Therapeutic high affinity T cell receptor targeting a KRASG12D cancer neoantigen von Poole, Andrew, Karuppiah, Vijaykumar, Hartt, Annabelle, Haidar, Jaafar N., Moureau, Sylvie, Dobrzycki, Tomasz, Hayes, Conor, Rowley, Christopher, Dias, Jorge, Harper, Stephen, Barnbrook, Keir, Hock, Miriam, Coles, Charlotte, Yang, Wei, Aleksic, Milos, Lin, Aimee Bence, Robinson, Ross, Dukes, Joe D., Liddy, Nathaniel, Van der Kamp, Marc, Plowman, Gregory D., Vuidepot, Annelise, Cole, David K., Whale, Andrew D., Chillakuri, Chandramouli

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The HLA A0201–restricted hTERT540–548 peptide is not detected on tumor cells by a CTL clone or a high-affinity T-cell receptor von Purbhoo, Marco A., Li, Yi, Sutton, Deborah H., Brewer, Joanna E., Gostick, Emma, Bossi, Giovanna, Laugel, Bruno, Moysey, Ruth, Baston, Emma, Liddy, Nathaniel, Cameron, Brian, Bennett, Alan D., Ashfield, Rebecca, Milicic, Anita, Price, David A., Classon, Brendan J., Sewell, Andrew K., Jakobsen, Bent K.

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Different affinity windows for virus and cancer‐specific T‐cell receptors: Implications for therapeutic strategies von Aleksic, Milos, Liddy, Nathaniel, Molloy, Peter E., Pumphrey, Nick, Vuidepot, Annelise, Chang, Kyong‐Mi, Jakobsen, Bent K.

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Specificity of bispecific T cell receptors and antibodies targeting peptide-HLA von Holland, Christopher J, Crean, Rory M, Pentier, Johanne M, de Wet, Ben, Lloyd, Angharad, Srikannathasan, Velupillai, Lissin, Nikolai, Lloyd, Katy A, Blicher, Thomas H, Conroy, Paul J, Hock, Miriam, Pengelly, Robert J, Spinner, Thomas E, Cameron, Brian, Potter, Elizabeth A, Jeyanthan, Anitha, Molloy, Peter E, Sami, Malkit, Aleksic, Milos, Liddy, Nathaniel, Robinson, Ross A, Harper, Stephen, Lepore, Marco, Pudney, Chris R, van der Kamp, Marc W, Rizkallah, Pierre J, Jakobsen, Bent K, Vuidepot, Annelise, Cole, David K

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Monoclonal TCR-redirected tumor cell killing von Liddy, Nathaniel, Bossi, Giovanna, Adams, Katherine J, Lissina, Anna, Mahon, Tara M, Hassan, Namir J, Gavarret, Jessie, Bianchi, Frayne C, Pumphrey, Nicholas J, Ladell, Kristin, Gostick, Emma, Sewell, Andrew K, Lissin, Nikolai M, Harwood, Naomi E, Molloy, Peter E, Li, Yi, Cameron, Brian J, Sami, Malkit, Baston, Emma E, Todorov, Penio T, Paston, Samantha J, Dennis, Rebecca E, Harper, Jane V, Dunn, Steve M, Ashfield, Rebecca, Johnson, Andy, McGrath, Yvonne, Plesa, Gabriela, June, Carl H, Kalos, Michael, Price, David A, Vuidepot, Annelise, Williams, Daniel D, Sutton, Deborah H, Jakobsen, Bent K

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TCR‐induced alteration of primary MHC peptide anchor residue von Madura, Florian, Rizkallah, Pierre J., Legut, Mateusz, Holland, Christopher J., Fuller, Anna, Bulek, Anna, Schauenburg, Andrea J., Trimby, Andrew, Hopkins, Jade R., Wells, Stephen A., Godkin, Andrew, Miles, John J., Sami, Malkit, Li, Yi, Liddy, Nathaniel, Jakobsen, Bent K., Loveridge, E. Joel, Cole, David K., Sewell, Andrew K.

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Directed evolution of human T-cell receptors with picomolar affinities by phage display von Li, Yi, Moysey, Ruth, Molloy, Peter E, Vuidepot, Anne-Lise, Mahon, Tara, Baston, Emma, Dunn, Steven, Liddy, Nathaniel, Jacob, Jansen, Jakobsen, Bent K, Boulter, Jonathan M

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Abstract B001: Generation of ImmTACTM molecules: Engineering high-affinity soluble T-cell receptors for the treatment of cancer von Bombik, Izabela, Bortoluzzi, Alessio, Mai, Nicole, Preston, Andrew, Vuidepot, Annelise, Jakobsen, Bent K., Liddy, Nathaniel

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T-cell Receptor (TCR)-Peptide Specificity Overrides Affinity-enhancing TCR-Major Histocompatibility Complex Interactions von Cole, David K., Miles, Kim M., Madura, Florian, Holland, Christopher J., Schauenburg, Andrea J.A., Godkin, Andrew J., Bulek, Anna M., Fuller, Anna, Akpovwa, Hephzibah J.E., Pymm, Phillip G., Liddy, Nathaniel, Sami, Malkit, Li, Yi, Rizkallah, Pierre J., Jakobsen, Bent K., Sewell, Andrew K.

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Visualization and Characterisation of Melan A Epitope (25–35)/HLA-A2 Complex by High Affinity Soluble Monoclonal T Cell Receptors (mTCRs) von Paston, Samantha, Avidex Ltd, Abingdon, Oxfordshire, England, Adams, Katherine, Ms, Avidex Ltd, Abingdon, Oxfordshire, England, Bossi, Giovanna, Avidex Ltd, Abingdon, Oxfordshire, England, Liddy, Nathaniel, Avidex Ltd, Abingdon, Oxfordshire, England, Sutton, Deborah, Avidex Ltd, Abingdon, Oxfordshire, England, Mahon, Tara, Avidex Ltd, Abingdon, Oxfordshire, England, Molloy, Peter, Avidex Ltd, Abingdon, Oxfordshire, England, Gostick, Emma, Avidex Ltd, Abingdon, Oxfordshire, England, Sewell, Andy, Department of Medical Biochemistry and Immunology, Cardiff, England, Jakobsen, Bent, Avidex Ltd, Abingdon, Oxfordshire, England

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TCR affinity and specificity requirements for human regulatory T-cell function von Plesa, Gabriela, Zheng, Lingjie, Medvec, Andrew, Wilson, Caleph B., Robles-Oteiza, Camila, Liddy, Nathaniel, Bennett, Alan D., Gavarret, Jessie, Vuidepot, Annelise, Zhao, Yangbing, Blazar, Bruce R., Jakobsen, Bent K., Riley, James L.

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T-cell Receptor Specificity Maintained by Altered Thermodynamics von Madura, Florian, Rizkallah, Pierre J., Miles, Kim M., Holland, Christopher J., Bulek, Anna M., Fuller, Anna, Schauenburg, Andrea J.A., Miles, John J., Liddy, Nathaniel, Sami, Malkit, Li, Yi, Hossain, Moushumi, Baker, Brian M., Jakobsen, Bent K., Sewell, Andrew K., Cole, David K.

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High-affinity T cell receptor ImmTAC® bispecific efficiently redirects T cells to kill tumor cells expressing the cancer-testis antigen PRAME von Ribeiro, Ana R, Britton-Rivet, Camille, Collins, Laura, Carreira, Ricardo J, Moureau, Sylvie, Benlahrech, Adel, Stanhope, Sarah, Harper, Stephen, Liddy, Nathaniel, Mahon, Tara M, Petrovic, Kristina, Fife, Mark, Depoil, David, Addis, Philip, Bedke, Nicole, Bouard, Lucie, O'Dwyer, Ronan, Gascoyne, Duncan, Ranade, Koustubh

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Abstract 4873: ImmTACs re-direct the immune system efficiently to eradicate cancer von Bossi, Giovanna, Kenefeck, Rupert, Caroline Boudousquie, Caroline, Harper, Jane, Dukes, Joseph, Liddy, Nathaniel, Paston, Samantha, Mahon, Tara, Molloy, Peter, Sami, Malkit, Baston, Emma, Cameron, Brian, Vuidepot, Annelise, Hassan, Namir, Jakobsen, Bent K.

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Therapeutic high affinity T cell receptor targeting a KRAS G12D cancer neoantigen von Poole, Andrew, Karuppiah, Vijaykumar, Hartt, Annabelle, Haidar, Jaafar N, Moureau, Sylvie, Dobrzycki, Tomasz, Hayes, Conor, Rowley, Christopher, Dias, Jorge, Harper, Stephen, Barnbrook, Keir, Hock, Miriam, Coles, Charlotte, Yang, Wei, Aleksic, Milos, Lin, Aimee Bence, Robinson, Ross, Dukes, Joe D, Liddy, Nathaniel, Van der Kamp, Marc, Plowman, Gregory D, Vuidepot, Annelise, Cole, David K, Whale, Andrew D, Chillakuri, Chandramouli

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Abstract 4872: Developing high affinity, soluble T cell receptors for the treatment of cancer von Knox, Andrew, Chester, Fiona, Bianchi, Frayne, Bailey, Sarah, Bouard, Lucie, Liddy, Nathaniel, Bossi, Giovanna, Harper, Jane, Dukes, Joseph, Paston, Samantha, Mahon, Tara, Gavarret, Jessie, Molloy, Peter, Sami, Malkit, Baston, Emma, Cameron, Brian, Powlesland, Alex, Todorov, Penio, Johnson, Andrew, Ebner, Martin, McGrath, Yvonne, Hassan, Namir, Vuidepot, Annelise, Jakobsen, Bent

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Abstract 2900: IMCgp100: A novel bi-specific biologic for the treatment of malignant melanoma von Hassan, Namir J., Bossi, Giovanna, Baker, Debbie, Adams, Katherine, Harper, Jane, Dukes, Joseph, Liddy, Nathaniel, Paston, Samantha, McGrath, Yvonne, Mahon, Tara, Molloy, Peter, Sami, Malkit, Baston, Emma, Cameron, Brian, Johnson, Andrew, Vuidepot, Annelise, Linette, Gerry, Kalos, Michael, June, Carl, Jakobsen, Bent

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Abstract 670: ImmTACs: Bi-specific TCR-anti-CD3 fusions for potent re-directed killing of cancer cells von Bossi, Giovanna, Baker, Debbie, Adams, Katherine, Harper, Jane, Dukes, Joseph, Liddy, Nathaniel, Paston, Samantha, McGrath, Yvonne, Mahon, Tara, Molloy, Pater, Sami, Malkit, Baston, Emma, Cameron, Brian, Johnson, Andrew, Vuidepot, Annelise, Hassan, Namir, Jakobsen, Bent

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T-cell Receptor Specificity Maintained by Altered Thermodynamics<inline-graphic xlink:href="sbox.jpg"/> von Madura, Florian, Rizkallah, Pierre J, Miles, Kim M, Holland, Christopher J, Bulek, Anna M, Fuller, Anna, Schauenburg, Andrea JA, Miles, John J, Liddy, Nathaniel, Sami, Malkit, Li, Yi, Hossain, Moushumi, Baker, Brian M, Jakobsen, Bent K, Sewell, Andrew K, Cole, David K

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Abstract 3525: IMCgp100: A novel bi-specific biologic for the treatment of malignant melanoma von Hassan, Namir J., Adams, Katherine, Bossi, Giovanna, Harper, Jane, Buisson, Sandrine, Paston, Samantha, Liddy, Nathaniel, Ashfield, Rebecca, Gavarret, Jessie, Bianchi, Frayne, Baston, Emma, Baker, Debbie, Ladell, Kristin, Sewell, Andrew, Li, Yi, Cameron, Brian, Johnson, Andrew, Vuidepot, Annelise, Todorov, Penio, Kalos, Michael, June, Carl, Karakousis, Giorgos, Linette, Gerry, Price, David A., Williams, Daniel, McGrath, Yvonne, Jakobsen, Bent K.

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