Blockade of the AHR restricts a Treg-macrophage suppressive axis induced by L-Kynurenine von Campesato, Luis Felipe, Budhu, Sadna, Tchaicha, Jeremy, Weng, Chien-Huan, Gigoux, Mathieu, Cohen, Ivan Jose, Redmond, David, Mangarin, Levi, Pourpe, Stephane, Liu, Cailian, Zappasodi, Roberta, Zamarin, Dmitriy, Cavanaugh, Jill, Castro, Alfredo C., Manfredi, Mark G., McGovern, Karen, Merghoub, Taha, Wolchok, Jedd D.

Volltext

Genetic Basis for Clinical Response to CTLA-4 Blockade in Melanoma von Snyder, Alexandra, Makarov, Vladimir, Merghoub, Taha, Yuan, Jianda, Zaretsky, Jesse M, Desrichard, Alexis, Walsh, Logan A, Postow, Michael A, Wong, Phillip, Ho, Teresa S, Hollmann, Travis J, Bruggeman, Cameron, Kannan, Kasthuri, Li, Yanyun, Elipenahli, Ceyhan, Liu, Cailian, Harbison, Christopher T, Wang, Lisu, Ribas, Antoni, Wolchok, Jedd D, Chan, Timothy A

Volltext

Rational design of anti-GITR-based combination immunotherapy von Zappasodi, Roberta, Sirard, Cynthia, Li, Yanyun, Budhu, Sadna, Abu-Akeel, Mohsen, Liu, Cailian, Yang, Xia, Zhong, Hong, Newman, Walter, Qi, Jingjing, Wong, Phillip, Schaer, David, Koon, Henry, Velcheti, Vamsidhar, Hellmann, Matthew D., Postow, Michael A., Callahan, Margaret K., Wolchok, Jedd D., Merghoub, Taha

Volltext

Pre-existing Immunity to Oncolytic Virus Potentiates Its Immunotherapeutic Efficacy von Ricca, Jacob M., Oseledchyk, Anton, Walther, Tyler, Liu, Cailian, Mangarin, Levi, Merghoub, Taha, Wolchok, Jedd D., Zamarin, Dmitriy

Volltext

Loss of NF1 in Cutaneous Melanoma Is Associated with RAS Activation and MEK Dependence von NISSAN, Moriah H, PRATILAS, Christine A, MERGHOUB, Taha, RIBAS, Antoni, CHAPMAN, Paul B, YAEGER, Rona, TAYLOR, Barry S, SCHULTZ, Nikolaus, BERGER, Michael F, ROSEN, Neal, SOLIT, David B, JONES, Alexis M, RAMIREZ, Ricardo, WON, Helen, CAILIAN LIU, TIWARI, Shakuntala, LI KONG, HANRAHAN, Aphrothiti J, ZHAN YAO

Volltext

Recombinant human interleukin-7 (CYT107) promotes T-cell recovery after allogeneic stem cell transplantation von Perales, Miguel-Angel, Goldberg, Jenna D., Yuan, Jianda, Koehne, Guenther, Lechner, Lauren, Papadopoulos, Esperanza B., Young, James W., Jakubowski, Ann A., Zaidi, Bushra, Gallardo, Humilidad, Liu, Cailian, Rasalan, Teresa, Wolchok, Jedd D., Croughs, Therese, Morre, Michel, Devlin, Sean M., van den Brink, Marcel R.M.

Volltext

Targeting Phosphatidylserine Enhances the Anti-tumor Response to Tumor-Directed Radiation Therapy in a Preclinical Model of Melanoma von Budhu, Sadna, Giese, Rachel, Gupta, Aditi, Fitzgerald, Kelly, Zappasodi, Roberta, Schad, Sara, Hirschhorn, Daniel, Campesato, Luis Felipe, De Henau, Olivier, Gigoux, Mathieu, Liu, Cailian, Mazo, Gregory, Deng, Liang, Barker, Christopher A., Wolchok, Jedd D., Merghoub, Taha

Volltext

Agonist anti-GITR monoclonal antibody induces melanoma tumor immunity in mice by altering regulatory T cell stability and intra-tumor accumulation von Cohen, Adam D, Schaer, David A, Liu, Cailian, Li, Yanyun, Hirschhorn-Cymmerman, Daniel, Kim, Soo Chong, Diab, Adi, Rizzuto, Gabrielle, Duan, Fei, Perales, Miguel A, Merghoub, Taha, Houghton, Alan N, Wolchok, Jedd D

Volltext

Increased p53 expression induced by APR-246 reprograms tumor-associated macrophages to augment immune checkpoint blockade von Ghosh, Arnab, Michels, Judith, Mezzadra, Riccardo, Venkatesh, Divya, Dong, Lauren, Gomez, Ricardo, Samaan, Fadi, Ho, Yu-Jui, Campesato, Luis Felipe, Mangarin, Levi, Fak, John, Suek, Nathan, Holland, Aliya, Liu, Cailian, Abu-Akeel, Mohsen, Bykov, Yonina, Zhong, Hong, Fitzgerald, Kelly, Budhu, Sadna, Chow, Andrew, Zappasodi, Roberta, Panageas, Katherine S, de Henau, Olivier, Ruscetti, Marcus, Lowe, Scott W, Merghoub, Taha, Wolchok, Jedd D

Volltext

Agonist anti-gitr antibody enhances vaccine-induced CD8+ T-cell responses and tumor immunity von COHEN, Adam D, DIAB, Adi, SAKAGUCHI, Shimon, HOUGHTON, Alan N, PERALES, Miguel-Angel, WOLCHOK, Jedd D, RIZZUTO, Gabrielle, MERGHOUB, Taha, HUGGINS, Deonka, CAILIAN LIU, JO TURK, Mary, RESTIFO, Nicholas P

Volltext

TYRP1 directed CAR T cells control tumor progression in preclinical melanoma models von Hackett, Christopher S, Hirschhorn, Daniel, Tang, Meixian S, Purdon, Terence J, Marouf, Yacine, Piersigilli, Alessandra, Agaram, Narasimhan P, Liu, Cailian, Schad, Sara E, de Stanchina, Elisa, Rafiq, Sarwish, Monette, Sebastien, Wolchok, Jedd D, Merghoub, Taha, Brentjens, Renier J

Volltext

878 T cell immunotherapies recruit and activate neutrophils to eliminate tumor antigen escape variants von Hirschhorn, Daniel, Budhu, Sadna, Kraehenbuehl, Lukas, Gigoux, Mathieu, Schröder, David, Chow, Andrew, Ricca, Jacob M, Gasmi, Billel, De Henau, Olivier, Mangarin, Levi Mark B, Li, Yanyun, Flamar, Anne-Laure, Choi, Heyjin, Cortez, Czrina A, Liu, Cailian, Holland, Aliya, Schad, Sara, Schulze, Isabell, Hamadene, Linda, Warner, Allison Betof, Hollmann, Travis, Arora, Arshi, Panageas, Katherine S, Duhen, Rebekka, Weinberg, Andrew D, Rizzuto, Gabrielle A, Spencer, Christine N, Ng, David, He, Xue-Yan, Albrengues, Jean, Redmond, David, Egeblad, Mikala, Wolchok, Jedd D, Merghoub, Taha

Volltext

493 Tired and hungry: a potential role for CD47 in T cell exhaustion von Mangarin, Levi, Liu, Cailian, Zappasodi, Roberta, Holland, Pamela, Wolchok, Jedd, Merghoub, Taha, Weng, Chien-Huan, Schroder, David

Volltext

Cyclophosphamide enhances the antitumor potency of GITR engagement by increasing oligoclonal cytotoxic T cell fitness von Hirschhorn, Daniel, Betof Warner, Allison, Maniyar, Rachana, Chow, Andrew, Mangarin, Levi Mb, Cohen, Adam D, Hamadene, Linda, Rizzuto, Gabrielle A, Budhu, Sadna, Suek, Nathan, Liu, Cailian, Houghton, Alan N, Merghoub, Taha, Wolchok, Jedd D

Volltext

99 T cell immunotherapies trigger neutrophil activation to eliminate tumor antigen escape variants von Hirschhorn, Daniel, Budhu, Sadna, Schröder, David, kraehenbuehl, Lukas, Flammar, Anne-Laurent, Chow, Andrew, Schulze, Isabell, Schad, Sara, Ricca, Jacob, Gasmi, Billel, Henau, Olivier De, Mangarin, Levi, Redmond, David, Cortez, Czrina, Liu, Cailian, Holland, Aliya, Gigoux, Mathieu, Arora, Asrhi, Panageas, Katherine, Rizzuto, Gabrielle, Albrengues, Jean, Egeblad, Mikala, Wolchok, Jedd, Merghoub, Taha

Volltext

Overcoming resistance to checkpoint blockade therapy by targeting PI3Kγ in myeloid cells von De Henau, Olivier, Rausch, Matthew, Winkler, David, Campesato, Luis Felipe, Liu, Cailian, Cymerman, Daniel Hirschhorn, Budhu, Sadna, Ghosh, Arnab, Pink, Melissa, Tchaicha, Jeremy, Douglas, Mark, Tibbitts, Thomas, Sharma, Sujata, Proctor, Jennifer, Kosmider, Nicole, White, Kerry, Stern, Howard, Soglia, John, Adams, Julian, Palombella, Vito J., McGovern, Karen, Kutok, Jeffery L., Wolchok, Jedd D., Merghoub, Taha

Volltext

CTLA-4 blockade drives loss of Treg stability in glycolysis-low tumours von Zappasodi, Roberta, Serganova, Inna, Cohen, Ivan J., Maeda, Masatomo, Shindo, Masahiro, Senbabaoglu, Yasin, Watson, McLane J., Leftin, Avigdor, Maniyar, Rachana, Verma, Svena, Lubin, Matthew, Ko, Myat, Mane, Mayuresh M., Zhong, Hong, Liu, Cailian, Ghosh, Arnab, Abu-Akeel, Mohsen, Ackerstaff, Ellen, Koutcher, Jason A., Ho, Ping-Chih, Delgoffe, Greg M., Blasberg, Ronald, Wolchok, Jedd D., Merghoub, Taha

Volltext

Frequent MAGE mutations in human melanoma von Caballero, Otavia L, Zhao, Qi, Rimoldi, Donata, Stevenson, Brian J, Svobodová, Suzanne, Devalle, Sylvie, Röhrig, Ute F, Pagotto, Anna, Michielin, Olivier, Speiser, Daniel, Wolchok, Jedd D, Liu, Cailian, Pejovic, Tanja, Odunsi, Kunle, Brasseur, Francis, Van den Eynde, Benoit J, Old, Lloyd J, Lu, Xin, Cebon, Jonathan, Strausberg, Robert L, Simpson, Andrew J

Volltext

524 Tim-4+ resident macrophages impair anti-tumor immunity in the serous body cavities By sequestering viable and cytotoxic CD8+ T cells expressing high levels of phosphatidylserin... von Chow, Andrew, Schad, Sara, Green, Michael, Hellmann, Matthew, Ceglia, Nicholas, Allaj, Viola, Zago, Giulia, Shah, Nisarg, Sharma, Sai, Mattar, Marissa, Chan, Joseph, Rizvi, Hira, Zhong, Hong, Liu, Cailian, Bykov, Yonina, Zamarin, Dmitriy, Shi, Hongyu, Budhu, Sadna, Wohlhieter, Corrin, Uddin, Fathema, Gupta, Aditi, Khodos, Inna, Waninger, Jessica, Qin, Angel, Balachandran, Vinod, Zou, Weiping, Shah, Sohrab, McPherson, Andrew, Panageas, Katherine, Lewis, Jason, Perry, Justin, Stanchina, Elisa de, Sen, Triparna, Poirier, John, Wolchok, Jedd, Rudin, Charles, Merghoub, Taha

Volltext

Genomic Features of Response to Combination Immunotherapy in Patients with Advanced Non-Small-Cell Lung Cancer von Hellmann, Matthew D., Nathanson, Tavi, Rizvi, Hira, Creelan, Benjamin C., Sanchez-Vega, Francisco, Ahuja, Arun, Ni, Ai, Novik, Jacki B., Mangarin, Levi M.B., Abu-Akeel, Mohsen, Liu, Cailian, Sauter, Jennifer L., Rekhtman, Natasha, Chang, Eliza, Callahan, Margaret K., Chaft, Jamie E., Voss, Martin H., Tenet, Megan, Li, Xue-Mei, Covello, Kelly, Renninger, Andrea, Vitazka, Patrik, Geese, William J., Borghaei, Hossein, Rudin, Charles M., Antonia, Scott J., Swanton, Charles, Hammerbacher, Jeff, Merghoub, Taha, McGranahan, Nicholas, Snyder, Alexandra, Wolchok, Jedd D.

Volltext