Interleukin (IL)-22 and IL-17 are coexpressed by Th17 cells and cooperatively enhance expression of antimicrobial peptides von Liang, Spencer C, Tan, Xiang-Yang, Luxenberg, Deborah P, Karim, Riyez, Dunussi-Joannopoulos, Kyriaki, Collins, Mary, Fouser, Lynette A

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AL008 Enhances Myeloid Antitumor Function by Inhibiting SIRPα Signaling and Activating Fc Receptors von Yang, Jingping, Deresa, Isaiah, Ho, Wei-Hsien, Long, Hua, Maslyar, Daniel, Rosenthal, Arnon, Liang, Spencer C, Pincetic, Andrew

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Regulation of PD‐1, PD‐L1, and PD‐L2 expression during normal and autoimmune responses von Liang, Spencer C., Latchman, Yvette E., Buhlmann, Janet E., Tomczak, Michal F., Horwitz, Bruce H., Freeman, Gordon J., Sharpe, Arlene H.

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PVRIG and PVRL2 Are Induced in Cancer and Inhibit CD8 + T-cell Function von Whelan, Sarah, Ophir, Eran, Kotturi, Maya F, Levy, Ofer, Ganguly, Sudipto, Leung, Ling, Vaknin, Ilan, Kumar, Sandeep, Dassa, Liat, Hansen, Kyle, Bernados, David, Murter, Benjamin, Soni, Abha, Taube, Janis M, Fader, Amanda Nickles, Wang, Tian-Li, Shih, Ie-Ming, White, Mark, Pardoll, Drew M, Liang, Spencer C

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An IL-17F/A Heterodimer Protein Is Produced by Mouse Th17 Cells and Induces Airway Neutrophil Recruitment von Liang, Spencer C, Long, Andrew J, Bennett, Frann, Whitters, Matthew J, Karim, Riyez, Collins, Mary, Goldman, Samuel J, Dunussi-Joannopoulos, Kyriaki, Williams, Cara M. M, Wright, Jill F, Fouser, Lynette A

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Tissue expression of PD-L1 mediates peripheral T cell tolerance von Keir, Mary E, Liang, Spencer C, Guleria, Indira, Latchman, Yvette E, Qipo, Andi, Albacker, Lee A, Koulmanda, Maria, Freeman, Gordon J, Sayegh, Mohamed H, Sharpe, Arlene H

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IL-22 induces an acute-phase response von Liang, Spencer C, Nickerson-Nutter, Cheryl, Pittman, Debra D, Carrier, Yijun, Goodwin, Debra G, Shields, Kathleen M, Lambert, Andre-Jean, Schelling, Scott H, Medley, Quintus G, Ma, Hak-Ling, Collins, Mary, Dunussi-Joannopoulos, Kyriaki, Fouser, Lynette A

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PVRIG is a novel natural killer cell immune checkpoint receptor in acute myeloid leukemia von Li, Jessica, Whelan, Sarah, Kotturi, Maya F, Meyran, Deborah, D'Souza, Criselle, Hansen, Kyle, Liang, Spencer, Hunter, John, Trapani, Joseph A, Neeson, Paul J

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IL-22 is required for Th17 cell-mediated pathology in a mouse model of psoriasis-like skin inflammation von Ma, Hak-Ling, Liang, Spencer, Li, Jing, Napierata, Lee, Brown, Tom, Benoit, Stephen, Senices, Mayra, Gill, Davinder, Dunussi-Joannopoulos, Kyriaki, Collins, Mary, Nickerson-Nutter, Cheryl, Fouser, Lynette A, Young, Deborah A

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PD-L1-Deficient Mice Show That PD-L1 on T Cells, Antigen-Presenting Cells, and Host Tissues Negatively Regulates T Cells von Latchman, Yvette E., Liang, Spencer C., Wu, Yin, Chernova, Tatyana, Sobel, Raymond A., Klemm, Martina, Kuchroo, Vijay K., Freeman, Gordon J., Sharpe, Arlene H., Nathenson, Stanley G.

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COM902, a novel therapeutic antibody targeting TIGIT augments anti-tumor T cell function in combination with PVRIG or PD-1 pathway blockade von Hansen, Kyle, Kumar, Sandeep, Logronio, Kathryn, Whelan, Sarah, Qurashi, Samir, Cheng, Hsin-Yuan, Drake, Andrew, Tang, Margaret, Wall, Patrick, Bernados, David, Leung, Ling, Ophir, Eran, Alteber, Zoya, Cojocaru, Gady, Galperin, Moran, Frenkel, Masha, White, Mark, Hunter, John, Liang, Spencer C., Kotturi, Maya F.

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ILDR2 Is a Novel B7-like Protein That Negatively Regulates T Cell Responses von Hecht, Iris, Toporik, Amir, Podojil, Joseph R, Vaknin, Ilan, Cojocaru, Gady, Oren, Anat, Aizman, Elizabeta, Liang, Spencer C, Leung, Ling, Dicken, Yosef, Novik, Amit, Marbach-Bar, Nadav, Elmesmari, Aziza, Tange, Clare, Gilmour, Ashley, McIntyre, Donna, Kurowska-Stolarska, Mariola, McNamee, Kay, Leitner, Judith, Greenwald, Shirley, Dassa, Liat, Levine, Zurit, Steinberger, Peter, Williams, Richard O, Miller, Stephen D, McInnes, Iain B, Neria, Eyal, Rotman, Galit

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Depletion of regulatory T cells by targeting folate receptor 4 enhances the potency of a GM-CSF-secreting tumor cell immunotherapy von Liang, Spencer C, Moskalenko, Marina, Van Roey, Melinda, Jooss, Karin

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Endothelial expression of PD‐L1 and PD‐L2 down‐regulates CD8+ T cell activation and cytolysis von Rodig, Nancy, Ryan, Timothy, Allen, Jessica A., Pang, Hong, Grabie, Nir, Chernova, Tatyana, Greenfield, Edward A., Liang, Spencer C., Sharpe, Arlene H., Lichtman, Andrew H., Freeman, Gordon J.

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PD‐L1 and PD‐L2 have distinct roles in regulating host immunity to cutaneous leishmaniasis von Liang, Spencer C., Greenwald, Rebecca J., Latchman, Yvette E., Rosas, Lucia, Satoskar, Abhay, Freeman, Gordon J., Sharpe, Arlene H.

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Computational discovery and experimental validation of novel drug targets in immuno-oncology von Levy, Ofer, Machelnkin, Arthur, Rotman, Galit, Toporik, Amir, Cojocaro, Gady, Dassa, Liat, Vaknin, Ilan, Liang, Spencer, Hunter, John, Neria, Eyal, Levin, Zurit

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Identification of novel immune checkpoints as targets for cancer immunotherapy von Levy, Ofer, Toporic, Amir, Cojocaru, Gady, Dassa, Liat, Vaknin, Ilan, Kfir, Tal Fridman, Barbiro, Inbal, Neria, Eyal, Machlenkin, Arthur, Liang, Spencer, Sameach-Greenwald, Shirley, Levin, Zurit, Rotman, Galit, Hunter, John

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IL-21 Has a Pathogenic Role in a Lupus-Prone Mouse Model and Its Blockade with IL-21R.Fc Reduces Disease Progression von Herber, Deborah, Brown, Thomas P, Liang, Spencer, Young, Deborah A, Collins, Mary, Dunussi-Joannopoulos, Kyri

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Systems biology analysis of immune signaling in peripheral blood mononuclear cells (PBMC) of melanoma patients receiving ipilimumab; basis for clinical response biomarker identific... von Hotson, Drew, Alvarado, Ryan, Conroy, Andrew, Putta, Santosh, Simeone, Ester, Esposito, Assunta, Capone, Mariaelena, Madonna, Gabriele, Grimaldi, Antonio M, Rosen, David, Liang, Spencer, Cesano, Alessandra, Ascierto, Paolo A, Hawtin, Rachael

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Abstract 613: AL009 is a multi-Siglec inhibitor engineered to bind myeloid cells that enhances innate and adaptive immunity to cancer von Nalle, Sam, Lam, Helen, Barner, Cheryl, Long, Hua, Liang, Spencer, Rosenthal, Arnon, Maslyar, Daniel

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