Why Do SGLT2 Inhibitors Inhibit Only 30―50% of Renal Glucose Reabsorption in Humans? von LIU, Jiwen (jim), LEE, Taeweon, DEFRONZO, Ralph A

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Discovery of AMG 232, a Potent, Selective, and Orally Bioavailable MDM2–p53 Inhibitor in Clinical Development von Sun, Daqing, Li, Zhihong, Rew, Yosup, Gribble, Michael, Bartberger, Michael D, Beck, Hilary P, Canon, Jude, Chen, Ada, Chen, Xiaoqi, Chow, David, Deignan, Jeffrey, Duquette, Jason, Eksterowicz, John, Fisher, Benjamin, Fox, Brian M, Fu, Jiasheng, Gonzalez, Ana Z, Gonzalez-Lopez De Turiso, Felix, Houze, Jonathan B, Huang, Xin, Jiang, Min, Jin, Lixia, Kayser, Frank, Liu, Jiwen (Jim), Lo, Mei-Chu, Long, Alexander M, Lucas, Brian, McGee, Lawrence R, McIntosh, Joel, Mihalic, Jeff, Oliner, Jonathan D, Osgood, Tao, Peterson, Matthew L, Roveto, Philip, Saiki, Anne Y, Shaffer, Paul, Toteva, Maria, Wang, Yingcai, Wang, Yu Chung, Wortman, Sarah, Yakowec, Peter, Yan, Xuelei, Ye, Qiuping, Yu, Dongyin, Yu, Ming, Zhao, Xiaoning, Zhou, Jing, Zhu, Jiang, Olson, Steven H, Medina, Julio C

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Activation of FFA1 mediates GLP-1 secretion in mice. Evidence for allosterism at FFA1 von Xiong, Yumei, Swaminath, Gayathri, Cao, Qiong, Yang, Li, Guo, Qi, Salomonis, Heather, Lu, Jenny, Houze, Jonathan B., Dransfield, Paul J., Wang, Yingcai, Liu, Jiwen (Jim), Wong, Simon, Schwandner, Ralf, Steger, Franziska, Baribault, Helene, Liu, Lily, Coberly, Suzanne, Miao, Lynn, Zhang, Jane, Lin, Daniel C.-H., Schwarz, Margrit

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Discovery and Optimization of Potent GPR40 Full Agonists Containing Tricyclic Spirocycles von Wang, Yingcai, Liu, Jiwen (Jim), Dransfield, Paul J, Zhu, Liusheng, Wang, Zhongyu, Du, Xiaohui, Jiao, Xianyun, Su, Yongli, Li, An-rong, Brown, Sean P, Kasparian, Annie, Vimolratana, Marc, Yu, Ming, Pattaropong, Vatee, Houze, Jonathan B, Swaminath, Gayathri, Tran, Thanhvien, Nguyen, Khanh, Guo, Qi, Zhang, Jane, Zhuang, Run, Li, Frank, Miao, Lynn, Bartberger, Michael D, Correll, Tiffany L, Chow, David, Wong, Simon, Luo, Jian, Lin, Daniel C.-H, Medina, Julio C

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Discovery and optimization of N-(3-(1,3-dioxo-2,3-dihydro-1H-pyrrolo[3,4-c]pyridin-4-yloxy)phenyl)benzenesulfonamides as novel GPR119 agonists von Yu, Ming, Ken Zhang, Jian, Wang, Yingcai, Zhu, Jiang, Kayser, Frank, Medina, Julio C, Siegler, Karen, Conn, Marion, Shan, Bei, Grillo, Mark P, Coward, Peter, Jim Liu, Jiwen

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Discovery of the imidazole-derived GPR40 agonist AM-3189 von Ma, Zhihua, Lin, Daniel C.-H., Sharma, Rajiv, Liu, Jinqian, Zhu, Liusheng, Li, An-Rong, Kohn, Todd, Wang, Yingcai, Liu, Jiwen (Jim), Bartberger, Michael D., Medina, Julio C., Zhuang, Run, Li, Frank, Zhang, Jane, Luo, Jian, Wong, Simon, Tonn, George R., Houze, Jonathan B.

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Discovery and optimization of arylsulfonyl 3-(pyridin-2-yloxy)anilines as novel GPR119 agonists von Zhang, Jian (Ken), Li, An-Rong, Yu, Ming, Wang, Yingcai, Zhu, Jiang, Kayser, Frank, Medina, Julio C., Siegler, Karen, Conn, Marion, Shan, Bei, Grillo, Mark P., Eksterowicz, John, Coward, Peter, Liu, Jiwen (Jim)

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Optimization of GPR40 Agonists for Type 2 Diabetes von Liu, Jiwen (Jim), Wang, Yingcai, Ma, Zhihua, Schmitt, Mike, Zhu, Liusheng, Brown, Sean P, Dransfield, Paul J, Sun, Ying, Sharma, Rajiv, Guo, Qi, Zhuang, Run, Zhang, Jane, Luo, Jian, Tonn, George R, Wong, Simon, Swaminath, Gayathri, Medina, Julio C, Lin, Daniel C.-H, Houze, Jonathan B

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Discovery and optimization of 5-(2-((1-(phenylsulfonyl)-1,2,3,4-tetrahydroquinolin-7-yl)oxy)pyridin-4-yl)-1,2,4-oxadiazoles as novel gpr119 agonists von Wang, Yingcai, Yu, Ming, Zhu, Jiang, Zhang, Jian Ken, Kayser, Frank, Medina, Julio C, Siegler, Karen, Conn, Marion, Shan, Bei, Grillo, Mark P, Liu, Jiwen Jim, Coward, Peter

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Optimization beyond AMG 232: Discovery and SAR of sulfonamides on a piperidinone scaffold as potent inhibitors of the MDM2-p53 protein–protein interaction von Wang, Yingcai, Zhu, Jiang, Liu, Jiwen (Jim), Chen, Xiaoqi, Mihalic, Jeff, Deignan, Jeffrey, Yu, Ming, Sun, Daqing, Kayser, Frank, McGee, Lawrence R., Lo, Mei-Chu, Chen, Ada, Zhou, Jing, Ye, Qiuping, Huang, Xin, Long, Alexander M., Yakowec, Peter, Oliner, Jonathan D., Olson, Steven H., Medina, Julio C.

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Discovery of Potent and Simplified Piperidinone-Based Inhibitors of the MDM2–p53 Interaction von Yu, Ming, Wang, Yingcai, Zhu, Jiang, Bartberger, Michael D, Canon, Jude, Chen, Ada, Chow, David, Eksterowicz, John, Fox, Brian, Fu, Jiasheng, Gribble, Michael, Huang, Xin, Li, Zhihong, Liu, Jiwen (Jim), Lo, Mei-chu, McMinn, Dustin, Oliner, Jonathan D, Osgood, Tao, Rew, Yosup, Saiki, Anne Y, Shaffer, Paul, Yan, Xuelei, Ye, Qiuping, Yu, Dongyin, Zhao, Xiaoning, Zhou, Jing, Olson, Steven H, Medina, Julio C, Sun, Daqing

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Improving the Pharmacokinetics of GPR40/FFA1 Full Agonists von Du, Xiaohui, Dransfield, Paul J, Lin, Daniel C.-H, Wong, Simon, Wang, Yingcai, Wang, Zhongyu, Kohn, Todd, Yu, Ming, Brown, Sean P, Vimolratana, Marc, Zhu, Liusheng, Li, An-Rong, Su, Yongli, Jiao, Xianyun, Liu, Jiwen (Jim), Swaminath, Gayathri, Tran, Thanhvien, Luo, Jian, Zhuang, Run, Zhang, Jane, Guo, Qi, Li, Frank, Connors, Richard, Medina, Julio C, Houze, Jonathan B

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Optimization of phenylacetic acid derivatives for CRTH2 and DP selective antagonism von Wang, Yingcai, Fu, Zice, Schmitt, Michael, Wang, Xuemei, Shen, Wang, Rickel, Erika, Martin, Tod, Budelsky, Alison, Marshall, Derek, Collins, Tassie, Tang, H. Lucy, Medina, Julio C., Liu, Jiwen (Jim)

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Solving time-dependent CYP3A4 inhibition for a series of indole-phenylacetic acid dual antagonists of the PGD(2) receptors CRTH2 and DP von Johnson, Michael G, Liu, Jim Jiwen, Li, An-Rong, van Lengerich, Bettina, Wang, Sophie, Medina, Julio C, Collins, Tassie L, Danao, Jay, Seitz, Lisa, Willee, Angela, D'Souza, Warren, Budelsky, Alison L, Fan, Peter W, Wong, Simon G W

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Optimization of phenylacetic acid derivatives for balanced CRTH2 and DP dual antagonists von Liu, Jiwen (Jim), Wang, Yingcai, Johnson, Michael G., Li, An-Rong, Shen, Wang, Wang, Xuemei, Su, Yongli, Brown, Matthew, Van Lengerich, Bettina, Rickel, Erika, Martin, Tod, Budelsky, Alison, Seitz, Lisa, Danao, Jay, Tang, H. Lucy, Collins, Tassie, Medina, Julio C.

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Aminopyrazole–Phenylalanine Based GPR142 Agonists: Discovery of Tool Compound and in Vivo Efficacy Studies von Yu, Ming, Lizarzaburu, Mike, Motani, Alykhan, Fu, Zice, Du, Xiaohui, Liu, Jiwen (Jim), Jiao, Xianyun, Lai, SuJen, Fan, Peter, Fu, Angela, Liu, Qingxiang, Murakoshi, Michiko, Nara, Futoshi, Oda, Kozo, Okuyama, Ryo, Reagan, Jeff D, Watanabe, Nobuaki, Yamazaki, Mami, Xiong, Yumei, Zhang, Ying, Zhuang, Run, Lin, Daniel C.-H, Houze, Jonathan B, Medina, Julio C, Li, Leping

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Benzodiazepinone Derivatives as CRTH2 Antagonists von Liu, Jiwen (Jim), Cheng, Alan C, Tang, H. Lucy, Medina, Julio C

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Solving time-dependent CYP3A4 inhibition for a series of indole-phenylacetic acid dual antagonists of the PGD2 receptors CRTH2 and DP von Johnson, Michael G., Liu, Jim (Jiwen), Li, An-Rong, van Lengerich, Bettina, Wang, Sophie, Medina, Julio C., Collins, Tassie L., Danao, Jay, Seitz, Lisa, Willee, Angela, D’Souza, Warren, Budelsky, Alison L., Fan, Peter W., Wong, Simon G.W.

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Biolink Model: A universal schema for knowledge graphs in clinical, biomedical, and translational science von Moxon, Sierra A. T., Bruskiewich, Richard, Dancik, Vlado, Dumontier, Michel, Fecho, Karamarie, Putman, Tim, Qin, Guangrong, Ramsey, Stephen A., Soman, Karthik, Thessen, Anne E., Haendel, Melissa A., Mungall, Christopher J., Ahalt, Stanley C., Alden, John, Alkanaq, Ahmed, Avila, Ricardo, Baumgartner, Andrew, Belhu, Basazin, Brandon, Namdi, Burtt, Noel, Byrd, William, Callaghan, Jackson, Cano, Marco Alvarado, Celebi, Remzi, Champion, James, Chen, Zhehuan, Chung, Lawrence, Cohen, Kevin, Costanzo, Maria, Dai, Cheng, Dančík, Vlado, Dougherty, Jennifer, Gardner, Vicki, Glen, Amy, Goel, Prateek, Gormley, Joseph, Greyber, Alon, Haaland, Perry, Hanspers, Kristina, He, Kaiwen, Hinderer, Eugene W., Hubal, Robert, Issabekova, Tursynay, Jarrell, Matthew, Jenkins, Lindsay, Kang, Jimin, Kim, Keum Joo, Knowles, Michael, Koesterer, Ryan, Korn, Daniel, Koslicki, David, Krishnamurthy, Ashok, Kvarfordt, Lindsey, Leigh, Margaret, Magis, Andrew, Mamidi, Tarun, Mantilla, Michelle, Massung, Jeffrey, Mauldin, Denise, McMurry, Julie, Mease, Philip, Mendoza, Luis, Mersmann, Marian, Muller, Sandrine, Muluka, Arun Teja, Osborne, John, Owen, Phil, Patton, Michael, Peden, David B., Peene, R. Carter, Pfaff, Emily, Price, Guthrie, Raj, Shruti, Reilly, Jason, Roach, Jared, Roper, Ryan T., Rosenblatt, Greg, Rubin, Irit, Scott, Erik, Sharma, Priya, Shrestha, Manil, Sinha, Meghamala, Southall, Noel, Stillwell, Lisa, Strasser, Michael " Michi", Tinglin, Jillian, Tropsha, Alexander, Vaidya, Gaurav, Viola, Adam, Wang, Max, Weber, Rosina, Wei, Qi, Whitlock, Jordan, Williams, Mark D., Xin, Jiwen Kevin, Xu, Hao, Xu, Colleen, Yao, Yao, Zhou, Eric, Zisk, Tom

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Progress toward a universal biomedical data translator von Thessen, Anne E., Roper, Ryan T., Southall, Noel, Ta, Casey, Xu, Hao, Byrd, William, Dančík, Vlado, Duby, Marc P., Dumontier, Michel, Glusman, Gustavo, Hinderer, Eugene W., Johs, Adam, Su, Andrew I., Qin, Guangrong, Zhu, Qian, Dougherty, Jennifer, Magis, Andrew, Smith, Brett, Chen, Zhehuan, Azevedo, Ricardo De Miranda, Lee, Jay, Weng, Chunhua, Yilmaz, Arif, Santos, Eugene, Yakaboski, Chase, Deutsch, Eric, Koslicki, David, Kvarfordt, Lindsey, Ma, Chunyu, Wood, Erica, Roach, Jared, Williams, Andrew, Gormley, Joseph, Zisk, Tom, Hoatlin, Maureen, Pico, Alexander, Riutta, Anders, Xu, Colleen, Ahalt, Stanley C., Knowles, Michael, Krishnamurthy, Ashok, Mandal, Meisha, Peden, David B., Cox, Steven, Vaidya, Gaurav, Wang, Max, Alkanaq, Ahmed, Costanzo, Maria, Koesterer, Ryan, Flannick, Jason, Kluge, Alexandria, Strasser, Michael “ Michi”, Chung, Lawrence, Kang, Jimin, Mantilla, Michelle, Muller, Sandrine, Persaud, Bria, Wei, Qi, Dai, Cheng, Duvvuri, Venkata, Mauldin, Denise, Korn, Daniel, Mesbah, Abrar, Tropsha, Alexander, Mersmann, Marian, Morton, Kenny, Lin, Jason, Avila, Ricardo, Wu, Chunlei, Cano, Marco Alvarado, Issabekova, Tursynay, McMurry, Julie, Cohen, Kevin, He, Kaiwen, Mamidi, Tarun, Might, Matthew, Osborne, John, Tran‐Nguyen, Thi, Crouse, Andrew, Belhu, Basazin, Stillwell, Lisa, Grotthuss, Marcin, Wang, Patrick, Zhou, Xinghua, Sinha, Meghamala, Raj, Shruti, Peene, R. Carter, McClelland, Jason, Leigh, Margaret, Zhou, Eric, Amin, Nada, Fehrmann, Nathaniel, Foksinska, Aleksandra M., Jenkins, Lindsay, He, Kaiwen, Jarrell, Matthew, Pollard, Elizabeth, Rucka, Sienna, Tinglin, Jillian, Zheng, Marissa

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