Discovery and SAR of Novel 2,3-Dihydroimidazo[1,2-c]quinazoline PI3K Inhibitors: Identification of Copanlisib (BAY 80-6946) von Scott, William J., Hentemann, Martin F., Rowley, R. Bruce, Bull, Cathy O., Jenkins, Susan, Bullion, Ann M., Johnson, Jeffrey, Redman, Anikó, Robbins, Arthur H., Esler, William, Fracasso, R. Paul, Garrison, Timothy, Hamilton, Mark, Michels, Martin, Wood, Jill E., Wilkie, Dean P., Xiao, Hong, Levy, Joan, Stasik, Enrico, Liu, Ningshu, Schaefer, Martina, Brands, Michael, Lefranc, Julien

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Amines Bearing Tertiary Substituents by Tandem Enantioselective Carbolithiation–Rearrangement of Vinylureas von Tait, Michael, Donnard, Morgan, Minassi, Alberto, Lefranc, Julien, Bechi, Beatrice, Carbone, Giorgio, O’Brien, Peter, Clayden, Jonathan

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Targeting the aryl hydrocarbon receptor (AhR) with BAY 2416964: a selective small molecule inhibitor for cancer immunotherapy von Kober, Christina, Roewe, Julian, Schmees, Norbert, Roese, Lars, Roehn, Ulrike, Bader, Benjamin, Stoeckigt, Detlef, Prinz, Florian, Gorjánácz, Mátyás, Roider, Helge Gottfried, Olesch, Catherine, Leder, Gabriele, Irlbacher, Horst, Lesche, Ralf, Lefranc, Julien, Oezcan-Wahlbrink, Mine, Batra, Ankita Sati, Elmadany, Nirmeen, Carretero, Rafael, Sahm, Katharina, Oezen, Iris, Cichon, Frederik, Baumann, Daniel, Sadik, Ahmed, Opitz, Christiane A, Weinmann, Hilmar, Hartung, Ingo V, Kreft, Bertolt, Offringa, Rienk, Platten, Michael, Gutcher, Ilona

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The potent AMPK inhibitor BAY-3827 shows strong efficacy in androgen-dependent prostate cancer models von Lemos, Clara, Schulze, Volker K., Baumgart, Simon J., Nevedomskaya, Ekaterina, Heinrich, Tobias, Lefranc, Julien, Bader, Benjamin, Christ, Clara D., Briem, Hans, Kuhnke, Lara P., Holton, Simon J., Bömer, Ulf, Lienau, Philip, von Nussbaum, Franz, Nising, Carl F., Bauser, Marcus, Hägebarth, Andrea, Mumberg, Dominik, Haendler, Bernard

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Synthetic approaches towards alkaloids bearing α-tertiary amines von Hager, Anastasia, Vrielink, Nina, Hager, Dominik, Lefranc, Julien, Trauner, Dirk

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Carbolithiation of N-alkenyl ureas and N-alkenyl carbamates von Lefranc, Julien, Minassi, Alberto, Clayden, Jonathan

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Quaternary centres bearing nitrogen (α-tertiary amines) as products of molecular rearrangements von Clayden, Jonathan, Donnard, Morgan, Lefranc, Julien, Tetlow, Daniel J

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The Novel ATR Inhibitor BAY 1895344 Is Efficacious as Monotherapy and Combined with DNA Damage-Inducing or Repair-Compromising Therapies in Preclinical Cancer Models von Wengner, Antje M., Siemeister, Gerhard, Luecking, Ulrich, Lefranc, Julien, Wortmann, Lars, Lienau, Philip, Bader, Benjamin, Boemer, Ulf, Moosmayer, Dieter, Eberspaecher, Uwe, Golfier, Sven, Schatz, Christoph A., Baumgart, Simon J., Haendler, Bernard, Lejeune, Pascale, Schlicker, Andreas, von Nussbaum, Franz, Brands, Michael, Ziegelbauer, Karl, Mumberg, Dominik

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Nickel‐Catalyzed N‐Arylation of NH‐Sulfoximines with Aryl Halides via Paired Electrolysis von Liu, Dong, Liu, Zhao‐Ran, Ma, Cong, Jiao, Ke‐Jin, Sun, Bing, Wei, Lei, Lefranc, Julien, Herbert, Simon, Mei, Tian‐Sheng

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Damage Incorporated: Discovery of the Potent, Highly Selective, Orally Available ATR Inhibitor BAY 1895344 with Favorable Pharmacokinetic Properties and Promising Efficacy in Monot... von Lücking, Ulrich, Wortmann, Lars, Wengner, Antje M, Lefranc, Julien, Lienau, Philip, Briem, Hans, Siemeister, Gerhard, Bömer, Ulf, Denner, Karsten, Schäfer, Martina, Koppitz, Marcus, Eis, Knut, Bartels, Florian, Bader, Benjamin, Bone, Wilhelm, Moosmayer, Dieter, Holton, Simon J, Eberspächer, Uwe, Grudzinska-Goebel, Joanna, Schatz, Christoph, Deeg, Gesa, Mumberg, Dominik, von Nussbaum, Franz

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Discovery of BAY-985, a Highly Selective TBK1/IKKε Inhibitor von Lefranc, Julien, Schulze, Volker Klaus, Hillig, Roman Christian, Briem, Hans, Prinz, Florian, Mengel, Anne, Heinrich, Tobias, Balint, Jozsef, Rengachari, Srinivasan, Irlbacher, Horst, Stöckigt, Detlef, Bömer, Ulf, Bader, Benjamin, Gradl, Stefan Nikolaus, Nising, Carl Friedrich, von Nussbaum, Franz, Mumberg, Dominik, Panne, Daniel, Wengner, Antje Margret

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Back in Person: Frontiers in Medicinal Chemistry 2023 von Gehringer, Matthias, Pape, Felix, Méndez, María, Barbie, Philipp, Unzue Lopez, Andrea, Lefranc, Julien, Klingler, Franca-Maria, Hessler, Gerhard, Langer, Thierry, Diamanti, Eleonora, Schiedel, Matthias

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Tandem β-Alkylation−α-Arylation of Amines by Carbolithiation and Rearrangement of N-Carbamoyl Enamines (Vinyl Ureas) von Clayden, Jonathan, Donnard, Morgan, Lefranc, Julien, Minassi, Alberto, Tetlow, Daniel J

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Abstract 321: Synergistic activity of the ATR inhibitor BAY 1895344 in combination with DNA damage inducing and DNA repair compromising therapies in preclinical tumor models von Wengner, Antje Margret, Siemeister, Gerhard, Luecking, Ulrich, Lefranc, Julien, Meyer, Kirstin, Lagkadinou, Eleni, Haendler, Bernard, Lejeune, Pascale, Mumberg, Dominik

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Abstract 838: Synergistic in vivo activity of the ATR inhibitor BAY 1895344 in combination with the targeted alpha therapy radium-223 dichloride in a preclinical tumor model mimick... von Wengner, Antje Margret, Siemeister, Gerhard, Luecking, Ulrich, Lefranc, Julien, Scholz, Arne, Suominen, Mari, Meyer, Kirstin, Lagkadinou, Eleni, Mumberg, Dominik

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Intramolecular Vinylation of Secondary and Tertiary Organolithiums von Lefranc, Julien, Fournier, Anne M, Mingat, Gaëlle, Herbert, Simon, Marcelli, Tommaso, Clayden, Jonathan

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Frontiers in Medicinal Chemistry 2022 Goes Virtual von Diamanti, Eleonora, Méndez, María, Ross, Tatjana, Kuttruff, Christian A., Lefranc, Julien, Klingler, Franca‐Maria, Nussbaum, Franz, Jung, Manfred, Gehringer, Matthias

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Abstract 5873: BAY-3827, a selective inhibitor of AMPK for the evaluation of the role of AMPK in Myc-dependent tumors von Lemos, Clara, Schulze, Volker K., Bader, Benjamin, Christ, Clara D., Briem, Hans, Politz, Oliver, Prinz, Florian, Holton, Simon, Heinrich, Tobias, Lefranc, Julien, Lienau, Philip, Scholz, Arne, Nussbaum, Franz von, Nising, Carl Friedrich, Mumberg, Dominik, Bauser, Marcus, Hägebarth, Andrea

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Abstract 160: High target binding affinity with long lasting cellular target engagement and high dose intermittent schedule of PI3K inhibitor copanlisib contribute to the potent an... von Fernández-Montalván, Amaury E., Georgi, Victoria, Vasta, James, Glaeske, Sarah, Puetter, Vera, Robers, Matthew B., Moenning, Ursula, Sturz, Andrea, Lefranc, Julien, Ziegelbauer, Karl, Brands, Michael, Stegmann, Christian, Scott, William J., Liu, Ningshu

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Abstract 983: Identification of potent, highly selective and orally available ATR inhibitor BAY 1895344 with favorable PK properties and promising efficacy in monotherapy and combi... von Luecking, Ulrich T., Lefranc, Julien, Wengner, Antje, Wortmann, Lars, Schick, Hans, Briem, Hans, Siemeister, Gerhard, Lienau, Philip, Schatz, Christoph, Bader, Benjamin, Deeg, Gesa, Nussbaum, Franz von, Brands, Michael, Mumberg, Dominik, Ziegelbauer, Karl

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