Humanized Mouse Models of Clinical Disease von Walsh, Nicole C, Kenney, Laurie L, Jangalwe, Sonal, Aryee, Ken-Edwin, Greiner, Dale L, Brehm, Michael A, Shultz, Leonard D

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Dual roles of neutrophils in metastatic colonization are governed by the host NK cell status von Li, Peishan, Lu, Ming, Shi, Jiayuan, Hua, Li, Gong, Zheng, Li, Qing, Shultz, Leonard D., Ren, Guangwen

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MEK Guards Proteome Stability and Inhibits Tumor-Suppressive Amyloidogenesis via HSF1 von Tang, Zijian, Dai, Siyuan, He, Yishu, Doty, Rosalinda A., Shultz, Leonard D., Sampson, Stephen Byers, Dai, Chengkai

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Humanized mice in translational biomedical research von Shultz, Leonard D, Ishikawa, Fumihiko, Greiner, Dale L

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Humanized mice in studying efficacy and mechanisms of PD‐1‐targeted cancer immunotherapy von Wang, Minan, Yao, Li‐Chin, Cheng, Mingshan, Cai, Danying, Martinek, Jan, Pan, Chong‐Xian, Shi, Wei, Ma, Ai‐Hong, Vere White, Ralph W., Airhart, Susan, Liu, Edison T., Banchereau, Jacques, Brehm, Michael A., Greiner, Dale L., Shultz, Leonard D., Palucka, Karolina, Keck, James G.

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Convergent Mutations and Kinase Fusions Lead to Oncogenic STAT3 Activation in Anaplastic Large Cell Lymphoma von Crescenzo, Ramona, Abate, Francesco, Lasorsa, Elena, Tabbo’, Fabrizio, Gaudiano, Marcello, Chiesa, Nicoletta, Di Giacomo, Filomena, Spaccarotella, Elisa, Barbarossa, Luigi, Ercole, Elisabetta, Todaro, Maria, Boi, Michela, Acquaviva, Andrea, Ficarra, Elisa, Novero, Domenico, Rinaldi, Andrea, Tousseyn, Thomas, Rosenwald, Andreas, Kenner, Lukas, Cerroni, Lorenzo, Tzankov, Alexander, Ponzoni, Maurilio, Paulli, Marco, Weisenburger, Dennis, Chan, Wing C., Iqbal, Javeed, Piris, Miguel A., Zamo’, Alberto, Ciardullo, Carmela, Rossi, Davide, Gaidano, Gianluca, Pileri, Stefano, Tiacci, Enrico, Falini, Brunangelo, Shultz, Leonard D., Mevellec, Laurence, Vialard, Jorge E., Piva, Roberto, Bertoni, Francesco, Rabadan, Raul, Inghirami, Giorgio

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AK002, a Humanized Sialic Acid-Binding Immunoglobulin-Like Lectin-8 Antibody that Induces Antibody-Dependent Cell-Mediated Cytotoxicity against Human Eosinophils and Inhibits Mast... von Youngblood, Bradford A., Brock, Emily C., Leung, John, Falahati, Rustom, Bryce, Paul J., Bright, Jessica, Williams, Jason, Shultz, Leonard D., Greiner, Dale L., Brehm, Michael A., Bebbington, Christopher, Tomasevic, Nenad

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Overcoming Current Limitations in Humanized Mouse Research von Brehm, Michael A., Shultz, Leonard D., Luban, Jeremy, Greiner, Dale L.

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Retroviruses use CD169-mediated trans-infection of permissive lymphocytes to establish infection von Sewald, Xaver, Ladinsky, Mark S., Uchil, Pradeep D., Beloor, Jagadish, Pi, Ruoxi, Herrmann, Christin, Motamedi, Nasim, Murrooka, Thomas T., Brehm, Michael A., Greiner, Dale L., Shultz, Leonard D., Mempel, Thorsten R., Bjorkman, Pamela J., Kumar, Priti, Mothes, Walther

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Generation of improved humanized mouse models for human infectious diseases von Brehm, Michael A., Wiles, Michael V., Greiner, Dale L., Shultz, Leonard D.

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Inhibition of bromodomain proteins for the treatment of human diffuse large B-cell lymphoma von Trabucco, Sally E, Gerstein, Rachel M, Evens, Andrew M, Bradner, James E, Shultz, Leonard D, Greiner, Dale L, Zhang, Hong

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Induction of cell cycle entry eliminates human leukemia stem cells in a mouse model of AML von Ishikawa, Fumihiko, Saito, Yoriko, Uchida, Naoyuki, Tanaka, Satoshi, Suzuki, Nahoko, Tomizawa-Murasawa, Mariko, Sone, Akiko, Najima, Yuho, Takagi, Shinsuke, Aoki, Yuki, Wake, Atsushi, Taniguchi, Shuichi, Shultz, Leonard D

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Humanized mouse model of mast cell–mediated passive cutaneous anaphylaxis and passive systemic anaphylaxis von Bryce, Paul J., PhD, Falahati, Rustom, PhD, Kenney, Laurie L., PhD, Leung, John, BS, Bebbington, Christopher, PhD, Tomasevic, Nenad, PhD, Krier, Rebecca A., MS, Hsu, Chia-Lin, PhD, Shultz, Leonard D., PhD, Greiner, Dale L., PhD, Brehm, Michael A., PhD

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α Cell Function and Gene Expression Are Compromised in Type 1 Diabetes von Brissova, Marcela, Haliyur, Rachana, Saunders, Diane, Shrestha, Shristi, Dai, Chunhua, Blodgett, David M., Bottino, Rita, Campbell-Thompson, Martha, Aramandla, Radhika, Poffenberger, Gregory, Lindner, Jill, Pan, Fong Cheng, von Herrath, Matthias G., Greiner, Dale L., Shultz, Leonard D., Sanyoura, May, Philipson, Louis H., Atkinson, Mark, Harlan, David M., Levy, Shawn E., Prasad, Nripesh, Stein, Roland, Powers, Alvin C.

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A deficiency of ceramide biosynthesis causes cerebellar purkinje cell neurodegeneration and lipofuscin accumulation von Zhao, Lihong, Spassieva, Stefka D, Jucius, Thomas J, Shultz, Leonard D, Shick, H Elizabeth, Macklin, Wendy B, Hannun, Yusuf A, Obeid, Lina M, Ackerman, Susan L

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Regulated Splicing of the α6 Integrin Cytoplasmic Domain Determines the Fate of Breast Cancer Stem Cells von Goel, Hira Lal, Gritsko, Tatiana, Pursell, Bryan, Chang, Cheng, Shultz, Leonard D., Greiner, Dale L., Norum, Jens Henrik, Toftgard, Rune, Shaw, Leslie M., Mercurio, Arthur M.

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A laminin 511 matrix is regulated by TAZ and functions as the ligand for the α6Bβ1 integrin to sustain breast cancer stem cells von Chang, Cheng, Goel, Hira Lal, Gao, Huijie, Pursell, Bryan, Shultz, Leonard D, Greiner, Dale L, Ingerpuu, Sulev, Patarroyo, Manuel, Cao, Shiliang, Lim, Elgene, Mao, Junhao, McKee, Karen Kulju, Yurchenco, Peter D, Mercurio, Arthur M

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A Salmonella nanoparticle mimic overcomes multidrug resistance in tumours von Mercado-Lubo, Regino, Zhang, Yuanwei, Zhao, Liang, Rossi, Kyle, Wu, Xiang, Zou, Yekui, Castillo, Antonio, Leonard, Jack, Bortell, Rita, Greiner, Dale L., Shultz, Leonard D., Han, Gang, McCormick, Beth A.

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Chemotherapy-resistant human AML stem cells home to and engraft within the bone-marrow endosteal region von Saito, Yoriko, Shultz, Leonard D, Saito, Noriyuki, Miyamoto, Toshihiro, Yoshida, Shuro, Hijikata, Atsushi, Nakamura, Ryu, Ohara, Osamu, Lyons, Bonnie, Ishikawa, Fumihiko, Taniguchi, Shuichi, Kitamura, Hiroshi, Fukata, Mitsuhiro, Uchida, Naoyuki, Tomiyama, Hiroko, Tanaka, Toru, Akashi, Koichi, Tanaka, Satoshi, Harada, Mine, Ohshima, Koichi

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Genes adapt to outsmart gene-targeting strategies in mutant mouse strains by skipping exons to reinitiate transcription and translation von Hosur, Vishnu, Low, Benjamin E, Li, Daniel, Stafford, Grace A, Kohar, Vivek, Shultz, Leonard D, Wiles, Michael V

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