Intestinal P‐gp and Putative Hepatic OATP1B Induction: International Transporter Consortium Perspective on Drug Development Implications von Zamek‐Gliszczynski, Maciej J., Patel, Mitesh, Yang, Xinning, Lutz, Justin D., Chu, Xiaoyan, Brouwer, Kim L. R., Lai, Yurong, Lee, Caroline A., Neuhoff, Sibylle, Paine, Mary F., Sugiyama, Yuichi, Taskar, Kunal S., Galetin, Aleksandra

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Breast cancer resistance protein (ABCG2) in clinical pharmacokinetics and drug interactions: practical recommendations for clinical victim and perpetrator drug-drug interaction stu... von Lee, Caroline A, O'Connor, Meeghan A, Ritchie, Tasha K, Galetin, Aleksandra, Cook, Jack A, Ragueneau-Majlessi, Isabelle, Ellens, Harma, Feng, Bo, Taub, Mitchell E, Paine, Mary F, Polli, Joseph W, Ware, Joseph A, Zamek-Gliszczynski, Maciej J

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Industry Perspective on Contemporary Protein-Binding Methodologies: Considerations for Regulatory Drug-Drug Interaction and Related Guidelines on Highly Bound Drugs von Di, Li, Breen, Christopher, Chambers, Rob, Eckley, Sean T., Fricke, Robert, Ghosh, Avijit, Harradine, Paul, Kalvass, J. Cory, Ho, Stacy, Lee, Caroline A., Marathe, Punit, Perkins, Everett J., Qian, Mark, Tse, Susanna, Yan, Zhengyin, Zamek-Gliszczynski, Maciej J.

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Identifying a selective substrate and inhibitor pair for the evaluation of CYP2J2 activity von Lee, Caroline A, Jones, 3rd, J P, Katayama, Jonathan, Kaspera, Rüdiger, Jiang, Ying, Freiwald, Sascha, Smith, Evan, Walker, Gregory S, Totah, Rheem A

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Identification of Novel Substrates for Human Cytochrome P450 2J2 von LEE, Caroline A, NEUL, David, CLOUSER-ROCHE, Andrea, DALVIE, Deepak, WESTER, Michael R, YING JIANG, JONES, J. P, FREIWALD, Sascha, ZIENTEK, Michael, TOTAH, Rheem A

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Transporter-dependent cytotoxicity of antiviral drugs in primary cultures of human proximal tubular cells von Lash, Lawrence H., Lee, Caroline A., Wilker, Clynn, Shah, Vishal

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Membrane transporters in drug development von Giacomini, Kathleen M, Huang, Shiew-Mei, Tweedie, Donald J, Benet, Leslie Z, Brouwer, Kim L R, Chu, Xiaoyan, Dahlin, Amber, Evers, Raymond, Fischer, Volker, Hillgren, Kathleen M, Hoffmaster, Keith A, Ishikawa, Toshihisa, Keppler, Dietrich, Kim, Richard B, Lee, Caroline A, Niemi, Mikko, Polli, Joseph W, Sugiyama, Yuichi, Swaan, Peter W, Ware, Joseph A, Wright, Stephen H, Yee, Sook Wah, Zamek-Gliszczynski, Maciej J, Zhang, Lei

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In Vitro Assessment of the Drug-Drug Interaction Potential of Verinurad and Its Metabolites as Substrates and Inhibitors of Metabolizing Enzymes and Drug Transporters von Gopaul, V. Sashi, Vildhede, Anna, Andersson, Tommy B., Erlandsson, Fredrik, Lee, Caroline A., Johansson, Susanne, Hilgendorf, Constanze

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Transporter Expression in Noncancerous and Cancerous Liver Tissue from Donors with Hepatocellular Carcinoma and Chronic Hepatitis C Infection Quantified by LC-MS/MS Proteomics von Billington, Sarah, Ray, Adrian S, Salphati, Laurent, Xiao, Guangqing, Chu, Xiaoyan, Humphreys, W Griffith, Liao, Mingxiang, Lee, Caroline A, Mathias, Anita, Hop, Cornelis E C A, Rowbottom, Christopher, Evers, Raymond, Lai, Yurong, Kelly, Edward J, Prasad, Bhagwat, Unadkat, Jashvant D

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ITC Commentary on Metformin Clinical Drug–Drug Interaction Study Design That Enables an Efficacy‐ and Safety‐Based Dose Adjustment Decision von Zamek‐Gliszczynski, Maciej J., Chu, Xiaoyan, Cook, Jack A., Custodio, Joseph M., Galetin, Aleksandra, Giacomini, Kathleen M., Lee, Caroline A., Paine, Mary F., Ray, Adrian S., Ware, Joseph A., Wittwer, Matthias B., Zhang, Lei

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Characterization of Stereoselective Metabolism, Inhibitory Effect on Uric Acid Uptake Transporters, and Pharmacokinetics of Lesinurad Atropisomers von Yang, Chun, Zhou, Dongmei, Shen, Zancong, Wilson, David M, Renner, Matthew, Miner, Jeffrey N, Girardet, Jean-Luc, Lee, Caroline A

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Metabolism and Disposition of Verinurad, a Uric Acid Reabsorption Inhibitor, in Humans von Lee, Caroline A, Yang, Chun, Shah, Vishal, Shen, Zancong, Wilson, David M, Ostertag, Traci M, Girardet, Jean-Luc, Hall, Jesse, Gillen, Michael

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Safety, Pharmacokinetics, and Pharmacodynamics of Etrasimod: Single and Multiple Ascending Dose Studies in Healthy Adults von Lee, Caroline A., Schreiber, Stefan, Bressler, Brian, Adams, John W., Oh, Dooman Alexander, Tang, Yong Q., Zhang, Jinkun, Komori, Heather Kiyomi, Grundy, John S.

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Disposition and Mass Balance of Etrasimod in Healthy Subjects and In Vitro Determination of the Enzymes Responsible for Its Oxidative Metabolism von Lee, Caroline A., Oh, D. Alexander, Tang, Yong, Yi, Ping, Bashir, Mohammad, English, Stephen, Croft, Marie, Blackburn, Anthony, Bloom, Steve, Gilder, Kye, Grundy, John S.

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In vitro characterization of axitinib interactions with human efflux and hepatic uptake transporters: implications for disposition and drug interactions von Reyner, Eric L, Sevidal, Samantha, West, Mark A, Clouser-Roche, Andrea, Freiwald, Sascha, Fenner, Katherine, Ullah, Mohammed, Lee, Caroline A, Smith, Bill J

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Digoxin Is Not a Substrate for Organic Anion-Transporting Polypeptide Transporters OATP1A2, OATP1B1, OATP1B3, and OATP2B1 but Is a Substrate for a Sodium-Dependent Transporter Expr... von TAUB, Mitchell E, MEASE, Kirsten, SANE, Rucha S, WATSON, Cory A, LIANGFU CHEN, ELLENS, Harma, HIRAKAWA, Brad, REYNER, Eric L, JANI, Marton, LEE, Caroline A

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Effects of renal function on pharmacokinetics and pharmacodynamics of lesinurad in adult volunteers von Gillen, Michael, Valdez, Shakti, Zhou, Dongmei, Kerr, Bradley, Lee, Caroline A, Shen, Zancong

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Application of receiver operating characteristic analysis to refine the prediction of potential digoxin drug interactions von Ellens, Harma, Deng, Shibing, Coleman, Joann, Bentz, Joe, Taub, Mitchell E, Ragueneau-Majlessi, Isabelle, Chung, Sophie P, Herédi-Szabó, Krisztina, Neuhoff, Sibylle, Palm, Johan, Balimane, Praveen, Zhang, Lei, Jamei, Masoud, Hanna, Imad, O'Connor, Michael, Bednarczyk, Dallas, Forsgard, Malin, Chu, Xiaoyan, Funk, Christoph, Guo, Ailan, Hillgren, Kathleen M, Li, Libin, Pak, Anne Y, Perloff, Elke S, Rajaraman, Ganesh, Salphati, Laurent, Taur, Jan-Shiang, Weitz, Dietmar, Wortelboer, Heleen M, Xia, Cindy Q, Xiao, Guangqing, Yamagata, Tetsuo, Lee, Caroline A

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Refining the In Vitro and In Vivo Critical Parameters for P-Glycoprotein, [I]/IC50 and [I2]/IC50, That Allow for the Exclusion of Drug Candidates from Clinical Digoxin Interaction... von Cook, Jack A, Feng, Bo, Fenner, Katherine S, Kempshall, Sarah, Liu, Ray, Rotter, Charles, Smith, Dennis A, Troutman, Matthew D, Ullah, Mohammed, Lee, Caroline A

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Effect of Renal Impairment on the Pharmacokinetics and Pharmacodynamics of Verinurad, a Selective Uric Acid Reabsorption Inhibitor von Smith, William B., Hall, Jesse, Berg, Jolene K., Kazimir, Michal, Yamamoto, Amy, Walker, Susan, Lee, Caroline A., Shen, Zancong, Wilson, David M., Zhou, Dongmei, Gillen, Michael, Marbury, Thomas C.

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