Discovery and Synthesis of a Phosphoramidate Prodrug of a Pyrrolo[2,1‑f][triazin-4-amino] Adenine C‑Nucleoside (GS-5734) for the Treatment of Ebola and Emerging Viruses von Siegel, Dustin, Hui, Hon C, Doerffler, Edward, Clarke, Michael O, Chun, Kwon, Zhang, Lijun, Neville, Sean, Carra, Ernest, Lew, Willard, Ross, Bruce, Wang, Queenie, Wolfe, Lydia, Jordan, Robert, Soloveva, Veronica, Knox, John, Perry, Jason, Perron, Michel, Stray, Kirsten M, Barauskas, Ona, Feng, Joy Y, Xu, Yili, Lee, Gary, Rheingold, Arnold L, Ray, Adrian S, Bannister, Roy, Strickley, Robert, Swaminathan, Swami, Lee, William A, Bavari, Sina, Cihlar, Tomas, Lo, Michael K, Warren, Travis K, Mackman, Richard L

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Preclinical Characterization of GS-9669, a Thumb Site II Inhibitor of the Hepatitis C Virus NS5B Polymerase von FENAUX, Martijn, ENG, Stacey, LAZERWITH, Scott E, LEW, Willard, QI LIU, MERTZMAN, Michael, MORGANELLI, Philip, LIANHONG XU, HONG YE, JENNIFER ZHANG, MATLES, Mike, MURRAY, Bernard P, LEAVITT, Stephanie A, MWANGI, Judy, JINGYU ZHANG, HASHASH, Ahmad, KRAWCZYK, Steve H, BIDGOOD, Alison M, APPLEBY, Todd C, WATKINS, William J, LEE, Yu-Jen, MABERY, Eric M, YANG TIAN, BYUN, Daniel, CANALES, Eda, CLARKE, Michael O, DOERFFLER, Edward

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Structure−Activity Relationship Studies of Novel Carbocyclic Influenza Neuraminidase Inhibitors von Kim, Choung U, Lew, Willard, Williams, Matthew A, Wu, Huiwei, Zhang, Lijun, Chen, Xiaowu, Escarpe, Paul A, Mendel, Dirk B, Laver, W. Graeme, Stevens, Raymond C

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Design and synthesis of 2-amino-isoxazolopyridines as Polo-like kinase inhibitors von Hanan, Emily J., Fucini, Raymond V., Romanowski, Michael J., Elling, Robert A., Lew, Willard, Purkey, Hans E., VanderPorten, Erica C., Yang, Wenjin

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Oral Administration of a Prodrug of the Influenza Virus Neuraminidase Inhibitor GS 4071 Protects Mice and Ferrets against Influenza Infection von MENDEL, D. B, TAI, C. Y, LEW, W, WILLIAMS, M. A, ZHANG, L, CHEN, M. S, BISCHOFBERGER, N, KIM, C. U, ESCARPE, P. A, LI, W, SIDWELL, R. W, HUFFMAN, J. H, SWEET, C, JAKEMAN, K. J, MERSON, J, LACY, S. A

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Identification of GS 4104 as an Orally Bioavailable Prodrug of the Influenza Virus Neuraminidase Inhibitor GS 4071 von WEIXING LI, ESCARPE, P. A, KIM, C. U, BISCHOFBERGER, N, CHEN, M. S, MENDEL, D. B, EISENBERG, E. J, CUNDY, K. C, SWEET, C, JAKEMAN, K. J, MERSON, J, LEW, W, WILLIAMS, M, LIJUN ZHANG

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Practical Total Synthesis of the Anti-Influenza Drug GS-4104 von Rohloff, John C, Kent, Kenneth M, Postich, Michael J, Becker, Mark W, Chapman, Harlan H, Kelly, Daphne E, Lew, Willard, Louie, Michael S, McGee, Lawrence R, Prisbe, Ernest J, Schultze, Lisa M, Yu, Richard H, Zhang, Lijun

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Characterization of Human Influenza Virus Variants Selected In Vitro in the Presence of the Neuraminidase Inhibitor GS 4071 von TAI, C. Y, ESCARPE, P. A, SIDWELL, R. W, WILLIAMS, M. A, LEW, W, HUIWEI WU, KIM, C. U, MENDEL, D. B

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Discovery of the First C‑Nucleoside HCV Polymerase Inhibitor (GS-6620) with Demonstrated Antiviral Response in HCV Infected Patients von Cho, Aesop, Zhang, Lijun, Xu, Jie, Lee, Rick, Butler, Thomas, Metobo, Sammy, Aktoudianakis, Vangelis, Lew, Willard, Ye, Hong, Clarke, Michael, Doerffler, Edward, Byun, Daniel, Wang, Ting, Babusis, Darius, Carey, Anne C., German, Polina, Sauer, Dorothea, Zhong, Weidong, Rossi, Stephen, Fenaux, Martijn, McHutchison, John G., Perry, Jason, Feng, Joy, Ray, Adrian S., Kim, Choung U.

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Early Process Development of an LPAR1 Antagonist, GS-2278 von Kadunce, Nathaniel, Wagner, Anna M., Cottell, Jeromy, Dao, Kathy, Dixon, Darryl D., Hodur, Blanka M., Holte, Dane, Ischay, Michael A., Kang, Jihun, Kim, Seongtaek, Kim, Young Ho, Koo, Seung Moh, Lew, Willard, Man, Lucas, Methuku, Kashi Reddy, Morrison, Henry, Parker, Patrick D., Siler, David A., Wong, Chloe Y.

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Process Development and Scale-Up of a Protease Inhibitor for the Treatment of HIV Featuring the Preparation of a Neopentyl Grignard Reagent and Development of a One-Pot Curtius Rea... von Ischay, Michael A., Hoang, Brittanie, Steinhuebel, Dietrich P., Chin, Matthew R., Dixon, Darryl D., Elfgren, Danielle, Heumann, Lars, Lew, Willard, Mundal, Devon A., Neville, Sean T., Shah, Nisha P., Shi, Bing, Tripp, Jonathan C., Wang, Queenie

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Discovery of GS-9669, a Thumb Site II Non-Nucleoside Inhibitor of NS5B for the Treatment of Genotype 1 Chronic Hepatitis C Infection von Lazerwith, Scott E., Lew, Willard, Zhang, Jennifer, Morganelli, Philip, Liu, Qi, Canales, Eda, Clarke, Michael O., Doerffler, Edward, Byun, Daniel, Mertzman, Michael, Ye, Hong, Chong, Lee, Xu, Lianhong, Appleby, Todd, Chen, Xiaowu, Fenaux, Martijn, Hashash, Ahmad, Leavitt, Stephanie A., Mabery, Eric, Matles, Mike, Mwangi, Judy W., Tian, Yang, Lee, Yu-Jen, Zhang, Jingyu, Zhu, Christine, Murray, Bernard P., Watkins, William J.

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Structure-activity relationships of carbocyclic influenza neuraminidase inhibitors von Williams, Matthew A., Lew, Willard, Mendel, Dirk B., Tai, Chun Y., Escarpe, Paul A., Laver, W.Graeme, Stevens, Raymond C., Kim, Choung U.

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Discovery of a 2′-fluoro-2′-C-methyl C-nucleotide HCV polymerase inhibitor and a phosphoramidate prodrug with favorable properties von Kirschberg, Thorsten A., Metobo, Sammy, Clarke, Michael O., Aktoudianakis, Vangelis, Babusis, Darius, Barauskas, Ona, Birkus, Gabriel, Butler, Thomas, Byun, Daniel, Chin, Gregory, Doerffler, Edward, Edwards, Thomas E., Fenaux, Martijn, Lee, Rick, Lew, Willard, Mish, Michael R., Murakami, Eisuke, Park, Yeojin, Squires, Neil H., Tirunagari, Neeraj, Wang, Ting, Whitcomb, Mark, Xu, Jie, Yang, Huiling, Ye, Hong, Zhang, Lijun, Appleby, Todd C., Feng, Joy Y., Ray, Adrian S., Cho, Aesop, Kim, Choung U.

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Influenza Neuraminidase Inhibitors Possessing a Novel Hydrophobic Interaction in the Enzyme Active Site:  Design, Synthesis, and Structural Analysis of Carbocyclic Sialic Acid Anal... von Kim, Choung U, Lew, Willard, Williams, Matthew A, Liu, Hongtao, Zhang, Lijun, Swaminathan, S, Bischofberger, Norbert, Chen, Ming S, Mendel, Dirk B, Tai, Chun Y, Laver, W. Graeme, Stevens, Raymond C

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Discovery of a potent and selective Aurora kinase inhibitor von Oslob, Johan D., Romanowski, Michael J., Allen, Darin A., Baskaran, Subramanian, Bui, Minna, Elling, Robert A., Flanagan, William M., Fung, Amy D., Hanan, Emily J., Harris, Shannon, Heumann, Stacey A., Hoch, Ute, Jacobs, Jeffrey W., Lam, Joni, Lawrence, Chris E., McDowell, Robert S., Nannini, Michelle A., Shen, Wang, Silverman, Jeffrey A., Sopko, Michelle M., Tangonan, Bradley T., Teague, Juli, Yoburn, Josh C., Yu, Chul H., Zhong, Min, Zimmerman, Kristin M., O’Brien, Tom, Lew, Willard

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2-Aminobenzimidazoles as potent Aurora kinase inhibitors von Zhong, Min, Bui, Minna, Shen, Wang, Baskaran, Subramanian, Allen, Darin A., Elling, Robert A., Flanagan, W. Michael, Fung, Amy D., Hanan, Emily J., Harris, Shannon O., Heumann, Stacey A., Hoch, Ute, Ivy, Sheryl N., Jacobs, Jeffrey W., Lam, Stuart, Lee, Heman, McDowell, Robert S., Oslob, Johan D., Purkey, Hans E., Romanowski, Michael J., Silverman, Jeffrey A., Tangonan, Bradley T., Taverna, Pietro, Yang, Wenjin, Yoburn, Josh C., Yu, Chul H., Zimmerman, Kristin M., O’Brien, Tom, Lew, Willard

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Identification of Potent and Selective Small-Molecule Inhibitors of Caspase-3 through the Use of Extended Tethering and Structure-Based Drug Design von Choong, Ingrid C, Lew, Willard, Lee, Dennis, Pham, Phuongly, Burdett, Matthew T, Lam, Joni W, Wiesmann, Christian, Luong, Tinh N, Fahr, Bruce, DeLano, Warren L, McDowell, Robert S, Allen, Darin A, Erlanson, Daniel A, Gordon, Eric M, O'Brien, Tom

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Design and synthesis of 2-amino-pyrazolopyridines as Polo-like kinase 1 inhibitors von Fucini, Raymond V., Hanan, Emily J., Romanowski, Michael J., Elling, Robert A., Lew, Willard, Barr, Kenneth J., Zhu, Jiang, Yoburn, Joshua C., Liu, Yang, Fahr, Bruce T., Fan, Junfa, Lu, Yafan, Pham, Phuongly, Choong, Ingrid C., VanderPorten, Erica C., Bui, Minna, Purkey, Hans E., Evanchik, Marc J., Yang, Wenjin

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C3-Thia and C3-carba isosteres of a carbocyclic influenza neuraminidase inhibitor, (3R,4R,5S)-4-acetamido-5-amino-3-propoxyl-1-cyclohexene-1-carboxylic acid von Lew, Willard, Williams, Matthew A., Mendel, Dirk B., Escarpe, Paul A., Kim, Choung U.

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