Discovery and Cocrystal Structure of Benzodiazepinedione HDM2 Antagonists That Activate p53 in Cells von Grasberger, Bruce L, Lu, Tianbao, Schubert, Carsten, Parks, Daniel J, Carver, Theodore E, Koblish, Holly K, Cummings, Maxwell D, LaFrance, Louis V, Milkiewicz, Karen L, Calvo, Raul R, Maguire, Diane, Lattanze, Jennifer, Franks, Carol F, Zhao, Shuyuan, Ramachandren, Kannan, Bylebyl, Gwendolyn R, Zhang, Marie, Manthey, Carl L, Petrella, Eugene C, Pantoliano, Michael W, Deckman, Ingrid C, Spurlino, John C, Maroney, Anna C, Tomczuk, Bruce E, Molloy, Christopher J, Bone, Roger F

Volltext

Discovery and Clinical Evaluation of 1-{N-[2-(Amidinoaminooxy)ethyl]amino}carbonylmethyl-6-methyl-3-[2,2-difluoro-2-phenylethylamino]pyrazinone (RWJ-671818), a Thrombin Inhibitor w... von Lu, Tianbao, Markotan, Thomas, Ballentine, Shelley K, Giardino, Edward C, Spurlino, John, Brown, Kathryn, Maryanoff, Bruce E, Tomczuk, Bruce E, Damiano, Bruce P, Shukla, Umesh, End, David, Andrade-Gordon, Patricia, Bone, Roger F, Player, Mark R

Volltext

Design, Synthesis, and Biological Evaluation of Novel Potent and Selective αvβ3/αvβ5 Integrin Dual Inhibitors with Improved Bioavailability. Selection of the Molecular Core von Marugán, Juan José, Manthey, Carl, Anaclerio, Beth, Lafrance, Lou, Lu, Tianbao, Markotan, Tom, Leonard, Kristi A, Crysler, Carl, Eisennagel, Stephen, Dasgupta, Malini, Tomczuk, Bruce

Volltext

2-(2-Chloro-6-fluorophenyl)acetamides as potent thrombin inhibitors von Lee, Lily, Kreutter, Kevin D., Pan, Wenxi, Crysler, Carl, Spurlino, John, Player, Mark R., Tomczuk, Bruce, Lu, Tianbao

Volltext

7-Fluoroindazoles as Potent and Selective Inhibitors of Factor Xa von Lee, Yu-Kai, Parks, Daniel J, Lu, Tianbao, Thieu, Tho V, Markotan, Thomas, Pan, Wenxi, McComsey, David F, Milkiewicz, Karen L, Crysler, Carl S, Ninan, Nisha, Abad, Marta C, Giardino, Edward C, Maryanoff, Bruce E, Damiano, Bruce P, Player, Mark R

Volltext

Enhanced pharmacokinetic properties of 1,4-benzodiazepine-2,5-dione antagonists of the HDM2-p53 protein–protein interaction through structure-based drug design von Parks, Daniel J., LaFrance, Louis V., Calvo, Raul R., Milkiewicz, Karen L., José Marugán, Juan, Raboisson, Pierre, Schubert, Carsten, Koblish, Holly K., Zhao, Shuyuan, Franks, Carol F., Lattanze, Jennifer, Carver, Theodore E., Cummings, Maxwell D., Maguire, Diane, Grasberger, Bruce L., Maroney, Anna C., Lu, Tianbao

Volltext

Novel 1,4-benzodiazepine-2,5-diones as Hdm2 antagonists with improved cellular activity von Leonard, Kristi, Marugan, Juan Jose, Raboisson, Pierre, Calvo, Raul, Gushue, Joan M., Koblish, Holly K., Lattanze, Jennifer, Zhao, Shuyuan, Cummings, Maxwell D., Player, Mark R., Maroney, Anna C., Lu, Tianbao

Volltext

Orally efficacious thrombin inhibitors with cyanofluorophenylacetamide as the P2 motif von Kreutter, Kevin D., Lu, Tianbao, Lee, Lily, Giardino, Edward C., Patel, Sharmila, Huang, Hui, Xu, Guozhang, Fitzgerald, Mark, Haertlein, Barbara J., Mohan, Venkatraman, Crysler, Carl, Eisennagel, Stephen, Dasgupta, Malini, McMillan, Martin, Spurlino, John C., Huebert, Norman D., Maryanoff, Bruce E., Tomczuk, Bruce E., Damiano, Bruce P., Player, Mark R.

Volltext

Enantiomerically pure 1,4-benzodiazepine-2,5-diones as Hdm2 antagonists von Marugan, Juan Jose, Leonard, Kristi, Raboisson, Pierre, Gushue, Joan M., Calvo, Raul, Koblish, Holly K., Lattanze, Jennifer, Zhao, Shuyuan, Cummings, Maxwell D., Player, Mark R., Schubert, Carsten, Maroney, Anna C., Lu, Tianbao

Volltext

Oxyguanidines. Part 2: Discovery of a novel orally active thrombin inhibitor through structure-based drug design and parallel synthesis von TIANBAO LU, MARKOTAN, Thomas, BONE, Roger, COPPO, Frank, TOMCZUK, Bruce, CRYSLER, Carl, EISENNAGEL, Stephen, SPURLINO, John, GREMMINGER, Lisa, SOLL, Richard M, GIARDINO, Edward C

Volltext

Oxyguanidines: application to non-peptidic phenyl-based thrombin inhibitors von Tomczuk, Bruce, Lu, Tianbao, Soll, Richard M, Fedde, Cynthia, Wang, Aihua, Murphy, Larry, Crysler, Carl, Dasgupta, Malini, Eisennagel, Stephen, Spurlino, John, Bone, Roger

Volltext

PYRAZOLOPYRROLOPYRIDAZINES AND THEIR USES AS PDGFR INHIBITORS von LU, Tianbao, LIU, Zhijie

Volltext bestellen

PYRAZOLOPYRIMIDINES AND THEIR USES AS PDGFR INHIBITORS von LU, Tianbao, BAUMAN, David, LIU, Zhijie

Volltext bestellen

PYRAZOLOPYRIMIDINES AND THEIR USES AS PDGFR INHIBITORS von LU, Tianbao, BAUMAN, David, LIU, Zhijie

Volltext bestellen

IMIDAZOLIN-5-ONE DERIVATIVE USEFUL AS FASN INHIBITORS FOR THE TREATMENT OF CANCER von CONNOLLY, PETER J, LU, TIANBAO

Volltext bestellen

PYRAZOLOPYRIMIDINES AND THEIR USES AS PDGFR INHIBITORS von LU, Tianbao, BAUMAN, David, LIU, Zhijie

Volltext bestellen

BENZAMIDE DERIVATIVE USEFUL AS FASN INHIBITORS FOR THE TREATMENT OF CANCER von CONNOLLY, PETER J, LU, TIANBAO

Volltext bestellen

DIPHENYLPYRAZINE COMPOUNDS AS PRODRUGS von LU, Tianbao, BODE, Wilhelmina, AMSSOMS, Katie, SCHIPS, Tobias

Volltext bestellen

PYRAZOLOPYRIMIDINES AND THEIR USES AS PDGFR INHIBITORS von BAUMAN, DAVID, LIU, ZHIJIE, LU, TIANBAO

Volltext bestellen

PYRAZOLOPYRIMIDINES AND THEIR USES AS PDGFR INHIBITORS von LU, Tianbao, BAUMAN, David, LIU, Zhijie

Volltext bestellen