A microfluidics platform for combinatorial drug screening on cancer biopsies von Eduati, Federica, Utharala, Ramesh, Madhavan, Dharanija, Neumann, Ulf Peter, Longerich, Thomas, Cramer, Thorsten, Saez-Rodriguez, Julio, Merten, Christoph A.

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Gut microbiome-mediated bile acid metabolism regulates liver cancer via NKT cells von Ma, Chi, Han, Miaojun, Heinrich, Bernd, Fu, Qiong, Zhang, Qianfei, Sandhu, Milan, Agdashian, David, Terabe, Masaki, Berzofsky, Jay A, Fako, Valerie, Ritz, Thomas, Longerich, Thomas, Theriot, Casey M, McCulloch, John A, Roy, Soumen, Yuan, Wuxing, Thovarai, Vishal, Sen, Shurjo K, Ruchirawat, Mathuros, Korangy, Firouzeh, Wang, Xin Wei, Trinchieri, Giorgio, Greten, Tim F

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Distinct Functions of Senescence-Associated Immune Responses in Liver Tumor Surveillance and Tumor Progression von Eggert, Tobias, Wolter, Katharina, Ji, Juling, Ma, Chi, Yevsa, Tetyana, Klotz, Sabrina, Medina-Echeverz, José, Longerich, Thomas, Forgues, Marshonna, Reisinger, Florian, Heikenwalder, Mathias, Wang, Xin Wei, Zender, Lars, Greten, Tim F.

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Therapeutic inhibition of inflammatory monocyte recruitment reduces steatohepatitis and liver fibrosis von Krenkel, Oliver, Puengel, Tobias, Govaere, Olivier, Abdallah, Ali T., Mossanen, Jana C., Kohlhepp, Marlene, Liepelt, Anke, Lefebvre, Eric, Luedde, Tom, Hellerbrand, Claus, Weiskirchen, Ralf, Longerich, Thomas, Costa, Ivan G., Anstee, Quentin M., Trautwein, Christian, Tacke, Frank

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A complex secretory program orchestrated by the inflammasome controls paracrine senescence von Acosta, Juan Carlos, Banito, Ana, Wuestefeld, Torsten, Georgilis, Athena, Janich, Peggy, Morton, Jennifer P., Athineos, Dimitris, Kang, Tae-Won, Lasitschka, Felix, Andrulis, Mindaugas, Pascual, Gloria, Morris, Kelly J., Khan, Sadaf, Jin, Hong, Dharmalingam, Gopuraja, Snijders, Ambrosius P., Carroll, Thomas, Capper, David, Pritchard, Catrin, Inman, Gareth J., Longerich, Thomas, Sansom, Owen J., Benitah, Salvador Aznar, Zender, Lars, Gil, Jesús

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Necroptosis microenvironment directs lineage commitment in liver cancer von Seehawer, Marco, Heinzmann, Florian, D’Artista, Luana, Harbig, Jule, Roux, Pierre-François, Hoenicke, Lisa, Dang, Hien, Klotz, Sabrina, Robinson, Lucas, Doré, Grégory, Rozenblum, Nir, Kang, Tae-Won, Chawla, Rishabh, Buch, Thorsten, Vucur, Mihael, Roth, Mareike, Zuber, Johannes, Luedde, Tom, Sipos, Bence, Longerich, Thomas, Heikenwälder, Mathias, Wang, Xin Wei, Bischof, Oliver, Zender, Lars

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Gut Microbiome Directs Hepatocytes to Recruit MDSCs and Promote Cholangiocarcinoma von Zhang, Qianfei, Ma, Chi, Duan, Yi, Heinrich, Bernd, Rosato, Umberto, Diggs, Laurence P, Ma, Lichun, Roy, Soumen, Fu, Qiong, Brown, Zachary J, Wabitsch, Simon, Thovarai, Vishal, Fu, Jianyang, Feng, Dechun, Ruf, Benjamin, Cui, Linda L, Subramanyam, Varun, Frank, Karen M, Wang, Sophie, Kleiner, David E, Ritz, Thomas, Rupp, Christian, Gao, Bin, Longerich, Thomas, Kroemer, Alexander, Wang, Xin Wei, Ruchirawat, Mathuros, Korangy, Firouzeh, Schnabl, Bernd, Trinchieri, Giorgio, Greten, Tim F

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Intestinal dysbiosis augments liver disease progression via NLRP3 in a murine model of primary sclerosing cholangitis von Liao, Lijun, Schneider, Kai Markus, Galvez, Eric J C, Frissen, Mick, Marschall, Hanns-Ulrich, Su, Huan, Hatting, Maximilian, Wahlström, Annika, Haybaeck, Johannes, Puchas, Philip, Mohs, Antje, Peng, Jin, Bergheim, Ina, Nier, Anika, Hennings, Julia, Reißing, Johanna, Zimmermann, Henning W, Longerich, Thomas, Strowig, Till, Liedtke, Christian, Cubero, Francisco J, Trautwein, Christian

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Recruitment and activation of a lipid kinase by hepatitis C virus NS5A is essential for integrity of the membranous replication compartment von Reiss, Simon, Rebhan, Ilka, Backes, Perdita, Romero-Brey, Ines, Erfle, Holger, Matula, Petr, Kaderali, Lars, Poenisch, Marion, Blankenburg, Hagen, Hiet, Marie-Sophie, Longerich, Thomas, Diehl, Sarah, Ramirez, Fidel, Balla, Tamas, Rohr, Karl, Kaul, Artur, Bühler, Sandra, Pepperkok, Rainer, Lengauer, Thomas, Albrecht, Mario, Eils, Roland, Schirmacher, Peter, Lohmann, Volker, Bartenschlager, Ralf

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Targeted therapy with vemurafenib in BRAF(V600E)-mutated anaplastic thyroid cancer von Lang, Matthias, Longerich, Thomas, Anamaterou, Chrysanthi

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Insulin‐like growth factor 2 mRNA‐binding protein 1 (IGF2BP1) is an important protumorigenic factor in hepatocellular carcinoma von Gutschner, Tony, Hämmerle, Monika, Pazaitis, Nikolaos, Bley, Nadine, Fiskin, Evgenij, Uckelmann, Hannah, Heim, Andreas, Groβ, Matthias, Hofmann, Nina, Geffers, Robert, Skawran, Britta, Longerich, Thomas, Breuhahn, Kai, Schirmacher, Peter, Mühleck, Britta, Hüttelmaier, Stefan, Diederichs, Sven

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Methylome analysis and integrative profiling of human HCCs identify novel protumorigenic factors von Neumann, Olaf, Kesselmeier, Miriam, Geffers, Robert, Pellegrino, Rossella, Radlwimmer, Bernhard, Hoffmann, Katrin, Ehemann, Volker, Schemmer, Peter, Schirmacher, Peter, Lorenzo Bermejo, Justo, Longerich, Thomas

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Targeting CCl4‐induced liver fibrosis by RNA interference–mediated inhibition of cyclin E1 in mice von Bangen, Jörg‐Martin, Hammerich, Linda, Sonntag, Roland, Baues, Maike, Haas, Ute, Lambertz, Daniela, Longerich, Thomas, Lammers, Twan, Tacke, Frank, Trautwein, Christian, Liedtke, Christian

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The liver-specific microRNA miR-122 controls systemic iron homeostasis in mice von Castoldi, Mirco, Vujic Spasic, Maja, Altamura, Sandro, Elmén, Joacim, Lindow, Morten, Kiss, Judit, Stolte, Jens, Sparla, Richard, D'Alessandro, Lorenza A, Klingmüller, Ursula, Fleming, Robert E, Longerich, Thomas, Gröne, Hermann J, Benes, Vladimir, Kauppinen, Sakari, Hentze, Matthias W, Muckenthaler, Martina U

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The long non-coding RNA LINC00152 is essential for cell cycle progression through mitosis in HeLa cells von Nötzold, Linda, Frank, Lukas, Gandhi, Minakshi, Polycarpou-Schwarz, Maria, Groß, Matthias, Gunkel, Manuel, Beil, Nina, Erfle, Holger, Harder, Nathalie, Rohr, Karl, Trendel, Jakob, Krijgsveld, Jeroen, Longerich, Thomas, Schirmacher, Peter, Boutros, Michael, Erhardt, Sylvia, Diederichs, Sven

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The degree of liver injury determines the role of p21 in liver regeneration and hepatocarcinogenesis in mice von Buitrago‐Molina, Laura Elisa, Marhenke, Silke, Longerich, Thomas, Sharma, Amar Deep, Boukouris, Aristeidis E., Geffers, Robert, Guigas, Bruno, Manns, Michael P., Vogel, Arndt

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Receptor for advanced glycation endproducts (RAGE) is a key regulator of oval cell activation and inflammation‐associated liver carcinogenesis in mice von Pusterla, Tobias, Nèmeth, Julia, Stein, Ilan, Wiechert, Lars, Knigin, David, Marhenke, Silke, Longerich, Thomas, Kumar, Varun, Arnold, Bernd, Vogel, Arndt, Bierhaus, Angelika, Pikarsky, Eli, Hess, Jochen, Angel, Peter

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Disruption of de novo fatty acid synthesis via acetyl‐CoA carboxylase 1 inhibition prevents acute graft‐versus‐host disease von Raha, Solaiman, Raud, Brenda, Oberdörfer, Linda, Castro, Carla N., Schreder, Alina, Freitag, Jenny, Longerich, Thomas, Lochner, Matthias, Sparwasser, Tim, Berod, Luciana, Koenecke, Christian, Prinz, Immo

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Increased liver stiffness in alcoholic liver disease:Differentiating fibrosis from steatohepatitis von Mueller, Sebastian, Millonig, Gunda, Sarovska, Lucie, Friedrich, Stefanie, Reimann, Frank M, Pritsch, Maria, Eisele, Silke, Stickel, Felix, Longerich, Thomas, Schirmacher, Peter, Seitz, Helmut Karl

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The necroptosis-inducing kinase RIPK3 dampens adipose tissue inflammation and glucose intolerance von Gautheron, Jérémie, Vucur, Mihael, Schneider, Anne T., Severi, Ilenia, Roderburg, Christoph, Roy, Sanchari, Bartneck, Matthias, Schrammen, Peter, Diaz, Mauricio Berriel, Ehling, Josef, Gremse, Felix, Heymann, Felix, Koppe, Christiane, Lammers, Twan, Kiessling, Fabian, Van Best, Niels, Pabst, Oliver, Courtois, Gilles, Linkermann, Andreas, Krautwald, Stefan, Neumann, Ulf P., Tacke, Frank, Trautwein, Christian, Green, Douglas R., Longerich, Thomas, Frey, Norbert, Luedde, Mark, Bluher, Matthias, Herzig, Stephan, Heikenwalder, Mathias, Luedde, Tom

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