LAG Time in the Era of Immunotherapy-New Molecular Insights Into the Immunosuppression Mechanism of Lymphocyte Activation Gene-3 von Luca, Vincent C

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Antibodies to Interleukin-2 Elicit Selective T Cell Subset Potentiation through Distinct Conformational Mechanisms von Spangler, Jamie B., Tomala, Jakub, Luca, Vincent C., Jude, Kevin M., Dong, Shen, Ring, Aaron M., Votavova, Petra, Pepper, Marion, Kovar, Marek, Garcia, K. Christopher

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Notch-Jagged complex structure implicates a catch bond in tuning ligand sensitivity von Luca, Vincent C., Kim, Byoung Choul, Ge, Chenghao, Kakuda, Shinako, Wu, Di, Roein-Peikar, Mehdi, Haltiwanger, Robert S., Zhu, Cheng, Ha, Taekjip, Garcia, K. Christopher

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The inhibitory receptor TIM-3 limits activation of the cGAS-STING pathway in intra-tumoral dendritic cells by suppressing extracellular DNA uptake von de Mingo Pulido, Álvaro, Hänggi, Kay, Celias, Daiana P., Gardner, Alycia, Li, Jie, Batista-Bittencourt, Bruna, Mohamed, Eslam, Trillo-Tinoco, Jimena, Osunmakinde, Olabisi, Peña, Reymi, Onimus, Alexis, Kaisho, Tsuneyasu, Kaufmann, Johanna, McEachern, Kristen, Soliman, Hatem, Luca, Vincent C., Rodriguez, Paulo C., Yu, Xiaoqing, Ruffell, Brian

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Structural basis for Notch1 engagement of Delta-like 4 von Luca, Vincent C., Jude, Kevin M., Pierce, Nathan W., Nachury, Maxence V., Fischer, Suzanne, Garcia, K. Christopher

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New tricks for an old pathway: emerging Notch-based biotechnologies and therapeutics von Medina, Elliot, Perez, David H., Antfolk, Daniel, Luca, Vincent C.

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Structural basis of GPBAR activation and bile acid recognition von Yang, Fan, Mao, Chunyou, Guo, Lulu, Lin, Jingyu, Ming, Qianqian, Xiao, Peng, Wu, Xiang, Shen, Qingya, Guo, Shimeng, Shen, Dan-Dan, Lu, Ruirui, Zhang, Linqi, Huang, Shenming, Ping, Yuqi, Zhang, Chenlu, Ma, Cheng, Zhang, Kai, Liang, Xiaoying, Shen, Yuemao, Nan, Fajun, Yi, Fan, Luca, Vincent C., Zhou, Jiuyao, Jiang, Changtao, Sun, Jin-Peng, Xie, Xin, Yu, Xiao, Zhang, Yan

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Surrogate R-spondins for tissue-specific potentiation of Wnt Signaling von Luca, Vincent C, Miao, Yi, Li, Xingnan, Hollander, Michael J, Kuo, Calvin J, Garcia, K Christopher

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Crystal Structure of the Japanese Encephalitis Virus Envelope Protein von LUCA, Vincent C, ABIMANSOUR, Jad, NELSON, Christopher A, FREMONT, Daved H

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Intratumoural heterogeneity generated by Notch signalling promotes small-cell lung cancer von Lim, Jing Shan, Ibaseta, Alvaro, Fischer, Marcus M., Cancilla, Belinda, O’Young, Gilbert, Cristea, Sandra, Luca, Vincent C., Yang, Dian, Jahchan, Nadine S., Hamard, Cécile, Antoine, Martine, Wislez, Marie, Kong, Christina, Cain, Jennifer, Liu, Yu-Wang, Kapoun, Ann M., Garcia, K. Christopher, Hoey, Timothy, Murriel, Christopher L., Sage, Julien

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Progenitor identification and SARS-CoV-2 infection in human distal lung organoids von Salahudeen, Ameen A., Choi, Shannon S., Rustagi, Arjun, Zhu, Junjie, van Unen, Vincent, de la O, Sean M., Flynn, Ryan A., Margalef-Català, Mar, Santos, António J. M., Ju, Jihang, Batish, Arpit, Usui, Tatsuya, Zheng, Grace X. Y., Edwards, Caitlin E., Wagar, Lisa E., Luca, Vincent, Anchang, Benedict, Nagendran, Monica, Nguyen, Khanh, Hart, Daniel J., Terry, Jessica M., Belgrader, Phillip, Ziraldo, Solongo B., Mikkelsen, Tarjei S., Harbury, Pehr B., Glenn, Jeffrey S., Garcia, K. Christopher, Davis, Mark M., Baric, Ralph S., Sabatti, Chiara, Amieva, Manuel R., Blish, Catherine A., Desai, Tushar J., Kuo, Calvin J.

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Notch1 Phase Separation Coupled Percolation facilitates target gene expression and enhancer looping von Foran, Gregory, Hallam, Ryan Douglas, Megaly, Marvel, Turgambayeva, Anel, Antfolk, Daniel, Li, Yifeng, Luca, Vincent C., Necakov, Aleksandar

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Structure of the planar cell polarity cadherins Fat4 and Dachsous1 von Medina, Elliot, Easa, Yathreb, Lester, Daniel K., Lau, Eric K., Sprinzak, David, Luca, Vincent C.

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Soluble and multivalent Jag1 DNA origami nanopatterns activate Notch without pulling force von Smyrlaki, Ioanna, Fördős, Ferenc, Rocamonde-Lago, Iris, Wang, Yang, Shen, Boxuan, Lentini, Antonio, Luca, Vincent C., Reinius, Björn, Teixeira, Ana I., Högberg, Björn

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LAG3 ectodomain structure reveals functional interfaces for ligand and antibody recognition von Ming, Qianqian, Celias, Daiana P., Wu, Chao, Cole, Aidan R., Singh, Srishti, Mason, Charlotte, Dong, Shen, Tran, Timothy H., Amarasinghe, Gaya K., Ruffell, Brian, Luca, Vincent C.

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Inhibition of Delta-induced Notch signaling using fucose analogs von Schneider, Michael, Kumar, Vivek, Nordstrøm, Lars Ulrik, Feng, Lei, Takeuchi, Hideyuki, Hao, Huilin, Luca, Vincent C, Garcia, K Christopher, Stanley, Pamela, Wu, Peng, Haltiwanger, Robert S

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Affinity-matured DLL4 ligands as broad-spectrum modulators of Notch signaling von Gonzalez-Perez, David, Das, Satyajit, Antfolk, Daniel, Ahsan, Hadia S., Medina, Elliot, Dundes, Carolyn E., Jokhai, Rayyan T., Egan, Emily D., Blacklow, Stephen C., Loh, Kyle M., Rodriguez, Paulo C., Luca, Vincent C.

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Structural basis for mouse LAG3 interactions with the MHC class II molecule I-Ab von Ming, Qianqian, Antfolk, Daniel, Price, David A., Manturova, Anna, Medina, Elliot, Singh, Srishti, Mason, Charlotte, Tran, Timothy H., Smalley, Keiran S. M., Leung, Daisy W., Luca, Vincent C.

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Discovery of an Orally Bioavailable Small-Molecule Inhibitor for the β-Catenin/B-Cell Lymphoma 9 Protein-Protein Interaction von Wang, Zhen, Zhang, Min, Quereda, Victor, Frydman, Sylvia M, Ming, Qianqian, Luca, Vincent C, Duckett, Derek R, Ji, Haitao

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