Novel DNA Damage Checkpoints Mediating Cell Death Induced by the NEDD8-Activating Enzyme Inhibitor MLN4924 von BLANK, Jonathan L, LIU, Xiaozhen J, MILHOLLEN, Michael A, LIGHTCAP, Eric S, COSMOPOULOS, Katherine, BOUCK, David C, GARCIA, Khristofer, BERNARD, Hugues, TAYBER, Olga, HATHER, Greg, LIU, Ray, NARAYANAN, Usha

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MYC Regulation of a "Poor-Prognosis" Metastatic Cancer Cell State von Wolfer, Anita, Wittner, Ben S., Irimia, Daniel, Flavin, Richard J., Lupien, Mathieu, Gunawardane, Ruwanthi N., Meyer, Clifford A., Lightcap, Eric S., Tamayo, Pablo, Mesirov, Jill P., Liu, X. Shirley, Shioda, Toshi, Toner, Mehmet, Loda, Massimo, Brown, Myles, Brugge, Joan S., Ramaswamy, Sridhar

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Quantitative Proteomic Analysis of Cellular Protein Modulation upon Inhibition of the NEDD8-Activating Enzyme by MLN4924 von Liao, Hua, Liu, Xiaozhen J., Blank, Jonathan L., Bouck, David C., Bernard, Hugues, Garcia, Khristofer, Lightcap, Eric S.

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Functional role and oncogene-regulated expression of the BH3-only factor Bmf in mammary epithelial anoikis and morphogenesis von Schmelzle, Tobias, Mailleux, Arnaud A, Overholtzer, Michael, Carroll, Jason S, Solimini, Nicole L, Lightcap, Eric S, Veiby, Ole P, Brugge, Joan S

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Genome-Wide siRNA Screen for Modulators of Cell Death Induced by Proteasome Inhibitor Bortezomib von SIQUAN CHEN, BLANK, Jonathan L, BURKHARDT, Anne L, WEI CHEN, GARCIA, Khristofer, SAPPAL, Darshan S, GRAY, Jesse, HALES, Paul, LEROY, Patrick J, RINGELING, John, RABINO, Claudia, SPELMAN, James J, PETERS, Theodore, MORGENSTERN, Jay P, LIGHTCAP, Eric S, LIU, Xiaozhen J, RAPPOLI, David M, PICKARD, Michael D, MENON, Saurabh, JIE YU, DRISCOLL, Denise L, LINGARAJ, Trupti

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Probing the roles of SUMOylation in cancer cell biology by using a selective SAE inhibitor von He, Xingyue, Riceberg, Jessica, Soucy, Teresa, Koenig, Erik, Minissale, James, Gallery, Melissa, Bernard, Hugues, Yang, Xiaofeng, Liao, Hua, Rabino, Claudia, Shah, Pooja, Xega, Kristina, Yan, Zhong-hua, Sintchak, Mike, Bradley, John, Xu, He, Duffey, Matt, England, Dylan, Mizutani, Hirotake, Hu, Zhigen, Guo, Jianping, Chau, Ryan, Dick, Lawrence R, Brownell, James E, Newcomb, John, Langston, Steve, Lightcap, Eric S, Bence, Neil, Pulukuri, Sai M

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Complementary Whole-Genome Technologies Reveal the Cellular Response to Proteasome Inhibition by PS-341 von Fleming, James A., Lightcap, Eric S., Sadis, Seth, Thoroddsen, Vala, Bulawa, Christine E., Blackman, Ronald K.

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Proteasome Inhibition Measurements: Clinical Application von Lightcap, Eric S, McCormack, Teresa A, Pien, Christine S, Chau, Vincent, Adams, Julian, Elliott, Peter J

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PERK Inhibition by HC-5404 Sensitizes Renal Cell Carcinoma Tumor Models to Antiangiogenic Tyrosine Kinase Inhibitors von Stokes, Michael E, Calvo, Veronica, Fujisawa, Sho, Dudgeon, Crissy, Huang, Sharon, Ballal, Nupur, Shen, Leyi, Gasparek, Jennifer, Betzenhauser, Matthew, Taylor, Simon J, Staschke, Kirk A, Rigby, Alan C, Mulvihill, Mark J, Bose, Nandita, Lightcap, Eric S, Surguladze, David

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Nedd8-activating enzyme inhibitor MLN4924 provides synergy with mitomycin C through interactions with ATR, BRCA1/BRCA2, and chromatin dynamics pathways von Garcia, Khristofer, Blank, Jonathan L, Bouck, David C, Liu, Xiaozhen J, Sappal, Darshan S, Hather, Greg, Cosmopoulos, Katherine, Thomas, Michael P, Kuranda, Mike, Pickard, Michael D, Liu, Ray, Bandi, Syamala, Smith, Peter G, Lightcap, Eric S

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Acoustic Liquid Handling for Rapid siRNA Transfection Optimization von Xiao, Andrew S., Lightcap, Eric S., Bouck, David C.

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Akt and ERK control the proliferative response of mammary epithelial cells to the growth factors IGF-1 and EGF through the cell cycle inhibitor p57Kip2 von Worster, Devin T, Schmelzle, Tobias, Solimini, Nicole L, Lightcap, Eric S, Millard, Bjorn, Mills, Gordon B, Brugge, Joan S, Albeck, John G

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Activation of GCN2 By HC-7366 Results in Significant Anti-Tumor Efficacy As Monotherapy and Overcomes Resistance Mechanisms When Combined with Venetoclax in AML von Tameire, Feven, Collette, Nicholas, Fujisawaa, Sho, Bieging-Rolett, Kathryn, Dudgeon, Crissy, Stokes, Michael E., Harrison, Ben, LaCayo, Ashley, Wojnarowicz, Paulina, Drees, Jeremy, Staschke, Kirk A., Surguladze, David, Lightcap, Eric S., Bose, Nandita

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Purification and inactivation of 3-hydroxyanthranilic acid 3,4-dioxygenase from beef liver von Nandi, Dhirendra, Lightcap, Eric S, Koo, Yumee Kim, Lu, Xingliang, Quancard, Jean, Silverman, Richard B

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Abstract 4010: Inhibition of PERK by HC-5404 sensitizes clear cell renal cell carcinoma tumor models to anti-angiogenic tyrosine kinase inhibitors von Stokes, Michael E., Calvo, Veronica, Dudgeon, Crissy, Fujisawa, Sho, Huang, Sharon, Shen, Leyi, Ballal, Nupur, McGinley, Joe, Liu, David, Mulvihill, Mark J., Rigby, Alan C., Bose, Nandita, Lightcap, Eric S., Surguladze, David

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Abstract C55: Nedd8-activating enzyme inhibitor pevonedistat synergizes with cisplatin and carboplatin through interference with nucleotide excision repair and interstrand cross-li... von Bouck, David C., Garcia, Khristofer, Blank, Jonathan L., Liu, Xiaozhen J., Bernard, Hugues, Berger, Allison J., Kuranda, Mike, Koenig, Erik, Lightcap, Eric S.

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Abstract C233: Activation of p53 by the NEDD8 activating enzyme inhibitor MLN4924 is independent of Cdt1 and involves the cullin-RING ligase CRL4-DTL von Blank, Jonathan L., Liu, Xiaozhen J., Bernard, Hugues, Liao, Hua, Cosmopoulos, Katherine, Lightcap, Eric S.

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Abstract A30: Activation of GCN2 by HC-7366 results in significant anti-tumor efficacy as monotherapy and in combination with Venetoclax in AML models von Tameire, Feven, Wojnarowicz, Paulina M., Fujisawa, Sho, Huang, Sharon, Reilly, Owen, Dudgeon, Crissy, Collette, Nicholas, Drees, Jeremy, Bieging-Rolett, Kathryn, Kangas, Takashi O, Zhang, Weiyu, Fumagalli, Maria, Dewji, Iman, Li, Yunfang, Chan, Anissa SH, Qiu, Xiaohong, Harrison, Ben, LaCayo, Ashley, Staschke, Kirk A., Rigby, Alan C., Ramurthy, Savithri, Lightcap, Eric S., Surguladze, David, Bose, Nandita

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Abstract 6231: Activation of GCN2 by HC-7366 results in significant antitumor efficacy as monotherapy and in combination with multiple standard of care agents in various solid canc... von Tameire, Feven, Wojnarowicz, Paulina, Dudgeon, Crissy, Fujisawa, Sho, Huang, Sharon, Reilly, Owen B., Collette, Nicholas, Drees, Jeremy, Bieging-Rolett, Kathryn, Kangas, Takashi O., Zhang, Weiyu, Fumagalli, Maria, Dewji, Iman, Li, Yunfang, Chan, Anissa SH, Qiu, Xiaohong, Harrison, Ben, LaCayo, Ashley, Cordova, Ricardo A., Staschke, Kirk A., Rigby, Alan C., Ramurthy, Savithri, Lightcap, Eric S., Surguladze, David, Bose, Nandita

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Slow-Binding Inhibition of γ-Aminobutyric Acid Aminotransferase by Hydrazine Analogues von Lightcap, Eric S, Silverman, Richard B

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