Discovery, Multiparametric Optimization, and Solid-State Driven Identification of CHF-6550, a Novel Soft Dual Pharmacology Muscarinic Antagonist and β 2 Agonist (MABA) for the Inha... von Carzaniga, Laura, Linney, Ian D, Rizzi, Andrea, Schmidt, Wolfgang, Knight, Christopher K, Mileo, Valentina, Amadei, Francesco, Pastore, Fiorella, Miglietta, Daniela, Cesari, Nicola, Riccardi, Benedetta, Mazzucato, Roberta, Ghidini, Eleonora, Blackaby, Wesley P, Patacchini, Riccardo, Battipaglia, Loredana, Villetti, Gino, Puccini, Paola, Catinella, Silvia, Civelli, Maurizio, Rancati, Fabio

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Discovery, Multiparametric Optimization, and Solid-State Driven Identification of CHF-6550, a Novel Soft Dual Pharmacology Muscarinic Antagonist and β2 Agonist (MABA) for the Inhal... von Carzaniga, Laura, Linney, Ian D., Rizzi, Andrea, Schmidt, Wolfgang, Knight, Christopher K., Mileo, Valentina, Amadei, Francesco, Pastore, Fiorella, Miglietta, Daniela, Cesari, Nicola, Riccardi, Benedetta, Mazzucato, Roberta, Ghidini, Eleonora, Blackaby, Wesley P., Patacchini, Riccardo, Battipaglia, Loredana, Villetti, Gino, Puccini, Paola, Catinella, Silvia, Civelli, Maurizio, Rancati, Fabio

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Discovery of a novel class of inhaled dual pharmacology muscarinic antagonist and β 2 agonist (MABA) for the treatment of chronic obstructive pulmonary disease (COPD) von Rancati, Fabio, Linney, Ian D, Rizzi, Andrea, Delcanale, Maurizio, Knight, Chris K, Schmidt, Wolfgang, Pastore, Fiorella, Riccardi, Benedetta, Mileo, Valentina, Carnini, Chiara, Cesari, Nicola, Blackaby, Wesley P, Patacchini, Riccardo, Carzaniga, Laura

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Discovery of Clinical Candidate CHF-6366: A Novel Super-soft Dual Pharmacology Muscarinic Antagonist and β2 Agonist (MABA) for the Inhaled Treatment of Respiratory Diseases von Carzaniga, Laura, Linney, Ian D., Rizzi, Andrea, Delcanale, Maurizio, Schmidt, Wolfgang, Knight, Christopher K., Pastore, Fiorella, Miglietta, Daniela, Carnini, Chiara, Cesari, Nicola, Riccardi, Benedetta, Mileo, Valentina, Venturi, Luca, Moretti, Elisa, Blackaby, Wesley P., Patacchini, Riccardo, Accetta, Alessandro, Biagetti, Matteo, Bassani, Franco, Tondelli, Marina, Murgo, Annalisa, Battipaglia, Loredana, Villetti, Gino, Puccini, Paola, Catinella, Silvia, Civelli, Maurizio, Rancati, Fabio

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Discovery of a novel class of inhaled dual pharmacology muscarinic antagonist and β2 agonist (MABA) for the treatment of chronic obstructive pulmonary disease (COPD) von Rancati, Fabio, Linney, Ian D., Rizzi, Andrea, Delcanale, Maurizio, Knight, Chris K., Schmidt, Wolfgang, Pastore, Fiorella, Riccardi, Benedetta, Mileo, Valentina, Carnini, Chiara, Cesari, Nicola, Blackaby, Wesley P., Patacchini, Riccardo, Carzaniga, Laura

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Flexible Strategy for the Synthesis of Pyrrolizidine Alkaloids von Donohoe, Timothy J, Thomas, Rhian E, Cheeseman, Matthew D, Rigby, Caroline L, Bhalay, Gurdip, Linney, Ian D

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685 A highly selective and potent HPK1 inhibitor enhances immune cell activation and induces robust tumor growth inhibition in a murine syngeneic tumor model von Ciccone, David, Lazari, Vad, Linney, Ian, Briggs, Michael, Carreiro, Samantha, McElwee, Joshua, Waddell, Ian, Hill, Chris, Loh, Christine, Tummino, Peter, Collis, Alan, Kaila, Neelu

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An Enzymatic Approach to the Desymmetrization of Disubstituted Pyrrolines von Donohoe, Timothy J, Rigby, Caroline L, Thomas, Rhian E, Nieuwenhuys, William F, Bhatti, Farrah L, Cowley, Andrew R, Bhalay, Gurdip, Linney, Ian D

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Optimization of 1,3,4-Benzotriazepine-Based CCK2 Antagonists to Obtain Potent, Orally Active Inhibitors of Gastrin-Mediated Gastric Acid Secretion von McDonald, Iain M, Black, James W, Buck, Ildiko M, Dunstone, David J, Griffin, Eric P, Harper, Elaine A, Hull, Robert A. D, Kalindjian, S. Barret, Lilley, Elliot J, Linney, Ian D, Pether, Michael J, Roberts, Sonia P, Shaxted, Mark E, Spencer, John, Steel, Katherine I. M, Sykes, David A, Walker, Martin K, Watt, Gillian F, Wright, Laurence, Wright, Paul T, Xun, Wei

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Discovery and Characterization of Novel, Potent, Non-Peptide Parathyroid Hormone-1 Receptor Antagonists von McDonald, Iain M, Austin, Carol, Buck, Ildiko M, Dunstone, David J, Gaffen, John, Griffin, Eric, Harper, Elaine A, Hull, Robert A. D, Kalindjian, S. Barret, Linney, Ian D, Low, Caroline M. R, Patel, Dipa, Pether, Michael J, Raynor, Michelle, Roberts, Sonia P, Shaxted, Mark E, Spencer, John, Steel, Katherine I. M, Sykes, David A, Wright, Paul T, Xun, Wei

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Achiral, selective CCK2 receptor antagonists based on a 1,3,5-benzotriazepine-2,4-dione template von SPENCER, John, GAFFEN, John, GRIFFIN, Eric, HARPER, Elaine A, LINNEY, Ian D, MCDONALD, Iain M, ROBERTS, Sonia P, SHAXTED, Mark E, ADATIA, Trushar, BASHALL, Alan

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Novel, Achiral 1,3,4-Benzotriazepine Analogues of 1,4-Benzodiazepine-Based CCK2 Antagonists That Display High Selectivity over CCK1 Receptors von McDonald, Iain M, Austin, Carol, Buck, Ildiko M, Dunstone, David J, Griffin, Eric, Harper, Elaine A, Hull, Robert A. D, Kalindjian, S. Barret, Linney, Ian D, Low, Caroline M. R, Pether, Michael J, Spencer, John, Wright, Paul T, Adatia, Trushar, Bashall, Alan

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Abstract 1649: Mechanistic understanding of HPK1 inhibition on enhanced human T cell activation and tumor immunity in a syngeneic model von Ciccone, David, Lazari, Vad, Linney, Ian, Briggs, Michael, Carreiro, Samantha, Loh, Christine, Tummino, Peter, McElwee, Joshua, Collis, Alan, Kaila, Neelu

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Design, Synthesis, and Structure−Activity Relationships of Novel Non-Imidazole Histamine H3 Receptor Antagonists von Linney, Ian D, Buck, Ildiko M, Harper, Elaine A, Kalindjian, S. Barret, Pether, Michael J, Shankley, Nigel P, Watt, Gillian F, Wright, Paul T

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Partial Reduction of Annulated Heterocycles as a General Route to Medium Rings Containing Oxygen and Nitrogen von Donohoe, Timothy J, Raoof, Ali, Linney, Ian D, Helliwell, Madeleine

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Optimization of the in Vitro and in Vivo Properties of a Novel Series of 2,4,5-Trisubstituted Imidazoles as Potent Cholecystokinin-2 (CCK2) Antagonists von Buck, Ildiko M, Black, James W, Cooke, Tracey, Dunstone, David J, Gaffen, John D, Griffin, Eric P, Harper, Elaine A, Hull, Robert A. D, Kalindjian, S. Barret, Lilley, Elliot J, Linney, Ian D, Low, Caroline M. R, McDonald, Iain M, Pether, Michael J, Roberts, Sonia P, Shankley, Nigel P, Shaxted, Mark E, Steel, Katherine I. M, Sykes, David A, Tozer, Matthew J, Watt, Gillian F, Walker, Martin K, Wright, Laurence, Wright, Paul T

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Abstract 942: HPK1, hematopoietic progenitor kinase 1, is a promising therapeutic target for cancer immunotherapy von Ciccone, David, Rocnik, Jennifer, Lazari, Vad, Linney, Ian, Briggs, Michael, Collis, Alan, Loh, Christine, Ashwell, Mark, Montana, John, Tummino, Peter, Kaila, Neelu

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Discovery of Clinical Candidate CHF-6366: A Novel Super-soft Dual Pharmacology Muscarinic Antagonist and β 2 Agonist (MABA) for the Inhaled Treatment of Respiratory Diseases von Carzaniga, Laura, Linney, Ian D., Rizzi, Andrea, Delcanale, Maurizio, Schmidt, Wolfgang, Knight, Christopher K., Pastore, Fiorella, Miglietta, Daniela, Carnini, Chiara, Cesari, Nicola, Riccardi, Benedetta, Mileo, Valentina, Venturi, Luca, Moretti, Elisa, Blackaby, Wesley P., Patacchini, Riccardo, Accetta, Alessandro, Biagetti, Matteo, Bassani, Franco, Tondelli, Marina, Murgo, Annalisa, Battipaglia, Loredana, Villetti, Gino, Puccini, Paola, Catinella, Silvia, Civelli, Maurizio, Rancati, Fabio

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2,7-Dioxo-2,3,4,5,6,7-hexahydro-1H-benzo[h][1,4]diazonine as a New Template for the Design of CCK2 Receptor Antagonists von McDonald, Iain M, Dunstone, David J, Kalindjian, S. Barret, Linney, Ian D, Low, Caroline M. R, Pether, Michael J, Steel, Katherine I. M, Tozer, Matthew J, Vinter, J. G

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Synthesis of Enantiopure Dihydropyranones:  Aldol-Based Ring Expansion of Dihydrofurans von Donohoe, Timothy J, Raoof, Ali, Freestone, Graeme C, Linney, Ian D, Cowley, Andrew, Helliwell, Madeleine

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