Widespread Genetic Heterogeneity in Multiple Myeloma: Implications for Targeted Therapy von Lohr, Jens G., Stojanov, Petar, Carter, Scott L., Cruz-Gordillo, Peter, Lawrence, Michael S., Auclair, Daniel, Sougnez, Carrie, Knoechel, Birgit, Gould, Joshua, Saksena, Gordon, Cibulskis, Kristian, McKenna, Aaron, Chapman, Michael A., Straussman, Ravid, Levy, Joan, Perkins, Louise M., Keats, Jonathan J., Schumacher, Steven E., Rosenberg, Mara, Anderson, Kenneth C., Richardson, Paul, Krishnan, Amrita, Lonial, Sagar, Kaufman, Jonathan, Siegel, David S., Vesole, David H., Roy, Vivek, Rivera, Candido E., Rajkumar, S. Vincent, Kumar, Shaji, Fonseca, Rafael, Ahmann, Greg J., Bergsagel, P. Leif, Stewart, A. Keith, Hofmeister, Craig C., Efebera, Yvonne A., Jagannath, Sundar, Chari, Ajai, Trudel, Suzanne, Reece, Donna, Wolf, Jeffrey, Martin, Thomas, Zimmerman, Todd, Rosenbaum, Cara, Jakubowiak, Andrzej J., Lebovic, Daniel, Vij, Ravi, Stockerl-Goldstein, Keith, Getz, Gad, Golub, Todd R.

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Landscape of Somatic Retrotransposition in Human Cancers von Lee, Eunjung, Iskow, Rebecca, Yang, Lixing, Gokcumen, Omer, Haseley, Psalm, Luquette, Lovelace J., Lohr, Jens G., Harris, Christopher C., Ding, Li, Wilson, Richard K., Wheeler, David A., Gibbs, Richard A., Kucherlapati, Raju, Lee, Charles, Kharchenko, Peter V., Park, Peter J.

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A phase II trial of all-trans retinoic acid (ATRA) in advanced adenoid cystic carcinoma von Hanna, Glenn J., ONeill, Anne, Cutler, Jennifer M., Flynn, Michelle, Vijaykumar, Tushara, Clark, John R., Wirth, Lori J., Lorch, Jochen H., Park, Jong C., Mito, Jeffrey K., Lohr, Jens G., Kaufman, Jeffrey, Burr, Nicole Spardy, Zon, Leonard I., Haddad, Robert I.

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Whole-exome sequencing of circulating tumor cells provides a window into metastatic prostate cancer von Lohr, Jens G, Adalsteinsson, Viktor A, Cibulskis, Kristian, Choudhury, Atish D, Rosenberg, Mara, Cruz-Gordillo, Peter, Francis, Joshua M, Zhang, Cheng-Zhong, Shalek, Alex K, Satija, Rahul, Trombetta, John J, Lu, Diana, Tallapragada, Naren, Tahirova, Narmin, Kim, Sora, Blumenstiel, Brendan, Sougnez, Carrie, Lowe, Alarice, Wong, Bang, Auclair, Daniel, Van Allen, Eliezer M, Nakabayashi, Mari, Lis, Rosina T, Lee, Gwo-Shu M, Li, Tiantian, Chabot, Matthew S, Ly, Amy, Taplin, Mary-Ellen, Clancy, Thomas E, Loda, Massimo, Regev, Aviv, Meyerson, Matthew, Hahn, William C, Kantoff, Philip W, Golub, Todd R, Getz, Gad, Boehm, Jesse S, Love, J Christopher

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The Mutational Landscape of Circulating Tumor Cells in Multiple Myeloma von Mishima, Yuji, Paiva, Bruno, Shi, Jiantao, Park, Jihye, Manier, Salomon, Takagi, Satoshi, Massoud, Mira, Perilla-Glen, Adriana, Aljawai, Yosra, Huynh, Daisy, Roccaro, Aldo M., Sacco, Antonio, Capelletti, Marzia, Detappe, Alexandre, Alignani, Diego, Anderson, Kenneth C., Munshi, Nikhil C., Prosper, Felipe, Lohr, Jens G., Ha, Gavin, Freeman, Samuel S., Van Allen, Eliezer M., Adalsteinsson, Viktor A., Michor, Franziska, San Miguel, Jesus F., Ghobrial, Irene M.

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An epigenetic mechanism of resistance to targeted therapy in T cell acute lymphoblastic leukemia von Knoechel, Birgit, Roderick, Justine E, Williamson, Kaylyn E, Zhu, Jiang, Lohr, Jens G, Cotton, Matthew J, Gillespie, Shawn M, Fernandez, Daniel, Ku, Manching, Wang, Hongfang, Piccioni, Federica, Silver, Serena J, Jain, Mohit, Pearson, Daniel, Kluk, Michael J, Ott, Christopher J, Shultz, Leonard D, Brehm, Michael A, Greiner, Dale L, Gutierrez, Alejandro, Stegmaier, Kimberly, Kung, Andrew L, Root, David E, Bradner, James E, Aster, Jon C, Kelliher, Michelle A, Bernstein, Bradley E

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Genomic discovery and clonal tracking in multiple myeloma by cell-free DNA sequencing von Guo, Guangwu, Raje, Noopur S., Seifer, Charles, Kloeber, Jake, Isenhart, Randi, Ha, Gavin, Yee, Andrew J., O’Donnell, Elizabeth K., Tai, Yu-Tzu, Richardson, Paul G., Bianchi, Giada, Laubach, Jacob P., Warren, Diane, Gemme, Erica, Voisine, Jordan, Frede, Julia, Kokkalis, Antonis, Yun, Huiyoung, Dimitrova, Valeriya, Vijaykumar, Tushara, Meyerson, Matthew, Munshi, Nikhil C., Anderson, Kenneth C., Knoechel, Birgit, Lohr, Jens G.

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Comprehensive characterization of circulating and bone marrow-derived multiple myeloma cells at minimal residual disease von Waldschmidt, Johannes M., Anand, Praveen, Knoechel, Birgit, Lohr, Jens G.

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Tracking myeloma tumor DNA in peripheral blood von Waldschmidt, Johannes M., Vijaykumar, Tushara, Knoechel, Birgit, Lohr, Jens G.

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Single-cell RNA-seq reveals developmental plasticity with coexisting oncogenic states and immune evasion programs in ETP-ALL von Anand, Praveen, Guillaumet-Adkins, Amy, Dimitrova, Valeriya, Yun, Huiyoung, Drier, Yotam, Sotudeh, Noori, Rogers, Anna, Ouseph, Madhu M., Nair, Monica, Potdar, Sayalee, Isenhart, Randi, Kloeber, Jake A., Vijaykumar, Tushara, Niu, Leili, Vincent, Tiffaney, Guo, Guangwu, Frede, Julia, Harris, Marian H., Place, Andrew E., Silverman, Lewis B., Teachey, David T., Lane, Andrew A., DeAngelo, Daniel J., Aster, Jon C., Bernstein, Bradley E., Lohr, Jens G., Knoechel, Birgit

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Dynamic transcriptional reprogramming leads to immunotherapeutic vulnerabilities in myeloma von Frede, Julia, Anand, Praveen, Sotudeh, Noori, Pinto, Ricardo A., Nair, Monica S., Stuart, Hannah, Yee, Andrew J., Vijaykumar, Tushara, Waldschmidt, Johannes M., Potdar, Sayalee, Kloeber, Jake A., Kokkalis, Antonis, Dimitrova, Valeriya, Mann, Mason, Laubach, Jacob P., Richardson, Paul G., Anderson, Kenneth C., Raje, Noopur S., Knoechel, Birgit, Lohr, Jens G.

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Single-Cell Profiling Reveals Metabolic Reprogramming as a Resistance Mechanism in BRAF -Mutated Multiple Myeloma von Waldschmidt, Johannes M, Kloeber, Jake A, Anand, Praveen, Frede, Julia, Kokkalis, Antonis, Dimitrova, Valeriya, Potdar, Sayalee, Nair, Monica S, Vijaykumar, Tushara, Im, Nam Gyu, Guillaumet-Adkins, Amy, Chopra, Nitish, Stuart, Hannah, Budano, Lillian, Sotudeh, Noori, Guo, Guangwu, Grassberger, Clemens, Yee, Andrew J, Laubach, Jacob P, Richardson, Paul G, Anderson, Kenneth C, Raje, Noopur S, Knoechel, Birgit, Lohr, Jens G

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The Role of Minimal Residual Disease Testing in Myeloma Treatment Selection and Drug Development: Current Value and Future Applications von Anderson, Kenneth C, Auclair, Daniel, Kelloff, Gary J, Sigman, Caroline C, Avet-Loiseau, Hervé, Farrell, Ann T, Gormley, Nicole J, Kumar, Shaji K, Landgren, Ola, Munshi, Nikhil C, Cavo, Michele, Davies, Faith E, Di Bacco, Alessandra, Dickey, Jennifer S, Gutman, Steven I, Higley, Howard R, Hussein, Mohamad A, Jessup, J Milburn, Kirsch, Ilan R, Little, Richard F, Loberg, Robert D, Lohr, Jens G, Mukundan, Lata, Omel, James L, Pugh, Trevor J, Reaman, Gregory H, Robbins, Michael D, Sasser, A Kate, Valente, Nancy, Zamagni, Elena

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Dual role of signaling pathways in myeloma requires cell type–specific targeting of ligand-receptor interactions von Hernandez-Lopez, Pablo, Vijaykumar, Tushara, Anand, Praveen, Auclair, Daniel, Frede, Julia, Knoechel, Birgit, Lohr, Jens G.

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Cell-free DNA for the detection of emerging treatment failure in relapsed/ refractory multiple myeloma von Waldschmidt, Johannes M., Yee, Andrew J., Vijaykumar, Tushara, Pinto, Ricardo A., Frede, Julia, Anand, Praveen, Bianchi, Giada, Guo, Guangwu, Potdar, Sayalee, Seifer, Charles, Nair, Monica S., Kokkalis, Antonis, Kloeber, Jake A., Shapiro, Samantha, Budano, Lillian, Mann, Mason, Friedman, Robb, Lipe, Brea, Campagnaro, Erica, O’Donnell, Elizabeth K., Zhang, Cheng-Zhong, Laubach, Jacob P., Munshi, Nikhil C., Richardson, Paul G., Anderson, Kenneth C., Raje, Noopur S., Knoechel, Birgit, Lohr, Jens G.

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Discovery and prioritization of somatic mutations in diffuse large B-cell lymphoma (DLBCL) by whole-exome sequencing von Lohr, Jens G, Stojanov, Petar, Lawrence, Michael S, Auclair, Daniel, Chapuy, Bjoern, Sougnez, Carrie, Cruz-Gordillo, Peter, Knoechel, Birgit, Asmann, Yan W, Slager, Susan L, Novak, Anne J, Dogan, Ahmet, Ansell, Stephen M, Link, Brian K, Zou, Lihua, Gould, Joshua, Saksena, Gordon, Stransky, Nicolas, Rangel-Escareño, Claudia, Fernandez-Lopez, Juan Carlos, Hidalgo-Miranda, Alfredo, Melendez-Zajgla, Jorge, Hernández-Lemus, Enrique, Schwarz-Cruz y Celis, Angela, Imaz-Rosshandler, Ivan, Ojesina, Akinyemi I, Jung, Joonil, Pedamallu, Chandra S, Lander, Eric S, Habermann, Thomas M, Cerhan, James R, Shipp, Margaret A, Getz, Gad, Golub, Todd R

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Loss of metabolic fitness drives tumor resistance after CAR-NK cell therapy and can be overcome by cytokine engineering von Li, Li, Mohanty, Vakul, Dou, Jinzhuang, Huang, Yuefan, Banerjee, Pinaki P, Miao, Qi, Lohr, Jens G, Vijaykumar, Tushara, Frede, Julia, Knoechel, Birgit, Muniz-Feliciano, Luis, Laskowski, Tamara J, Liang, Shaoheng, Moyes, Judy S, Nandivada, Vandana, Basar, Rafet, Kaplan, Mecit, Daher, May, Liu, Enli, Li, Ye, Acharya, Sunil, Lin, Paul, Shanley, Mayra, Rafei, Hind, Marin, David, Mielke, Stephan, Champlin, Richard E, Shpall, Elizabeth J, Chen, Ken, Rezvani, Katayoun

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Regulatory Programs of B-cell Activation and Germinal Center Reaction Allow B-ALL Escape from CD19 CAR T-cell Therapy von Im, Nam Gyu, Guillaumet-Adkins, Amy, Wal, Megha, Rogers, Anna J, Frede, Julia, Havig, Claire C, Yang, Jing, Anand, Praveen, Stegmann, Sarah K, Waldschmidt, Johannes M, Sotudeh, Noori, Niu, Leili, Voisine, Jordan, Schweiger, Michal R, Grassberger, Clemens, Lohr, Jens G, Knoechel, Birgit

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Genomics of lymphoid malignancies reveal major activation pathways in lymphocytes von Knoechel, Birgit, Lohr, Jens G

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Implementation of a prostate cancer‐specific targeted sequencing panel for credentialing of patient‐derived cell lines and genomic characterization of patient samples von Stover, Elizabeth H., Oh, Coyin, Keskula, Paula, Choudhury, Atish D., Tseng, Yuen‐Yi, Adalsteinsson, Viktor A., Lohr, Jens G., Thorner, Aaron R., Ducar, Matthew, Kryukov, Gregory V., Ha, Gavin, Rosenberg, Mara, Freeman, Samuel S., Zhang, Zhenwei, Wu, Xiaoyun, Van Allen, Eliezer M., Takeda, David Y., Loda, Massimo, Wu, Chin‐Lee, Taplin, Mary‐Ellen, Garraway, Levi A., Boehm, Jesse S., Huang, Franklin W.

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