Quantitation of Lysosomal Trapping of Basic Lipophilic Compounds Using In Vitro Assays and In Silico Predictions Based on the Determination of the Full pH Profile of the Endo-/Lyso... von Schmitt, Maximilian V, Lienau, Philip, Fricker, Gert, Reichel, Andreas

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Identification of Atuveciclib (BAY 1143572), the First Highly Selective, Clinical PTEFb/CDK9 Inhibitor for the Treatment of Cancer von Lücking, Ulrich, Scholz, Arne, Lienau, Philip, Siemeister, Gerhard, Kosemund, Dirk, Bohlmann, Rolf, Briem, Hans, Terebesi, Ildiko, Meyer, Kirstin, Prelle, Katja, Denner, Karsten, Bömer, Ulf, Schäfer, Martina, Eis, Knut, Valencia, Ray, Ince, Stuart, von Nussbaum, Franz, Mumberg, Dominik, Ziegelbauer, Karl, Klebl, Bert, Choidas, Axel, Nussbaumer, Peter, Baumann, Matthias, Schultz‐Fademrecht, Carsten, Rühter, Gerd, Eickhoff, Jan, Brands, Michael

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Sagopilone crosses the blood-brain barrier in vivo to inhibit brain tumor growth and metastases von Hoffmann, Jens, Fichtner, Iduna, Lemm, Margit, Lienau, Philip, Hess-Stumpp, Holger, Rotgeri, Andrea, Hofmann, Birte, Klar, Ulrich

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Systematic Analysis of the Whole-Body Tissue Distribution and Fatty Acid Compositions of Membrane Lipids in CD1 and NMRI Mice and Wistar Rats von Liu, Xiaohui, Reichel, Andreas, Yang, Tao, Wang, Yusong, Wang, Xueying, Jiao, Yupei, Ruan, Huabin, Schmitt, Maximilian V., Xu, Lina, Lienau, Philip

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Exploration of Novel Chemical Space: Synthesis and in vitro Evaluation of N‐Functionalized Tertiary Sulfonimidamides von Izzo, Flavia, Schäfer, Martina, Lienau, Philip, Ganzer, Ursula, Stockman, Robert, Lücking, Ulrich

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A Probabilistic Approach to Classifying Metabolic Stability von Schwaighofer, Anton, Schroeter, Timon, Mika, Sebastian, Hansen, Katja, ter Laak, Antonius, Lienau, Philip, Reichel, Andreas, Heinrich, Nikolaus, Müller, Klaus-Robert

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The Novel ATR Inhibitor BAY 1895344 Is Efficacious as Monotherapy and Combined with DNA Damage-Inducing or Repair-Compromising Therapies in Preclinical Cancer Models von Wengner, Antje M., Siemeister, Gerhard, Luecking, Ulrich, Lefranc, Julien, Wortmann, Lars, Lienau, Philip, Bader, Benjamin, Boemer, Ulf, Moosmayer, Dieter, Eberspaecher, Uwe, Golfier, Sven, Schatz, Christoph A., Baumgart, Simon J., Haendler, Bernard, Lejeune, Pascale, Schlicker, Andreas, von Nussbaum, Franz, Brands, Michael, Ziegelbauer, Karl, Mumberg, Dominik

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Optimizing Classification of Drug-Drug Interaction Potential for CYP450 Isoenzyme Inhibition Assays in Early Drug Discovery von Krippendorff, Ben-Fillippo, Lienau, Philip, Reichel, Andreas, Huisinga, Wilhelm

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Extension of the Mechanistic Tissue Distribution Model of Rodgers and Rowland by Systematic Incorporation of Lysosomal Trapping: Impact on Unbound Partition Coefficient and Volume... von Schmitt, Maximilian, Reichel, Andreas, Liu, Xiaohui, Fricker, Gert, Lienau, Philip

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Increasing Complexity: A Practical Synthetic Approach to Three‐Dimensional, Cyclic Sulfoximines and First Insights into Their in Vitro Properties von Boulard, Emilie, Zibulski, Vivien, Oertel, Luisa, Lienau, Philip, Schäfer, Martina, Ganzer, Ursula, Lücking, Ulrich

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BAY 1000394, a novel cyclin-dependent kinase inhibitor, with potent antitumor activity in mono- and in combination treatment upon oral application von Siemeister, Gerhard, Lücking, Ulrich, Wengner, Antje M, Lienau, Philip, Steinke, Wolfram, Schatz, Christoph, Mumberg, Dominik, Ziegelbauer, Karl

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Changing for the Better: Discovery of the Highly Potent and Selective CDK9 Inhibitor VIP152 Suitable for Once Weekly Intravenous Dosing for the Treatment of Cancer von Lücking, Ulrich, Kosemund, Dirk, Böhnke, Niels, Lienau, Philip, Siemeister, Gerhard, Denner, Karsten, Bohlmann, Rolf, Briem, Hans, Terebesi, Ildiko, Bömer, Ulf, Schäfer, Martina, Ince, Stuart, Mumberg, Dominik, Scholz, Arne, Izumi, Raquel, Hwang, Stuart, von Nussbaum, Franz

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Cyclin-dependent kinase 9 is a novel specific molecular target in adult T-cell leukemia/lymphoma von Narita, Tomoko, Ishida, Takashi, Ito, Asahi, Masaki, Ayako, Kinoshita, Shiori, Suzuki, Susumu, Takino, Hisashi, Yoshida, Takashi, Ri, Masaki, Kusumoto, Shigeru, Komatsu, Hirokazu, Imada, Kazunori, Tanaka, Yuetsu, Takaori-Kondo, Akifumi, Inagaki, Hiroshi, Scholz, Arne, Lienau, Philip, Kuroda, Taruho, Ueda, Ryuzo, Iida, Shinsuke

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Quantitative molecular tissue atlas of Bis(monoacylglycero)phosphate and phosphatidylglycerol membrane lipids in rodent organs generated by methylation assisted high resolution mas... von Wang, Xueying, Schmitt, Maximilian V., Xu, Lina, Jiao, Yupei, Guo, Lvjun, Lienau, Philip, Reichel, Andreas, Liu, Xiaohui

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Damage Incorporated: Discovery of the Potent, Highly Selective, Orally Available ATR Inhibitor BAY 1895344 with Favorable Pharmacokinetic Properties and Promising Efficacy in Monot... von Lücking, Ulrich, Wortmann, Lars, Wengner, Antje M, Lefranc, Julien, Lienau, Philip, Briem, Hans, Siemeister, Gerhard, Bömer, Ulf, Denner, Karsten, Schäfer, Martina, Koppitz, Marcus, Eis, Knut, Bartels, Florian, Bader, Benjamin, Bone, Wilhelm, Moosmayer, Dieter, Holton, Simon J, Eberspächer, Uwe, Grudzinska-Goebel, Joanna, Schatz, Christoph, Deeg, Gesa, Mumberg, Dominik, von Nussbaum, Franz

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Design, Synthesis, and Pharmacological Characterization of a Neutral, Non-Prodrug Thrombin Inhibitor with Good Oral Pharmacokinetics von Hillisch, Alexander, Gericke, Kersten M, Allerheiligen, Swen, Roehrig, Susanne, Schaefer, Martina, Tersteegen, Adrian, Schulz, Simone, Lienau, Philip, Gnoth, Mark, Puetter, Vera, Hillig, Roman C, Heitmeier, Stefan

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Novel Mps1 Kinase Inhibitors with Potent Antitumor Activity von Wengner, Antje M, Siemeister, Gerhard, Koppitz, Marcus, Schulze, Volker, Kosemund, Dirk, Klar, Ulrich, Stoeckigt, Detlef, Neuhaus, Roland, Lienau, Philip, Bader, Benjamin, Prechtl, Stefan, Raschke, Marian, Frisk, Anna-Lena, von Ahsen, Oliver, Michels, Martin, Kreft, Bertolt, von Nussbaum, Franz, Brands, Michael, Mumberg, Dominik, Ziegelbauer, Karl

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The Lab Oddity Prevails: Discovery of Pan-CDK Inhibitor (R)-S-Cyclopropyl-S-(4-{[4-{[(1R,2R)-2-hydroxy-1-methylpropyl]oxy}-5-(trifluoromethyl)pyrimidin-2-yl]amino}phenyl)sulfoximid... von Lücking, Ulrich, Jautelat, Rolf, Krüger, Martin, Brumby, Thomas, Lienau, Philip, Schäfer, Martina, Briem, Hans, Schulze, Julia, Hillisch, Alexander, Reichel, Andreas, Wengner, Antje Margret, Siemeister, Gerhard

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BAY 1143269, a novel MNK1 inhibitor, targets oncogenic protein expression and shows potent anti-tumor activity von Santag, Susann, Siegel, Franziska, Wengner, Antje M, Lange, Claudia, Bömer, Ulf, Eis, Knut, Pühler, Florian, Lienau, Philip, Bergemann, Linda, Michels, Martin, von Nussbaum, Franz, Mumberg, Dominik, Petersen, Kirstin

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Discovery and Characterization of BAY-805, a Potent and Selective Inhibitor of Ubiquitin-Specific Protease USP21 von Göricke, Fabian, Vu, Victoria, Smith, Leanna, Scheib, Ulrike, Böhm, Raphael, Akkilic, Namik, Wohlfahrt, Gerd, Weiske, Jörg, Bömer, Ulf, Brzezinka, Krzysztof, Lindner, Niels, Lienau, Philip, Gradl, Stefan, Beck, Hartmut, Brown, Peter J., Santhakumar, Vijayaratnam, Vedadi, Masoud, Barsyte-Lovejoy, Dalia, Arrowsmith, Cheryl H., Schmees, Norbert, Petersen, Kirstin

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