Balancing charge in the complementarity-determining regions of humanized mAbs without affecting pI reduces non-specific binding and improves the pharmacokinetics von Datta-Mannan, Amita, Thangaraju, Arunkumar, Leung, Donmienne, Tang, Ying, Witcher, Derrick R, Lu, Jirong, Wroblewski, Victor J

Volltext

Post-hoc assessment of the immunogenicity of three antibodies reveals distinct immune stimulatory mechanisms von Walsh, Robin E., Lannan, Megan, Wen Yi, Wang Xiaoli, Moreland, Christopher A., Willency, Jill, Knierman, Michael D., Spindler, Laura, Liu Ling, Zeng Wei, Rocha, Guilherme V., Obungu, Victor, Lu Jirong, Kaliyaperumal, Arunan, Ferrante, Andrea, Siegel, Robert, Malherbe, Laurent P.

Volltext

Influence of physiochemical properties on the subcutaneous absorption and bioavailability of monoclonal antibodies von Datta-Mannan, Amita, Estwick, Selina, Zhou, Chen, Choi, Hiuwan, Douglass, Nicole E., Witcher, Derrick R., Lu, Jirong, Beidler, Catherine, Millican, Rohn

Volltext

Reconstruction of 3D structures of MET antibodies from electron microscopy 2D class averages von Chen, Qi, Vieth, Michal, Timm, David E, Humblet, Christine, Schneidman-Duhovny, Dina, Chemmama, Ilan E, Sali, Andrej, Zeng, Wei, Lu, Jirong, Liu, Ling

Volltext

FcRn affinity-pharmacokinetic relationship of five human IgG4 antibodies engineered for improved in vitro FcRn binding properties in cynomolgus monkeys von Datta-Mannan, Amita, Chow, Chi-Kin, Dickinson, Craig, Driver, David, Lu, Jirong, Witcher, Derrick R, Wroblewski, Victor J

Volltext

Canadian Anatomic Kidney Score: Quantitative Macroscopic Assessment of Donor Kidney Quality for Transplantation von Matti, Danny, Offerni, Juliano, Roshanov, Pavel S, Lu, Jirong, Guo, Yanbo, Lebedeva, Victoria, Ai Li, Erica, Abed, Haider, Luke, William, Sener, Alp, Luke, Patrick P

Volltext

In Vivo Deamidation Characterization of Monoclonal Antibody by LC/MS/MS von Huang, Lihua, Lu, Jirong, Wroblewski, Victor J, Beals, John M, Riggin, Ralph M

Volltext

Oligomerization and Cooperative RNA Synthesis Activity of Hepatitis C Virus RNA-Dependent RNA Polymerase von Wang, Q May, Hockman, Michelle A, Staschke, Kirk, Johnson, Robert B, Case, Katharine A, Lu, Jirong, Parsons, Steve, Zhang, Faming, Rathnachalam, Radhakrishnan, Kirkegaard, Karla, Colacino, Joseph M

Volltext

Retrovirus-mediated delivery of an IL-4 receptor antagonist inhibits allergic responses in a murine model of asthma von Wang, GuiLan, Lu, JiRong

Volltext

Phase 1 clinical trial demonstrated that MUC1 positive metastatic seminal vesicle cancer can be effectively eradicated by modified Anti-MUC1 chimeric antigen receptor transduced T... von You, Fengtao, Jiang, Licui, Zhang, Bozhen, Lu, Qiang, Zhou, Qiao, Liao, Xiaoyang, Wu, Hong, Du, Kaiqi, Zhu, Youcai, Meng, Huimin, Gong, Zhishu, Zong, Yunhui, Huang, Lei, Lu, Man, Tang, Jirong, Li, Yafen, Zhai, Xiaochen, Wang, Xiangling, Ye, Sisi, Chen, Dan, Yuan, Lei, Qi, Lin, Yang, Lin

Volltext

Choosing the larger kidney on CT volumetry: a study on the early post-donation kidney function of living donors von Kyaw, Lin, Thandapani, Karthik, Tan, Lynnette, Peng, Hong Min, Goh, Benjamin, Lu, Jirong, Raman, Lata, Tai, Bee Choo, Anantharaman, Vathsala, Tiong, Ho Yee

Volltext

Generation and characterization of ixekizumab, a humanized monoclonal antibody that neutralizes interleukin-17A von Liu, Ling, Lu, Jirong, Allan, Barrett W, Tang, Ying, Tetreault, Jonathan, Chow, Chi-Kin, Barmettler, Barbra, Nelson, James, Bina, Holly, Huang, Lihua, Wroblewski, Victor J, Kikly, Kristine

Volltext

Key Considerations in the Recovery and Resumption of Surgical Services after the COVID-19 Pandemic von Tan, Yi Quan, Lu, Jirong, Wang, Ziting, Tiong, Ho Yee, Chiong, Edmund

Volltext

Key Considerations in the Recovery and Resumption of Surgical Services after the COVID-19 Pandemic von Tan, Yi Quan, Lu, Jirong, Wang, Ziting, Tiong, Ho Yee, Chiong, Edmund

Volltext

Rapid Analysis of Antibody Self-Association in Complex Mixtures Using Immunogold Conjugates von Sule, Shantanu V, Dickinson, Craig D, Lu, Jirong, Chow, Chi-Kin, Tessier, Peter M

Volltext

Training improves laparoscopic tasks performance and decreases operator workload von Hu, Jesse S. L., Lu, Jirong, Tan, Wee Boon, Lomanto, Davide

Volltext

Systemic immune‐checkpoint blockade with anti‐PD1 antibodies does not alter cerebral amyloid‐β burden in several amyloid transgenic mouse models von Latta‐Mahieu, Martine, Elmer, Bradford, Bretteville, Alexis, Wang, Yaming, Lopez‐Grancha, Mati, Goniot, Philippe, Moindrot, Nicolas, Ferrari, Paul, Blanc, Véronique, Schussler, Nathalie, Brault, Emmanuel, Roudières, Valérie, Blanchard, Véronique, Yang, Zhi‐Yong, Barneoud, Pascal, Bertrand, Philippe, Roucourt, Bart, Carmans, Sofie, Bottelbergs, Astrid, Mertens, Liesbeth, Wintmolders, Cindy, Larsen, Peter, Hersley, Caroline, McGathey, Tyler, Racke, Margaret M., Liu, Ling, Lu, Jirong, O'Neill, Michael J., Riddell, David R., Ebneth, Andreas, Nabel, Gary J., Pradier, Laurent

Volltext

Development of tibulizumab, a tetravalent bispecific antibody targeting BAFF and IL-17A for the treatment of autoimmune disease von Benschop, Robert J, Chow, Chi-Kin, Tian, Yu, Nelson, James, Barmettler, Barbra, Atwell, Shane, Clawson, David, Chai, Qing, Jones, Bryan, Fitchett, Jon, Torgerson, Stacy, Ji, Yan, Bina, Holly, Hu, Ningjie, Ghanem, Mahmoud, Manetta, Joseph, Wroblewski, Victor J, Lu, Jirong, Allan, Barrett W

Volltext

Abstract 873: A novel MET-EGFR bispecific antibody LY3164530 shows advantage over combining MET and EGFR antibodies in tumor inhibition and overcome resistance von Liu, Ling, Zeng, Wei, Chedid, Marcio, Zeng, Yi, Tschang, Sheng-hung, Tian, Yu, Tang, Ying, Lu, Jirong

Volltext

Detection and characterization of an early folding intermediate of T4 lysozyme using pulsed hydrogen exchange and two-dimensional NMR von Lu, Jirong, Dahlquist, Frederick W

Volltext