Site-specific conjugation of a cytotoxic drug to an antibody improves the therapeutic index von Junutula, Jagath R, Raab, Helga, Clark, Suzanna, Bhakta, Sunil, Leipold, Douglas D, Weir, Sylvia, Chen, Yvonne, Simpson, Michelle, Tsai, Siao Ping, Dennis, Mark S, Lu, Yanmei, Meng, Y Gloria, Ng, Carl, Yang, Jihong, Lee, Chien C, Duenas, Eileen, Gorrell, Jeffrey, Katta, Viswanatham, Kim, Amy, McDorman, Kevin, Flagella, Kelly, Venook, Rayna, Ross, Sarajane, Spencer, Susan D, Lee Wong, Wai, Lowman, Henry B, Vandlen, Richard, Sliwkowski, Mark X, Scheller, Richard H, Polakis, Paul, Mallet, William

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Engineering Human IgG1 Affinity to Human Neonatal Fc Receptor: Impact of Affinity Improvement on Pharmacokinetics in Primates von Yeung, Yik Andy, Leabman, Maya K, Marvin, Jonathan S, Qiu, Julia, Adams, Camellia W, Lien, Samantha, Starovasnik, Melissa A, Lowman, Henry B

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Widespread monoclonal IgE antibody convergence to an immunodominant, proanaphylactic Ara h 2 epitope in peanut allergy von Croote, Derek, Wong, Joyce J W, Pecalvel, Cyprien, Leveque, Edouard, Casanovas, Natacha, Kamphuis, Jasper B J, Creeks, Paige, Romero, Johanna, Sohail, Saba, Bedinger, Daniel, Nadeau, Kari C, Chinthrajah, Rebecca S, Reber, Laurent L, Lowman, Henry B

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Preclinical efficacy of peanut-specific IgG4 antibody therapeutic IGNX001 von Croote, Derek, Wong, Joyce J.W., Creeks, Paige, Aruva, Venu, Landers, Jeffrey J., Kwok, Matthew, Jama, Zainab, Hamilton, Robert G., Santos, Alexandra F., O’Konek, Jessica J., Ferrini, Roger, Thomas, G. Roger, Lowman, Henry B.

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Therapeutic peptides von Lien, Samantha, Lowman, Henry B

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Rapid identification of reactive cysteine residues for site-specific labeling of antibody-Fabs von Junutula, Jagath R., Bhakta, Sunil, Raab, Helga, Ervin, Karen E., Eigenbrot, Charles, Vandlen, Richard, Scheller, Richard H., Lowman, Henry B.

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Nanoparticle Formulation Derived from Carboxymethyl Cellulose, Polyethylene Glycol, and Cabazitaxel for Chemotherapy Delivery to the Brain von Bteich, Joseph, Ernsting, Mark J, Mohammed, Mohammed, Kiyota, Taira, McKee, Trevor D, Trikha, Mohit, Lowman, Henry B, Sokoll, Kenneth K

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Establishing a Link Between Amino Acid Sequences and Self-Associating and Viscoelastic Behavior of Two Closely Related Monoclonal Antibodies von Yadav, Sandeep, Sreedhara, Alavattam, Kanai, Sonoko, Liu, Jun, Lien, Samantha, Lowman, Henry, Kalonia, Devendra S., Shire, Steven J.

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Evaluation of IgE Antibodies to Omalizumab (Xolair®) and Their Potential Correlation to Anaphylaxis von Baker, Dana L., Nakamura, Gerald R., Lowman, Henry B., Fischer, Saloumeh Kadkhodayan

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Pharmacokinetics of Humanized Monoclonal Anti-Tumor Necrosis Factor-α Antibody and Its Neonatal Fc Receptor Variants in Mice and Cynomolgus Monkeys von RONG DENG, LOYET, Kelly M, LIEN, Samantha, LYER, Suhasini, DEFORGE, Laura E, THEIL, Frank-Peter, LOWMAN, Henry B, FIELDER, Paul J, PRABHU, Saileta

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A therapeutic anti-VEGF antibody with increased potency independent of pharmacokinetic half-life von Yeung, Yik Andy, Wu, Xiumin, Reyes, 2nd, Arthur E, Vernes, Jean-Michel, Lien, Samantha, Lowe, John, Maia, Mauricio, Forrest, William F, Meng, Y Gloria, Damico, Lisa A, Ferrara, Napoleone, Lowman, Henry B

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Ranibizumab inhibits multiple forms of biologically active vascular endothelial growth factor in vitro and in vivo von Lowe, John, Araujo, James, Yang, Jihong, Reich, Mike, Oldendorp, Amy, Shiu, Vanessa, Quarmby, Valerie, Lowman, Henry, Lien, Samantha, Gaudreault, Jacques, Maia, Mauricio

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FIZZ1, a novel cysteine-rich secreted protein associated with pulmonary inflammation, defines a new gene family von Holcomb, Ilona N., Kabakoff, Rhona C., Chan, Betty, Baker, Thad W., Gurney, Austin, Henzel, William, Nelson, Chris, Lowman, Henry B., Wright, Barbara D., Skelton, Nicholas J., Frantz, Gretchen D., Tumas, Daniel B., Peale, Jr, Franklin V., Shelton, David L., Hébert, Caroline C.

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Mice expressing a humanized form of VEGF-A may provide insights into the safety and efficacy of anti-VEGF antibodies von Gerber, Hans-Peter, Wu, Xiumin, Yu, Lanlan, Wiesmann, Christian, Liang, Xiao Huan, Lee, Chingwei V, Fuh, Germaine, Olsson, Christine, Damico, Lisa, Xie, David, Meng, Y. Gloria, Gutierrez, Johnny, Corpuz, Racquel, Li, Bing, Hall, Linda, Rangell, Linda, Ferrando, Ron, Lowman, Henry, Peale, Franklin, Ferrara, Napoleone

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VEGF and the Fab fragment of a humanized neutralizing antibody: crystal structure of the complex at 2.4 å resolution and mutational analysis of the interface von Muller, Yves A, Chen, Yvonne, Christinger, Hans W, Li, Bing, Cunningham, Brian C, Lowman, Henry B, de Vos, Abraham M

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[21] Phage display for selection of novel binding peptides von Sidhu, Sachdev S., Lowman, Henry B., Cunningham, Brian C., Wells, James A.

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Redesigning an Antibody Fragment for Faster Association with Its Antigen von Marvin, Jonathan S., Lowman, Henry B.

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Technology comparisons for anti-therapeutic antibody and neutralizing antibody assays in the context of an anti-TNF pharmacokinetic study von Loyet, Kelly M., Deng, Rong, Liang, Wei-Ching, Wu, Yan, Lowman, Henry B., DeForge, Laura E.

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Abstract 835: TRPH-222, a novel anti-CD22 antibody drug conjugate (ADC), has significant anti-tumor activity in NHL xenografts and reduces B cells in monkeys von Maclaren, Ann P., Levin, Nancy, Lowman, Henry

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IGNX001 Abrogates Peanut-mediated Mast Cell Degranulation and Murine Anaphylaxis von Croote, Derek, Wong, Joyce, Creeks, Paige, Aruva, Venu, Grossman, Jessica, Ferrini, Roger, Lowman, Henry, Landers, Jeffrey, O'Konek, Jessica, Thomas, Roger

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