Development of a therapeutic anti-HtrA1 antibody and the identification of DKK3 as a pharmacodynamic biomarker in geographic atrophy von Tom, Irene, Pham, Victoria C., Katschke, Kenneth J., Li, Wei, Liang, Wei-Ching, Gutierrez, Johnny, Young, Andrew Ah, Figueroa, Isabel, Eshghi, Shadi Toghi, Lee, ChingWei V., Kanodia, Jitendra, Snipas, Scott J., Salvesen, Guy S., Lai, Phillip, Honigberg, Lee, van Lookeren Campagne, Menno, Kirchhofer, Daniel, Baruch, Amos, Lill, Jennie R.

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Inhibition of VEGF-C modulates distal lymphatic remodeling and secondary metastasis von Gogineni, Alvin, Caunt, Maresa, Crow, Ailey, Lee, Chingwei V, Fuh, Germaine, van Bruggen, Nicholas, Ye, Weilan, Weimer, Robby M

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A Two-in-One Antibody against HER3 and EGFR Has Superior Inhibitory Activity Compared with Monospecific Antibodies von Schaefer, Gabriele, Haber, Lauric, Crocker, Lisa M., Shia, Steven, Shao, Lily, Dowbenko, Donald, Totpal, Klara, Wong, Anne, Lee, Chingwei V., Stawicki, Scott, Clark, Robyn, Fields, Carter, Lewis Phillips, Gail D., Prell, Rodney A., Danilenko, Dimitry M., Franke, Yvonne, Stephan, Jean-Philippe, Hwang, Jiyoung, Wu, Yan, Bostrom, Jenny, Sliwkowski, Mark X., Fuh, Germaine, Eigenbrot, Charles

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Mutational landscape of antibody variable domains reveals a switch modulating the interdomain conformational dynamics and antigen binding von Koenig, Patrick, Lee, Chingwei V., Walters, Benjamin T., Janakiraman, Vasantharajan, Stinson, Jeremy, Patapoff, Thomas W., Fuh, Germaine

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Deep Sequencing-guided Design of a High Affinity Dual Specificity Antibody to Target Two Angiogenic Factors in Neovascular Age-related Macular Degeneration von Koenig, Patrick, Lee, Chingwei V., Sanowar, Sarah, Wu, Ping, Stinson, Jeremy, Harris, Seth F., Fuh, Germaine

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Variants of the Antibody Herceptin That Interact with HER2 and VEGF at the Antigen Binding Site von Bostrom, Jenny, Yu, Shang-Fan, Kan, David, Appleton, Brent A, Lee, Chingwei V, Billeci, Karen, Man, Wenyan, Peale, Franklin, Ross, Sarajane, Wiesmann, Christian, Fuh, Germaine

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Rapid Development of Glaucoma Via ITV Nonselective ANGPT 1/2 Antibody: A Potential Role for ANGPT/TIE2 Signaling in Primate Aqueous Humor Outflow von Thackaberry, Evan A, Zhou, Yi, Zuch de Zafra, Christina L, Fuh, Germaine, Lee, Chingwei V, Sanowar, Sarah, Ridgway, John B, Kusi, Aija M, Farman, Cindy, Booler, Helen, Sheinson, Daniel, Rasmussen, Carol A, Miller, Paul E, Wakshull, Eric, Yan, Minhong, Bantseev, Vladimir

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Assessing therapeutic responses in Kras mutant cancers using genetically engineered mouse models von Hamilton, Patricia, Devasthali, Vidusha, Bou Reslan, Hani, Nannini, Michelle A, Cheng, Jason H, Johnson, Leisa, Ho, Calvin C K, Lee, Chingwei V, Fuh, Germaine, Forrest, William F, Molina, Rafael, Clermont, Anne C, Cao, Timothy C, Carano, Richard A D, Yu, Ron X, Koeppen, Hartmut, Plowman, Gregory D, Singh, Mallika, Lima, Anthony, Thompson, Jennifer D

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Cross-species Vascular Endothelial Growth Factor (VEGF)-blocking Antibodies Completely Inhibit the Growth of Human Tumor Xenografts and Measure the Contribution of Stromal VEGF von Liang, Wei-Ching, Wu, Xiumin, Peale, Franklin V., Lee, Chingwei V., Meng, Y. Gloria, Gutierrez, Johnny, Fu, Ling, Malik, Ajay K., Gerber, Hans-Peter, Ferrara, Napoleone, Fuh, Germaine

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Design and Pharmacokinetic Characterization of Novel Antibody Formats for Ocular Therapeutics von Gadkar, Kapil, Pastuskovas, Cinthia V, Le Couter, Jennifer E, Elliott, J Michael, Zhang, Jianhuan, Lee, Chingwei V, Sanowar, Sarah, Fuh, Germaine, Kim, Hok Seon, Lombana, T Noelle, Spiess, Christoph, Nakamura, Makia, Hass, Phil, Shatz, Whitney, Meng, Y Gloria, Scheer, Justin M

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Tuning the specificity of a Two-in-One Fab against three angiogenic antigens by fully utilizing the information of deep mutational scanning von Koenig, Patrick, Sanowar, Sarah, Lee, Chingwei V, Fuh, Germaine

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A two-in-one antibody engineered from a humanized interleukin 4 antibody through mutation in heavy chain complementarity-determining regions von Lee, Chingwei V, Koenig, Patrick, Fuh, Germaine

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Interaction between Bevacizumab and Murine VEGF-A: A Reassessment von Yu, Lanlan, Wu, Xiumin, Cheng, Zhiyong, Lee, Chingwei V, LeCouter, Jennifer, Campa, Claudio, Fuh, Germaine, Lowman, Henry, Ferrara, Napoleone

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Structure-Function Studies of Two Synthetic Anti-vascular Endothelial Growth Factor Fabs and Comparison with the Avastin™ Fab von Fuh, Germaine, Wu, Ping, Liang, Wei-Ching, Ultsch, Mark, Lee, Chingwei V., Moffat, Barbara, Wiesmann, Christian

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Mice expressing a humanized form of VEGF-A may provide insights into the safety and efficacy of anti-VEGF antibodies von Gerber, Hans-Peter, Wu, Xiumin, Yu, Lanlan, Wiesmann, Christian, Liang, Xiao Huan, Lee, Chingwei V, Fuh, Germaine, Olsson, Christine, Damico, Lisa, Xie, David, Meng, Y. Gloria, Gutierrez, Johnny, Corpuz, Racquel, Li, Bing, Hall, Linda, Rangell, Linda, Ferrando, Ron, Lowman, Henry, Peale, Franklin, Ferrara, Napoleone

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High-affinity Human Antibodies from Phage-displayed Synthetic Fab Libraries with a Single Framework Scaffold von Lee, Chingwei V, Liang, Wei-Ching, Dennis, Mark S, Eigenbrot, Charles, Sidhu, Sachdev S, Fuh, Germaine

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Translation levels control multi-spanning membrane protein expression von Kim, Hok Seon, Ernst, James A, Brown, Cecilia, Bostrom, Jenny, Fuh, Germaine, Lee, Chingwei V, Huang, Arthur, Vandlen, Richard L, Yansura, Daniel G

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Improving Antibody Binding Affinity and Specificity for Therapeutic Development von Bostrom, Jenny, Lee, Chingwei V., Haber, Lauric, Fuh, Germaine

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Synthetic anti-BR3 antibodies that mimic BAFF binding and target both human and murine B cells von Lee, Chingwei V., Hymowitz, Sarah G., Wallweber, Heidi J., Gordon, Nathaniel C., Billeci, Karen L., Tsai, Siao-Ping, Compaan, Deanne M., Yin, JianPing, Gong, Qian, Kelley, Robert F., DeForge, Laura E., Martin, Flavius, Starovasnik, Melissa A., Fuh, Germaine

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Bivalent antibody phage display mimics natural immunoglobulin von Lee, Chingwei V., Sidhu, Sachdev S., Fuh, Germaine

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