Crystal shape modification through cycles of dissolution and growth: Attainable regions and experimental validation von Lovette, Michael A., Muratore, Matteo, Doherty, Michael F.

Volltext

Chiral control of enantiomers through crystallization: Moving from ternary phase diagrams to design spaces von Lovette, Michael A.

Volltext

Perspectives on the Current State, Challenges, and Opportunities in Pharmaceutical Crystallization Process Development von Cote, Aaron, Erdemir, Deniz, Girard, Kevin P, Green, Daniel A, Lovette, Michael A, Sirota, Eric, Nere, Nandkishor K

Volltext

Predictive Modeling of Supersaturation-Dependent Crystal Shapes von Lovette, Michael A, Doherty, Michael F

Volltext

Crystal Shape Engineering von Lovette, Michael A, Browning, Andrea Robben, Griffin, Derek W, Sizemore, Jacob P, Snyder, Ryan C, Doherty, Michael F

Volltext

Continuous Process Improvement in the Manufacture of Carfilzomib, Part 2: An Improved Process for Synthesis of the Epoxyketone Warhead von Beaver, Matthew G, Shi, Xianqing, Riedel, Jan, Patel, Parth, Zeng, Alicia, Corbett, Michael T, Robinson, Jo Anna, Parsons, Andrew T, Cui, Sheng, Baucom, Kyle, Lovette, Michael A, Içten, Elçin, Brown, Derek B, Allian, Ayman, Flick, Tawnya G, Chen, Wendy, Yang, Ning, Walker, Shawn D

Volltext

Implementing Continuous Manufacturing for the Final Methylation Step in the AMG 397 Process to Deliver Key Quality Attributes von Tom, Janine K, Achmatowicz, Michal M, Beaver, Matthew G, Colyer, John, Ericson, Ari, Hwang, Tsang-Lin, Jiao, Nancy, Langille, Neil F, Liu, Min, Lovette, Michael A, Sangodkar, Rahul P, Sharvan Kumar, Srividya, Spada, Simone, Perera, Damith, Sheeran, Jillian, Campbell, Kiersten, Doherty, Timothy, Ford, David D, Fang, Yuan-Qing, Rossi, Emiliano, Santoni, Gabriella, Cui, Sheng, Walker, Shawn D

Volltext

Kink Rate Model for the General Case of Organic Molecular Crystals von Kim, Seung Ha, Dandekar, Preshit, Lovette, Michael A, Doherty, Michael F

Volltext

Solubility Model to Guide Solvent Selection in Synthetic Process Development von Lovette, Michael A.

Volltext

Reinterpreting edge energies calculated from crystal growth experiments von Lovette, Michael A., Doherty, Michael F.

Volltext

Axial Chirality in the Sotorasib Drug Substance, Part 1: Development of a Classical Resolution to Prepare an Atropisomerically Pure Sotorasib Intermediate von Parsons, Andrew T., Caille, Seb, Caporini, Marc A., Griffin, Daniel J., Lovette, Michael A., Powazinik, William, St-Pierre, Gabrielle

Volltext

Evaluation of Predictive Solubility Models in Pharmaceutical Process Developmentan Enabling Technologies Consortium Collaboration von Lovette, Michael A., Albrecht, Jacob, Ananthula, Ravi S., Ricci, Francesco, Sangodkar, Rahul, Shah, Mansi S., Tomasi, Simone

Volltext

Multisite models to determine the distribution of kink sites adjacent to low-energy edges von Lovette, Michael A, Doherty, Michael F

Volltext

A Continuous Process for Manufacturing Apremilast. Part I: Process Development and Intensification by Utilizing Flow Chemistry Principles von Hsieh, Hsiao-Wu, Cohen, Carolyn M., Griffin, Daniel J., Ananthoji, Padmini, Avci, Nadide Hazal, Brown, Derek B., Ericson, Ari, Fostinis, James D., Irfan, Muhammad, Langille, Neil, Lovette, Michael A., Murray, James I., Spada, Simone, Thiel, Oliver R., Aiello, Frankie, Daou, Joseph, Goudas-Salomon, Nicole, Pan, Ende, Sarkar, Nandini, Wimalasinghe, Rasangi, Wu, Zufan Steven, Zeng, Alicia, Beaver, Matthew G.

Volltext

Development of a Commercial Manufacturing Process for Sotorasib, a First-in-Class KRASG12C Inhibitor von Zhang, Liang, Griffin, Daniel J., Beaver, Matthew G., Blue, Laura E., Borths, Christopher J., Brown, Derek B., Caille, Seb, Chen, Ying, Cherney, Alan H., Cochran, Brian M., Colyer, John T., Corbett, Michael T., Correll, Tiffany L., Crockett, Richard D., Dai, Xi-Jie, Dornan, Peter K., Farrell, Robert P., Hedley, Simon J., Hsieh, Hsiao-Wu, Huang, Liang, Huggins, Seth, Liu, Min, Lovette, Michael A., Quasdorf, Kyle, Reifman, Jonathan, Robinson, Jo Anna, Sangodkar, Rahul P., Sharma, Sonika, Kumar, Srividya Sharvan, Smith, Austin G., St-Pierre, Gabrielle, Tedrow, Jason S., Thiel, Oliver R., Truong, Jonathan V., Walker, Shawn D., Wei, Carolyn S., Wilsily, Ashraf, Xie, Yong, Yang, Ning, Parsons, Andrew T.

Volltext

Needle-Shaped Crystals: Causality and Solvent Selection Guidance Based on Periodic Bond Chains von Lovette, Michael A, Doherty, Michael F

Volltext

Development of a Commercial Manufacturing Process for Sotorasib, a First-in-Class KRAS G12C Inhibitor von Zhang, Liang, Griffin, Daniel J., Beaver, Matthew G., Blue, Laura E., Borths, Christopher J., Brown, Derek B., Caille, Seb, Chen, Ying, Cherney, Alan H., Cochran, Brian M., Colyer, John T., Corbett, Michael T., Correll, Tiffany L., Crockett, Richard D., Dai, Xi-Jie, Dornan, Peter K., Farrell, Robert P., Hedley, Simon J., Hsieh, Hsiao-Wu, Huang, Liang, Huggins, Seth, Liu, Min, Lovette, Michael A., Quasdorf, Kyle, Powazinik, William, Reifman, Jonathan, Robinson, Jo Anna, Sangodkar, Rahul P., Sharma, Sonika, Kumar, Srividya Sharvan, Smith, Austin G., St-Pierre, Gabrielle, Tedrow, Jason S., Thiel, Oliver R., Truong, Jonathan V., Walker, Shawn D., Wei, Carolyn S., Wilsily, Ashraf, Xie, Yong, Yang, Ning, Parsons, Andrew T.

Volltext

거대환식 MCL-1 저해제 중간체의 폐환 합성 von CHERNEY ALAN H, SMITH AUSTIN G, TEDROW JASON S, ST PIERRE GABRIELLE, ERICSON ARI, BEAVER MATTHEW G, BAUCOM KYLE D, COLYER JOHN T, ROOSEN PHILIPP C, SANGODKAR RAHUL P, LOVETTE MICHAEL A, CUI SHENG, THIEL OLIVER RALF, HUANG LIANG, MILBURN ROBERT RONALD

Volltext bestellen

Ring closing synthesis of macrocyclic Mcl-1 inhibitor intermediates von CHERNEY, Alan H, SANGODKAR, Rahul P, CUI, Sheng, THIEL, Oliver Ralf, ROOSEN, Philipp C, ST-PIERRE, Gabrielle, MILBURN, Robert Ronald, TEDROW, Jason S, COLYER, John T, ERICSON, Ari, SMITH, Austin G, HUANG, Liang, BEAVER, Matthew G, BAUCOM, Kyle D, LOVETTE, Michael A

Volltext bestellen

Ring Closing Synthesis of Macrocyclic MCL-1 Inhibitor Intermediates von CHERNEY, Alan H, SANGODKAR, Rahul P, CUI, Sheng, THIEL, Oliver Ralf, ROOSEN, Philipp C, ST-PIERRE, Gabrielle, MILBURN, Robert Ronald, TEDROW, Jason S, COLYER, John T, ERICSON, Ari, SMITH, Austin G, HUANG, Liang, BEAVER, Matthew G, BAUCOM, Kyle D, LOVETTE, Michael A

Volltext bestellen