MYC and MCL1 Cooperatively Promote Chemotherapy-Resistant Breast Cancer Stem Cells via Regulation of Mitochondrial Oxidative Phosphorylation von Lee, Kyung-min, Giltnane, Jennifer M., Balko, Justin M., Schwarz, Luis J., Guerrero-Zotano, Angel L., Hutchinson, Katherine E., Nixon, Mellissa J., Estrada, Mónica V., Sánchez, Violeta, Sanders, Melinda E., Lee, Taekyu, Gómez, Henry, Lluch, Ana, Pérez-Fidalgo, J. Alejandro, Wolf, Melissa Magdalene, Andrejeva, Gabriela, Rathmell, Jeffrey C., Fesik, Stephen W., Arteaga, Carlos L.

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Discovery of Potent Myeloid Cell Leukemia 1 (Mcl-1) Inhibitors Using Fragment-Based Methods and Structure-Based Design von Friberg, Anders, Vigil, Dominico, Zhao, Bin, Daniels, R. Nathan, Burke, Jason P, Garcia-Barrantes, Pedro M, Camper, DeMarco, Chauder, Brian A, Lee, Taekyu, Olejniczak, Edward T, Fesik, Stephen W

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Approach for targeting Ras with small molecules that activate SOS-mediated nucleotide exchange von Burns, Michael C., Qi Sun, Daniels, R. Nathan, Camper, DeMarco, Kennedy, J. Phillip, Phan, Jason, Olejniczak, Edward T., Lee, Taekyu, Waterson, Alex G., Rossanese, Olivia W., Fesik, Stephen W.

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Discovery of a Tetracyclic Quinoxaline Derivative as a Potent and Orally Active Multifunctional Drug Candidate for the Treatment of Neuropsychiatric and Neurological Disorders von Li, Peng, Zhang, Qiang, Robichaud, Albert J, Lee, Taekyu, Tomesch, John, Yao, Wei, Beard, J. David, Snyder, Gretchen L, Zhu, Hongwen, Peng, Youyi, Hendrick, Joseph P, Vanover, Kimberly E, Davis, Robert E, Mates, Sharon, Wennogle, Lawrence P

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Ribosome subunit attrition and activation of the p53-MDM4 axis dominate the response of MLL-rearranged cancer cells to WDR5 WIN site inhibition von Howard, Gregory Caleb, Wang, Jing, Rose, Kristie L, Jones, Camden, Patel, Purvi, Tsui, Tina, Florian, Andrea C, Vlach, Logan, Lorey, Shelly L, Grieb, Brian C, Smith, Brianna N, Slota, Macey J, Reynolds, Elizabeth M, Goswami, Soumita, Savona, Michael R, Mason, Frank M, Lee, Taekyu, Fesik, Stephen, Liu, Qi, Tansey, William P

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418 The antiplatelet effects of EPA, an omega-3 fatty acid, are mediated by its 12-lipoxygenase metabolite, 12-HEPE von Goerger, Krista, Lee, Taekyu, Gilmore, Devin, Tran, Michelle, Holman, Theodore R., Holinstat, Michael

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Suppression of the ERK–SRF axis facilitates somatic cell reprogramming von Huh, Sejong, Song, Hwa-Ryung, Jeong, Geuk-Rae, Jang, Hyejin, Seo, Nan-Hee, Lee, Ju-Hyun, Yi, Ji-Yeun, Lee, Byongsun, Choi, Hyun Woo, Do, Jeong Tae, Kim, Jin-Su, Lee, Soo-Hong, Jung, Jae-Won, Lee, Taekyu, Shim, Jaekyung, Han, Myung-Kwan, Lee, Tae-Hee

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Music for Sleep and Wake-up: An Empirical Study von Lee, Taekyu, Moon, Seong-Eun, Baek, Jongsoo, Lee, Jong-Seok, Kim, Songkuk

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0854 Observation-based Diurnal Sleepiness Inventory (ODSI) is associated with Objective Sleepiness via Psychomotor Vigilance Task von Pak, Victoria, Russell, Kate, Gooneratne, Nalaka, Cox, John, Servaes, Stijn, Lee, Taekyu, Onen, Hakki, Onen, Fannie

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A Novel MCL1 Inhibitor Combined with Venetoclax Rescues Venetoclax-Resistant Acute Myelogenous Leukemia von Ramsey, Haley E, Fischer, Melissa A, Lee, Taekyu, Gorska, Agnieszka E, Arrate, Maria Pia, Fuller, Londa, Boyd, Kelli L, Strickland, Stephen A, Sensintaffar, John, Hogdal, Leah J, Ayers, Gregory D, Olejniczak, Edward T, Fesik, Stephen W, Savona, Michael R

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Discovery of Small Molecules that Bind to K-Ras and Inhibit Sos-Mediated Activation von Sun, Qi, Burke, Jason P., Phan, Jason, Burns, Michael C., Olejniczak, Edward T., Waterson, Alex G., Lee, Taekyu, Rossanese, Olivia W., Fesik, Stephen W.

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Microbial production of levulinic acid from glucose by engineered Pseudomonas putida KT2440 von Kim, Hyun Jin, Kim, Byung Chan, Park, Hanna, Cho, Geunsang, Lee, Taekyu, Kim, Hee Taek, Bhatia, Shashi Kant, Yang, Yung-Hun

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Structure-based discovery of potent WD repeat domain 5 inhibitors that demonstrate efficacy and safety in preclinical animal models von Teuscher, Kevin B, Chowdhury, Somenath, Meyers, Kenneth M, Tian, Jianhua, Sai, Jiqing, Van Meveren, Mayme, South, Taylor M, Sensintaffar, John L, Rietz, Tyson A, Goswami, Soumita, Wang, Jing, Grieb, Brian C, Lorey, Shelly L, Howard, Gregory C, Liu, Qi, Moore, William J, Stott, Gordon M, Tansey, William P, Lee, Taekyu, Fesik, Stephen W

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Discovery of 2‑Indole-acylsulfonamide Myeloid Cell Leukemia 1 (Mcl-1) Inhibitors Using Fragment-Based Methods von Pelz, Nicholas F, Bian, Zhiguo, Zhao, Bin, Shaw, Subrata, Tarr, James C, Belmar, Johannes, Gregg, Claire, Camper, DeMarco V, Goodwin, Craig M, Arnold, Allison L, Sensintaffar, John L, Friberg, Anders, Rossanese, Olivia W, Lee, Taekyu, Olejniczak, Edward T, Fesik, Stephen W

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Fragment-based screening of programmed death ligand 1 (PD-L1) von Perry, Evan, Mills, Jonathan J., Zhao, Bin, Wang, Feng, Sun, Qi, Christov, Plamen P., Tarr, James C., Rietz, Tyson A., Olejniczak, Edward T., Lee, Taekyu, Fesik, Stephen

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Expanded profiling of WD repeat domain 5 inhibitors reveals actionable strategies for the treatment of hematologic malignancies von Meyer, Christian T, Smith, Brianna N, Wang, Jing, Teuscher, Kevin B, Grieb, Brian C, Howard, Gregory C, Silver, Alexander J, Lorey, Shelly L, Stott, Gordon M, Moore, William J, Lee, Taekyu, Savona, Michael R, Weissmiller, April M, Liu, Qi, Quaranta, Vito, Fesik, Stephen W, Tansey, William P

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Optimization of Potent and Selective Tricyclic Indole Diazepinone Myeloid Cell Leukemia‑1 Inhibitors Using Structure-Based Design von Shaw, Subrata, Bian, Zhiguo, Zhao, Bin, Tarr, James C, Veerasamy, Nagarathanam, Jeon, Kyu Ok, Belmar, Johannes, Arnold, Allison L, Fogarty, Stuart A, Perry, Evan, Sensintaffar, John L, Camper, DeMarco V, Rossanese, Olivia W, Lee, Taekyu, Olejniczak, Edward T, Fesik, Stephen W

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Discovery of Potent Myeloid Cell Leukemia‑1 (Mcl-1) Inhibitors That Demonstrate in Vivo Activity in Mouse Xenograft Models of Human Cancer von Lee, Taekyu, Christov, Plamen P, Shaw, Subrata, Tarr, James C, Zhao, Bin, Veerasamy, Nagarathanam, Jeon, Kyu Ok, Mills, Jonathan J, Bian, Zhiguo, Sensintaffar, John L, Arnold, Allison L, Fogarty, Stuart A, Perry, Evan, Ramsey, Haley E, Cook, Rebecca S, Hollingshead, Melinda, Davis Millin, Myrtle, Lee, Kyung-min, Koss, Brian, Budhraja, Amit, Opferman, Joseph T, Kim, Kwangho, Arteaga, Carlos L, Moore, William J, Olejniczak, Edward T, Savona, Michael R, Fesik, Stephen W

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Fragment-Based Discovery of Small Molecules Bound to T‑Cell Immunoglobulin and Mucin Domain-Containing Molecule 3 (TIM-3) von Rietz, Tyson A, Teuscher, Kevin B, Mills, Jonathan J, Gogliotti, Rocco D, Lepovitz, Lance T, Scaggs, W. Rush, Yoshida, Keisuke, Luong, Kelvin, Lee, Taekyu, Fesik, Stephen W

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Discovery of Tricyclic Indoles That Potently Inhibit Mcl‑1 Using Fragment-Based Methods and Structure-Based Design von Burke, Jason P, Bian, Zhiguo, Shaw, Subrata, Zhao, Bin, Goodwin, Craig M, Belmar, Johannes, Browning, Carrie F, Vigil, Dominico, Friberg, Anders, Camper, DeMarco V, Rossanese, Olivia W, Lee, Taekyu, Olejniczak, Edward T, Fesik, Stephen W

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