2‑((1S)‑1-((6-Amino-5-cyano-4-pyrimidinyl)amino)ethyl)-6-fluoro‑N‑methyl-3-(2-pyridinyl)-4-quinolineca... von Gonzalez-Lopez de Turiso, Felix, Hao, Xiaolin, Shin, Youngsook, Bui, Minna, Campuzano, Iain D. G, Cardozo, Mario, Dunn, Michelle C, Duquette, Jason, Fisher, Benjamin, Foti, Robert S, Henne, Kirk, He, Xiao, Hu, Yi-Ling, Kelly, Ron C, Johnson, Michael G, Lucas, Brian S, McCarter, John, McGee, Lawrence R, Medina, Julio C, Metz, Daniela, San Miguel, Tisha, Mohn, Deanna, Tran, Thuy, Vissinga, Christine, Wannberg, Sharon, Whittington, Douglas A, Whoriskey, John, Yu, Gang, Zalameda, Leeanne, Zhang, Xuxia, Cushing, Timothy D

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Addressing PXR liabilities of phthalazine-based hedgehog/smoothened antagonists using novel pyridopyridazines von Kaizerman, Jacob A., Aaron, Wade, An, Songzhu, Austin, Richard, Brown, Matt, Chong, Angela, Huang, Tom, Hungate, Randall, Jiang, Ben, Johnson, Michael G., Lee, Gary, Lucas, Brian S., Orf, Jessica, Rong, Minqing, Toteva, Maria M., Wickramasinghe, Dineli, Xu, Guifen, Ye, Qiuping, Zhong, Wendy, McMinn, Dustin L.

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Discovery of amide replacements that improve activity and metabolic stability of a bis-amide smoothened antagonist hit von Brown, Matthew L., Aaron, Wade, Austin, Richard J., Chong, Angela, Huang, Tom, Jiang, Ben, Kaizerman, Jacob A., Lee, Gary, Lucas, Brian S., McMinn, Dustin L., Orf, Jessica, Rong, Minqing, Toteva, Maria M., Xu, Guifen, Ye, Qiuping, Zhong, Wendy, DeGraffenreid, Michael R., Wickramasinghe, Dineli, Powers, Jay P., Hungate, Randall, Johnson, Michael G.

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Palladium(0)-Mediated Desymmetrization of Meso Tetraols:  An Approach to the C3−C17 Bis-oxane Segment of Phorboxazoles A and B von Lucas, Brian S, Burke, Steven D

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Design of 1-piperazinyl-4-arylphthalazines as potent Smoothened antagonists von Lucas, Brian S., Aaron, Wade, An, Songzhu, Austin, Richard J., Brown, Matthew, Chan, Hon, Chong, Angela, Hungate, Randall, Huang, Tom, Jiang, Ben, Johnson, Michael G., Kaizerman, Jacob A., Lee, Gary, McMinn, Dustin L., Orf, Jessica, Powers, Jay P., Rong, Minqing, Toteva, Maria M., Uyeda, Craig, Wickramasinghe, Dineli, Xu, Guifen, Ye, Qiuping, Zhong, Wendy

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A Catalytic Enantioselective Hetero Diels−Alder Approach to the C20−C32 Segment of the Phorboxazoles von Lucas, Brian S, Luther, Laura M, Burke, Steven D

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Development of an Efficient Process for the Preparation of Sch 39166:  Aziridinium Chemistry on Scale von Gala, Dinesh, Dahanukar, Vilas H, Eckert, Jeffery M, Lucas, Brian S, Schumacher, Doris P, Zavialov, Ilia A, Buholzer, Patrik, Kubisch, Peter, Mergelsberg, Ingrid, Scherer, Dominik

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Reaction of aziridinium ions with organometallic reagents: optimization of the key step of ecopipam synthesis von Andrews, David R, Dahanukar, Vilas H, Eckert, Jeffrey M, Gala, Dinesh, Lucas, Brian S, Schumacher, Doris P, Zavialov, Ilia A

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Anaesthesia in a parturient with Noonan's syndrome von GRANGE, C. S, HEID, R, LUCAS, S. B, ROSS, P. L. E, DOUGLAS, M. J

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Compounds that inhibit Mcl-1 protein von Lucas, Brian S

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COMPOUNDS THAT INHIBIT MCL-1 PROTEIN von LUCAS, BRIAN S, PARAS, NICK A

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MDM2 PROCESSES OF MAKING AND CRYSTALLINE FORMS OF A MDM2 INHIBITOR von COCHRAN BRIAN, WIEDEMANN SEAN, FOX BRIAN M, CAILLE SEBASTIEN, BIO MATTHEW, WORTMAN SARAH, LUCAS BRIAN S, VOUNATSOS FILISATY, MCGEE LAWRENCE R, FANG YUANQING

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COMPOUNDS THAT INHIBIT MCL-1 PROTEIN von LUCAS, Brian S, PARAS, Nick A

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MDM2 PROCESSES OF MAKING AND CRYSTALLINE FORMS OF A MDM2 INHIBITOR von COCHRAN BRIAN, WIEDEMANN SEAN, FOX BRIAN M, CAILLE SEBASTIEN, BIO MATTHEW, WORTMAN SARAH, LUCAS BRIAN S, VOUNATSOS FILISATY, MCGEE LAWRENCE R, FANG YUANQING

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Processes of making and crystalline forms of a MDM2 inhibitor von BIO, Matthew, FOX, Brian M, COCHRAN, Brian, FANG, Yuanqing, CAILLE, Sebastien, LUCAS, Brian S, WIEDEMANN, Sean, MCGEE, Lawrence R, VOUNATSOS, Filisaty, WORTMAN, Sarah

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Processes of making and crystalline forms of a MDM2 inhibitor von BIO, Matthew, FOX, Brian M, COCHRAN, Brian, FANG, Yuanqing, CAILLE, Sebastien, LUCAS, Brian S, WIEDEMANN, Sean, MCGEE, Lawrence R, VOUNATSOS, Filisaty, WORTMAN, Sarah

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