Flaviviral Protease Inhibitors Identified by Fragment-Based Library Docking into a Structure Generated by Molecular Dynamics von Ekonomiuk, Dariusz, Su, Xun-Cheng, Ozawa, Kiyoshi, Bodenreider, Christophe, Lim, Siew Pheng, Otting, Gottfried, Huang, Danzhi, Caflisch, Amedeo

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Mutagenesis of the Dengue Virus Type 2 NS5 Methyltransferase Domain von Kroschewski, Helga, Lim, Siew Pheng, Butcher, Rebecca E., Yap, Thai Leong, Lescar, Julien, Wright, Peter J., Vasudevan, Subhash G., Davidson, Andrew D.

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Ten years of dengue drug discovery: Progress and prospects von Lim, Siew Pheng, Wang, Qing-Yin, Noble, Christian G., Chen, Yen-Liang, Dong, Hongping, Zou, Bin, Yokokawa, Fumiaki, Nilar, Shahul, Smith, Paul, Beer, David, Lescar, Julien, Shi, Pei-Yong

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Potent Allosteric Dengue Virus NS5 Polymerase Inhibitors: Mechanism of Action and Resistance Profiling von Lim, Siew Pheng, Noble, Christian Guy, Seh, Cheah Chen, Soh, Tingjin Sherryl, El Sahili, Abbas, Chan, Grace Kar Yarn, Lescar, Julien, Arora, Rishi, Benson, Timothy, Nilar, Shahul, Manjunatha, Ujjini, Wan, Kah Fei, Dong, Hongping, Xie, Xuping, Shi, Pei-Yong, Yokokawa, Fumiaki

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A Patent Review on SARS Coronavirus Papain‐Like Protease (PLpro) Inhibitors von Brian Chia, C. S., Pheng Lim, Siew

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A crystal structure of the Dengue virus NS5 protein reveals a novel inter-domain interface essential for protein flexibility and virus replication von Zhao, Yongqian, Soh, Tingjin Sherryl, Zheng, Jie, Chan, Kitti Wing Ki, Phoo, Wint Wint, Lee, Chin Chin, Tay, Moon Y F, Swaminathan, Kunchithapadam, Cornvik, Tobias C, Lim, Siew Pheng, Shi, Pei-Yong, Lescar, Julien, Vasudevan, Subhash G, Luo, Dahai

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Flavivirus RNA methylation von Dong, Hongping, Fink, Katja, Züst, Roland, Lim, Siew Pheng, Qin, Cheng-Feng, Shi, Pei-Yong

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Molecular basis for specific viral RNA recognition and 2′-O-ribose methylation by the dengue virus nonstructural protein 5 (NS5) von Zhao, Yongqian, Soh, Tingjin Sherryl, Lim, Siew Pheng, Chung, Ka Yan, Swaminathan, Kunchithapadam, Vasudevan, Subhash G., Shi, Pei-Yong, Lescar, Julien, Luo, Dahai

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Discovery of Potent Non-Nucleoside Inhibitors of Dengue Viral RNA-Dependent RNA Polymerase from a Fragment Hit Using Structure-Based Drug Design von Yokokawa, Fumiaki, Nilar, Shahul, Noble, Christian G, Lim, Siew Pheng, Rao, Ranga, Tania, Stefani, Wang, Gang, Lee, Gladys, Hunziker, Jürg, Karuna, Ratna, Manjunatha, Ujjini, Shi, Pei-Yong, Smith, Paul W

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Polymerases of hepatitis C viruses and flaviviruses: Structural and mechanistic insights and drug development von Caillet-Saguy, Célia, Lim, Siew Pheng, Shi, Pei-Yong, Lescar, Julien, Bressanelli, Stéphane

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Strategies for development of dengue virus inhibitors von Noble, Christian G., Chen, Yen-Liang, Dong, Hongping, Gu, Feng, Lim, Siew Pheng, Schul, Wouter, Wang, Qing-Yin, Shi, Pei-Yong

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Conformational Flexibility of the Dengue Virus RNA-Dependent RNA Polymerase Revealed by a Complex with an Inhibitor von Noble, Christian G, Lim, Siew Pheng, Chen, Yen-Liang, Liew, Chong Wai, Yap, Lijian, Lescar, Julien, Shi, Pei-Yong

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Structural basis for the activation of flaviviral NS3 proteases from dengue and West Nile virus von Hommel, Ulrich, Erbel, Paul, Schiering, Nikolaus, D'Arcy, Allan, Renatus, Martin, Kroemer, Markus, Lim, Siew Pheng, Yin, Zheng, Keller, Thomas H, Vasudevan, Subhash G

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Serotype-specific Differences in Dengue Virus Non-structural Protein 5 Nuclear Localization von Hannemann, Holger, Sung, Po-Yu, Chiu, Han-Chen, Yousuf, Amjad, Bird, Jim, Lim, Siew Pheng, Davidson, Andrew D.

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2'-O methylation of internal adenosine by flavivirus NS5 methyltransferase von Dong, Hongping, Chang, David C, Hua, Maggie Ho Chia, Lim, Siew Pheng, Chionh, Yok Hian, Hia, Fabian, Lee, Yie Hou, Kukkaro, Petra, Lok, Shee-Mei, Dedon, Peter C, Shi, Pei-Yong

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Towards the design of antiviral inhibitors against flaviviruses: The case for the multifunctional NS3 protein from Dengue virus as a target von Lescar, Julien, Luo, Dahai, Xu, Ting, Sampath, Aruna, Lim, Siew Pheng, Canard, Bruno, Vasudevan, Subhash G.

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West Nile virus drug discovery von Lim, Siew Pheng, Shi, Pei-Yong

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Activation of Peripheral Blood Mononuclear Cells by Dengue Virus Infection Depotentiates Balapiravir von Chen, Yen-Liang, Abdul Ghafar, Nahdiyah, Karuna, Ratna, Fu, Yilong, Lim, Siew Pheng, Schul, Wouter, Gu, Feng, Herve, Maxime, Yokohama, Fumiaki, Wang, Gang, Cerny, Daniela, Fink, Katja, Blasco, Francesca, Shi, Pei-Yong

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Targeting SARS-CoV-2 and host cell receptor interactions von Lim, Siew Pheng

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Functional Profiling of Recombinant NS3 Proteases from All Four Serotypes of Dengue Virus Using Tetrapeptide and Octapeptide Substrate Libraries von Li, Jun, Lim, Siew Pheng, Beer, David, Patel, Viral, Wen, Daying, Tumanut, Christine, Tully, David C, Williams, Jennifer A, Jiricek, Jan, Priestle, John P, Harris, Jennifer L, Vasudevan, Subhash G

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