Longitudinal high-dimensional analysis identifies immune features associating with response to anti-PD-1 immunotherapy von Leung, Elaine Lai-Han, Li, Run-Ze, Fan, Xing-Xing, Wang, Lily Yan, Wang, Yan, Jiang, Zebo, Huang, Jumin, Pan, Hu-Dan, Fan, Yue, Xu, Hongmei, Wang, Feng, Rui, Haopeng, Wong, Piu, Sumatoh, Hermi, Fehlings, Michael, Nardin, Alessandra, Gavine, Paul, Zhou, Longen, Cao, Yabing, Liu, Liang

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Small molecule targeting the Hec1/Nek2 mitotic pathway suppresses tumor cell growth in culture and in animal von Wu, Guikai, Qiu, Xiao-Long, Zhou, Longen, Zhu, Jiewen, Chamberlin, Richard, Lau, Johnson, Chen, Phang-Lang, Lee, Wen-Hwa

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A novel small molecule RAD51 inactivator overcomes imatinib‐resistance in chronic myeloid leukaemia von Zhu, Jiewen, Zhou, Longen, Wu, Guikai, Konig, Heiko, Lin, Xiaoqin, Li, Guideng, Qiu, Xiao‐Long, Chen, Chi‐Fen, Hu, Chun‐Mei, Goldblatt, Erin, Bhatia, Ravi, Chamberlin, A. Richard, Chen, Phang‐Lang, Lee, Wen‐Hwa

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Determinants of response to daratumumab in Epstein-Barr virus-positive natural killer and T-cell lymphoma von Mustafa, Nurulhuda, Nee, Adina Huey Fang, Chooi, Jing Yuan, Toh, Sabrina Hui Min, Chung, Tae-Hoon, Selvarajan, Viknesvaran, Fan, Shuangyi, Ng, Siok Bian, Poon, Michelle, Chan, Esther, Lee, Joanne, Chee, Yen Lin, Jeyasekharan, Anand D, Zhou, Longen, Yang, Jennifer, Chng, Wee Joo

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A novel role of the chromokinesin Kif4A in DNA damage response von Wu, Guikai, Zhou, Longen, Khidr, Lily, Guo, Xuning Emily, Kim, Wankee, Lee, Young Mi, Krasieva, Tatiana, Chen, Phang-Lang

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α4β1 Integrin Mediates Selective Endothelial Cell Responses to Thrombospondins 1 and 2 In Vitro and Modulates Angiogenesis In Vivo von Calzada, Maria J, Zhou, Longen, Sipes, John M, Zhang, Jane, Krutzsch, Henry C, Iruela-Arispe, M Luisa, Annis, Douglas S, Mosher, Deane F, Roberts, David D

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Discovery and Pharmacological Characterization of JNJ-64619178, a Novel Small-Molecule Inhibitor of PRMT5 with Potent Antitumor Activity von Brehmer, Dirk, Beke, Lijs, Wu, Tongfei, Millar, Hillary J, Moy, Christopher, Sun, Weimei, Mannens, Geert, Pande, Vineet, Boeckx, An, van Heerde, Erika, Nys, Thomas, Gustin, Emmanuel M, Verbist, Bie, Zhou, Longen, Fan, Yue, Bhargava, Vipul, Safabakhsh, Pegah, Vinken, Petra, Verhulst, Tinne, Gilbert, Angelique, Rai, Sumit, Graubert, Timothy A, Pastore, Friederike, Fiore, Danilo, Gu, Junchen, Johnson, Amy, Philippar, Ulrike, Morschhäuser, Barbara, Walker, David, De Lange, Desiree, Keersmaekers, Vikki, Viellevoye, Marcel, Diels, Gaston, Schepens, Wim, Thuring, Jan Willem, Meerpoel, Lieven, Packman, Kathryn, Lorenzi, Matthew V, Laquerre, Sylvie

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Immune profiling of patients with extranodal natural killer/T cell lymphoma treated with daratumumab von Qing, Min, Zhou, Tianyuan, Perova, Tatiana, Abraham, Yann, Sweeney, Cheryl, Krevvata, Maria, Zhang, Xiaokang, Qi, Ming, Gao, Grace, Kim, Tae Min, Yao, Ming, Cho, Seok-Goo, Eom, Hyeon Seok, Lim, Soon Thye, Yeh, Su-peng, Kwong, Yok Lam, Yoon, Dok Hyun, Kim, Jin Seok, Kim, Won Seog, Zhou, Longen, Attar, Ricardo, Verona, Raluca I.

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CD55 and CD59 Can Limit the Anti-Tumor Efficacy of Daratumumab in Natural Killer/T-Cell Lymphoma von Mustafa, Nurulhuda, Nee, Adina Huey Fang, Chooi, Jing Yuan, Toh, Sabrina Hui Min, Hee, Yan Ting, Selvarajan, Viknesvaran, Zhou, Longen, Yang, Jennifer, Chng, Wee Joo

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Discovery and Pharmacological Characterization of JNJ-64619178, a Novel Small-Molecule Inhibitor of PRMT5 with Potent Antitumor Activity von Brehmer, Dirk, Beke, Lijs, Wu, Tongfei, Millar, Hillary J, Moy, Christopher, Sun, Weimei, Mannens, Geert, Pande, Vineet, Boeckx, An, van Heerde, Erika, Nys, Thomas, Gustin, Emmanuel M, Verbist, Bie, Zhou, Longen, Fan, Yue, Bhargava, Vipul, Safabakhsh, Pegah, Vinken, Petra, Verhulst, Tinne, Gilbert, Angelique, Rai, Sumit, Graubert, Timothy A, Pastore, Friederike, Fiore, Danilo, Gu, Junchen, Johnson, Amy, Philippar, Ulrike, Morschhauser, Barbara, Walker, David, De Lange, Desiree, Keersmaekers, Vikki, Viellevoye, Marcel, Diels, Gaston, Schepens, Wim, Thuring, Jan Willem, Meerpoel, Lieven, Packman, Kathryn, Lorenzi, Matthew, Laquerre, Sylvie

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Efficacy, safety, and pharmacokinetics of teclistamab in Chinese patients with relapsed/refractory multiple myeloma from the China cohort of MajesTEC-1 von Cai, Zhen, Xia, Zhongjun, He, Ai-Li, Dong, Yu-Jun, Wang, Yafei, Liao, Aijun, Song, Yang, Song Mm, Juanjuan, Uhlar, Clarissa, Chastain, Katherine, Watkins, Latisha, Luo, Xinchao, Huang, Lin, Niu, Zhuolu, Quijano Cardé, Natalia A, Guo, Yue, Xu, Hongmei, Verona, Raluca I, Zhou, Longen, Li, Jingyun, Fu, Weijun, Niu, Ting, Du, Juan

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Synthesis and Biological Evaluation of a Series of Novel Inhibitor of Nek2/Hec1 Analogues von Qiu, Xiao-Long, Li, Guideng, Wu, Guikai, Zhu, Jiewen, Zhou, Longen, Chen, Phang-Lang, Chamberlin, A. Richard, Lee, Wen-Hwa

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High efficacy vasopermeability drug candidates identified by screening in an ex ovo chorioallantoic membrane model von Pink, Desmond, Luhrs, Keith A., Zhou, Longen, Schulte, Wendy, Chase, Jennifer, Frosch, Christian, Haberl, Udo, Nguyen, Van, Roy, Aparna I., Lewis, John D., Zijlstra, Andries, Parseghian, Missag H.

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Abstract 1747: BGB324, a selective small molecule Axl kinase inhibitor to overcome EMT-associated drug resistance in carcinomas: Therapeutic rationale and early clinical studies von Wnuk-Lipinska, Katarzyna, Tiron, Crina, Gausdal, Gro, Sandal, Tone, Frink, Robin, Hinz, Stefan, Hellesøy, Monica, Ahmed, Lavina, Haugen, Hallvard, Liang, Xiao, Blø, Magnus, Micklem, David, Yule, Murray, Minna, John, Zhou, Longen, Brekken, Rolf, Lorens, James

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Abstract B30: Selective small molecule AXL inhibitor BGB324 overcomes acquired drug resistance in non-small cell lung carcinoma models von Wnuk-Lipinska, Katarzyna, Gausdal, Gro, Sandal, Tone, Frink, Robin, Hinz, Stefan, Hellesøy, Monica, Ahmed, Lavina, Haugen, Hallvard, Xiao, Liang, Blø, Magnus, Micklem, David, Minna, John, Brekken, Rolf, Zhou, Longen, Lorens, James

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Identification of heat shock protein 60 as a molecular mediator of alpha 3 beta 1 integrin activation von Barazi, Heba O, Zhou, Longen, Templeton, Nancy Smyth, Krutzsch, Henry C, Roberts, David D

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Endogenous thrombospondin-1 is not necessary for proliferation but is permissive for vascular smooth muscle cell responses to platelet-derived growth factor von Isenberg, J. Scott, Calzada, Maria J., Zhou, Longen, Guo, Nenghua, Lawler, Jack, Wang, Xue-Qing, Frazier, William A., Roberts, David D.

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Synthesis and Biological Evaluation of a Series of Novel Inhibitor of Nek2/Hecl Analogues von QIU, Xiao-Long, GUIDENG LI, GUIKAI WU, JIEWEN ZHU, LONGEN ZHOU, CHEN, Phang-Lang, CHAMBERLIN, A. Richard, LEE, Wen-Hwa

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Small Molecules Targeting Rad51 Recombinase Synergize with Imatinib and Overcome Imatinib-Resistance in CML von Zhou, Longen, Zhu, Jiewen, Konig, Heiko, Lin, Xiaoqin, Bhatia, Ravi, Chamberlin, A. Richard, Chen, Phang-Lang, Lee, Wen-Hwa

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α 4 β 1 Integrin Mediates Selective Endothelial Cell Responses to Thrombospondins 1 and 2 In Vitro and Modulates Angiogenesis In Vivo von Calzada, Maria J., Zhou, Longen, Sipes, John M., Zhang, Jane, Krutzsch, Henry C., Iruela-Arispe, M. Luisa, Annis, Douglas S., Mosher, Deane F., Roberts, David D.

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