Clinical Probes and Endogenous Biomarkers as Substrates for Transporter Drug‐Drug Interaction Evaluation: Perspectives From the International Transporter Consortium von Chu, Xiaoyan, Liao, Mingxiang, Shen, Hong, Yoshida, Kenta, Zur, Arik A., Arya, Vikram, Galetin, Aleksandra, Giacomini, Kathleen M., Hanna, Imad, Kusuhara, Hiroyuki, Lai, Yurong, Rodrigues, David, Sugiyama, Yuichi, Zamek‐Gliszczynski, Maciej J., Zhang, Lei

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Abundance of Phase 1 and 2 Drug-Metabolizing Enzymes in Alcoholic and Hepatitis C Cirrhotic Livers: A Quantitative Targeted Proteomics Study von Prasad, Bhagwat, Bhatt, Deepak Kumar, Johnson, Katherine, Chapa, Revathi, Chu, Xiaoyan, Salphati, Laurent, Xiao, Guangqing, Lee, Caroline, Hop, Cornelis E.C.A., Mathias, Anita, Lai, Yurong, Liao, Mingxiang, Humphreys, William G., Kumer, Sean C., Unadkat, Jashvant D.

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Positron Emission Tomography Imaging of [11C]Rosuvastatin Hepatic Concentrations and Hepatobiliary Transport in Humans in the Absence and Presence of Cyclosporin A von Billington, Sarah, Shoner, Steven, Lee, Scott, Clark‐Snustad, Kindra, Pennington, Matthew, Lewis, David, Muzi, Mark, Rene, Shirley, Lee, Jean, Nguyen, Tot Bui, Kumar, Vineet, Ishida, Kazuya, Chen, Laigao, Chu, Xiaoyan, Lai, Yurong, Salphati, Laurent, Hop, Cornelis E.C.A., Xiao, Guangqing, Liao, Mingxiang, Unadkat, Jashvant D.

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A Comparison of Total and Plasma Membrane Abundance of Transporters in Suspended, Plated, Sandwich-Cultured Human Hepatocytes Versus Human Liver Tissue Using Quantitative Targeted... von Kumar, Vineet, Salphati, Laurent, Hop, Cornelis E.C.A., Xiao, Guangqing, Lai, Yurong, Mathias, Anita, Chu, Xiaoyan, Humphreys, W. Griffith, Liao, Mingxiang, Heyward, Scott, Unadkat, Jashvant D.

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In Vitro Drug-Induced Liver Injury Prediction: Criteria Optimization of Efflux Transporter IC50 and Physicochemical Properties von Yucha, Robert W, He, Kan, Shi, Qin, Cai, Lining, Nakashita, Yukie, Xia, Cindy Q, Liao, Mingxiang

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Evaluation of absorption, distribution, metabolism, and excretion of [14C]-rucaparib, a poly(ADP-ribose) polymerase inhibitor, in patients with advanced solid tumors von Liao, Mingxiang, Watkins, Simon, Nash, Eileen, Isaacson, Jeff, Etter, Jeff, Beltman, Jeri, Fan, Rong, Shen, Li, Mutlib, Abdul, Kemeny, Vendel, Pápai, Zsuzsanna, van Tilburg, Pascal, Xiao, Jim J.

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A phase 1, open-label, drug–drug interaction study of rucaparib with rosuvastatin and oral contraceptives in patients with advanced solid tumors von Liao, Mingxiang, Jeziorski, Krzysztof G., Tomaszewska-Kiecana, Monika, Láng, István, Jasiówka, Marek, Skarbová, Viera, Centkowski, Piotr, Ramlau, Rodryg, Górnaś, Maria, Lee, John, Edwards, Sarah, Habeck, Jenn, Nash, Eileen, Grechko, Nikolay, Xiao, Jim J.

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Pharmacokinetics and safety of rucaparib in patients with advanced solid tumors and hepatic impairment von Grechko, Nikolay, Skarbova, Viera, Tomaszewska-Kiecana, Monika, Ramlau, Rodryg, Centkowski, Piotr, Drew, Yvette, Dziadziuszko, Rafal, Zemanova, Milada, Beltman, Jeri, Nash, Eileen, Habeck, Jenn, Liao, Mingxiang, Xiao, Jim

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Fasiglifam (TAK-875) Alters Bile Acid Homeostasis in Rats and Dogs: A Potential Cause of Drug Induced Liver Injury von Wolenski, Francis S, Zhu, Andy Z X, Johnson, Mike, Yu, Shaoxia, Moriya, Yuu, Ebihara, Takuya, Csizmadia, Vilmos, Grieves, Jessica, Paton, Martin, Liao, Mingxiang, Gemski, Christopher, Pan, Liping, Vakilynejad, Majid, Dragan, Yvonne P, Chowdhury, Swapan K, Kirby, Patrick J

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A Role for Protein Phosphorylation in Cytochrome P450 3A4 Ubiquitin-dependent Proteasomal Degradation von Wang, YongQiang, Liao, Mingxiang, Hoe, Nicholas, Acharya, Poulomi, Deng, Changhui, Krutchinsky, Andrew N., Correia, Maria Almira

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Can transporter-expressing cells predict rosuvastatin uptake clearance in suspended or plated human hepatocytes? von Kumar, Vineet, Salphati, Laurent, Hop, Cornelis E.C.A., Rowbottom, Christopher, Xiao, Guangqing, Lai, Yurong, Mathias, Anita, Chu, Xiaoyan, Humphreys, W. Griffith, Liao, Mingxiang, Chen, Laigao, Tóth, Beáta, Juhasz, Viktoria, Heyward, Scott, Unadkat, Jashvant

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Does plasma membrane and total transporter abundance differ between suspended, plated, sandwich culture hepatocytes and human liver tissue? von Kumar, Vineet, Salphati, Laurent, Hop, Cornelis E.C.A., Rowbottom, Christopher, Xiao, Guangqing, Lai, Yurong, Mathias, Anita, Chu, Xiaoyan, Humphreys, W.Griffith, Liao, Mingxiang, Chen, Laigao, Heyward, Scott, Unadkat, Jashvant

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Liver Cytochrome P450 3A Endoplasmic Reticulum-associated Degradation von Acharya, Poulomi, Liao, Mingxiang, Engel, Juan C., Correia, Maria Almira

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Endoplasmic Reticulum-Associated Degradation of Cytochrome P450 CYP3A4 in Saccharomyces cerevisiae: Further Characterization of Cellular Participants and Structural Determinants von Liao, Mingxiang, Faouzi, Saadia, Karyakin, Andrey, Correia, Maria Almira

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Clinical Pharmacokinetics and Pharmacodynamics of Rucaparib von Liao, Mingxiang, Beltman, Jeri, Giordano, Heidi, Harding, Thomas C., Maloney, Lara, Simmons, Andrew D., Xiao, Jim J.

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Transporter Expression in Liver Tissue from Subjects with Alcoholic or Hepatitis C Cirrhosis Quantified by Targeted Quantitative Proteomics von Wang, Li, Collins, Carol, Kelly, Edward J, Chu, Xiaoyan, Ray, Adrian S, Salphati, Laurent, Xiao, Guangqing, Lee, Caroline, Lai, Yurong, Liao, Mingxiang, Mathias, Anita, Evers, Raymond, Humphreys, William, Hop, Cornelis E C A, Kumer, Sean C, Unadkat, Jashvant D

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Population Pharmacokinetic Modeling of Lucitanib in Patients with Advanced Cancer von Liao, Mingxiang, Zhou, Jie, Wride, Kenton, Lepley, Denise, Cameron, Terri, Sale, Mark, Xiao, Jim

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Prediction of Transporter-Mediated Rosuvastatin Hepatic Uptake Clearance and Drug Interaction in Humans Using Proteomics-Informed REF Approach von Kumar, Vineet, Yin, Mengyue, Ishida, Kazuya, Salphati, Laurent, Hop, Cornelis E.C.A., Rowbottom, Christopher, Xiao, Guangqing, Lai, Yurong, Mathias, Anita, Chu, Xiaoyan, Humphreys, W. Griffith, Liao, Mingxiang, Nerada, Zsuzsanna, Szilvásy, Nóra, Heyward, Scott, Unadkat, Jashvant D.

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Vacuolar Degradation of Rat Liver CYP2B1 in Saccharomyces cerevisiae: Further Validation of the Yeast Model and Structural Implications for the Degradation of Mammalian Endoplasmic... von Liao, Mingxiang, Zgoda, Victor G., Murray, Bernard P., Correia, Maria Almira

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Transporter Expression in Noncancerous and Cancerous Liver Tissue from Donors with Hepatocellular Carcinoma and Chronic Hepatitis C Infection Quantified by LC-MS/MS Proteomics von Billington, Sarah, Ray, Adrian S., Salphati, Laurent, Xiao, Guangqing, Chu, Xiaoyan, Humphreys, W. Griffith, Liao, Mingxiang, Lee, Caroline A., Mathias, Anita, Hop, Cornelis E.C.A., Rowbottom, Christopher, Evers, Raymond, Lai, Yurong, Kelly, Edward J., Prasad, Bhagwat, Unadkat, Jashvant D.

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