Longitudinal single-cell RNA sequencing of patient-derived primary cells reveals drug-induced infidelity in stem cell hierarchy von Sharma, Ankur, Cao, Elaine Yiqun, Kumar, Vibhor, Zhang, Xiaoqian, Leong, Hui Sun, Wong, Angeline Mei Lin, Ramakrishnan, Neeraja, Hakimullah, Muhammad, Teo, Hui Min Vivian, Chong, Fui Teen, Chia, Shumei, Thangavelu, Matan Thangavelu, Kwang, Xue Lin, Gupta, Ruta, Clark, Jonathan R., Periyasamy, Giridharan, Iyer, N. Gopalakrishna, DasGupta, Ramanuj

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A KRAS-responsive long non-coding RNA controls microRNA processing von Shi, Lei, Magee, Peter, Fassan, Matteo, Sahoo, Sudhakar, Leong, Hui Sun, Lee, Dave, Sellers, Robert, Brullé-Soumaré, Laura, Cairo, Stefano, Monteverde, Tiziana, Volinia, Stefano, Smith, Duncan D., Di Leva, Gianpiero, Galuppini, Francesca, Paliouras, Athanasios R., Zeng, Kang, O’Keefe, Raymond, Garofalo, Michela

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Pre-clinical activity of combined LSD1 and mTORC1 inhibition in MLL-translocated acute myeloid leukaemia von Deb, Gauri, Wingelhofer, Bettina, Amaral, Fabio M. R., Maiques-Diaz, Alba, Chadwick, John A., Spencer, Gary J., Williams, Emma L., Leong, Hui-Sun, Maes, Tamara, Somervaille, Tim C. P.

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Phenotype-driven precision oncology as a guide for clinical decisions one patient at a time von Chia, Shumei, Low, Joo-Leng, Zhang, Xiaoqian, Kwang, Xue-Lin, Chong, Fui-Teen, Sharma, Ankur, Bertrand, Denis, Toh, Shen Yon, Leong, Hui-Sun, Thangavelu, Matan T., Hwang, Jacqueline S. G., Lim, Kok-Hing, Skanthakumar, Thakshayeni, Tan, Hiang-Khoon, Su, Yan, Hui Choo, Siang, Hentze, Hannes, Tan, Iain B. H., Lezhava, Alexander, Tan, Patrick, Tan, Daniel S. W., Periyasamy, Giridharan, Koh, Judice L. Y., Gopalakrishna Iyer, N., DasGupta, Ramanuj

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Analysis of circulating cell-free DNA identifies KRAS copy number gain and mutation as a novel prognostic marker in Pancreatic cancer von Mohan, Sumitra, Ayub, Mahmood, Rothwell, Dominic G., Gulati, Sakshi, Kilerci, Bedirhan, Hollebecque, Antoine, Sun Leong, Hui, Smith, Nigel K., Sahoo, Sudhakar, Descamps, Tine, Zhou, Cong, Hubner, Richard A., McNamara, Mairéad G., Lamarca, Angela, Valle, Juan W., Dive, Caroline, Brady, Ged

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Vulnerability of drug‐resistant EML4‐ALK rearranged lung cancer to transcriptional inhibition von Paliouras, Athanasios R, Buzzetti, Marta, Shi, Lei, Donaldson, Ian J, Magee, Peter, Sahoo, Sudhakar, Leong, Hui‐Sun, Fassan, Matteo, Carter, Matthew, Di Leva, Gianpiero, Krebs, Matthew G, Blackhall, Fiona, Lovly, Christine M, Garofalo, Michela

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A chemical genetic screen identifies Aurora kinases as a therapeutic target in EGFR T790M negative, gefitinib-resistant head and neck squamous cell carcinoma (HNSCC) von Low, Joo-Leng, Lau, Dawn Pingxi, Zhang, Xiaoqian, Kwang, Xue-Lin, Rohatgi, Neha, Chan, Jane Vin, Chong, Fui-Teen, Wong, Stephen Qi Rong, Leong, Hui-Sun, Thangavelu, Matan Thangavelu, Rikka, Shivaji, Skanderup, Anders Martin Jacobsen, Tan, Daniel Shao Weng, Periyasamy, Giridharan, Koh, Judice Lie Yong, Iyer, N Gopalakrishna, DasGupta, Ramanuj

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Oncogenic KRAS Regulates Tumor Cell Signaling via Stromal Reciprocation von Tape, Christopher J., Ling, Stephanie, Dimitriadi, Maria, McMahon, Kelly M., Worboys, Jonathan D., Leong, Hui Sun, Norrie, Ida C., Miller, Crispin J., Poulogiannis, George, Lauffenburger, Douglas A., Jørgensen, Claus

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Hit screening with multivariate robust outlier detection von Leong, Hui Sun, Zhang, Tianhui, Corrigan, Adam, Serrano, Alessia, Künzel, Ulrike, Mullooly, Niamh, Wiggins, Ceri, Wang, Yinhai, Novick, Steven

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Vasculogenic mimicry in small cell lung cancer von Williamson, Stuart C., Metcalf, Robert L., Trapani, Francesca, Mohan, Sumitra, Antonello, Jenny, Abbott, Benjamin, Leong, Hui Sun, Chester, Christopher P. E., Simms, Nicole, Polanski, Radoslaw, Nonaka, Daisuke, Priest, Lynsey, Fusi, Alberto, Carlsson, Fredrika, Carlsson, Anders, Hendrix, Mary J. C., Seftor, Richard E. B., Seftor, Elisabeth A., Rothwell, Dominic G., Hughes, Andrew, Hicks, James, Miller, Crispin, Kuhn, Peter, Brady, Ged, Simpson, Kathryn L., Blackhall, Fiona H., Dive, Caroline

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Long noncoding RNA EGFR-AS1 mediates epidermal growth factor receptor addiction and modulates treatment response in squamous cell carcinoma von Tan, Daniel S W, Chong, Fui Teen, Leong, Hui Sun, Toh, Shen Yon, Lau, Dawn P, Kwang, Xue Lin, Zhang, Xiaoqian, Sundaram, Gopinath M, Tan, Gek San, Chang, Mei Mei, Chua, Boon Tin, Lim, Wan Teck, Tan, Eng Huat, Ang, Mei Kim, Lim, Tony K H, Sampath, Prabha, Chowbay, Balram, Skanderup, Anders J, DasGupta, Ramanuj, Iyer, N Gopalakrishna

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Single cell analysis in head and neck cancer reveals potential immune evasion mechanisms during early metastasis von Quah, Hong Sheng, Cao, Elaine Yiqun, Suteja, Lisda, Li, Constance H., Leong, Hui Sun, Chong, Fui Teen, Gupta, Shilpi, Arcinas, Camille, Ouyang, John F., Ang, Vivian, Celhar, Teja, Zhao, Yunqian, Tay, Hui Chen, Chan, Jerry, Takahashi, Takeshi, Tan, Daniel S. W., Biswas, Subhra K., Rackham, Owen J. L., Iyer, N. Gopalakrishna

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PDGFR-modulated miR-23b cluster and miR-125a-5p suppress lung tumorigenesis by targeting multiple components of KRAS and NF-kB pathways von Naidu, Srivatsava, Shi, Lei, Magee, Peter, Middleton, Justin D., Laganá, Alessandro, Sahoo, Sudhakar, Leong, Hui Sun, Galvin, Melanie, Frese, Kristopher, Dive, Caroline, Guzzardo, Vincenza, Fassan, Matteo, Garofalo, Michela

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Targeting Cancer Stem Cell Plasticity Through Modulation of Epidermal Growth Factor and Insulin‐Like Growth Factor Receptor Signaling in Head and Neck Squamous Cell Cancer von Leong, Hui Sun, Chong, Fui Teen, Sew, Pui Hoon, Lau, Dawn P., Wong, Bernice H., Teh, Bin-Tean, Tan, Daniel S.W., Iyer, N. Gopalakrishna

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High-throughput immunoglobulin repertoire analysis distinguishes between human IgM memory and switched memory B-cell populations von Wu, Yu-Chang, Kipling, David, Leong, Hui Sun, Martin, Victoria, Ademokun, Alexander A., Dunn-Walters, Deborah K.

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Genetic profiling of tumours using both circulating free DNA and circulating tumour cells isolated from the same preserved whole blood sample von Rothwell, Dominic G., Smith, Nigel, Morris, Daniel, Leong, Hui Sun, Li, Yaoyong, Hollebecque, Antoine, Ayub, Mahmood, Carter, Louise, Antonello, Jenny, Franklin, Lynsey, Miller, Crispin, Blackhall, Fiona, Dive, Caroline, Brady, Ged

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Paracrine Factors of Human Fetal MSCs Inhibit Liver Cancer Growth Through Reduced Activation of IGF-1R/PI3K/Akt Signaling von Yulyana, Yulyana, Ho, Ivy A W, Sia, Kian Chuan, Newman, Jennifer P, Toh, Xin Yi, Endaya, Berwini B, Chan, Jerry K Y, Gnecchi, Massimiliano, Huynh, Hung, Chung, Alexander Y F, Lim, Kiat Hon, Leong, Hui Sun, Iyer, Narayanan Gopalakrishna, Hui, Kam Man, Lam, Paula Y P

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KRAS induces lung tumorigenesis through microRNAs modulation von Shi, Lei, Middleton, Justin, Jeon, Young-Jun, Magee, Peter, Veneziano, Dario, Laganà, Alessandro, Leong, Hui-Sun, Sahoo, Sudhakar, Fassan, Matteo, Booton, Richard, Shah, Rajesh, Crosbie, Philip A. J., Garofalo, Michela

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Frequent Derepression of the Mesenchymal Transcription Factor Gene FOXC1 in Acute Myeloid Leukemia von Somerville, Tim D.D., Wiseman, Daniel H., Spencer, Gary J., Huang, Xu, Lynch, James T., Leong, Hui Sun, Williams, Emma L., Cheesman, Edmund, Somervaille, Tim C.P.

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RUNX1B Expression Is Highly Heterogeneous and Distinguishes Megakaryocytic and Erythroid Lineage Fate in Adult Mouse Hematopoiesis von Draper, Julia E, Sroczynska, Patrycja, Tsoulaki, Olga, Leong, Hui Sun, Fadlullah, Muhammad Z H, Miller, Crispin, Kouskoff, Valerie, Lacaud, Georges

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