Pharmacological AMPK activation induces transcriptional responses congruent to exercise in skeletal and cardiac muscle, adipose tissues and liver von Muise, Eric S, Guan, Hong-Ping, Liu, Jinqi, Nawrocki, Andrea R, Yang, Xiaodong, Wang, Chuanlin, Rodríguez, Carlos G, Zhou, Dan, Gorski, Judith N, Kurtz, Marc M, Feng, Danqing, Leavitt, Kenneth J, Wei, Lan, Wilkening, Robert R, Apgar, James M, Xu, Shiyao, Lu, Ku, Feng, Wen, Li, Ying, He, Huaibing, Previs, Stephen F, Shen, Xiaolan, van Heek, Margaret, Souza, Sandra C, Rosenbach, Mark J, Biftu, Tesfaye, Erion, Mark D, Kelley, David E, Kemp, Daniel M, Myers, Robert W, Sebhat, Iyassu K

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Structure-based design of potent and selective inhibitors of collagenase-3 (MMP-13) von Kim, Soong-Hoon, Pudzianowski, Andrew T., Leavitt, Kenneth J., Barbosa, Joseph, McDonnell, Patricia A., Metzler, William J., Rankin, Bruce M., Liu, Richard, Vaccaro, Wayne, Pitts, William

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Discovery and Preclinical Evaluation of [4-[[1-(3-fluorophenyl)methyl]-1H-indazol-5-ylamino]-5-methylpyrrolo[2,1-f][1,2,4]triazin-6-yl]carbamic Acid, (3S)-3-Morpholinylmethyl Ester... von Gavai, Ashvinikumar V, Fink, Brian E, Fairfax, David J, Martin, Gregory S, Rossiter, Lana M, Holst, Christian L, Kim, Soong-Hoon, Leavitt, Kenneth J, Mastalerz, Harold, Han, Wen-Ching, Norris, Derek, Goyal, Bindu, Swaminathan, Shankar, Patel, Bharat, Mathur, Arvind, Vyas, Dolatrai M, Tokarski, John S, Yu, Chiang, Oppenheimer, Simone, Zhang, Hongjian, Marathe, Punit, Fargnoli, Joseph, Lee, Francis Y, Wong, Tai W, Vite, Gregory D

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New dual inhibitors of EGFR and HER2 protein tyrosine kinases von Fink, Brian E., Vite, Gregory D., Mastalerz, Harold, Kadow, John F., Kim, Soong-Hoon, Leavitt, Kenneth J., Du, Karen, Crews, Donald, Mitt, Toomas, Wong, Tai W., Hunt, John T., Vyas, Dolatrai M., Tokarski, John S.

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Identification of 2-amino-5-(thioaryl)thiazoles as inhibitors of nerve growth factor receptor TrkA von Kim, Soong-Hoon, Tokarski, John S., Leavitt, Kenneth J., Fink, Brian E., Salvati, Mark E., Moquin, Robert, Obermeier, Mary T., Trainor, George L., Vite, Gregory G., Stadnick, Linda K., Lippy, Jonathan S., You, Dan, Lorenzi, Matthew V., Chen, Ping

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Pyrrolopyridazine MEK inhibitors von Chen, Zhong, Kim, Soong-Hoon, Barbosa, Stephanie A., Huynh, Tram, Tortolani, David R., Leavitt, Kenneth J., Wei, Donna D., Manne, Veeraswamy, Ricca, Carolyn S., Gullo-Brown, Johnni, Poss, Michael A., Vaccaro, Wayne, Salvati, Mark E.

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Discovery and Preclinical Studies of (R)-1-(4-(4-Fluoro-2-methyl-1H-indol-5-yloxy)-5- methylpyrrolo[2,1-f][1,2,4]triazin-6-yloxy)propan- 2-ol (BMS-540215), an In Vivo Active Potent... von Bhide, Rajeev S, Cai, Zhen-Wei, Zhang, Yong-Zheng, Qian, Ligang, Wei, Donna, Barbosa, Stephanie, Lombardo, Louis J, Borzilleri, Robert M, Zheng, Xiaoping, Wu, Laurence I, Barrish, Joel C, Kim, Soong-Hoon, Leavitt, Kenneth, Mathur, Arvind, Leith, Leslie, Chao, Sam, Wautlet, Barri, Mortillo, Steven, Jeyaseelan, Robert, Kukral, Daniel, Hunt, John T, Kamath, Amrita, Fura, Aberra, Vyas, Viral, Marathe, Punit, D'Arienzo, Celia, Derbin, George, Fargnoli, Joseph

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5-((4-Aminopiperidin-1-yl)methyl)pyrrolotriazine dual inhibitors of EGFR and HER2 protein tyrosine kinases von Mastalerz, Harold, Chang, Ming, Chen, Ping, Fink, Brian E., Gavai, Ashvinikumar, Han, Wen-Ching, Johnson, Walter, Langley, David, Lee, Francis Y., Leavitt, Kenneth, Marathe, Punit, Norris, Derek, Oppenheimer, Simone, Sleczka, Bogdan, Tarrant, James, Tokarski, John S., Vite, Gregory D., Vyas, Dolatrai M., Wong, Henry, Wong, Tai W., Zhang, Hongjian, Zhang, Guifen

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Discovery and Preclinical Evaluation of [4-[[1-(3-fluorophenyl)methyl]-1 H -indazol-5-ylamino]-5-methylpyrrolo[2,1- f ][1,2,4]triazin-6-yl]carbamic Acid, (3 S )-3-Morpholinylmethyl... von Gavai, Ashvinikumar V., Fink, Brian E., Fairfax, David J., Martin, Gregory S., Rossiter, Lana M., Holst, Christian L., Kim, Soong-Hoon, Leavitt, Kenneth J., Mastalerz, Harold, Han, Wen-Ching, Norris, Derek, Goyal, Bindu, Swaminathan, Shankar, Patel, Bharat, Mathur, Arvind, Vyas, Dolatrai M., Tokarski, John S., Yu, Chiang, Oppenheimer, Simone, Zhang, Hongjian, Marathe, Punit, Fargnoli, Joseph, Lee, Francis Y., Wong, Tai W., Vite, Gregory D.

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SAR and pH Stability of Cyano-Substituted Epothilones von Regueiro-Ren, Alicia, Leavitt, Kenneth, Kim, Soong-Hoon, Höfle, Gerhard, Kiffe, Michael, Gougoutas, Jack Z, DiMarco, John D, Lee, Francis Y. F, Fairchild, Craig R, Long, Byron H, Vite, Gregory D

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SPIROPIPERIDINE ALLOSTERIC MODULATORS OF NICOTINIC ACETYLCHOLINE RECEPTORS von CAMPBELL, Brian, CHOBANIAN, Harry, GRESHOCK, Thomas, RADA, Vanessa, FELLS, James, BELL, Ian, LEAVITT, Kenneth, CROWLEY, Brendan, GUIADEEN, Deodial

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SPIROPIPERIDIN SOM ALLOSTERISKE MODULATORER AF NICOTINACETYLCHOLINRECEPTORER von LEAVITT, Kenneth, J, BELL, Ian, M, RADA, Vanessa, L, CROWLEY, Brendan, M, CAMPBELL, Brian, T, GUIADEEN, Deodial, G, CHOBANIAN, Harry, R, FELLS, James, I, GRESHOCK, Thomas, J

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SPIROPIPERIDINE ALLOSTERIC MODULATORS OF NICOTINIC ACETYLCHOLINE RECEPTORS von LEAVITT, Kenneth, J, BELL, Ian, M, RADA, Vanessa, L, CROWLEY, Brendan, M, CAMPBELL, Brian, T, GUIADEEN, Deodial, G, CHOBANIAN, Harry, R, FELLS, James, I, GRESHOCK, Thomas, J

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Allosteric modulators of nicotinic acetylcholine receptors von Crowley, Brendan, Huff, Belinda, Suen, Linda, Campbell, Brian, Rada, Vanessa, Greshock, Thomas, Leavitt, Kenneth, Sanders, John, Guiadeen, Deodial, Duffy, Joseph, Harvey, Andrew John, Bell, Ian, Shipe, William

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Discovery and preclinical studies of (R)-1-(4-(4-fluoro-2-methyl- 1H-indol-5-yloxy)-5-methylpyrrolo[2,1-/][1,2,4]triazin-6-yloxy)propan2-ol (BMS-540215), an in vivo active potent V... von BHIDE, Rajeev S, CAI, Zhen-Wei, BARRISH, Joel C, KIM, Soong-Hoon, LEAVITT, Kenneth, MATHUR, Arvind, LEITH, Leslie, CHAO, Sam, WAUTLET, Barri, MORTILLO, Steven, JEYASEELAN, Robert, KUKRAL, Daniel, ZHANG, Yong-Zheng, HUNT, John T, KAMATH, Amrita, FURA, Aberra, VYAS, Viral, MARATHE, Punit, D'ARIENZO, Celia, DERBIN, George, FARGNOLI, Joseph, LIGANG QIAN, WEI, Donna, BARBOSA, Stephanie, LOMBARDO, Louis J, BORZILLERI, Robert M, XIAOPING ZHENG, WU, Laurence I

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SPIROPIPERIDINE ALLOSTERIC MODULATORS OF NICOTINIC ACETYLCHOLINE RECEPTORS von LEAVITT, KENNETH J, CROWLEY, BRENDAN M, CHOBANIAN, HARRY R, GRESHOCK, THOMAS J, RADA, VANESSA L, BELL, IAN M, CAMPBELL, BRIAN T, GUIADEEN, DEODIAL G, FELLS, JAMES I

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SPIROPIPERIDINE ALLOSTERIC MODULATORS OF NICOTINIC ACETYLCHOLINE RECEPTORS von LEAVITT, Kenneth, J, BELL, Ian, M, RADA, Vanessa, L, CROWLEY, Brendan, M, Guiadiin, Deodial, G, CAMPBELL, Brian, T, CHOBANIAN, Harry, R, FELLS, James, I, GRESHOCK, Thomas, J

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ALLOSTERIC MODULATORS OF NICOTINIC ACETYLCHOLINE RECEPTORS von CAMPBELL, Brian, GRESHOCK, Thomas, RADA, Vanessa, DUFFY, Joseph, BELL, Ian, CROWLEY, Brendan, GUIADEEN, Deodial, LEAVITT, Kenneth, SANDERS, John, SHIPE, William, HUFF, Belinda, SUEN, Linda, HARVEY, Andrew John

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Spiropiperidine allosteric modulators of nicotinic acetylcholine receptors von Greshock, Thomas J, Leavitt, Kenneth J, Crowley, Brendan M, Fells, James I, Bell, Ian M, Rada, Vanessa L, Chobanian, Harry R, Guiadeen, Deodial G, Campbell, Brian T

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ALLOSTERIC MODULATORS OF NICOTINIC ACETYLCHOLINE RECEPTORS von CAMPBELL, BRIAN, T, SANDERS, JOHN, M, CROWLEY, BRENDAN M, HARVEY, ANDREW JOHN, SHIPE, WILLIAM, D, LEAVITT, KENNETH, J, BELL, IAN, M, RADA, VANESSA, L, GRESHOCK, THOMAS J, GUIADEEN, DEODIAL, G, DUFFY, JOSEPH, L, SUEN, LINDA, M, HUFF, BELINDA, C

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