ALARM NMR:  A Rapid and Robust Experimental Method To Detect Reactive False Positives in Biochemical Screens von Huth, Jeffrey R, Mendoza, Renaldo, Olejniczak, Edward T, Johnson, Robert W, Cothron, Darlene A, Liu, Yaya, Lerner, Claude G, Chen, Jun, Hajduk, Philip J

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An Ultraefficient Affinity-Based High-Throughout Screening Process: Application to Bacterial Cell Wall Biosynthesis Enzyme MurF von Comess, Kenneth M., Schurdak, Mark E., Voorbach, Martin J., Coen, Michael, Trumbull, Jonathan D., Yang, Houjun, Gao, Lan, Tang, Hua, Cheng, Xueheng, Lerner, Claude G., Mccall, J. Owen, Burns, David J., Beutel, Bruce A.

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Novel Approach to Mapping of Resistance Mutations in Whole Genomes by Using Restriction Enzyme Modulation of Transformation Efficiency von LERNER, Claude G, KAKAVAS, Stephan J, WAGNER, Christian, CHANG, Richard T, MERTA, Philip J, XIAOAN RUAN, METZGER, Randy E, BEUTEL, Bruce A

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DNA Cleavage Activities of Staphylococcus aureus Gyrase and Topoisomerase IV Stimulated by Quinolones and 2-Pyridones von SAIKI, A. Y. C, SHEN, L. L, CHEN, C.-M, BARANOWSKI, J, LERNER, C. G

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Structure of MurF from Streptococcus pneumoniae co‐crystallized with a small molecule inhibitor exhibits interdomain closure von Longenecker, Kenton L., Stamper, Geoffrey F., Hajduk, Philip J., Fry, Elizabeth H., Jakob, Clarissa G., Harlan, John E., Edalji, Rohinton, Bartley, Diane M., Walter, Karl A., Solomon, Larry R., Holzman, Thomas F., Gu, Yu Gui, Lerner, Claude G., Beutel, Bruce A., Stoll, Vincent S.

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Discovery of Potent Inhibitors of Dihydroneopterin Aldolase Using CrystaLEAD High-Throughput X-ray Crystallographic Screening and Structure-Directed Lead Optimization von Sanders, William J, Nienaber, Vicki L, Lerner, Claude G, McCall, J. Owen, Merrick, Sean M, Swanson, Susan J, Harlan, John E, Stoll, Vincent S, Stamper, Geoffrey F, Betz, Stephen F, Condroski, Kevin R, Meadows, Robert P, Severin, Jean M, Walter, Karl A, Magdalinos, Peter, Jakob, Clarissa G, Wagner, Rolf, Beutel, Bruce A

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Structure–activity relationships of novel potent MurF inhibitors von Gu, Yu Gui, Florjancic, Alan S., Clark, Richard F., Zhang, Tianyuan, Cooper, Curt S., Anderson, David D., Lerner, Claude G., McCall, J.Owen, Cai, Yingna, Black-Schaefer, Candace L., Stamper, Geoffrey F., Hajduk, Philip J., Beutel, Bruce A.

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Structure-based Optimization of MurF Inhibitors von Stamper, Geoffrey F., Longenecker, Kenton L., Fry, Elizabeth H., Jakob, Clarissa G., Florjancic, Alan S., Gu, Yu-Gui, Anderson, David D., Cooper, Curt S., Zhang, Tianyuan, Clark, Richard F., Cia, Yingna, Black-Schaefer, Candace L., Owen McCall, J., Lerner, Claude G., Hajduk, Philip J., Beutel, Bruce A., Stoll, Vincent S.

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Solution structure and function of an essential CMP kinase of Streptococcus pneumoniae von Yu, Liping, Mack, Jamey, Hajduk, Philip J., Kakavas, Steve J., Saiki, Anne Y.C., Lerner, Claude G., Olejniczak, Edward T.

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Novel inhibitors of bacterial protein synthesis: structure–activity relationships for 1,8-naphthyridine derivatives incorporating position 3 and 4 variants von Clark, Richard F., Wang, Sanyi, Ma, Zhenkun, Weitzberg, Moshe, Motter, Christopher, Tufano, Michael, Wagner, Rolf, Gu, Yu-Gui, Dandliker, Peter J., Lerner, Claude G., Chovan, Linda E., Cai, Yingna, Black-Schaefer, Candace L., Lynch, Linda, Kalvin, Douglas, Nilius, Angela M., Pratt, Steve D., Soni, Niru, Zhang, Tianyuan, Zhang, Xiaolin, Beutel, Bruce A.

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A Strategy for High-Throughput Assay Development Using Leads Derived from Nuclear Magnetic Resonance-Based Screening von Hajduk, Philip J., Betz, Stephen F., Mack, Jamey, Ruan, Xiaoan, Towne, Danli L., Lerner, Claude G., Beutel, Bruce A., Fesik, Stephen W.

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A Strategy for Discovery of Novel Broad-Spectrum Antibacterials Using a High-Throughput Streptococcus pneumoniae Transcription/Translation Screen von Pratt, Steven D., David, Caroline A., Black-Schaefer, Candace, Dandliker, Peter J., Xuei, Xiaoling, Warrior, Usha, Burns, David J., Zhong, Ping, Cao, Zhensheng, Saiki, Anne Y.C., Lerner, Claude G., Chovan, Linda E., Soni, Niru B., Nilius, Angela M., Wagenaar, Frank L., Merta, Philip J., Traphagen, Linda M., Beutel, Bruce A.

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Cold-sensitive conditional mutations in Era, an essential Escherichia coli GTPase, isolated by localized random polymerase chain reaction mutagenesis von Lerner, Claude G, Gulati, Poonam S, Inouye, Masayori

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Application of a fluorogenic substrate in the assay of proteolytic activity and in the discovery of a potent inhibitor of Candida albicans aspartic proteinase von Capobianco, John O., Lerner, Claude G., Goldman, Robert C.

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Low copy number plasmids for regulated low-level expression of cloned genes in Escherichia coli with blue/white insert screening capability von LERNER, C. G, INOUYE, M

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High Throughput Screen for Inhibitors of Bacterial DNA Topoisomerase I Using the Scintillation Proximity Assay von Lerner, Claude G., Chiang Saiki, Anne Y., Craig Mackinnon, A., Xuei, Xiaoling

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Solution structure and function of a conserved protein SP14.3 encoded by an essential Streptococcus pneumoniae gene von Yu, L, Gunasekera, A H, Mack, J, Olejniczak, E T, Chovan, L E, Ruan, X, Towne, D L, Lerner, C G, Fesik, S W

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From Bacterial Genomes to Novel Antibacterial Agents: Discovery, Characterization, and Antibacterial Activity of Compounds that Bind to HI0065 (YjeE) from Haemophilus influenzae von Lerner, Claude G., Hajduk, Philip J., Wagner, Rolf, Wagenaar, Frank L., Woodall, Charlotte, Gu, Yu‐Gui, Searle, Xenia B., Florjancic, Alan S., Zhang, Tianyuan, Clark, Richard F., Cooper, Curt S., Mack, Jamey C., Yu, Liping, Cai, Mengli, Betz, Steven F., Chovan, Linda E., McCall, J. Owen, Black‐Schaefer, Candace L., Kakavas, Stephan J., Schurdak, Mark E., Comess, Kenneth M., Walter, Karl A., Edalji, Rohinton, Dorwin, Sarah A., Smith, Richard A., Hebert, Eric J., Harlan, John E., Metzger, Randy E., Merta, Philip J., Baranowski, John L., Coen, Michael L., Thornewell, Susan J., Shivakumar, Annapur G., Saiki, Anne Y., Soni, Niru, Bui, Mai, Balli, Darlene J., Sanders, William J., Nilius, Angela M., Holzman, Thomas F., Fesik, Stephen W., Beutel, Bruce A.

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Nucleoside diphosphate kinase from Escherichia coli; its overproduction and sequence comparison with eukaryotic enzymes von Hama, Hiroko, Almaula, Niva, Lerner, Claude G., Inouye, Sumiko, Inouye, Masayori

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Characterization of the autophosphorylation of Era, an essential Escherichia coli GTPase von Sood, Poonam, Lerner, Claude G., Shimamoto, Toshi, Lu, Qing, Inouye, Masayori

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