Targeting Apoptosis Pathways for New Cancer Therapeutics von Bai, Longchuan, Wang, Shaomeng

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Discovery of QCA570 as an Exceptionally Potent and Efficacious Proteolysis Targeting Chimera (PROTAC) Degrader of the Bromodomain and Extra-Terminal (BET) Proteins Capable of Induc... von Qin, Chong, Hu, Yang, Zhou, Bing, Fernandez-Salas, Ester, Yang, Chao-Yie, Liu, Liu, McEachern, Donna, Przybranowski, Sally, Wang, Mi, Stuckey, Jeanne, Meagher, Jennifer, Bai, Longchuan, Chen, Zhuo, Lin, Mei, Yang, Jiuling, Ziazadeh, Danya N, Xu, Fuming, Hu, Jiantao, Xiang, Weiguo, Huang, Liyue, Li, Siwei, Wen, Bo, Sun, Duxin, Wang, Shaomeng

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Structure-Based Discovery of SD-36 as a Potent, Selective, and Efficacious PROTAC Degrader of STAT3 Protein von Zhou, Haibin, Bai, Longchuan, Xu, Renqi, Zhao, Yujun, Chen, Jianyong, McEachern, Donna, Chinnaswamy, Krishnapriya, Wen, Bo, Dai, Lipeng, Kumar, Praveen, Yang, Chao-Yie, Liu, Zhaomin, Wang, Mi, Liu, Liu, Meagher, Jennifer L, Yi, Han, Sun, Duxin, Stuckey, Jeanne A, Wang, Shaomeng

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Targeted Degradation of BET Proteins in Triple-Negative Breast Cancer von Bai, Longchuan, Zhou, Bing, Yang, Chao-Yie, Ji, Jiao, McEachern, Donna, Przybranowski, Sally, Jiang, Hui, Hu, Jiantao, Xu, Fuming, Zhao, Yujun, Liu, Liu, Fernandez-Salas, Ester, Xu, Jing, Dou, Yali, Wen, Bo, Sun, Duxin, Meagher, Jennifer, Stuckey, Jeanne, Hayes, Daniel F, Li, Shunqiang, Ellis, Matthew J, Wang, Shaomeng

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Mcl-1 levels critically impact the sensitivities of human colorectal cancer cells to APG-1252-M1, a novel Bcl-2/Bcl-XL dual inhibitor that induces Bax-dependent apoptosis von Yao, Weilong, Bai, Longchuan, Wang, Shaomeng, Zhai, Yifan, Sun, Shi-Yong

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BM-1197: a novel and specific Bcl-2/Bcl-xL inhibitor inducing complete and long-lasting tumor regression in vivo von Bai, Longchuan, Chen, Jianfang, McEachern, Donna, Liu, Liu, Zhou, Haibin, Aguilar, Angelo, Wang, Shaomeng

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Gli1 deletion prevents Helicobacter-induced gastric metaplasia and expansion of myeloid cell subsets von El-Zaatari, Mohamad, Kao, John Y, Tessier, Art, Bai, Longchuan, Hayes, Michael M, Fontaine, Clinton, Eaton, Kathryn A, Merchant, Juanita L

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Design of Small-Molecule Peptidic and Nonpeptidic Smac Mimetics von Sun, Haiying, Nikolovska-Coleska, Zaneta, Yang, Chao-Yie, Qian, Dongguang, Lu, Jianfeng, Qiu, Su, Bai, Longchuan, Peng, Yuefeng, Cai, Qian, Wang, Shaomeng

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LRIG1 Modulates Cancer Cell Sensitivity to Smac Mimetics by Regulating TNFα Expression and Receptor Tyrosine Kinase Signaling von LONGCHUAN BAI, MCEACHERN, Donna, YANG, Chao-Yie, JIANFENG LU, HAIYING SUN, SHAOMENG WANG

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Structure-Based Discovery of BM-957 as a Potent Small-Molecule Inhibitor of Bcl‑2 and Bcl-xL Capable of Achieving Complete Tumor Regression von Chen, Jianfang, Zhou, Haibin, Aguilar, Angelo, Liu, Liu, Bai, Longchuan, McEachern, Donna, Yang, Chao-Yie, Meagher, Jennifer L, Stuckey, Jeanne A, Wang, Shaomeng

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A role for CITED2, a CBP/p300 interacting protein, in colon cancer cell invasion von Bai, Longchuan, Merchant, Juanita L.

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Targeting Inhibitors of Apoptosis Proteins (IAPs) For New Breast Cancer Therapeutics von Wang, Shaomeng, Bai, Longchuan, Lu, Jianfeng, Liu, Liu, Yang, Chao-Yie, Sun, Haiying

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Small-molecule SMAC mimetics as new cancer therapeutics von Bai, Longchuan, Smith, David C, Wang, Shaomeng

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Radiosensitization of head and neck squamous cell carcinoma by a SMAC-mimetic compound, SM-164, requires activation of caspases von Yang, Jie, McEachern, Donna, Li, Wenyan, Davis, Mary A, Li, Hua, Morgan, Meredith A, Bai, Longchuan, Sebolt, Jonathan T, Sun, Haiying, Lawrence, Theodore S, Wang, Shaomeng, Sun, Yi

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Reduced Pepsin A Processing of Sonic Hedgehog in Parietal Cells Precedes Gastric Atrophy and Transformation von Zavros, Yana, Waghray, Meghna, Tessier, Arthur, Bai, Longchuan, Todisco, Andrea, L. Gumucio, Deborah, Samuelson, Linda C., Dlugosz, Andrzej, Merchant, Juanita L.

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Design, Synthesis, and Evaluation of Tricyclic, Conformationally Constrained Small-Molecule Mimetics of Second Mitochondria-Derived Activator of Caspases von Zhang, Bin, Nikolovska-Coleska, Zaneta, Zhang, Yan, Bai, Longchuan, Qiu, Su, Yang, Chao-Yie, Sun, Haiying, Wang, Shaomeng, Wu, Yikang

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Helicobacter pylori-secreted factors inhibit dendritic cell IL-12 secretion: a mechanism of ineffective host defense von Kao, John Y, Rathinavelu, Sivaprakash, Eaton, Kathryn A, Bai, Longchuan, Zavros, Yana, Takami, Mimi, Pierzchala, Anna, Merchant, Juanita L

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Design, synthesis, and evaluation of peptidomimetics containing Freidinger lactams as STAT3 inhibitors von GOMEZ, Cindy, LONGCHUAN BAI, JIAN ZHANG, NIKOLOVSKA-COLESKA, Zaneta, JIANYONG CHEN, HAN YI, SHAOMENG WANG

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ZBP-89 Promotes Growth Arrest through Stabilization of p53 von Bai, Longchuan, Merchant, Juanita L.

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Discovery of a Small-Molecule Degrader of Bromodomain and Extra-Terminal (BET) Proteins with Picomolar Cellular Potencies and Capable of Achieving Tumor Regression von Zhou, Bing, Hu, Jiantao, Xu, Fuming, Chen, Zhuo, Bai, Longchuan, Fernandez-Salas, Ester, Lin, Mei, Liu, Liu, Yang, Chao-Yie, Zhao, Yujun, McEachern, Donna, Przybranowski, Sally, Wen, Bo, Sun, Duxin, Wang, Shaomeng

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