Synthesis of the phorboxazoles—potent, architecturally novel marine natural products von Shultz, Zachary, Leahy, James W

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Structural and Mechanistic Analysis of Drosophila melanogaster Agmatine N-Acetyltransferase, an Enzyme that Catalyzes the Formation of N-Acetylagmatine von Dempsey, Daniel R., Nichols, Derek A., Battistini, Matthew R., Pemberton, Orville, Ospina, Santiago Rodriguez, Zhang, Xiujun, Carpenter, Anne-Marie, O’Flynn, Brian G., Leahy, James W., Kanwar, Ankush, Lewandowski, Eric M., Chen, Yu, Merkler, David J.

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Enantioselective Total Synthesis of CannabinoidsA Route for Analogue Development von Shultz, Zachary P, Lawrence, Grant A, Jacobson, Jeffrey M, Cruz, Emmanuel J, Leahy, James W

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Alkyne modified purines for assessment of activation of Plasmodium vivax hypnozoites and growth of pre-erythrocytic and erythrocytic stages in Plasmodium spp von Botnar, Alona, Lawrence, Grant, Maher, Steven P., Vantaux, Amélie, Witkowski, Benoît, Shiau, Justine C., Merino, Emilio F., De Vore, David, Yang, Christian, Murray, Cameron, Cassera, Maria B., Leahy, James W., Kyle, Dennis E.

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Naegleria fowleri: Protein structures to facilitate drug discovery for the deadly, pathogenic free-living amoeba von Tillery, Logan, Barrett, Kayleigh, Goldstein, Jenna, Lassner, Jared W, Osterhout, Bram, Tran, Nathan L, Xu, Lily, Young, Ryan M, Craig, Justin, Chun, Ian, Dranow, David M, Abendroth, Jan, Delker, Silvia L, Davies, Douglas R, Mayclin, Stephen J, Calhoun, Brandy, Bolejack, Madison J, Staker, Bart, Subramanian, Sandhya, Phan, Isabelle, Lorimer, Donald D, Myler, Peter J, Edwards, Thomas E, Kyle, Dennis E, Rice, Christopher A, Morris, James C, Leahy, James W, Manetsch, Roman, Barrett, Lynn K, Smith, Craig L, Van Voorhis, Wesley C

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Selective targeting of Plasmodium falciparum Hsp90 disrupts the 26S proteasome von Mansfield, Christopher R., Quan, Baiyi, Chirgwin, Michael E., Eduful, Benjamin, Hughes, Philip F., Neveu, Gaëlle, Sylvester, Kayla, Ryan, Daniel H., Kafsack, Björn F.C., Haystead, Timothy A.J., Leahy, James W., Fitzgerald, Michael C., Derbyshire, Emily R.

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Enantioselective Total Synthesis of the Antitumor Macrolide Rhizoxin D von Lafontaine, Jennifer A, Provencal, David P, Gardelli, Cristina, Leahy, James W

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Benzothiazole Substitution Analogs of Rhodacyanine Hsp70 Inhibitors Modulate Tau Accumulation von Hill, Shannon E., Beaulieu-Abdelahad, David, Lemus, Andrea, Webster, Jack M., Ospina, Santiago Rodriguez, Darling, April L., Martin, Mackenzie D., Patel, Shreya, Bridenstine, Liznair, Swonger, Ronald, Paul, Steven, Blackburn, Roy, Calcul, Laurent, Dickey, Chad A., Leahy, James W., Blair, Laura J.

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Targeting the FKBP51/GR/Hsp90 Complex to Identify Functionally Relevant Treatments for Depression and PTSD von Sabbagh, Jonathan J, Cordova, Ricardo A, Zheng, Dali, Criado-Marrero, Marangelie, Lemus, Andrea, Li, Pengfei, Baker, Jeremy D, Nordhues, Bryce A, Darling, April L, Martinez-Licha, Carlos, Rutz, Daniel A, Patel, Shreya, Buchner, Johannes, Leahy, James W, Koren, John, Dickey, Chad A, Blair, Laura J

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Discovery of a Novel Class of Highly Potent, Selective, ATP-Competitive, and Orally Bioavailable Inhibitors of the Mammalian Target of Rapamycin (mTOR) von Takeuchi, Craig S, Kim, Byung Gyu, Blazey, Charles M, Ma, Sunghoon, Johnson, Henry W. B, Anand, Neel K, Arcalas, Arlyn, Baik, Tae Gon, Buhr, Chris A, Cannoy, Jonah, Epshteyn, Sergey, Joshi, Anagha, Lara, Katherine, Lee, Matthew S, Wang, Longcheng, Leahy, James W, Nuss, John M, Aay, Naing, Aoyama, Ron, Foster, Paul, Lee, Jae, Lehoux, Isabelle, Munagala, Narsimha, Plonowski, Arthur, Rajan, Sharmila, Woolfrey, John, Yamaguchi, Kyoko, Lamb, Peter, Miller, Nicole

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Characterization of Arylalkylamine N‑Acyltransferase from Tribolium castaneum: An Investigation into a Potential Next-Generation Insecticide Target von O’Flynn, Brian G, Lewandowski, Eric M, Prins, Karin Claire, Suarez, Gabriela, McCaskey, Angelica N, Rios-Guzman, Nasha M, Anderson, Ryan L, Shepherd, Britney A, Gelis, Ioannis, Leahy, James W, Chen, Yu, Merkler, David J

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Identification and Characterization of Novel Bronchodilator Agonists Acting at Human Airway Smooth Muscle Cell TAS2R5 von Kim, Donghwa, An, Steven S, Lam, Hong, Leahy, James W, Liggett, Stephen B

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Shotgun Kinetic Target-Guided Synthesis Approach Enables the Discovery of Small-Molecule Inhibitors against Pathogenic Free-Living Amoeba Glucokinases von Kassu, Mintesinot, Parvatkar, Prakash T., Milanes, Jillian, Monaghan, Neil P., Kim, Chungsik, Dowgiallo, Matthew, Zhao, Yingzhao, Asakawa, Ami H., Huang, Lili, Wagner, Alicia, Miller, Brandon, Carter, Karissa, Barrett, Kayleigh F., Tillery, Logan M., Barrett, Lynn K., Phan, Isabelle Q., Subramanian, Sandhya, Myler, Peter J., Van Voorhis, Wesley C., Leahy, James W., Rice, Christopher A., Kyle, Dennis E., Morris, James, Manetsch, Roman

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Discovery of a Novel Series of Potent and Orally Bioavailable Phosphoinositide 3-Kinase γ Inhibitors von Leahy, James W, Buhr, Chris A, Johnson, Henry W. B, Kim, Byung Gyu, Baik, TaeGon, Cannoy, Jonah, Forsyth, Timothy P, Jeong, Joon Won, Lee, Matthew S, Ma, Sunghoon, Noson, Kevin, Wang, Longcheng, Williams, Matthew, Nuss, John M, Brooks, Eric, Foster, Paul, Goon, Leanne, Heald, Nathan, Holst, Charles, Jaeger, Christopher, Lam, Scott, Lougheed, Julie, Nguyen, Lam, Plonowski, Arthur, Song, Joanne, Stout, Thomas, Wu, Xiang, Yakes, Michael F, Yu, Peiwen, Zhang, Wentao, Lamb, Peter, Raeber, Olivia

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Identification of a Hit Series of Antileishmanial Compounds through the Use of Mixture-Based Libraries von Giulianotti, Marc A, Vesely, Brian A, Azhari, Ala, Souza, Ashley, LaVoi, Travis, Houghten, Richard A, Kyle, Dennis E, Leahy, James W

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Inactivation of peptidylglycine α-hydroxylating monooxygenase by cinnamic acid analogs von McIntyre, Neil R., Lowe, Edward W., Battistini, Matthew R., Leahy, James W., Merkler, David J.

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Synthesis and Activity of a New Series of Antileishmanial Agents von Kanwar, Ankush, Eduful, Benjamin J, Barbeto, Linda, Carletti Bonomo, Piero, Lemus, Andrea, Vesely, Brian A, Mutka, Tina S, Azhari, Ala, Kyle, Dennis E, Leahy, James W

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SAR and in vivo evaluation of 4-aryl-2-aminoalkylpyrimidines as potent and selective Janus kinase 2 (JAK2) inhibitors von Forsyth, Timothy, Kearney, Patrick C., Kim, Byung Gyu, Johnson, Henry W.B., Aay, Naing, Arcalas, Arlyn, Brown, David S., Chan, Vicky, Chen, Jeff, Du, Hongwang, Epshteyn, Sergey, Galan, Adam A., Huynh, Tai P., Ibrahim, Mohamed A., Kane, Brian, Koltun, Elena S., Mann, Grace, Meyr, Lisa E., Lee, Matthew S., Lewis, Gary L., Noguchi, Robin T., Pack, Michael, Ridgway, Brian H., Shi, Xian, Takeuchi, Craig S., Zu, Peiwen, Leahy, James W., Nuss, John M., Aoyama, Ron, Engst, Stefan, Gendreau, Steven B., Kassees, Robert, Li, Jia, Lin, Shwu-Hwa, Martini, Jean-Francois, Stout, Thomas, Tong, Philip, Woolfrey, John, Zhang, Wentao, Yu, Peiwen

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Discovery of a Novel Class of Potent and Orally Bioavailable Sphingosine 1-Phosphate Receptor 1 Antagonists von Ibrahim, Mohamed A, Johnson, Henry W. B, Jeong, Joon Won, Lewis, Gary L, Shi, Xian, Noguchi, Robin T, Williams, Matthew, Leahy, James W, Nuss, John M, Woolfrey, John, Banica, Monica, Bentzien, Frauke, Chou, Yu-Chien, Gibson, Anna, Heald, Nathan, Lamb, Peter, Mattheakis, Larry, Matthews, David, Shipway, Aaron, Wu, Xiang, Zhang, WenTao, Zhou, Sihong, Shankar, Geetha

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A Unified Total Synthesis of the Immunomodulators (−)-Rapamycin and (−)-27-Demethoxyrapamycin:  Construction of the C(21−42) Perimeters von Smith, Amos B, Condon, Stephen M, McCauley, John A, Leazer, Johnnie L, Leahy, James W, Maleczka, Robert E

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