Pyranonaphthoquinone Lactones: A New Class of AKT Selective Kinase Inhibitors Alkylate a Regulatory Loop Cysteine von Salaski, Edward J, Krishnamurthy, Girija, Ding, Wei-Dong, Yu, Ker, Insaf, Shabana S, Eid, Clark, Shim, Jaechul, Levin, Jeremy I, Tabei, Keiko, Toral-Barza, Lourdes, Zhang, Wei-Guo, McDonald, Leonard A, Honores, Erick, Hanna, Cilien, Yamashita, Ayako, Johnson, Bernard, Li, Zhong, Laakso, Leif, Powell, Dennis, Mansour, Tarek S

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Potent, selective, and orally bioavailable matrix metalloproteinase-13 inhibitors for the treatment of osteoarthritis von Hu, Yonghan, Xiang, Jason S., DiGrandi, Martin J., Du, Xuemei, Ipek, Manus, Laakso, Leif M., Li, Jianchang, Li, Wei, Rush, Thomas S., Schmid, Jean, Skotnicki, Jerauld S., Tam, Steve, Thomason, Jennifer R., Wang, Qin, Levin, Jeremy I.

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Discovery of lactoquinomycin and related pyranonaphthoquinones as potent and allosteric inhibitors of AKT/PKB: mechanistic involvement of AKT catalytic activation loop cysteines von Toral-Barza, Lourdes, Zhang, Wei-Guo, Huang, Xinyi, McDonald, Leonard A, Salaski, Edward J, Barbieri, Laurel R, Ding, Wei-Dong, Krishnamurthy, Girija, Hu, Yong Bo, Lucas, Judy, Bernan, Valerie S, Cai, Ping, Levin, Jeremy I, Mansour, Tarek S, Gibbons, James J, Abraham, Robert T, Yu, Ker

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Structure-Based Design of a Novel, Potent, and Selective Inhibitor for MMP-13 Utilizing NMR Spectroscopy and Computer-Aided Molecular Design von Chen, James M, Nelson, Frances C, Levin, Jeremy I, Mobilio, Dominick, Moy, Franklin J, Nilakantan, Ramaswamy, Zask, Arie, Powers, Robert

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Impact of Mobility on Structure-Based Drug Design for the MMPs von Moy, Franklin J, Chanda, Pranab K, Chen, James, Cosmi, Scott, Edris, Wade, Levin, Jeremy I, Rush, Thomas S, Wilhelm, James, Powers, Robert

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Discovery of a stable macrocyclic o-aminobenzamide Hsp90 inhibitor which significantly decreases tumor volume in a mouse xenograft model von Zapf, Christoph W., Bloom, Jonathan D., Li, Zhong, Dushin, Russell G., Nittoli, Thomas, Otteng, Mercy, Nikitenko, Antonia, Golas, Jennifer M., Liu, Hao, Lucas, Judy, Boschelli, Frank, Vogan, Erik, Olland, Andrea, Johnson, Mark, Levin, Jeremy I.

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Indazolylpyrazolopyrimidine as Highly Potent B-Raf Inhibitors with in Vivo Activity von Wang, Xiaolun, Berger, Dan M, Salaski, Edward J, Torres, Nancy, Dutia, Minu, Hanna, Cilien, Hu, Yongbo, Levin, Jeremy I, Powell, Dennis, Wojciechowicz, Donald, Collins, Karen, Frommer, Eileen, Lucas, Judy

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Synthesis and activity of tryptophan sulfonamide derivatives as novel non-hydroxamate TNF-α converting enzyme (TACE) inhibitors von Park, Kaapjoo, Gopalsamy, Ariamala, Aplasca, Alexis, Ellingboe, John W., Xu, Weixin, Zhang, Yuhua, Levin, Jeremy I.

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Late-stage optimization of a tercyclic class of S1P3-sparing, S1P1 receptor agonists von Horan, Joshua C., Kuzmich, Daniel, Liu, Pingrong, DiSalvo, Darren, Lord, John, Mao, Can, Hopkins, Tamara D., Yu, Hui, Harcken, Christian, Betageri, Raj, Hill-Drzewi, Melissa, Patenaude, Lori, Patel, Monica, Fletcher, Kimberly, Terenzzio, Donna, Linehan, Brian, Xia, Heather, Patel, Mita, Studwell, Debbie, Miller, Craig, Hickey, Eugene, Levin, Jeremy I., Smith, Dustin, Kemper, Raymond A., Modis, Louise K., Bannen, Lynne C., Chan, Diva S., Mac, Morrison B., Ng, Stephanie, Wang, Yong, Xu, Wei, Lemieux, René M.

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Discovery of highly potent and selective type I B-Raf kinase inhibitors von Wang, Xiaolun, Berger, Dan M., Salaski, Edward J., Torres, Nancy, Hu, Yongbo, Levin, Jeremy I., Powell, Dennis, Wojciechowicz, Donald, Collins, Karen, Frommer, Eileen

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Design and SAR of macrocyclic Hsp90 inhibitors with increased metabolic stability and potent cell-proliferation activity von Zapf, Christoph W., Bloom, Jonathan D., McBean, Jamie L., Dushin, Russell G., Nittoli, Thomas, Ingalls, Charles, Sutherland, Alan G., Sonye, John P., Eid, Clark N., Golas, Jennifer, Liu, Hao, Boschelli, Frank, Hu, Yongbo, Vogan, Erik, Levin, Jeremy I.

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Discovery of a macrocyclic o-aminobenzamide Hsp90 inhibitor with heterocyclic tether that shows extended biomarker activity and in vivo efficacy in a mouse xenograft model von Zapf, Christoph W., Bloom, Jonathan D., McBean, Jamie L., Dushin, Russell G., Golas, Jennifer M., Liu, Hao, Lucas, Judy, Boschelli, Frank, Vogan, Erik, Levin, Jeremy I.

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Macrocyclic lactams as potent Hsp90 inhibitors with excellent tumor exposure and extended biomarker activity von Zapf, Christoph W., Bloom, Jonathan D., McBean, Jamie L., Dushin, Russell G., Nittoli, Thomas, Otteng, Mercy, Ingalls, Charles, Golas, Jennifer M., Liu, Hao, Lucas, Judy, Boschelli, Frank, Hu, Yongbo, Vogan, Erik, Levin, Jeremy I.

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Non-hinge-binding pyrazolo[1,5- a]pyrimidines as potent B-Raf kinase inhibitors von Berger, Dan M., Torres, Nancy, Dutia, Minu, Powell, Dennis, Ciszewski, Greg, Gopalsamy, Ariamala, Levin, Jeremy I., Kim, Kyung-Hee, Xu, Weixin, Wilhelm, James, Hu, YongBo, Collins, Karen, Feldberg, Larry, Kim, Steven, Frommer, Eileen, Wojciechowicz, Donald, Mallon, Robert

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Novel pyrazolopyrimidines as highly potent B-Raf inhibitors von Di Grandi, Martin J., Berger, Dan M., Hopper, Darrin W., Zhang, Chunchun, Dutia, Minu, Dunnick, Alejandro L., Torres, Nancy, Levin, Jeremy I., Diamantidis, George, Zapf, Christoph W., Bloom, Jonathan D., Hu, YongBo, Powell, Dennis, Wojciechowicz, Donald, Collins, Karen, Frommer, Eileen

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Identification of potent and selective TACE inhibitors via the S1 pocket von Condon, Jeffrey S., Joseph-McCarthy, Diane, Levin, Jeremy I., Lombart, Henry-Georges, Lovering, Frank E., Sun, Linhong, Wang, Weiheng, Xu, Weixin, Zhang, Yuhua

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Identification of potent and selective MMP-13 inhibitors von Wu, Junjun, Rush, Thomas S., Hotchandani, Rajeev, Du, Xuemei, Geck, Mary, Collins, Elisabeth, Xu, Zhang-Bao, Skotnicki, Jerry, Levin, Jeremy I., Lovering, Frank E.

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Synthesis and SAR of highly selective MMP-13 inhibitors von Li, Jianchang, Rush, Thomas S., Li, Wei, DeVincentis, Dianne, Du, Xuemei, Hu, Yonghan, Thomason, Jennifer R., Xiang, Jason S., Skotnicki, Jerauld S., Tam, Steve, Cunningham, Kristina M., Chockalingam, Priya S., Morris, Elisabeth A., Levin, Jeremy I.

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Synthesis and activity of quinolinylmethyl P1′ α-sulfone piperidine hydroxamate inhibitors of TACE von Zhang, Chunchun, Lovering, Frank, Behnke, Mark, Zask, Arie, Sandanayaka, Vincent, Sun, Linhong, Zhu, Yi, Xu, Weixin, Zhang, Yuhua, Levin, Jeremy I.

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Structure-based design of TACE selective inhibitors: Manipulations in the S1′–S3′ pocket von Huang, Adrian, Joseph-McCarthy, Diane, Lovering, Frank, Sun, Linhong, Wang, Weiheng, Xu, Weixin, Zhu, Yi, Cui, Junqing, Zhang, Yuhua, Levin, Jeremy I.

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