Novel Protein-Based Pneumococcal Vaccines Administered with the Th1-Promoting Adjuvant IC31 Induce Protective Immunity against Pneumococcal Disease in Neonatal Mice von Olafsdottir, Thorunn Asta, Lingnau, Karen, Nagy, Eszter, Jonsdottir, Ingileif

Volltext

The two-component adjuvant IC31® boosts type i interferon production of human monocyte-derived dendritic cells via ligation of endosomal TLRs von Szabo, Attila, Gogolak, Peter, Pazmandi, Kitti, Kis-Toth, Katalin, Riedl, Karin, Wizel, Benjamin, Lingnau, Karen, Bacsi, Attila, Rethi, Bence, Rajnavolgyi, Eva

Volltext

Immunogenicity and safety of a novel therapeutic hepatitis C virus (HCV) peptide vaccine: A randomized, placebo controlled trial for dose optimization in 128 healthy subjects von Firbas, Christa, Jilma, Bernd, Tauber, Erich, Buerger, Vera, Jelovcan, Sandra, Lingnau, Karen, Buschle, Michael, Frisch, Jürgen, Klade, Christoph S.

Volltext

Adult-like anti-mycobacterial T cell and in vivo dendritic cell responses following neonatal immunization with Ag85B-ESAT-6 in the IC31 adjuvant von Kamath, Arun T, Rochat, Anne-Françoise, Valenti, Mario P, Agger, Else Marie, Lingnau, Karen, Andersen, Peter, Lambert, Paul-Henri, Siegrist, Claire-Anne

Volltext

First in humans: A new molecularly defined vaccine shows excellent safety and strong induction of long-lived Mycobacterium tuberculosis-specific Th1-cell like responses von Ottenhoff, Tom H. M., Doherty, T. Mark, van Dissel, Jaap T., Bang, Peter, Lingnau, Karen, Kromann, Ingrid, Andersen, Peter

Volltext

Correction: The Two-Component Adjuvant IC31® Boosts Type I Interferon Production of Human Monocyte-Derived Dendritic Cells via Ligation of Endosomal TLRs von Szabo, Attila, Gogolak, Peter, Pazmandi, Kitti, Kis-Toth, Katalin, Riedl, Karin, Wizel, Benjamin, Lingnau, Karen, Bacsi, Attila, Rethi, Bence, Rajnavolgyi, Eva

Volltext

A novel HIV vaccine adjuvanted by IC31 induces robust and persistent humoral and cellular immunity von Pattacini, Laura, Mize, Gregory J, Graham, Jessica B, Fluharty, Tayler R, Graham, Tisha M, Lingnau, Karen, Wizel, Benjamin, Perdiguero, Beatriz, Esteban, Mariano, Pantaleo, Giuseppe, Shen, Mingchao, Spies, Gregory A, McElrath, M Juliana, Lund, Jennifer M

Volltext

Identification of an Indispensable Role for Tyrosine Kinase 2 in CTL-Mediated Tumor Surveillance von SIMMA, Olivia, ZEBEDIN, Eva, FELZMANN, Thomas, MÜLLER, Mathias, DECKER, Thomas, SEXL, Veronika, STOIBER, Dagmar, NEUGEBAUER, Nina, SCHELLACK, Carola, PILZ, Andreas, CHANG-RODRIGUEZ, Souyet, LINGNAU, Karen, WEISZ, Eva, PUTZ, Eva Maria, PICKL, Winfried F

Volltext

Single-shot live-attenuated chikungunya vaccine in healthy adults: a phase 1, randomised controlled trial von Wressnigg, Nina, Hochreiter, Romana, Zoihsl, Oliver, Fritzer, Andrea, Bézay, Nicole, Klingler, Anton, Lingnau, Karen, Schneider, Martina, Lundberg, Urban, Meinke, Andreas, Larcher-Senn, Julian, Čorbic-Ramljak, Irena, Eder-Lingelbach, Susanne, Dubischar, Katrin, Bender, Wolfgang

Volltext

Interferon-Regulatory Factor 4 Is Essential for the Developmental Program of T Helper 9 Cells von Staudt, Valérie, Bothur, Evita, Klein, Matthias, Lingnau, Karen, Reuter, Sebastian, Grebe, Nadine, Gerlitzki, Bastian, Hoffmann, Markus, Ulges, Alexander, Taube, Christian, Dehzad, Nina, Becker, Marc, Stassen, Michael, Steinborn, Andrea, Lohoff, Michael, Schild, Hansjörg, Schmitt, Edgar, Bopp, Tobias

Volltext

A randomized, placebo-controlled, blinded phase 1 study investigating a novel inactivated, Vero cell-culture derived Zika virus vaccine von Wressnigg, Nina V, Hochreiter, Romana, Schneider, Martina, Obersriebnig, Michaela J, Bézay, Nicole I, Lingnau, Karen, Ramljak, Irena Čorbić, Dubischar, Katrin L, Eder-Lingelbach, Susanne

Volltext

Ag85B–ESAT-6 adjuvanted with IC31® promotes strong and long-lived Mycobacterium tuberculosis specific T cell responses in naïve human volunteers von van Dissel, Jaap T, Arend, Sandra M, Prins, Corine, Bang, Peter, Tingskov, Pernille Nyholm, Lingnau, Karen, Nouta, Jan, Klein, Michèl R, Rosenkrands, Ida, Ottenhoff, Tom H.M, Kromann, Ingrid, Doherty, T. Mark, Andersen, Peter

Volltext

IC31® and IC30, novel types of vaccine adjuvant based on peptide delivery systems von Lingnau, Karen, Riedl, Karin, von Gabain, Alexander

Volltext

Ag85B–ESAT-6 adjuvanted with IC31® promotes strong and long-lived Mycobacterium tuberculosis specific T cell responses in volunteers with previous BCG vaccination or tuberculosis i... von van Dissel, Jaap T, Soonawala, Darius, Joosten, Simone A, Prins, Corine, Arend, Sandra M, Bang, Peter, Tingskov, Pernille Nyholm, Lingnau, Karen, Nouta, Jan, Hoff, Søren T, Rosenkrands, Ida, Kromann, Ingrid, Ottenhoff, Tom H.M, Doherty, T. Mark, Andersen, Peter

Volltext

The novel adjuvant IC31® strongly improves influenza vaccine-specific cellular and humoral immune responses in young adult and aged mice von Riedl, Karin, Riedl, Rosemarie, von Gabain, Alexander, Nagy, Eszter, Lingnau, Karen

Volltext

Protective immunity to tuberculosis with Ag85B-ESAT-6 in a synthetic cationic adjuvant system IC31 von Agger, Else Marie, Rosenkrands, Ida, Olsen, Anja Weinreich, Hatch, Graham, Williams, Ann, Kritsch, Constantia, Lingnau, Karen, von Gabain, Alexander, Andersen, Claire Swetman, Korsholm, Karen Smith, Andersen, Peter

Volltext

IC31, a novel adjuvant signaling via TLR9, induces potent cellular and humoral immune responses von Schellack, Carola, Prinz, Karin, Egyed, Alena, Fritz, Jörg H., Wittmann, Barbara, Ginzler, Michael, Swatosch, Gabriele, Zauner, Wolfgang, Kast, Constantia, Akira, Shizuo, von Gabain, Alexander, Buschle, Michael, Lingnau, Karen

Volltext

Type I interferons as mediators of immune adjuvants for T- and B cell-dependent acquired immunity von Prchal, Michaela, Pilz, Andreas, Simma, Olivia, Lingnau, Karen, von Gabain, Alexander, Strobl, Birgit, Müller, Mathias, Decker, Thomas

Volltext

Th17/Th1 biased immunity to the pneumococcal proteins PcsB, StkP and PsaA in adults of different age von Schmid, Petra, Selak, Sanja, Keller, Michael, Luhan, Barbara, Magyarics, Zoltan, Seidel, Stefan, Schlick, Petra, Reinisch, Christoph, Lingnau, Karen, Nagy, Eszter, Grubeck-Loebenstein, Beatrix

Volltext

Dendritic Cells Require STAT-1 Phosphorylated at Its Transactivating Domain for the Induction of Peptide-Specific CTL von Pilz, Andreas, Kratky, Wolfgang, Stockinger, Silvia, Simma, Olivia, Kalinke, Ulrich, Lingnau, Karen, von Gabain, Alexander, Stoiber, Dagmar, Sexl, Veronika, Kolbe, Thomas, Rulicke, Thomas, Muller, Mathias, Decker, Thomas

Volltext