Accessing simply-substituted 4-hydroxytetrahydroisoquinolines via Pomeranz-Fritsch-Bobbitt reaction with non-activated and moderately-activated systems von Mottinelli, Marco, Leese, Mathew P, Potter, Barry V L

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2-Substituted Estradiol Bis-sulfamates, Multitargeted Antitumor Agents:  Synthesis, In Vitro SAR, Protein Crystallography, and In Vivo Activity von Leese, Mathew P, Leblond, Bertrand, Smith, Andrew, Newman, Simon P, Di Fiore, Anna, De Simone, Giuseppina, Supuran, Claudiu T, Purohit, Atul, Reed, Michael J, Potter, Barry V. L

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Quinazolinone-Based Anticancer Agents: Synthesis, Antiproliferative SAR, Antitubulin Activity, and Tubulin Co-crystal Structure von Dohle, Wolfgang, Jourdan, Fabrice L, Menchon, Grégory, Prota, Andrea E, Foster, Paul A, Mannion, Pascoe, Hamel, Ernest, Thomas, Mark P, Kasprzyk, Philip G, Ferrandis, Eric, Steinmetz, Michel O, Leese, Mathew P, Potter, Barry V. L

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Synthesis, Anti-tubulin and Antiproliferative SAR of Steroidomimetic Dihydroisoquinolinones von Leese, Mathew P., Jourdan, Fabrice L., Major, Meriel R., Dohle, Wolfgang, Thomas, Mark P., Hamel, Ernest, Ferrandis, Eric, Mahon, Mary F., Newman, Simon P., Purohit, Atul, Potter, Barry V. L.

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STX140 Is Efficacious In vitro and In vivo in Taxane-Resistant Breast Carcinoma Cells von NEWMAN, Simon P, FOSTER, Paul A, REED, Michael J, PUROHIT, Atul, STENGEL, Chloe, DAY, Joanna M, HO, Yaik T, JUDDE, Jean-Gabriel, LASSALLE, Myriam, PREVOST, Gregoire, LEESE, Mathew P, POTTER, Barry V. L

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Structure–Activity Relationships of C-17 Cyano-Substituted Estratrienes as Anticancer Agents von Leese, Mathew P, Jourdan, Fabrice L, Gaukroger, Keira, Mahon, Mary F, Newman, Simon P, Foster, Paul A, Stengel, Chloe, Regis-Lydi, Sandra, Ferrandis, Eric, Fiore, Anna Di, De Simone, Giuseppina, Supuran, Claudiu T, Purohit, Atul, Reed, Michael J, Potter, Barry V. L

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Inhibition of in vitro angiogenesis by 2‐methoxy‐ and 2‐ethyl‐estrogen sulfamates von Newman, Simon P., Leese, Mathew P., Purohit, Atul, James, David R.C., Rennie, Catherine E., Potter, Barry V.L., Reed, Michael J.

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N‐Phenyl‐1,2,3,4‐tetrahydroisoquinoline: An Alternative Scaffold for the Design of 17β‐Hydroxysteroid Dehydrogenase 1 Inhibitors von Mottinelli, Marco, Sinreih, Maša, Rižner, Tea L., Leese, Mathew P., Potter, Barry V. L.

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STX140 and STX641 Cause Apoptosis via the Intrinsic Mitochondrial Pathway and Down-regulate Survivin and XIAP Expression in Ovarian and Prostate Cancer Cells von FOSTER, Paul A, HO, Yaik T, NEWMAN, Simon P, LEESE, Mathew P, POTTER, Barry V. L, REED, Michael J, PUROHIT, Atul

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A New Micronized Formulation of 2-Methoxyestradiol-bis-sulfamate (STX140) is Therapeutically Potent against Breast Cancer von FOSTER, Paul A, NEWMAN, Simon P, REED, Michael J, PUROHIT, Atul, LEESE, Mathew P, BERNETIERE, Sonia, DIOLEZ, Christian, CAMARA, Jose, HACHER, Beatrice, BARONNET, Marie-Madeleine, ALI, Tauhid, POTTER, Barry V. L

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The In Vitro and In Vivo Activity of the Microtubule Disruptor STX140 Is Mediated by Hif-1 Alpha and CAIX Expression von Stengel, Chloe, Newman, Simon P, Leese, Mathew P, Thomas, Mark P, Potter, Barry V L, Reed, Michael J, Purohit, Atul, Foster, Paul A

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Targeted NF1 cancer therapeutics with multiple modes of action: small molecule hormone-like agents resembling the natural anticancer metabolite, 2-methoxyoestradiol von Shen, Yu-chi, Upadhyayula, Ravi, Cevallos, Stephanie, Messick, Ryan J, Hsia, Tammy, Leese, Mathew P, Jewett, Douglas M, Ferrer-Torres, Daysha, Roth, Therese M, Dohle, Wolfgang, Potter, Barry V L, Barald, Kate F

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A Comparison of Two Orally Bioavailable Anti-cancer Agents, IRC-110160 and STX140 von FOSTER, Paul A, STENGEL, C, ALI, Tauhid, LEESE, Mathew P, POTTER, Barry V. L, REED, Michael J, PUROHIT, Atul, NEWMAN, Simon P

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Synthesis, Antitubulin, and Antiproliferative SAR of Analogues of 2-Methoxyestradiol-3,17-O,O-bis-sulfamate von Jourdan, Fabrice, Leese, Mathew P, Dohle, Wolfgang, Hamel, Ernest, Ferrandis, Eric, Newman, Simon P, Purohit, Atul, Reed, Michael J, Potter, Barry V. L

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Structure–Activity Relationships of C-17-Substituted Estratriene-3-O-sulfamates as Anticancer Agents von Jourdan, Fabrice, Leese, Mathew P, Dohle, Wolfgang, Ferrandis, Eric, Newman, Simon P, Chander, Surinder, Purohit, Atul, Potter, Barry V. L

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Optimisation of Tetrahydroisoquinoline-Based Chimeric Microtubule Disruptors von Dohle, Wolfgang, Leese, Mathew P., Jourdan, Fabrice L., Chapman, Christopher J., Hamel, Ernest, Ferrandis, Eric, Potter, Barry V. L.

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3,17-Disubstituted 2-Alkylestra-1,3,5(10)-trien-3-ol Derivatives:  Synthesis, In Vitro and In Vivo Anticancer Activity von Bubert, Christian, Leese, Mathew P, Mahon, Mary F, Ferrandis, Eric, Regis-Lydi, Sandra, Kasprzyk, Philip G, Newman, Simon P, Ho, Yaik T, Purohit, Atul, Reed, Michael J, Potter, Barry V. L

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Tetrahydroisoquinolinone-Based Steroidomimetic and Chimeric Microtubule Disruptors von Leese, Mathew P., Jourdan, Fabrice L., Major, Meriel R., Dohle, Wolfgang, Hamel, Ernest, Ferrandis, Eric, Fiore, Ann, Kasprzyk, Philip G., Potter, Barry V. L.

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Synthesis, Antitubulin, and Antiproliferative SAR of C3/C1-Substituted Tetrahydroisoquinolines von Dohle, Wolfgang, Leese, Mathew P., Jourdan, Fabrice L., Major, Meriel R., Bai, Ruoli, Hamel, Ernest, Ferrandis, Eric, Kasprzyk, Philip G., Fiore, Ann, Newman, Simon P., Purohit, Atul, Potter, Barry V. L.

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A-Ring-Substituted Estrogen-3-O-sulfamates:  Potent Multitargeted Anticancer Agents von Leese, Mathew P, Hejaz, Hatem A. M, Mahon, Mary F, Newman, Simon P, Purohit, Atul, Reed, Michael J, Potter, Barry V. L

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