Brain Delivery of Single-Domain Antibodies: A Focus on VHH and VNAR von Pothin, Elodie, Lesuisse, Dominique, Lafaye, Pierre

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An innovative strategy to identify new targets for delivering antibodies to the brain has led to the exploration of the integrin family von Cegarra, Céline, Cameron, Béatrice, Chaves, Catarina, Dabdoubi, Tarik, Do, Tuan-Minh, Genêt, Bruno, Roudières, Valérie, Shi, Yi, Tchepikoff, Patricia, Lesuisse, Dominique

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An innovative strategy to identify new targets for delivering antibodies to the brain has led to the exploration of the integrin family von Céline Cegarra, Béatrice Cameron, Catarina Chaves, Tarik Dabdoubi, Tuan-Minh Do, Bruno Genêt, Valérie Roudières, Yi Shi, Patricia Tchepikoff, Dominique Lesuisse

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The solute carrier SLC7A1 may act as a protein transporter at the blood-brain barrier von Kurtyka, Magdalena, Wessely, Frank, Bau, Sarah, Ifie, Eseoghene, He, Liqun, de Wit, Nienke M., Pedersen, Alberte Bay Villekjær, Keller, Maximilian, Webber, Caleb, de Vries, Helga E., Ansorge, Olaf, Betsholtz, Christer, De Bock, Marijke, Chaves, Catarina, Brodin, Birger, Nielsen, Morten S., Neuhaus, Winfried, Bell, Robert D., Letoha, Tamás, Meyer, Axel H., Leparc, Germán, Lenter, Martin, Lesuisse, Dominique, Cader, Zameel M., Buckley, Stephen T., Loryan, Irena, Pietrzik, Claus U.

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Efficient and Modular Synthesis of New Structurally Diverse Functionalized [n]Paracyclophanes by a Ring-Distortion Strategy von Krieger, Jean-Philippe, Ricci, Gino, Lesuisse, Dominique, Meyer, Christophe, Cossy, Janine

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Non-Human Primate Blood–Brain Barrier and In Vitro Brain Endothelium: From Transcriptome to the Establishment of a New Model von Chaves, Catarina, Do, Tuan-Minh, Cegarra, Céline, Roudières, Valérie, Tolou, Sandrine, Thill, Gilbert, Rocher, Corinne, Didier, Michel, Lesuisse, Dominique

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Tetravalent Bispecific Tandem Antibodies Improve Brain Exposure and Efficacy in an Amyloid Transgenic Mouse Model von Do, Tuan-Minh, Capdevila, Cécile, Pradier, Laurent, Blanchard, Véronique, Lopez-Grancha, Mati, Schussler, Nathalie, Steinmetz, Anke, Beninga, Jochen, Boulay, Denis, Dugay, Philippe, Verdier, Patrick, Aubin, Nadine, Dargazanli, Gihad, Chaves, Catarina, Genet, Elisabeth, Lossouarn, Yves, Loux, Christophe, Michoux, François, Moindrot, Nicolas, Chanut, Franck, Gury, Thierry, Eyquem, Stéphanie, Valente, Delphine, Bergis, Olivier, Rao, Ercole, Lesuisse, Dominique

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Peptidomics of Haemonchus contortus von Buzy, Armelle, Allain, Camille, Harrington, John, Lesuisse, Dominique, Mikol, Vincent, Bruhn, David F, Maule, Aaron G, Guillemot, Jean-Claude

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Data on synthesis, ADME and pharmacological properties and early safety pharmacology evaluation of a series of novel NURR1/NOT agonist potentially useful for the treatment of Parki... von Malanda, André, Abécassis, Pierre-Yves, Barnéoud, Pascal, Brunel, Pascale, Taupin, Véronique, Vigé, Xavier, Lesuisse, Dominique

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Design of Potent IGF1-R Inhibitors Related to Bis-azaindoles von Nemecek, Conception, Metz, William A., Wentzler, Sylvie, Ding, Fa-Xiang, Venot, Corinne, Souaille, Catherine, Dagallier, Anne, Maignan, Sébastien, Guilloteau, Jean-Pierre, Bernard, François, Henry, Alain, Grapinet, Sandrine, Lesuisse, Dominique

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SAR and X-ray. A New Approach Combining Fragment-Based Screening and Rational Drug Design:  Application to the Discovery of Nanomolar Inhibitors of Src SH2 von Lesuisse, Dominique, Lange, Gudrun, Deprez, Pierre, Bénard, Didier, Schoot, Bernard, Delettre, Georges, Marquette, Jean-Pierre, Broto, Pierre, Jean-Baptiste, Véronique, Bichet, Paulette, Sarubbi, Edoardo, Mandine, Eliane

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Rhodium(III)-Catalyzed C–H Activation/Heterocyclization as a Macrocyclization Strategy. Synthesis of Macrocyclic Pyridones von Krieger, Jean-Philippe, Lesuisse, Dominique, Ricci, Gino, Perrin, Marc-Antoine, Meyer, Christophe, Cossy, Janine

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Unbound Brain-to-Plasma Partition Coefficient, Kp,uu,brain—a Game Changing Parameter for CNS Drug Discovery and Development von Loryan, Irena, Reichel, Andreas, Feng, Bo, Bundgaard, Christoffer, Shaffer, Christopher, Kalvass, Cory, Bednarczyk, Dallas, Morrison, Denise, Lesuisse, Dominique, Hoppe, Edmund, Terstappen, Georg C., Fischer, Holger, Di, Li, Colclough, Nicola, Summerfield, Scott, Buckley, Stephen T., Maurer, Tristan S., Fridén, Markus

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Efficient and Modular Synthesis of New Structurally Diverse Functionalized [n]Paracyclophanes by a Ring-Distortion Strategy von Krieger, Jean-Philippe, Ricci, Gino, Lesuisse, Dominique, Meyer, Christophe, Cossy, Janine

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Harnessing C−H Activation of Benzhydroxamates as a Macrocyclization Strategy: Synthesis of Structurally Diverse Macrocyclic Isoquinolones von Krieger, Jean-Philippe, Ricci, Gino, Lesuisse, Dominique, Meyer, Christophe, Cossy, Janine

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Unbound Brain-to-Plasma Partition Coefficient, K-p,K-uu,K-brain-a Game Changing Parameter for CNS Drug Discovery and Development von Loryan, Irena, Reichel, Andreas, Feng, Bo, Bundgaard, Christoffer, Shaffer, Christopher, Kalvass, Cory, Bednarczyk, Dallas, Morrison, Denise, Lesuisse, Dominique, Hoppe, Edmund, Terstappen, Georg C., Fischer, Holger, Di, Li, Colclough, Nicola, Summerfield, Scott, Buckley, Stephen T., Maurer, Tristan S., Fridén, Markus

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New formats for improving brain drug delivery of antibodies: the blood-brain barrier case von Lafaye, Pierre, Lesuisse, Dominique, Declèves, Xavier

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Development of a novel NURR1/NOT agonist from hit to lead and candidate for the potential treatment of Parkinson's disease von Lesuisse, Dominique, Malanda, André, Peyronel, Jean-François, Evanno, Yannick, Lardenois, Patrick, De-Peretti, Danielle, Abécassis, Pierre-Yves, Barnéoud, Pascal, Brunel, Pascale, Burgevin, Marie-Claude, Cegarra, Céline, Auger, Florian, Dommergue, Amélie, Lafon, Corinne, Even, Luc, Tsi, Joanna, Luc, Thy Phuong Hieu, Almario, Antonio, Olivier, Anne, Castel, Marie-Noëlle, Taupin, Véronique, Rooney, Thomas, Vigé, Xavier

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Améliorer le ciblage tissulaire des anticorps thérapeutiques par de nouveaux formats: L’exemple de la barrière hémato-encéphalique von Lafaye, Pierre, Lesuisse, Dominique, Declèves, Xavier

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Améliorer le ciblage tissulaire des anticorps thérapeutiques par de nouveaux formats von Lafaye, Pierre, Lesuisse, Dominique, Declèves, Xavier

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