Intravenous but not intrathecal central nervous system–directed chemotherapy improves survival in patients with testicular diffuse large B-cell lymphoma von Mannisto, S., Vähämurto, P., Pollari, M., Clausen, M.R., Jyrkkiö, S., Kellokumpu-Lehtinen, P.-L., Kovanen, P., Karjalainen-Lindsberg, M.-L., d’Amore, F., Leppä, S.

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TOBACCO SMOKING IMPAIRS SURVIVAL IN LYMPHOMA PATIENTS IN TWO FINNISH POPULATION‐BASED COHORTS von Reunamo, T., Mikkola, T., Laitinen, T., Bärlund, M., Österlund, P., Alanne, E., Jyrkkiö, S., Leppä, S., Minn, H., Heervä, E.

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Enhanced ctDNA Profiling Reveals Molecular Determinants of Response and Resistance in Relapsed and Refractory Mantle Cell Lymphoma (NLG‐MCL7‐VALERIA) von Meriranta, L., Kolstad, A., Hutchings, M., Pasanen, A., Niemann, C. Utoft, Riise, J., Christensen, J. Haaber, Wader, K. Fahl, Glimelius, I., Leppä, S., Jerkeman, M.

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CHARACTERIZATION OF CANCER ASSOCIATED FIBROBLASTS IN CLASSICAL HODGKIN LYMPHOMA von Karihtala, K., Leivonen, S.‐K., Karjalainen‐Lindsberg, M.‐L., Östman, A., Pellinen, T., Leppä, S.

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Final safety and efficacy results of copanlisib monotherapy in patients with relapsed or refractory iNHL: 6‐year follow‐up of CHRONOS‐1 von Dreyling, M., Santoro, A., Mollica, L., Leppä, S., Follows, G. A., Lenz, G., Kim, W. S., Nagler, A., Panayiotidis, P., Demeter, J., Özcan, M., Kosinova, M., Provencio, M., Magagnoli, M., Bouabdallah, K., Heo, D. S., Diong, C. P., Munoz, J., Cao, A., Hiemeyer, F., Odongo, F., Garcia‐Vargas, J., Childs, B. H., Zinzani, P. L.

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GLOFITAMAB MONOTHERAPY IN PATIENTS WITH RELAPSED/REFRACTORY (R/R) LARGE B‐CELL LYMPHOMA (LBCL): EXTENDED FOLLOW‐UP AND LANDMARK ANALYSES FROM A PIVOTAL PHASE II STUDY von Dickinson, M., Carlo‐Stella, C., Morschhauser, F., Falchi, L., Bachy, E., Cartron, G., Khan, C., Tani, M., Martinez‐Lopez, J., Bartlett, N., Salar, A., Brody, J., Leppä, S., Mulvihill, E., Lundberg, L., Relf, J., Xie, Y., Bottos, A., Humphrey, K., Hutchings, M.

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Alternative splicing discriminates molecular subtypes and has prognostic impact in diffuse large B-cell lymphoma von Leivonen, S-K, Taskinen, M, Cervera, A, Karjalainen-Lindsberg, M-L, Delabie, J, Holte, H, Lehtonen, R, Hautaniemi, S, Leppä, S

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Up-front rituximab maintenance improves outcome in patients with follicular lymphoma: a collaborative Nordic study von Madsen, C., Clausen, M.R., Plesner, T.L., Pasanen, A., Kuismanen, T., Bentzen, H.H., Jørgensen, J.M., Sillesen, I.B., Himmelstrup, B.M., Rønnov-Jessen, D., Jensen, K.R., Pettinger, A.M., Ludvigsen, M., Leppä, S., d'Amore, F.A.

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P1135: SUBCUTANEOUS EPCORITAMAB IN COMBINATION WITH RITXUIMAB + LENALIDOMIDE IN RELAPSED OR REFRACTORY FOLLICULAR LYMPHOMA: PHASE 1/2 TRIAL UPDATE von Belada, D., Leppä, S., Wahlin, B. E., Nijland, M., Christensen, J. H., Vos, S., Holte, H., Linton, K. M., Abbas, A., Wang, L., Dinh, M., Elliott, B., Falchi, L.

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CLINICAL SIGNIFICANCE OF T‐CELL EXHAUSTION IN PATIENTS WITH DIFFUSE LARGE B‐CELL LYMPHOMA von Leppä, S., Autio, M., Brück, O., Mustjoki, S., Jørgensen, J., Karjalainen‐Lindsberg, M., Beiske, K., Holte, H., Pellinen, T., Leivonen, S.

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Molecular features encoded in the ctDNA reveal heterogeneity and predict outcome in high-risk aggressive B-cell lymphoma von Meriranta, Leo, Alkodsi, Amjad, Pasanen, Annika, Lepistö, Maija, Mapar, Parisa, Blaker, Yngvild Nuvin, Jørgensen, Judit, Karjalainen-Lindsberg, Marja-Liisa, Fiskvik, Idun, Mikalsen, Lars Tore G., Autio, Matias, Björkholm, Magnus, Jerkeman, Mats, Fluge, Øystein, Brown, Peter, Jyrkkiö, Sirkku, Holte, Harald, Pitkänen, Esa, Ellonen, Pekka, Leppä, Sirpa

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SAFETY ANALYSIS OF PATIENTS WITH A MEDICAL HISTORY OF RESPIRATORY DISORDERS TREATED WITH COPANLISIB FROM THE CHRONOS‐1 STUDY IN RELAPSED OR REFRACTORY INDOLENT B‐CELL LYMPHOMA von Zinzani, P.L., Santoro, A., Leppä, S., Demeter, J., Follows, G.A., Lenz, G., Kim, W.S., Mollica, L., Nagler, A., Phipps Diong, C., Provencio, M., Magagnoli, M., Munoz, J., Miriyala, A., Liu, L., Zhang, M., Garcia‐Vargas, J., Childs, B.H., Dreyling, M.

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YOUNG HIGH RISK PATIENTS WITH DIFFUSE LARGE B‐CELL LYMPHOMA INCLUDING BCL‐2/MYC DOUBLE HIT LYMPHOMAS BENEFIT FROM DOSE‐DENSE IMMUNOCHEMOTHERAPY WITH EARLY CNS PROPHYLAXIS von Leppä, S., Jørgensen, J., Tierens, A., Meriranta, L., Østlie, I., Brown, P., Fagerli, U., Larsen, T.S., Mannisto, S., Munksgaard, L., Maisenhølder, M., Vasala, K., Meyer, P., Jerkeman, M., Björkholm, M., Fluge, Ø., Jyrkkiö, S., Ralfkiaer, E., Spetalen, S., Karjalainen‐Lindsberg, M., Holte, H.

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EFFICACY AND SAFETY IN HIGH‐RISK RELAPSED OR REFRACTORY INDOLENT FOLLICULAR LYMPHOMA PATIENTS TREATED WITH COPANLISIB von Dreyling, M., Santoro, A., Leppä, S., Demeter, J., Follows, G.A., Lenz, G., Kim, W.S., Mollica, L., Nagler, A., Phipps Diong, C., Provencio, M., Magagnoli, M., Munoz, J., Hiemeyer, F., Liu, L., Miriyala, A., Rodrigues, L., Garcia‐Vargas, J., Childs, B.H., Zinzani, P.L.

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Diverse functions of JNK signaling and c-Jun in stress response and apoptosis von Leppä, S, Bohmann, D

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Efficacy and safety of glycosphingolipid SSEA-4 targeting CAR-T cells in an ovarian carcinoma model von Monzo, Hector J, Kalander, Kerttu, Hyytiäinen, Marko M, Elbasani, Endrit, Wall, Johanna, Moyano-Galceran, Lidia, Tanjore Ramanathan, Jayendrakishore, Jukonen, Joonas J J, Laakkonen, Pirjo, Ristimäki, Ari, Carlson, Joseph W, Lehti, Kaisa, Salehi, Sahar, Puolakkainen, Pauli, Haglund, Caj, Seppänen, Hanna, Leppä, Sirpa, Ojala, Päivi M

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Prognostic impact of immunohistochemically defined germinal center phenotype in diffuse large B-cell lymphoma patients treated with immunochemotherapy von Nyman, Heidi, Adde, Magdalena, Karjalainen-Lindsberg, Marja-Liisa, Taskinen, Minna, Berglund, Mattias, Amini, Rose-Marie, Blomqvist, Carl, Enblad, Gunilla, Leppä, Sirpa

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ICE (ifosfamide, carboplatin, etoposide) as second-line chemotherapy in relapsed or primary progressive aggressive lymphoma - the Nordic Lymphoma Group experience von Jerkeman, M, Leppä, S, Kvaløy, S, Holte, H

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Long‐term safety and efficacy of the PI3K inhibitor copanlisib in patients with relapsed or refractory indolent lymphoma: 2‐year follow‐up of the CHRONOS‐1 study von Dreyling, Martin, Santoro, Armando, Mollica, Luigina, Leppä, Sirpa, Follows, George, Lenz, Georg, Kim, Won Seog, Nagler, Arnon, Dimou, Maria, Demeter, Judit, Özcan, Muhit, Kosinova, Marina, Bouabdallah, Krimo, Morschhauser, Franck, Stevens, Don A., Trevarthen, David, Munoz, Javier, Rodrigues, Liana, Hiemeyer, Florian, Miriyala, Ashok, Garcia‐Vargas, Jose, Childs, Barrett H., Zinzani, Pier Luigi

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Differential regulation of c-Jun by ERK and JNK during PC12 cell differentiation von Leppä, Sirpa, Saffrich, Rainer, Ansorge, Wilhelm, Bohmann, Dirk

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