Reversible glycosidic switch for secure delivery of molecular nanocargos von Burnouf, Pierre-Alain, Leu, Yu-Lin, Su, Yu-Cheng, Wu, Kenneth, Lin, Wei-Chi, Roffler, Steve R.

Volltext

Inhibition of gut microbial β-glucuronidase effectively prevents carcinogen-induced microbial dysbiosis and intestinal tumorigenesis von Cheng, Kai-Wen, Tseng, Chih-Hua, Chen, I.-Ju, Huang, Bo-Cheng, Liu, Hui-Ju, Ho, Kai-Wen, Lin, Wen-Wei, Chuang, Chih-Hung, Huang, Ming-Yii, Leu, Yu-Lin, Roffler, Steve R., Wang, Jaw-Yuan, Chen, Yeh-Long, Cheng, Tian-Lu

Volltext

Antiangiogenesis Targeting Tumor Microenvironment Synergizes Glucuronide Prodrug Antitumor Activity von JUAN, Ting-Yi, ROFFLER, Steve R, CHA, Tai-Lung, HOU, Hsien-San, HUANG, Shih-Ming, CHEN, Kai-Chuan, LEU, Yu-Lin, PRIJOVICH, Zeljko M, YU, Cheng-Ping, WU, Chang-Chieh, SUN, Guang-Huan

Volltext

Pharmacological inhibition of bacterial β-glucuronidase prevents irinotecan-induced diarrhea without impairing its antitumor efficacy in vivo von Cheng, Kai-Wen, Tseng, Chih-Hua, Tzeng, Cherng-Chyi, Leu, Yu-Lin, Cheng, Ta-Chun, Wang, Jaw-Yuan, Chang, Jia-Ming, Lu, Yun-Chi, Cheng, Chiu-Min, Chen, I-Ju, Cheng, Yi-An, Chen, Yeh-Long, Cheng, Tian-Lu

Volltext

Engineering stable and non-immunogenic immunoenzymes for cancer therapy via in situ generated prodrugs von Tseng, Yi-Han, Lin, Hsuan-Pei, Lin, Sung-Yao, Chen, Bing-Mae, Vo, Thanh Nguyet Nguyen, Yang, Shih-Hung, Lin, Yi-Chen, Prijovic, Zeljko, Czosseck, Andreas, Leu, Yu-Lin, Roffler, Steve R

Volltext

Specific Inhibition of Bacterial β‑Glucuronidase by Pyrazolo[4,3‑c]quinoline Derivatives via a pH-Dependent Manner To Suppress Chemotherapy-Induced Intestinal Toxicity von Cheng, Kai-Wen, Tseng, Chih-Hua, Yang, Chia-Ning, Tzeng, Cherng-Chyi, Cheng, Ta-Chun, Leu, Yu-Lin, Chuang, Yu-Chung, Wang, Jaw-Yuan, Lu, Yun-Chi, Chen, Yeh-Long, Cheng, Tian-Lu

Volltext

Discovery of Specific Inhibitors for Intestinal E. coli β-Glucuronidase through In Silico Virtual Screening von Chang, L. S., Cheng, Tian-Lu, Chen, Chien-Shu, Kao, Chien-Han, Huang, Chien-Chaio, Chuang, Chih-Hung, Leu, Yu-Lin, Cheng, Kai-Wen, Roffler, Steve R., Chuang, Kuo-Hsiang, Cheng, Ta-Chun, Hsieh, Yuan-Chin

Volltext

Synthesis and Antitumor Properties of BQC-Glucuronide, a Camptothecin Prodrug for Selective Tumor Activation von Prijovich, Zeljko M, Burnouf, Pierre-Alain, Chou, Hua-Cheng, Huang, Ping-Ting, Chen, Kai-Chuan, Cheng, Tian-Lu, Leu, Yu-Lin, Roffler, Steve R

Volltext

Effect of pH and human serum albumin on the cytotoxicity of a glucuronide prodrug of 9-aminocamptothecin von PRIJOVICH, Zeljko M, LEU, Yu-Lin, ROFFLER, Steve R

Volltext

Stability of the new prodrug 9-aminocamptothecin glucuronide (9ACG) in the presence of human serum albumin von Prijovich, Zeljko M., Leu, Yu-Lin, Roffler, Steve R.

Volltext

A Humanized Immunoenzyme with Enhanced Activity for Glucuronide Prodrug Activation in the Tumor Microenvironment von Chen, Kai-Chuan, Wu, Shih-Yen, Leu, Yu-Lin, Prijovich, Zeljko M, Chen, Bing-Mae, Wang, Hsin-Ell, Cheng, Tian-Lu, Roffler, Steve R

Volltext

ECSTASY, an adjustable membrane-tethered/soluble protein expression system for the directed evolution of mammalian proteins von Chen, Cheng-Pao, Hsieh, Yuan-Ting, Prijovich, Zeljko M., Chuang, Huai-Yao, Chen, Kai-Chuan, Lu, Wei-Cheng, Tseng, Qingzong, Leu, Yu-Lin, Cheng, Tian-Lu, Roffler, Steve R.

Volltext

Abstract A25: Humanized immunoenzyme with enhanced activity for glucuronide prodrug activation in the tumor microenvironment von Chen, Kaichuan, Leu, Yu-lin, Prijovich, Zeljko M., Roffler, Steve

Volltext

Directed Evolution of a Lysosomal Enzyme with Enhanced Activity at Neutral pH by Mammalian Cell-Surface Display von Chen, Kai-Chuan, Wu, Chia-Hung, Chang, Chuan-Yuan, Lu, Wei-Cheng, Tseng, Qingzong, Prijovich, Zeljko M., Schechinger, Wolfgang, Liaw, Yen-Chywan, Leu, Yu-Lin, Roffler, Steve R.

Volltext

Discovery of Specific Inhibitors for Intestinal E. coli [beta]-Glucuronidase through In Silico Virtual Screening von Ta-Chun, Cheng, Kuo-Hsiang Chuang, Roffler, Steve R, Kai-Wen, Cheng, Yu-Lin, Leu, Chih-Hung Chuang, Huang, Chien-Chaio, Chien-Han, Kao, Yuan-Chin, Hsieh, Long-Sen, Chang, Tian-Lu, Cheng, Chien-Shu, Chen

Volltext

P-352 Cure of human lung cancer xenografts by monotherapy with the new prodrug 9-aminocamptothecin glucoronide (9ACG) von Chen, Bing-Mae, Prijovich, Zeljko M., Leu, Yu-Lin, Chern, Ji-Wang, Roffler, Steve R.

Volltext

In vitro Studies of Functionalized Mesoporous Silica Nanoparticles for Photodynamic Therapy von Tu, Hsiung‐Lin, Lin, Yu‐Shen, Lin, Hsia‐Yu, Hung, Yann, Lo, Leu‐Wei, Chen, Yang‐Fang, Mou, Chung‐Yuan

Volltext

Implementing a Hand Gesture Recognition System Based on Range-Doppler Map von Jhaung, Yu-Chiao, Lin, Yu-Ming, Zha, Chiao, Leu, Jenq-Shiou, Köppen, Mario

Volltext

Diabetes mellitus and the risk of Alzheimer's disease: a nationwide population-based study von Huang, Chin-Chou, Chung, Chia-Min, Leu, Hsin-Bang, Lin, Liang-Yu, Chiu, Chun-Chih, Hsu, Chien-Yi, Chiang, Chia-Hung, Huang, Po-Hsun, Chen, Tzeng-Ji, Lin, Shing-Jong, Chen, Jaw-Wen, Chan, Wan-Leong

Volltext

Adipose-derived mesenchymal stem cell protects kidneys against ischemia-reperfusion injury through suppressing oxidative stress and inflammatory reaction von Chen, Yen-Ta, Sun, Cheuk-Kwan, Lin, Yu-Chun, Chang, Li-Teh, Chen, Yung-Lung, Tsai, Tzu-Hsien, Chung, Sheng-Ying, Chua, Sarah, Kao, Ying-Hsien, Yen, Chia-Hong, Shao, Pei-Lin, Chang, Kuan-Cheng, Leu, Steve, Yip, Hon-Kan

Volltext