SLFN11 Blocks Stressed Replication Forks Independently of ATR von Murai, Junko, Tang, Sai-Wen, Leo, Elisabetta, Baechler, Simone A., Redon, Christophe E., Zhang, Hongliang, Al Abo, Muthana, Rajapakse, Vinodh N., Nakamura, Eijiro, Jenkins, Lisa M. Miller, Aladjem, Mirit I., Pommier, Yves

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Putative DNA/RNA helicase Schlafen-11 (SLFN11) sensitizes cancer cells to DNA-damaging agents von Zoppoli, Gabriele, Regairaz, Marie, Leo, Elisabetta, Reinhold, William C, Varma, Sudhir, Ballestrero, Alberto, Doroshow, James H, Pommier, Yves

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The SMARCA2/4 ATPase Domain Surpasses the Bromodomain as a Drug Target in SWI/SNF-Mutant Cancers: Insights from cDNA Rescue and PFI-3 Inhibitor Studies von Vangamudi, Bhavatarini, Paul, Thomas A, Shah, Parantu K, Kost-Alimova, Maria, Nottebaum, Lisa, Shi, Xi, Zhan, Yanai, Leo, Elisabetta, Mahadeshwar, Harshad S, Protopopov, Alexei, Futreal, Andrew, Tieu, Trang N, Peoples, Mike, Heffernan, Timothy P, Marszalek, Joseph R, Toniatti, Carlo, Petrocchi, Alessia, Verhelle, Dominique, Owen, Dafydd R, Draetta, Giulio, Jones, Philip, Palmer, Wylie S, Sharma, Shikhar, Andersen, Jannik N

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SLFN11 informs on standard of care and novel treatments in a wide range of cancer models von Winkler, Claudia, Armenia, Joshua, Jones, Gemma N., Tobalina, Luis, Sale, Matthew J., Petreus, Tudor, Baird, Tarrion, Serra, Violeta, Wang, Anderson T., Lau, Alan, Garnett, Mathew J., Jaaks, Patricia, Coker, Elizabeth A., Pierce, Andrew J., O’Connor, Mark J., Leo, Elisabetta

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Structure-Guided Design of IACS-9571, a Selective High-Affinity Dual TRIM24-BRPF1 Bromodomain Inhibitor von Palmer, Wylie S, Poncet-Montange, Guillaume, Liu, Gang, Petrocchi, Alessia, Reyna, Naphtali, Subramanian, Govindan, Theroff, Jay, Yau, Anne, Kost-Alimova, Maria, Bardenhagen, Jennifer P, Leo, Elisabetta, Shepard, Hannah E, Tieu, Trang N, Shi, Xi, Zhan, Yanai, Zhao, Shuping, Barton, Michelle C, Draetta, Giulio, Toniatti, Carlo, Jones, Philip, Geck Do, Mary, Andersen, Jannik N

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Retrospective analysis of Schlafen11 (SLFN11) to predict the outcomes to therapies affecting the DNA damage response von Willis, Sophie E., Winkler, Claudia, Roudier, Martine P., Baird, Tarrion, Marco-Casanova, Paola, Jones, Emma V., Rowe, Philip, Rodriguez-Canales, Jaime, Angell, Helen K., Ng, Felicia S. L., Waring, Paul M., Hodgson, Darren, Ledermann, Jonathan A., Weberpals, Johanne I., Dean, Emma, Harrington, Elizabeth A., Barrett, J. Carl, Pierce, Andrew J., Leo, Elisabetta, Jones, Gemma N.

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Efficacy of dupilumab in atopic comorbidities associated with moderate‐to‐severe adult atopic dermatitis von Nettis, Eustachio, Patella, Vincenzo, Lombardo, Carla, Detoraki, Aikaterini, Macchia, Luigi, Di Leo, Elisabetta, Carbonara, Monica, Canonica, Giorgio W., Bonzano, Laura

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VEGF pathway inhibition potentiates PARP inhibitor efficacy in ovarian cancer independent of BRCA status von Bizzaro, Francesca, Fuso Nerini, Ilaria, Taylor, Molly A., Anastasia, Alessia, Russo, Massimo, Damia, Giovanna, Guffanti, Federica, Guana, Francesca, Ostano, Paola, Minoli, Lucia, Hattersley, Maureen M., Arnold, Stephanie, Ramos-Montoya, Antonio, Williamson, Stuart C., Galbiati, Alessandro, Urosevic, Jelena, Leo, Elisabetta, Cavallaro, Ugo, Ghilardi, Carmen, Barry, Simon T., Bani, Maria Rosa, Giavazzi, Raffaella

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Inhibition of Histone Deacetylase in Cancer Cells Slows Down Replication Forks, Activates Dormant Origins, and Induces DNA Damage von CONTI, Chiara, LEO, Elisabetta, EICHLER, Gabriel S, SORDET, Olivier, MARTIN, Melvenia M, FAN, Angela, ALADJEM, Mirit I, POMMIER, Yves

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Identification of potent and selective MTH1 inhibitors von Petrocchi, Alessia, Leo, Elisabetta, Reyna, Naphtali J., Hamilton, Matthew M., Shi, Xi, Parker, Connor A., Mseeh, Faika, Bardenhagen, Jennifer P., Leonard, Paul, Cross, Jason B., Huang, Sha, Jiang, Yongying, Cardozo, Mario, Draetta, Giulio, Marszalek, Joseph R., Toniatti, Carlo, Jones, Philip, Lewis, Richard T.

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PARP inhibition is a modulator of anti-tumor immune response in BRCA-deficient tumors von Staniszewska, Anna D., Armenia, Joshua, King, Matthew, Michaloglou, Chrysiis, Reddy, Avinash, Singh, Maneesh, San Martin, Maryann, Prickett, Laura, Wilson, Zena, Proia, Theresa, Russell, Deanna, Thomas, Morgan, Delpuech, Oona, O'Connor, Mark J., Leo, Elisabetta, Angell, Helen, Valge-Archer, Viia

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Idiopathic nonhistaminergic angioedema: A single‐center real‐life experience from Italy von Nettis, Eustachio, Di Leo, Elisabetta, Racanelli, Vito, Macchia, Luigi, Vacca, Angelo

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Efficacy of Dupilumab in Concomitant Atopic Dermatitis and Chronic Rhinosinusitis With Nasal Polyps: A Preliminary Study von Nettis, Eustachio, Patella, Vincenzo, Brancaccio, Raffaele, Detoraki, Caterina, Di Leo, Elisabetta, Incorvaia, Cristoforo, Macchia, Luigi, Pellacani, Giovanni, Bonzano, Laura

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Report on the first SLFN11 monothematic workshop: from function to role as a biomarker in cancer von Ballestrero, Alberto, Bedognetti, Davide, Ferraioli, Domenico, Franceschelli, Paola, Labidi-Galy, Sana Intidhar, Leo, Elisabetta, Murai, Junko, Pommier, Yves, Tsantoulis, Petros, Vellone, Valerio Gaetano, Zoppoli, Gabriele

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Immunologic contact urticaria to milk in an adult patient with severe atopic dermatitis von Foti, Caterina, Ambrogio, Francesca, Nettis, Eustachio, Di Leo, Elisabetta, Cassano, Nicoletta, Vena, Gino Antonio, Mortato, Edoardo, Romita, Paolo

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Polyethylene glycols and polysorbates: Two still neglected ingredients causing true IgE-mediated reactions von Calogiuri, Gianfranco, Foti, Caterina, Nettis, Eustachio, Di Leo, Elisabetta, Macchia, Luigi, Vacca, Angelo

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Safety and treatment compliance of subcutaneous immunotherapy: A 30-year retrospective study von Di Bona, Danilo, Magistà, Stefania, Masciopinto, Lucia, Lovecchio, Antonella, Loiodice, Roberto, Bilancia, Massimo, Albanesi, Marcello, Caiaffa, Maria Filomena, Nettis, Eustachio, Macchia, Luigi, Bariletto, Giuseppe, Carbonara, Annamaria, Cataldo, Vito, Damiani, Elisabetta, Di Leo, Elisabetta, Fiorino, Irene, Kourtis, Georgios, Laudadio, Valentina, Loconte, Filomena, Lotti, Anita, Mastromarco, Enza, Nenna, Saverio, Nico, Andrea, Pietrafesa, Maria, Rucco, Anna Simona, Strada, Silvana

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Dupilumab-Induced Bilateral Cicatricial Ectropion in Real Life von Nettis, Eustachio, Guerriero, Silvana, Masciopinto, Lucia, Di Leo, Elisabetta, Macchia, Luigi

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Occupational Exposure to Urban Air Pollution and Allergic Diseases von Vimercati, Luigi, Gatti, Maria Franca, Baldassarre, Antonio, Nettis, Eustachio, Favia, Nicola, Palma, Marco, Martina, Gabriella Lucia Maria, Di Leo, Elisabetta, Musti, Marina

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Abstract ND05: Discovery and first structural disclosure of AZD5305: A next generation, highly selective PARP1 inhibitor and trapper von Leo, Elisabetta, Johannes, Jeffrey

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