Recognizing and avoiding siRNA off-target effects for target identification and therapeutic application von Jackson, Aimee L, Linsley, Peter S

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MAST: a flexible statistical framework for assessing transcriptional changes and characterizing heterogeneity in single-cell RNA sequencing data von Finak, Greg, McDavid, Andrew, Yajima, Masanao, Deng, Jingyuan, Gersuk, Vivian, Shalek, Alex K, Slichter, Chloe K, Miller, Hannah W, McElrath, M Juliana, Prlic, Martin, Linsley, Peter S, Gottardo, Raphael

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Copy number loss of the interferon gene cluster in melanomas is linked to reduced T cell infiltrate and poor patient prognosis von Linsley, Peter S, Speake, Cate, Whalen, Elizabeth, Chaussabel, Damien

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Clonal kinetics and single-cell transcriptional profiling of CAR-T cells in patients undergoing CD19 CAR-T immunotherapy von Sheih, Alyssa, Voillet, Valentin, Hanafi, Laïla-Aïcha, DeBerg, Hannah A., Yajima, Masanao, Hawkins, Reed, Gersuk, Vivian, Riddell, Stanley R., Maloney, David G., Wohlfahrt, Martin E., Pande, Dnyanada, Enstrom, Mark R., Kiem, Hans-Peter, Adair, Jennifer E., Gottardo, Raphaël, Linsley, Peter S., Turtle, Cameron J.

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miR-146a is a significant brake on autoimmunity, myeloproliferation, and cancer in mice von Boldin, Mark P, Taganov, Konstantin D, Rao, Dinesh S, Yang, Lili, Zhao, Jimmy L, Kalwani, Manorama, Garcia-Flores, Yvette, Luong, Mui, Devrekanli, Asli, Xu, Jessica, Sun, Guizhen, Tay, Jia, Linsley, Peter S, Baltimore, David

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MicroRNA 21 Promotes Glioma Invasion by Targeting Matrix Metalloproteinase Regulators von Gabriely, Galina, Wurdinger, Thomas, Kesari, Santosh, Esau, Christine C., Burchard, Julja, Linsley, Peter S., Krichevsky, Anna M.

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MicroRNAs and Cell Cycle Regulation von Carleton, Michael, Cleary, Michele A., Linsley, Peter S.

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clinical utility of inhibiting CD28-mediated costimulation von Linsley, Peter S, Nadler, Steven G

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The Relationship of Immune Cell Signatures to Patient Survival Varies within and between Tumor Types von Linsley, Peter S, Chaussabel, Damien, Speake, Cate

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Germline-like TCR-α chains shared between autoreactive T cells in blood and pancreas von Linsley, Peter S., Nakayama, Maki, Balmas, Elisa, Chen, Janice, Barahmand-pour-Whitman, Fariba, Bansal, Shubham, Bottorff, Ty, Serti, Elisavet, Speake, Cate, Pugliese, Alberto, Cerosaletti, Karen

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Functional genomics identifies therapeutic targets for MYC-driven cancer von Toyoshima, Masafumi, Howie, Heather L, Imakura, Maki, Walsh, Ryan M, Annis, James E, Chang, Aaron N, Frazier, Jason, Chau, B. Nelson, Loboda, Andrey, Linsley, Peter S, Cleary, Michele A, Park, Julie R, Grandori, Carla

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Widespread siRNA "off-target" transcript silencing mediated by seed region sequence complementarity von Jackson, Aimee L, Burchard, Julja, Schelter, Janell, Chau, B Nelson, Cleary, Michele, Lim, Lee, Linsley, Peter S

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CTLA-4 and PD-1 Receptors Inhibit T-Cell Activation by Distinct Mechanisms von Parry, Richard V., Chemnitz, Jens M., Frauwirth, Kenneth A., Lanfranco, Anthony R., Braunstein, Inbal, Kobayashi, Sumire V., Linsley, Peter S., Thompson, Craig B., Riley, James L.

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Position-specific chemical modification of siRNAs reduces "off-target" transcript silencing von Jackson, Aimee L, Burchard, Julja, Leake, Devin, Reynolds, Angela, Schelter, Janell, Guo, Jie, Johnson, Jason M, Lim, Lee, Karpilow, Jon, Nichols, Kim, Marshall, William, Khvorova, Anastasia, Linsley, Peter S

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Noise amidst the silence: off-target effects of siRNAs? von Jackson, Aimee L., Linsley, Peter S.

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MicroRNAs in the miR-106b Family Regulate p21/CDKN1A and Promote Cell Cycle Progression von Ivanovska, Irena, Ball, Alexey S., Diaz, Robert L., Magnus, Jill F., Kibukawa, Miho, Schelter, Janell M., Kobayashi, Sumire V., Lim, Lee, Burchard, Julja, Jackson, Aimee L., Linsley, Peter S., Cleary, Michele A.

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Comparison of different miR-21 inhibitor chemistries in a cardiac disease model von Thum, Thomas, Chau, Nelson, Bhat, Balkrishen, Gupta, Shashi Kumar, Linsley, Peter S, Bauersachs, Johann, Engelhardt, Stefan

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Coordinated regulation of cell cycle transcripts by p53-Inducible microRNAs, miR-192 and miR-215 von Georges, Sara A, Biery, Matthew C, Kim, Soo-Yeon, Schelter, Janell M, Guo, Jane, Chang, Aaron N, Jackson, Aimee L, Carleton, Michael O, Linsley, Peter S, Cleary, Michele A, Chau, B Nelson

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PTPN22 R620W gene editing in T cells enhances low-avidity TCR responses von Anderson, Warren, Barahmand-Pour-Whitman, Fariba, Linsley, Peter S, Cerosaletti, Karen, Buckner, Jane H, Rawlings, David J

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Transcripts Targeted by the MicroRNA-16 Family Cooperatively Regulate Cell Cycle Progression von Linsley, Peter S., Schelter, Janell, Burchard, Julja, Kibukawa, Miho, Martin, Melissa M., Bartz, Steven R., Johnson, Jason M., Cummins, Jordan M., Raymond, Christopher K., Dai, Hongyue, Chau, Nelson, Cleary, Michele, Jackson, Aimee L., Carleton, Michael, Lim, Lee

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