Rethinking ovarian cancer: recommendations for improving outcomes von Bowtell, David D, Vaughan, Sebastian, Coward, Jermaine I, Bast, Robert C, Berchuck, Andy, Berek, Jonathan S, Brenton, James D, Coukos, George, Crum, Christopher C, Drapkin, Ronny, Etemadmoghadam, Dariush, Friedlander, Michael, Gabra, Hani, Kaye, Stan B, Lord, Chris J, Lengyel, Ernst, Levine, Douglas A, McNeish, Iain A, Menon, Usha, Mills, Gordon B, Nephew, Kenneth P, Oza, Amit M, Sood, Anil K, Stronach, Euan A, Walczak, Henning, Balkwill, Frances R

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Identification of gene fusion transcripts by transcriptome sequencing in BRCA1-mutated breast cancers and cell lines von Ha, Kevin C H, Lalonde, Emilie, Li, Lili, Cavallone, Luca, Natrajan, Rachael, Lambros, Maryou B, Mitsopoulos, Costas, Hakas, Jarle, Kozarewa, Iwanka, Fenwick, Kerry, Lord, Chris J, Ashworth, Alan, Vincent-Salomon, Anne, Basik, Mark, Reis-Filho, Jorge S, Majewski, Jacek, Foulkes, William D

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Mental health of children with vision impairment at 11 years of age von Harris, John, Lord, Chris

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Abstract 804: Trapped PARP1 cytotoxicity is modulated by the ubiquitin-dependentsegregase p97 von Krastev, Dragomir B., Lord, Chris

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Hypertension treatment and control rates Chart review in an academic family medicine clinic von Houlihan, Sara J, Simpson, Scot H, Cave, Andrew J, Flook, Nigel W, Hurlburt, Mary E, Lord, Chris J, Smith, Linda L, Sternberg, Harvey H

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Elucidating Prostate Cancer Behaviour During Treatment via Low-pass Whole-genome Sequencing of Circulating Tumour DNA von Sumanasuriya, Semini, Seed, George, Parr, Harry, Christova, Rossitza, Pope, Lorna, Bertan, Claudia, Bianchini, Diletta, Rescigno, Pasquale, Figueiredo, Ines, Goodall, Jane, Fowler, Gemma, Flohr, Penelope, Mehra, Niven, Neeb, Antje, Rekowski, Jan, Eisenberger, Mario, Sartor, Oliver, Oudard, Stéphane, Geffriaud-Ricouard, Christine, Ozatilgan, Ayse, Chadjaa, Mustapha, Macé, Sandrine, Lord, Chris, Baxter, Joe, Pettitt, Stephen, Lambros, Maryou, Sharp, Adam, Mateo, Joaquin, Carreira, Suzanne, Yuan, Wei, de Bono, Johann S.

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Abstract 2426: Exacerbation of oxidative DNA damage as a synthetic lethal approach in mismatch repair deficient tumors von Fontebasso, Yari, Hewish, Madeleine, Lord, Chris J., Ashworth, Alan

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PDTM-34. TARGETING H3.3G34R/V RE-WIRING OF THE EPIGENOME IN PAEDIATRIC GLIOBLASTOMA OF CHILDREN AND YOUNG ADULTS von Bjerke, Lynn, Mackay, Alan, Carvalho, Diana, Pemberton, Helen, Molinari, Valeria, Vinci, Maria, Carceller, Fernando, Marshall, Lynley, Moore, Andrew, Montero Carcaboso, Angel, Lord, Chris, Hargrave, Darren, Jones, Chris

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PDTM-33. ATRX LOSS CONFERS ENHANCED SENSITIVITY TO COMBINED PARP INHIBITION AND RADIOTHERAPY IN PAEDIATRIC GLIOBLASTOMA MODELS von Fazal Salom, Janat, Bjerke, Lynn, Carvalho, Diana, Boult, Jessica, Mackay, Alan, Pemberton, Helen, Molinari, Valeria, Clarke, Matthew, Vinci, Maria, Carceller, Fernando, Marshall, Lynley, Moore, Andrew, Montero Carcaboso, Angel, Lord, Chris, Robinson, Simon, Hargrave, Darren, Jones, Chris

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Abstract 932: Reversing PARP inhibitor resistance by targeting the replication stress response von O'Connor, Mark J., Cruz, Cristina, Castroviejo-Bermejo, Marta, Polanska, Urszula M., Jones, Gemma N., Wang, Anderson, Lai, Zhongwu, Forment, Josep, Bulusu, Krishna, Llop-Guevara, Alba, Dougherty, Brian, Saura, Cristina, Brough, Rachel, Lord, Chris J., Bruna, Alejandra, Caldas, Carlos, Fawell, Stephen, Barrett, J Carl, Critchlow, Susan E., Balmaña, Judith, Cadogan, Elaine, Serra, Violeta

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PDTM-31. DRUG SCREENING LINKED TO MOLECULAR PROFILING IDENTIFIES NOVEL DEPENDENCIES IN PATIENT-DERIVED PRIMARY CULTURES OF PAEDIATRIC HIGH GRADE GLIOMA AND DIPG von Mackay, Alan, Carvalho, Diana, Molinari, Valeria, Pemberton, Helen, Temelso, Sara, Burford, Anna, Clarke, Matthew, Fofana, Mariama, Boult, Jessica, Izquierdo, Elisa, Taylor, Katy, Bjerke, Lynn, Fazal Salom, Janat, Kessler, Ketty, Rogers, Rebecca, Marshall, Lynley, Carceller, Fernando, Pears, Jane, Moore, Andrew, Miele, Evelina, Carai, Andrea, Mastronuzzi, Angela, Robinson, Simon, Lord, Chris, Olaciregui, Nagore, Mora, Jaume, Montero Carcaboso, Angel, Hargrave, Darren, Vinci, Maria, Jones, Chris

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Profiling chemoresistance in pancreatic ductal adenocarcinoma and the stromal microenvironment stellate cancer-associated fibroblast von Johnson, Natalie, Spalding, Duncan, Lord, Chris

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Abstract B28: Screening for kinase dependencies in HPV-associated cancer von Fenton, Tim, Brough, Rachel, Williams, Luke, Bajrami, Ilirjana, Ashworth, Alan, Lord, Chris, Boshoff, Chris

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Post‐operative arterio‐venous fistula blood flow influences primary and secondary patency following access surgery von Benaragama, Kapila S., Barwell, Jennifer, Lord, Chris, John, Biku J., Babber, Adarsh, Sandoval, Shella, Lindsey, Ben, Fernando, Bimbi

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Abstract 2479: A functionally null RAD51D missense mutation is strongly associated with ovarian carcinoma von Rivera, Barbara, Iorio, Massimo R. Di, Frankum, Jessica, Nadaf, Javad, Fahiminiya, Somayyeh, Arcand, Suzanna L., Burk, David, Grapton, Damien, Tomiak, Eva, Hastings, Valerie, Hamel, Nancy, Wagener, Rabea, Aleynikova, Olga, Giroux, Sylvie, Hamdan, Fadi F., Orthwein, Alexandre, Zogopoulos, George, Rousseau, Francois, Berghuis, Albert, Provencher, Diane M., Rouleau, Guy A., Michaud, Jacques L., Mes-Masson, Anne-Marie, Majewski, Jacek, Bens, Susanne, Siebert, Reiner, Narod, Steven, Akbari, Mohammad, Lord, Chris J., Tonin, Patricia N., Dionne-Laporte, Alexandre, Foulkes, William D.

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SMOKING SUBSTITUTE SYSTEM von LORD, Chris

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Abstract 617: High-throughput screens identify PARP inhibition as being synthetically lethal with ERCC1 deficiency in non-small cell lung cancer cell lines von Postel-Vinay, Sophie C., Bajrami, Ilirjana, Friboulet, Luc, Aarts, Marieke, Fontebasso, Yari, Andre, Fabrice, Olaussen, Ken, Soria, Jean-Charles, Lord, Chris, Ashworth, Alan

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CONSUMABLE FOR A SMOKING SUBSTITUTE DEVICE von LORD, Chris, LOMAS, Pete

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Abstract 350: High-throughput drug screens identify novel synthetic lethal interactions with MLH1-deficient cancers von Hewish, Madeleine, Lord, Chris J., Martin, Sarah A., Cunningham, David, Ashworth, Alan

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AEROSOL DELIVERY DEVICE von Lomas, Peter, Lord, Chris

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